Z. Lygerou

发表

Maximal loading of MCM 2 / 4 in late G 1 1 Multi-step loading of human Mini Chromosome Maintenance proteins in live human cells *

P. Bastiaens, P. Kotsantis, H. Grecco, 2013 .

Multi-step Loading of Human Minichromosome Maintenance Proteins in Live Human Cells*

Zoi Lygerou, Philippe Bastiaens, Vassilis Roukos, 2013, The Journal of Biological Chemistry.

Control over DNA replication in time and space

Zoi Lygerou, Ioanna-Eleni Symeonidou, I. Symeonidou, 2012, FEBS letters.

Control of DNA replication licensing in a cell cycle

H. Nishitani, Z. Lygerou, 2002, Genes to cells : devoted to molecular & cellular mechanisms.

Dynamic recruitment of licensing factor Cdt1 to sites of DNA damage

P. Bastiaens, E. Stelzer, P. Kotsantis, 2011, Journal of Cell Science.

Stochastic hybrid modeling of DNA replication across a complete genome

Grigoriy E. Pinchuk, Samantha B. Reed, J. Lygeros, 2009 .

The Cdt1 protein is required to license DNA for replication in fission yeast

Zoi Lygerou, Takeharu Nishimoto, Paul Nurse, 2000, Nature.

CK1δ restrains lipin-1 induction, lipid droplet formation and cell proliferation under hypoxia by reducing HIF-1α/ARNT complex formation

U. Landegren, S. Siniossoglou, I. Mylonis, 2015, Cellular signalling.

Accurate Processing of a Eukaryotic Precursor Ribosomal RNA by Ribonuclease MRP in Vitro

B. Séraphin, D. Tollervey, Z. Lygerou, 1996, Science.

In silico analysis of DNA re-replication across a complete genome reveals cell-to-cell heterogeneity and genome plasticity

J. Lygeros, M. Rapsomaniki, S. Taraviras, 2020, bioRxiv.

Concise Review: Geminin—A Tale of Two Tails: DNA Replication and Transcriptional/Epigenetic Regulation in Stem Cells

D. Karamitros, S. Taraviras, Z. Lygerou, 2017, Stem cells.

Chromatin and Nuclear Architecture: Shaping DNA Replication in 3D.

S. Taraviras, Z. Lygerou, Patroula Nathanailidou, 2020, Trends in genetics : TIG.

DNA replication licensing.

H. Nishitani, Z. Lygerou, H Nishitani, 2004, Frontiers in bioscience : a journal and virtual library.

Direct binding of Cdt2 to PCNA is important for targeting the CRL4Cdt2 E3 ligase activity to Cdt1

T. Ishii, A. Perrakis, Tatsuro S. Takahashi, 2018, Life Science Alliance.

Direct binding of Cdt2 to PCNA is important for targeting the CRL4Cdt2 E3 ligase activity to Cdt1

T. Ishii, A. Perrakis, Tatsuro S. Takahashi, 2018, bioRxiv.

Mature T Cells Proliferation of Thymocytes and Differential Geminin Requirement for

H. Veiga-Fernandes, V. Pachnis, D. Karamitros, 2010 .

Differential Geminin Requirement for Proliferation of Thymocytes and Mature T Cells

D. Kioussis, H. Veiga-Fernandes, V. Pachnis, 2010, The Journal of Immunology.

Life without geminin

D. Kioussis, H. Veiga-Fernandes, V. Pachnis, 2010, Cell cycle.

Two E3 ubiquitin ligases, SCF‐Skp2 and DDB1‐Cul4, target human Cdt1 for proteolysis

K. Nakayama, K. Nakayama, C. Obuse, 2006, The EMBO journal.

The Licensing Factor Cdt1 Links Cell Cycle Progression to the DNA Damage Response

Spyridon Champeris Tsaniras, Z. Lygerou, Nickolaos-Nikiforos Giakoumakis, 2020, AntiCancer Research.

Cdt1 Is Differentially Targeted for Degradation by Anticancer Chemotherapeutic Drugs

P. Kotsantis, Vassilis Roukos, H. Nishitani, 2012, PloS one.

Proteolysis of DNA Replication Licensing Factor Cdt1 in S-phase Is Performed Independently of Geminin through Its N-terminal Region*

T. Nishimoto, H. Nishitani, Z. Lygerou, 2004, Journal of Biological Chemistry.

Mcidas and GemC1 are key regulators for the generation of multiciliated ependymal cells in the adult neurogenic niche

M. Götz, S. Taraviras, Z. Lygerou, 2015, Development.

CRL4Cdt2: Coupling Genome Stability to Ubiquitination.

H. Nishitani, S. Taraviras, Z. Lygerou, 2020, Trends in cell biology.

Analysis of Protein Kinetics Using Fluorescence Recovery After Photobleaching (FRAP).

M. Rapsomaniki, Z. Lygerou, Nickolaos-Nikiforos Giakoumakis, 2017, Methods in molecular biology.

Reduced Geminin levels promote cellular senescence

D. Karamitros, S. Taraviras, Z. Lygerou, 2013, Mechanisms of Ageing and Development.

Controlling centriole numbers: Geminin family members as master regulators of centriole amplification and multiciliogenesis

S. Taraviras, Z. Lygerou, Dafni-Eleftheria Pefani, 2018, Chromosoma.

Ras suppressor-1 (RSU1) exerts a tumor suppressive role with prognostic significance in lung adenocarcinoma

H. Kalofonos, V. Zolota, S. Taraviras, 2022, Clinical and Experimental Medicine.

Small Molecule Inhibitor Targeting CDT1/Geminin Protein Complex Promotes DNA Damage and Cell Death in Cancer Cells

D. Egan, Joe D. Lewis, A. Fish, 2022, Frontiers in Pharmacology.

Intrinsic neural stem cell properties define brain hypersensitivity to genotoxic stress

S. Taraviras, Z. Lygerou, V. Bravou, 2022, Stem cell reports.

Cdt1 and geminin are down-regulated upon cell cycle exit and are over-expressed in cancer-derived cell lines.

P. Nurse, G. Xouri, V. Pachnis, 2004, European journal of biochemistry.

Cell Cycle-dependent Subcellular Translocation of the Human DNA Licensing Inhibitor Geminin*

G. Xouri, H. Nishitani, I. Symeonidou, 2013, The Journal of Biological Chemistry.

License Withheld--Geminin Blocks DNA Replication

P. Nurse, Z. Lygerou, 2000, Science.

The fission yeast origin recognition complex is constitutively associated with chromatin and is differentially modified through the cell cycle

P. Nurse, Z. Lygerou, Paul Nurse, 1999 .

Mcidas and GemC1/Lynkeas specify embryonic radial glial cells

S. Taraviras, Z. Lygerou, C. Kyrousi, 2016, Neurogenesis.

Title: Mcidas and GemC1/Lynkeas are key regulators for the generation of multiciliated ependymal cells in the adult neurogenic niche.

M. Götz, S. Taraviras, Z. Lygerou, 2015 .

Expression of α-Defensins, CD20+ B-lymphocytes, and Intraepithelial CD3+ T-lymphocytes in the Intestinal Mucosa of Patients with Liver Cirrhosis: Emerging Mediators of Intestinal Barrier Function

Z. Lygerou, S. Assimakopoulos, K. Thomopoulos, 2018, Digestive Diseases and Sciences.

McIdas localizes at centrioles and controls centriole numbers through PLK4-dependent phosphorylation

M. Mann, Sihem Zitouni, M. Bettencourt-Dias, 2022, bioRxiv.

A Custom Ultra-Low-Cost 3D Bioprinter Supports Cell Growth and Differentiation

S. Taraviras, Z. Lygerou, S. Champeris Tsaniras, 2020, Frontiers in Bioengineering and Biotechnology.

Replication Licensing Aberrations, Replication Stress, and Genomic Instability.

S. Taraviras, Z. Lygerou, S. Champeris Tsaniras, 2019, Trends in biochemical sciences.

Metabolic regulation of the neural stem cell fate: Unraveling new connections, establishing new concepts

G. Gakis, S. Taraviras, Z. Lygerou, 2022, Frontiers in Neuroscience.

Visualizing the dynamics of histone variants in the S-phase nucleus

S. Taraviras, Z. Lygerou, Stella Maxouri, 2018, Genome Biology.

Cdt1 Interactions in the Licensing Process: A Model for Dynamic Spatio-temporal Control of Licensing

Maria Dimaki, Zoi Lygerou, P. Bastiaens, 2007, Cell cycle.

Mismatch repair regulates Cdt1 after UV damage

S. Taraviras, Z. Lygerou, Andreas Panagopoulos, 2017, Cell cycle.

Ex vivo analysis of DNA repair targeting in extreme rare cutaneous apocrine sweat gland carcinoma

J. Kononen, J. Rantala, O. Sangfelt, 2021, Oncotarget.

Cell cycle. License withheld--geminin blocks DNA replication.

P. Nurse, Z. Lygerou, 2000, Science.

53BP1‐mediated recruitment of RASSF1A to ribosomal DNA breaks promotes local ATM signaling

E. O’Neill, G. Velimezi, V. Gorgoulis, 2022, EMBO reports.

53BP1 mediated recruitment of RASSF1A at ribosomal DNA breaks facilitates local ATM signal amplification

G. Velimezi, V. Gorgoulis, D. Karamitros, 2021, bioRxiv.

Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability

L. Scorrano, Z. Livneh, J. Bartek, 2017, Genome Biology.

hPop1: an autoantigenic protein subunit shared by the human RNase P and RNase MRP ribonucleoproteins.

B. Séraphin, H. Pluk, Z. Lygerou, 1996, The EMBO journal.

Geminin deletion increases the number of fetal hematopoietic stem cells by affecting the expression of key transcription factors

V. Beneš, D. Kioussis, D. Karamitros, 2015, Development.

Geminin ablation in vivo enhances tumorigenesis through increased genomic instability

V. Gorgoulis, S. Taraviras, Z. Lygerou, 2018, The Journal of pathology.

The Human Licensing Factor for DNA Replication Cdt1 Accumulates in G1 and Is Destabilized after Initiation of S-phase*

Zoi Lygerou, Takeharu Nishimoto, T. Nishimoto, 2001, The Journal of Biological Chemistry.

Running title : Geminin ablation in vivo enhances tumorigenesis Conflicts of Interest

Spyridon Champeris Tsaniras, Lalioti, V. Gorgoulis, 2018 .

Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior.

Dimitris Kletsas, Jiri Bartek, Vassilis G Gorgoulis, 2007, Cancer research.

Licensing of DNA replication, cancer, pluripotency and differentiation: an interlinked world?

I. Symeonidou, S. Taraviras, Z. Lygerou, 2014, Seminars in cell & developmental biology.

Licensing regulators Geminin and Cdt1 identify progenitor cells of the mouse CNS in a specific phase of the cell cycle

F. Guillemot, O. Britz, R. Ramsay, 2007, Neuroscience.

RNA-seq and microarray Data Analysis related to skin psoriasis, Overview of Optimal Methods for RNA-seq Analysis and Application for Biomarker Discovery for Skin-related Disorders

S. Tsoka, Z. Lygerou, S. Mavroudi, 2019 .

The POP1 gene encodes a protein component common to the RNase MRP and RNase P ribonucleoproteins.

B. Séraphin, P. Mitchell, E. Petfalski, 1994, Genes & development.

T cell proliferation and homeostasis: an emerging role for the cell cycle inhibitor geminin.

D. Kioussis, D. Karamitros, S. Taraviras, 2011, Critical reviews in immunology.

A Novel Genetic Screen for snRNP Assembly Factors in Yeast Identifies a Conserved Protein, Sad1p, Also Required for Pre-mRNA Splicing

B. Séraphin, G. Christophides, Z. Lygerou, 1999, Molecular and Cellular Biology.

The yeast BDF1 gene encodes a transcription factor involved in the expression of a broad class of genes including snRNAs.

B. Séraphin, A. Sentenac, M. Carlson, 1994, Nucleic acids research.

GemC1 is a critical switch for neural stem cell generation in the postnatal brain

K. Kahle, N. Spassky, S. Taraviras, 2019, Glia.

GemC1 governs multiciliogenesis through direct interaction with and transcriptional regulation of p73

V. Beneš, S. Taraviras, Z. Lygerou, 2019, Journal of Cell Science.

Overexpression of the replication licensing regulators hCdt1 and hCdc6 characterizes a subset of non-small-cell lung carcinomas: synergistic effect with mutant p53 on tumor growth and chromosomal instability--evidence of E2F-1 transcriptional control over hCdt1.

Vassilis G Gorgoulis, Zoi Lygerou, A. Papavassiliou, 2004, The American journal of pathology.

Fanconi anemia proteins and genome fragility: unraveling replication defects for cancer therapy.

S. Taraviras, Z. Lygerou, Nibal Badra Fajardo, 2022, Trends in cancer.

Integrin-linked kinase (ILK) regulates KRAS, IPP complex and Ras suppressor-1 (RSU1) promoting lung adenocarcinoma progression and poor survival

H. Papadaki, H. Kalofonos, V. Zolota, 2020, Journal of Molecular Histology.

easyFRAP: an interactive, easy-to-use tool for qualitative and quantitative analysis of FRAP data

Maria Anna Rapsomaniki, Nickolaos-Nikiforos Giakoumakis, Stavros L. Taraviras, 2012, Bioinform..

GemC1 controls multiciliogenesis in the airway epithelium

S. Taraviras, Z. Lygerou, A. Papanastasiou, 2016, EMBO reports.

Geminin Regulates Cortical Progenitor Proliferation and Differentiation

D. Kioussis, F. Guillemot, V. Pachnis, 2011, Stem cells.

Inactivation of Geminin in neural crest cells affects the generation and maintenance of enteric progenitor cells, leading to enteric aganglionosis.

V. Pachnis, D. Natarajan, S. Taraviras, 2016, Developmental biology.

The Geminin and Idas Coiled Coils Preferentially Form a Heterodimer That Inhibits Geminin Function in DNA Replication Licensing*

J. Blow, A. Perrakis, P. J. Gillespie, 2013, The Journal of Biological Chemistry.

Idas, a Novel Phylogenetically Conserved Geminin-related Protein, Binds to Geminin and Is Required for Cell Cycle Progression*

A. Perrakis, I. Symeonidou, S. Taraviras, 2011, The Journal of Biological Chemistry.

TISSUE-SPECIFIC STEM CELLS Geminin Regulates Cortical Progenitor Proliferation and Differentiation

D. Kioussis, F. Guillemot, V. Pachnis, 2011 .

Geminin Cleavage during Apoptosis by Caspase-3 Alters Its Binding Ability to the SWI/SNF Subunit Brahma*

M. Wilm, Vassilis Roukos, M. Gentzel, 2007, Journal of Biological Chemistry.

Expression of Cdc18/Cdc6 and Cdt1 during G2 phase induces initiation of DNA replication

P. Nurse, Z. Lygerou, S. Yanow, 2001, The EMBO journal.

DNA Replication Control: Liquid-liquid Phase Separation Comes Into Play.

S. Taraviras, Z. Lygerou, Patroula Nathanailidou, 2020, Journal of molecular biochemistry.

Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing

R. Medema, D. Svergun, J. Blow, 2009, Proceedings of the National Academy of Sciences.

Fine‐tuning multiciliated cell differentiation at the post‐transcriptional level: contribution of miR‐34/449 family members

S. Taraviras, Z. Lygerou, S. Grigoriadis, 2021, Biological reviews of the Cambridge Philosophical Society.

Cdt1 overexpression drives colorectal carcinogenesis through origin overlicensing and DNA damage

T. Halazonetis, V. Gorgoulis, Vassilis Roukos, 2022, The Journal of pathology.

Aberrant replication licensing drives Copy Number Gains across species

V. Beneš, I. Symeonidou, S. Taraviras, 2020, bioRxiv.

A stochastic hybrid model of DNA replication incorporating 3D protein mobility dynamics

John Lygeros, María Rodríguez Martínez, Maria Anna Rapsomaniki, 2019, bioRxiv.

Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatin

Maria Dimaki, Zoi Lygerou, Peter J Verveer, 2007, The EMBO journal.

Parameter Identification for a DNA replication model

John Lygeros, Konstantinos Koutroumpas, Zoi Lygerou, 2008, 2008 8th IEEE International Conference on BioInformatics and BioEngineering.

How a radial glial cell decides to become a multiciliated ependymal cell

S. Taraviras, Z. Lygerou, C. Kyrousi, 2017, Glia.

DNA for replication in ® ssion yeast

P. Nurse, T. Nishimoto, H. Nishitani, 2022 .

The Cdt 1 protein is required to license DNA for replication in ® ssion yeast

P. Nurse, T. Nishimoto, H. Nishitani, 2022 .

EasyFRAP-web: a web-based tool for the analysis of fluorescence recovery after photobleaching data

Maria Anna Rapsomaniki, Grigorios Koulouras, Andreas Panagopoulos, 2018, Nucleic Acids Res..

DNA replication in the fission yeast: robustness in the face of uncertainty

John Lygeros, Sotiris Dimopoulos, Zoi Lygerou, 2006, Yeast.

Focal adhesion proteins in hepatocellular carcinoma: RSU1 a novel tumour suppressor with prognostic significance.

V. Tzelepi, Z. Lygerou, V. Bravou, 2022, Pathology, research and practice.

Ribosomal DNA and the nucleolus at the heart of aging.

S. Taraviras, Z. Lygerou, Dafni-Eleftheria Pefani, 2022, Trends in biochemical sciences.

Alterations in the spatiotemporal expression pattern of geminin during human epidermal morphogenesis.

S. Taraviras, Z. Lygerou, G. Stamatiou, 2023, Acta dermatovenerologica Alpina, Pannonica, et Adriatica.

The structure of the GemC1 coiled coil and its interaction with the Geminin family of coiled-coil proteins

A. Fish, A. Perrakis, S. Taraviras, 2015, Acta crystallographica. Section D, Biological crystallography.

Cortical Development and Brain Malformations: Insights From the Differential Regulation of Early Events of DNA Replication

S. Taraviras, Z. Lygerou, Argyro Kalogeropoulou, 2019, Front. Cell Dev. Biol..

Controlling S-phase onset in fission yeast.

P. Nurse, Z. Lygerou, 2000, Cold Spring Harbor symposia on quantitative biology.

3D Reconstitution of the Neural Stem Cell Niche: Connecting the Dots

G. Gakis, S. Taraviras, Z. Lygerou, 2021, Frontiers in Bioengineering and Biotechnology.

IPP Complex Reinforces Adhesion by Relaying Tension-Dependent Signals to Inhibit Integrin Turnover.

M. Rapsomaniki, Z. Lygerou, Katerina M. Vakaloglou, 2016, Cell reports.

Ras suppressor-1 (RSU1) exerts a tumor suppressive role with prognostic significance in lung adenocarcinoma

H. Kalofonos, V. Zolota, S. Taraviras, 2022, Clinical and Experimental Medicine.

Integrin-Linked-Kinase Overexpression Is Implicated in Mechanisms of Genomic Instability in Human Colorectal Cancer

H. Papadaki, S. Taraviras, Z. Lygerou, 2020, Digestive Diseases and Sciences.

Inference of protein kinetics by stochastic modeling and simulation of fluorescence recovery after photobleaching experiments

John Lygeros, Eugenio Cinquemani, Maria Anna Rapsomaniki, 2014, Bioinform..

Ribosomal DNA and the nucleolus at the heart of aging.

S. Taraviras, Z. Lygerou, Dafni-Eleftheria Pefani, 2022, Trends in biochemical sciences.

The fission yeast origin recognition complex is constitutively associated with chromatin and is differentially modified through the cell cycle.

P. Nurse, Z. Lygerou, 1999, Journal of cell science.

Seminars in Cell & Developmental Biology

M. Kelley, I. Symeonidou, S. Taraviras, 2013 .

Geminin Participates in Differentiation Decisions of Adult Neural Stem Cells Transplanted in the Hemiparkinsonian Mouse Brain.

S. Taraviras, Z. Lygerou, C. Kyrousi, 2017, Stem cells and development.

Geminin Regulates Cortical Progenitor Proliferation and Differentiation

D. Kioussis, F. Guillemot, V. Pachnis, 2011, Stem cells.

Stochastic hybrid modeling of DNA replication across a complete genome

Z. Lygerou, K. Koutroumpas, I. Legouras, 2008, Proceedings of the National Academy of Sciences.

Seminars in Cell & Developmental Biology

I. Symeonidou, S. Taraviras, Z. Lygerou, 2017 .