N. Arai

T. Tanimoto, M. Ikeda, M. Kurimoto, 2000, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

The structure of the IL4 gene and regulation of its expression.

K. Arai, N. Arai, Y. Naito, 1993, Research in immunology.

Interleukin-4 and interleukin-5 map to human chromosome 5 in a region encoding growth factors and receptors and are deleted in myeloid leukemias with a del(5q).

J. Rowley, R. Espinosa, R. Larson, 1989, Blood.

Transactivation Activity in T Cells Tissue-Specific Splicing and Is Essential for of NFATx1 Is Possibly Created by Carboxyl-Terminal 15-Amino Acid Sequence

K. Arai, E. Masuda, S. Imai, 1998 .

Transcriptional activator Tax of HTLV-1 binds to the NF-kappa B precursor p105.

M. Muramatsu, M. Yoshida, J. Fujisawa, 1992, Oncogene.

A Constitutively Nuclear Form of NFATx Shows Efficient Transactivation Activity and Induces Differentiation of CD4+CD8+ T Cells*

K. Arai, N. Arai, S. Adachi, 2002, The Journal of Biological Chemistry.

Effects of recombinant human interleukin-3 on CD34-enriched normal hematopoietic progenitors and on myeloblastic leukemia cells.

T. Yokota, C. Caux, M. Pébusque, 1988, Blood.

SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat

K. Arai, M. Yoshida, Y. Takebe, 1988, Molecular and cellular biology.

Multiple levels of regulation of Th2 cytokine gene expression.

A. O’Garra, N. Arai, I. Ferber, 1999, Cold Spring Harbor symposia on quantitative biology.

Studies on polypeptide-chain-elongation factors from an extreme thermophile, Thermus thermophilus HB8. 1. Purification and some properties of the purified factors.

K. Arai, T. Oshima, Y. Kaziro, 1978, European journal of biochemistry.

Preferential differentiation of inflammatory cells by recombinant human interleukins.

A. Dvorak, N. Arai, H. Saito, 1989, International archives of allergy and applied immunology.

Chromatin Remodeling and T Helper Subset Differentiation

K. Arai, N. Arai, Ken‐ichi Arai, 2000, IUBMB life.

Heterogeneity in terms of interleukin 4-dependent regulation of Fc epsilon...receptor/CD23 expression on chronic B-lymphocytic leukemia cells.

J. Yodoi, H. Imura, H. Ishida, 1989, Immunology letters.

Transcriptional control of cytokine genes.

K. Arai, N. Arai, L. Tsuruta, 1998, International reviews of immunology.

SAGE library screening reveals ILT7 as a specific plasmacytoid dendritic cell marker that regulates type I IFN production.

K. Arai, M. Cho, N. Arai, 2008, International immunology.

NF-ATx 1 NF-ATx 1 Recruit Calcineurin to Murine Regions in the N-Terminal Domain of Murine Two Independent Calcineurin-Binding

K. Arai, E. Masuda, N. Arai, 1999 .

Cis-acting DNA elements of mouse granulocyte-macrophage colony-stimulating factor gene responsive to Fc epsilon receptor cross-linking stimulation in the mouse mast cell line MC/9.

A. Miyajima, T. Heike, N. Arai, 1995, Journal of immunology.

The Expression and Characterization of Recombinant Mouse IL-3

K. Arai, T. Yokota, T. Mosmann, 1988 .

Analysis of full-length cDNA clones carrying GAL1 of Saccharomyces cerevisiae: a model system for cDNA expression.

K. Arai, H. Okayama, A. Miyajima, 1984, Nucleic acids research.

Ultrastructure of eosinophils and basophils stimulated to develop in human cord blood mononuclear cell cultures containing recombinant human interleukin-5 or interleukin-3.

A. Dvorak, N. Arai, H. Saito, 1989, Laboratory investigation; a journal of technical methods and pathology.

Cytokine signal networks and a new era in biomedical research.

K. Arai, S. Watanabe, N. Arai, 1997, Molecules and cells.

Multiple forms of recombinant murine interleukin-4 expressed in COS-7 monkey kidney cells.

N. Arai, H. Le, T. L. Nagabhushan, 1989, Biochimica et biophysica acta.

Signal transduction in Th clones: target of differential modulation by PGE2 may reside downstream of the PKC-dependent pathway.

K. Arai, R. Coffman, N. Arai, 1996, Cytokine.

Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons

A. Di Nardo, M. Gilliet, C. Conrad, 2010, The Journal of experimental medicine.

The molecular basis of T helper 1 and T helper 2 cell differentiation.

A. O’Garra, N. Arai, Anne O'Garra, 2000, Trends in cell biology.

Cdc7 as a potential new target for cancer therapy.

H. Masai, N. Arai, S. Ito, 2008, Drug news & perspectives.

Meth A fibrosarcoma cells express two transforming mutant p53 species.

Rotter, V. Rotter, G. Shaulsky, 1988, Oncogene.

Secretion of mature mouse interleukin-2 by Saccharomyces cerevisiae: use of a general secretion vector containing promoter and leader sequences of the mating pheromone alpha-factor.

K. Arai, M. Bond, A. Miyajima, 1985, Gene.

Use of a cDNA expression vector for isolation of mouse interleukin 2 cDNA clones: expression of T-cell growth-factor activity after transfection of monkey cells.

K. Arai, T. Yokota, T. Mosmann, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Human recombinant granulocyte-macrophage colony-stimulating factor and interleukin 3 cause basophil histamine release.

K. Arai, N. Arai, A. Kaplan, 1988, The Journal of clinical investigation.

Carboxyl-terminal 15-amino acid sequence of NFATx1 is possibly created by tissue-specific splicing and is essential for transactivation activity in T cells.

K. Arai, E. Masuda, S. Imai, 1998, Journal of immunology.

Definition of cis-Regulatory Elements of the Mouse Interleukin-5 Gene Promoter

K. Arai, T. Yokota, E. Masuda, 1995, The Journal of Biological Chemistry.

Complete nucleotide sequence of the chromosomal gene for human IL-4 and its expression.

S. Minoshima, M. Yoshida, J. Kudoh, 1989, Journal of immunology.

Gata-3 Induces T Helper Cell Type 2 (Th2) Cytokine Expression and Chromatin Remodeling in Committed Th1 Cells

Naoko Arai, A. O’Garra, N. Arai, 2000, The Journal of experimental medicine.

Structure of the Dnmt1 Reader Module Complexed with a Unique Two-Mono-Ubiquitin Mark on Histone H3 Reveals the Basis for DNA Methylation Maintenance.

A. Kidera, M. Shirakawa, F. Ishikawa, 2017, Molecular cell.

Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells.

H. Lee, A. O’Garra, N. Arai, 1999, Immunity.

Inhibition of NFATx Activation by an Oligopeptide: Disrupting the Interaction of NFATx with Calcineurin1

N. Arai, Ken‐ichi Arai, Jie Liu, 2001, The Journal of Immunology.

Complexes of Rep protein with ATP and DNA as a basis for helicase action.

K. Arai, A. Kornberg, N. Arai, 1981, The Journal of biological chemistry.

Structural and functional studies of the dnaB protein using limited proteolysis. Characterization of domains for DNA-dependent ATP hydrolysis and for protein association in the primosome.

K. Arai, Y. Kaziro, N. Arai, 1984, The Journal of biological chemistry.

Expression of the Fas ligand in cells of T cell lineage.

T. Yokota, S. Nagata, N. Arai, 1995, Journal of immunology.

The granulocyte-macrophage colony-stimulating factor promoter cis-acting element CLE0 mediates induction signals in T cells and is recognized by factors related to AP1 and NFAT

K. Arai, H. Tokumitsu, E. Masuda, 1993, Molecular and cellular biology.

Coordinate regulation of immune and inflammatory responses by T cell-derived lymphokines

K. Arai, T. Yokota, A. Miyajima, 1988 .

hematopoietic progenitors and on myeloblastic leukemia cells Effects of recombinant human interleukin-3 on CD34-enriched normal

T. Yokota, C. Caux, N. Arai, 2011 .

Characterization of cis-regulatory elements and nuclear factors conferring Th2-specific expression of the IL-5 gene: a role for a GATA-binding protein.

K. Arai, H. Lee, A. O’Garra, 1998, Journal of immunology.

Structural analysis of the mouse chromosomal gene encoding interleukin 4 which expresses B cell, T cell and mast cell stimulating activities

Takashi Yokota, Frank Lee, Naoko Arai, 1987, Nucleic Acids Res..

Enzyme studies of phi X174 DNA replication.

K. Arai, A. Kornberg, U. Hübscher, 1981, Progress in nucleic acid research and molecular biology.

ENZYME STUDIES OF ΦX174 DNA REPLICATION1

K. Arai, A. Kornberg, N. Arai, 1980 .

Nucleotide sequence of dnaB and the primary structure of the dnaB protein from Escherichia coli.

K. Arai, M. Bond, Y. Kaziro, 1984, The Journal of biological chemistry.

Control of NFATx1 nuclear translocation by a calcineurin-regulated inhibitory domain

K. Arai, E. Masuda, S. Imai, 1997, Molecular and cellular biology.

Isolation and Characterization of the Mouse Interleukin 3 Gene and Its Expression in Activated T Cells

K. Arai, R. Conaway, J. Conaway, 1988 .

Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction

L. Lanier, M. Cho, W. Cao, 2009, The Journal of experimental medicine.

Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region.

K. Arai, T. Yokota, N. Arai, 1998, International immunology.

NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus

K. Arai, H. Tokumitsu, C. Hannum, 1995, Molecular and cellular biology.

The carboxyl terminus of RAP30 is similar in sequence to region 4 of bacterial sigma factors and is required for function.

K. Arai, R. Conaway, J. Conaway, 1992, The Journal of biological chemistry.

In Vivo Ubiquitin Linkage-type Analysis Reveals that the Cdc48-Rad23/Dsk2 Axis Contributes to K48-Linked Chain Specificity of the Proteasome.

Y. Saeki, Keiji Tanaka, N. Arai, 2017, Molecules and Cells.

Regulation of IL-3, IL-4 and GM-CSF genes and signal transduction by their receptors.

M. Muramatsu, R. de Waal Malefyt, N. Arai, 1990, Lymphokine research.

Cytoplasmic proteasomes are not indispensable for cell growth in Saccharomyces cerevisiae.

Y. Saeki, Keiji Tanaka, N. Arai, 2013, Biochemical and biophysical research communications.

Molecular Biology of Interleukin 4 and Interleukin 5 Genes and Biology of their Products that Stimulate B Cells, T Cells and Hemopoietic Cells

K. Arai, J. Banchereau, T. Yokota, 1988, Immunological reviews.

Mechanism of the ribosome-dependent uncoupled GTPase reaction catalyzed by polypeptide chain elongation factor G.

Y. Kaziro, N. Arai, 1975, Journal of biochemistry.

Two independent calcineurin-binding regions in the N-terminal domain of murine NF-ATx1 recruit calcineurin to murine NF-ATx1.

K. Arai, E. Masuda, N. Arai, 1999, Journal of immunology.

Ub-ProT reveals global length and composition of protein ubiquitylation in cells

M. Komada, Y. Saeki, Keiji Tanaka, 2018, Nature Communications.

Rep protein as a helicase in an active, isolatable replication fork of duplex phi X174 DNA.

A. Kornberg, N. Arai, 1981, The Journal of biological chemistry.

Interleukin 1 modulates messenger RNA levels of lymphokines and of other molecules associated with T cell activation in the T cell lymphoma LBRM33-1A5.

K. Arai, H. Huang, L. Herzenberg, 1987, Journal of immunology.

Regulation of TLR 7 / 9 responses in plasmacytoid dendritic cells by BST 2 and ILT 7 receptor interaction

L. Lanier, M. Cho, W. Cao, 2009 .

Isolation and Characterization of Mouse and Human cDNA Clones Encoding IL-4 and IgA-Enhancing Factor/Eosinophil CSF (IL-5)

K. Arai, J. Banchereau, R. Coffman, 1987 .

The transcription factor Sp1 is required for induction of the murine GM-CSF promoter in T cells.

K. Arai, Y. Yamaguchi-Iwai, E. Masuda, 1994, Biochemical and biophysical research communications.

Calcineurin activates transcription from the GM-CSF promoter in synergy with either protein kinase C or NF-kappa B/AP-1 in T cells.

K. Arai, M. Muramatsu, N. Arai, 1994, Biochemical and biophysical research communications.

Characterization of NF(P), the nuclear factor that interacts with the regulatory P sequence (5'-CGAAAATTTCC-3') of the human interleukin-4 gene: relationship to NF-kappa B and NF-AT.

K. Arai, E. Masuda, N. Arai, 1994, Biochemical and biophysical research communications.

Isolation and characterization of multiple variants of recombinant human interleukin 4 expressed in mammalian cells.

Y. Takebe, N. Arai, H. Le, 1988, The Journal of biological chemistry.

Bovine papilloma virus encoded E2 protein activates lymphokine genes through DNA elements, distinct from the consensus motif, in the long control region of its own genome.

K. Arai, M. Yoshida, T. Heike, 1989, The EMBO journal.

Developmental changes of GM-CSF gene inducibility in embryonal carcinoma cells.

T. Heike, N. Arai, H. Mikawa, 1994, Molecular immunology.

Replication of øX174 DNA Reconstituted with Purified Enzymes

K. Arai, A. Kornberg, N. Arai, 1983 .

POLYPEPTIDE CHAIN ELONGATION FACTORS FROM AN EXTREME THERMOPHILE, THERMUS THERMOPHILUS HB8

K. Arai, Y. Kaziro, N. Arai, 1978 .

Further studies on the interaction of the polypeptide chain elongation factor G with guanine nucleotides.

K. Arai, Y. Kaziro, N. Arai, 1977, Journal of biochemistry.

Properties and function of the sulfhydryl group in the polypeptide chain elongation factor G from E. coli.

K. Arai, Y. Kaziro, S. Nakamura, 1977, Journal of biochemistry.

Conformational transition of polypeptide chain elongation factor G as determined by electron spin resonance.

K. Arai, Y. Kaziro, S. Ohnishi, 1976, Journal of biochemistry.

Formation of a binary complex between elongation factor G and guanine nucleotides.

K. Arai, Y. Kaziro, N. Arai, 1975, Journal of biochemistry.

Inducible and non-inducible factors co-operatively activate the GM-CSF promoter by interacting with two adjacent DNA motifs.

K. Arai, K. Sugimoto, N. Arai, 1990, International immunology.

Enzyme Studies of ϕX174 DNA Replication: Structure and Function of dnaB Protein, an Essential Replication Protein in the Primosome

N. Arai, N. Nakayama, K. Arai, 1983 .

Replication of phi X174 DNA with purified enzymes. II. Multiplication of the duplex form by coupling of continuous and discontinuous synthetic pathways.

A. Kornberg, N. Arai, K. Akai, 1981, The Journal of biological chemistry.

Replication of duplex DNA of phage phi X174 reconstituted with purified enzymes.

K. Arai, A. Kornberg, N. Arai, 1980, Proceedings of the National Academy of Sciences of the United States of America.

T Cell Activation Signals and Regulation of Lymphokine Gene by Viral and Cellular Transactivators

K. Arai, M. Muramatsu, T. Yokota, 1989 .

Four P-like elements are required for optimal transcription of the mouse IL-4 gene: involvement of a distinct set of nuclear factor of activated T cells and activator protein-1 family proteins.

K. Arai, T. Yokota, N. Arai, 1997, International immunology.

Purification of the 120 kDa component of the human nuclear factor of activated T cells (NF-AT): reconstitution of binding activity to the cis-acting element of the GM-CSF and IL-2 promoter with AP-1.

K. Arai, H. Tokumitsu, E. Masuda, 1993, Biochemical and biophysical research communications.

The role of CD11b in phagocytosis and dendritic cell development.

K. Arai, N. Arai, S. Miyatake, 2008, Immunology letters.

Calcineurin-dependent nuclear translocation of a murine transcription factor NFATx: molecular cloning and functional characterization.

T. Yokota, K. Arai, S. Imai, 1997, Molecular biology of the cell.

NFATx with Calcineurin Oligopeptide: Disrupting the Interaction of Inhibition of NFATx Activation by an

N. Arai, Jie Liu, K. Arai, 2001 .

Ub-ProT reveals global length and composition of protein ubiquitylation in cells

M. Komada, Y. Saeki, Keiji Tanaka, 2018, Nature Communications.

Interaction of guanosine 5'-diphosphate, 2'-(or 3'-) diphosphate(ppGpp) with elongation factors from E. coli.

K. Arai, Y. Kaziro, N. Arai, 1972, Biochemical and biophysical research communications.

In Vivo Ubiquitin Linkage-type Analysis Reveals that the Cdc48-Rad23/Dsk2 Axis Contributes to K48-Linked Chain Specificity of the Proteasome.

Y. Saeki, Keiji Tanaka, N. Arai, 2017, Molecules and Cells.

Cytoplasmic proteasomes are not indispensable for cell growth in Saccharomyces cerevisiae.

Y. Saeki, Keiji Tanaka, N. Arai, 2013, Biochemical and biophysical research communications.

Interleukin 4 (B-cell stimulatory factor 1) can enhance or antagonize the factor-dependent growth of hemopoietic progenitor cells.

D. Rennick, N. Arai, L. Gemmell, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Gata-3 Induces T Helper Cell Type 2 (Th2) Cytokine Expression and Chromatin Remodeling in Committed Th1 Cells

A. O’Garra, N. Arai, N. Takemoto, 2000, The Journal of experimental medicine.