H. Richardson

发表

Vinegar flies turn to porto for cell division cycle meeting.

H. Richardson, 2006, Developmental cell.

Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation

C. Lehner, Lynn Jones, H. Richardson, 1994, Cell.

Distinct modes of cyclin E/cdc2c kinase regulation and S-phase control in mitotic and endoreduplication cycles of Drosophila embryogenesis.

C. Lehner, H. Richardson, J. Knoblich, 1995, Genes & development.

decapentaplegic is required for arrest in G1 phase during Drosophila eye development.

J. Horsfield, H. Richardson, A. Penton, 1998, Development.

Tissue-specific regulation of cyclin E transcription during Drosophila melanogaster embryogenesis.

L. Jones, H. Richardson, R. Saint, 2000, Development.

Phosphorylation of Drosophila Brahma on CDK-phosphorylation sites is important for cell cycle regulation and differentiation

B. Sarcevic, O. Bernard, A. Deans, 2018, Cell cycle.

A cyclin B homolog in S. cerevisiae: Chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis

Daniel J. Lew, Curt Wittenberg, Katsunori Sugimoto, 1991, Cell.

Cyclin-B homologs in Saccharomyces cerevisiae function in S phase and in G2.

S. Reed, K. Sugimoto, H. Richardson, 1992, Genes & development.

The Brm-HDAC3-Erm repressor complex suppresses dedifferentiation in Drosophila type II neuroblast lineages

P. Robson, W. Sung, Zhizhuo Zhang, 2014, eLife.

The BTB-zinc Finger Transcription Factor Abrupt Acts as an Epithelial Oncogene in Drosophila melanogaster through Maintaining a Progenitor-like Cell State

Jessica E. Bolden, E. Blanco, J. Bolden, 2013, PLoS genetics.

A fission yeast B-type cyclin functioning early in the cell cycle

P. Russell, S. Reed, H. Richardson, 1991, Cell.

miR-9a mediates the role of Lethal giant larvae as an epithelial growth inhibitor in Drosophila

Daniela C. Zarnescu, D. Zarnescu, H. Richardson, 2017, Biology Open.

Analysis of Drosophila cyclin EI and II function during development: identification of an inhibitory zone within the morphogenetic furrow of the eye imaginal disc that blocks the function of cyclin EI but not cyclin EII.

H. Richardson, R. Saint, J. Secombe, 2002, Developmental biology.

Analysis of a Drosophila cyclin E hypomorphic mutation suggests a novel role for cyclin E in cell proliferation control during eye imaginal disc development.

H. Richardson, R. Saint, J. Secombe, 1998, Genetics.

The Scribble Cell Polarity Module in the Regulation of Cell Signaling in Tissue Development and Tumorigenesis.

H. Richardson, Marta Portela, M. Kvansakul, 2018, Journal of molecular biology.

The Scribble–Dlg–Lgl Module in Cell Polarity Regulation

H. Richardson, S. Russell, P. Humbert, 2015 .

Death takes a holiday—non‐apoptotic role for caspases in cell migration and invasion

H. Richardson, Marta Portela, 2013, EMBO reports.

scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila

H. Richardson, A. Brumby, 2003, The EMBO journal.

lgl Regulates the Hippo Pathway Independently of Fat/Dachs, Kibra/Expanded/Merlin and dRASSF/dSTRIPAK

H. Richardson, L. Parsons, N. Grzeschik, 2014, Cancers.

Lgl/aPKC and Crb regulate the Salvador/Warts/Hippo pathway

H. Richardson, L. Parsons, N. Grzeschik, 2010, Fly.

Dominant negative protein kinase mutations that confer a G1 arrest phenotype.

S. Reed, H. Richardson, M. Mendenhall, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Article Modelling Cooperative Tumorigenesis in Drosophila

H. Richardson, andMarta Portela, 2018 .

An Essential Role for the Caspase Dronc in Developmentally Programmed Cell Death in Drosophila *

J. Abrams, Sharad Kumar, P. Chen, 2000, The Journal of Biological Chemistry.

Modelling Cancer in Drosophila: The Next Generation

H. Richardson, L. Parsons, Louise Y. Cheng, 2013 .

Using Drosophila melanogaster to map human cancer pathways

H. Richardson, A. Brumby, Anthony M. Brumby, 2005, Nature Reviews Cancer.

Regulation of Notch signaling and endocytosis by the Lgl neoplastic tumor suppressor

H. Richardson, Marta Portela, L. Parsons, 2015, Cell cycle.

Characterization of the DrosophilaCaspase, DAMM*

Sharad Kumar, H. Richardson, L. Quinn, 2001, The Journal of Biological Chemistry.

STRICA, a novel Drosophila melanogaster caspase with an unusual serine/threonine-rich prodomain, interacts with DIAP1 and DIAP2

H. Richardson, L. Quinn, J. Doumanis, 2001, Cell Death and Differentiation.

Drosophila cyclin E transcription

Lynn Jones, H. Richardson, R. Saint, 2000 .

Ptp61F integrates Hippo, TOR, and actomyosin pathways to control three-dimensional organ size.

Peng Liu, H. Richardson, Peng Liu, 2022, Cell reports.

Lgl Regulates Notch Signaling via Endocytosis, Independently of the Apical aPKC-Par6-Baz Polarity Complex

H. Richardson, Marta Portela, L. Parsons, 2014, Current Biology.

cdc25 M-phase inducer.

K. Sadhu, P. Russell, C. McGowan, 1991, Cold Spring Harbor symposia on quantitative biology.

Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer.

H. Richardson, S. Russell, P. Humbert, 2003, BioEssays : news and reviews in molecular, cellular and developmental biology.

Screening for Anti-cancer Drugs in Drosophila

H. Richardson, P. Humbert, Lee F. Willoughby, 2015 .

Tumor-derived MMPs regulate cachexia in a Drosophila cancer model.

Verena C. Wimmer, B. Parker, M. Zavortink, 2021, Developmental cell.

Drosophila models of cancer

H. Richardson, 2015, AIMS Genetics.

An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery

H. Richardson, J. Parisot, I. Street, 2012, Disease Models & Mechanisms.

A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer

C. Mitsiades, J. Penninger, A. Wernitznig, 2018, PLoS genetics.

Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species

C. Mitsiades, J. Penninger, K. Simpson, 2017, Oncogene.

Lgl, aPKC, and Crumbs Regulate the Salvador/Warts/Hippo Pathway through Two Distinct Mechanisms

K. Harvey, H. Richardson, L. Parsons, 2010, Current Biology.

An essential G1 function for cyclin-like proteins in yeast

Curt Wittenberg, F. Cross, S. Reed, 1989, Cell.

APC/CFzr/Cdh1 promotes cell cycle progression during the Drosophila endocycle

M. Asano, M. Lilly, H. Richardson, 2008, Development.

Geminin regulates neuronal differentiation by antagonizing Brg1 activity.

K. Kroll, H. Richardson, Seongjin Seo, 2005, Genes & development.

Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module

H. Richardson, A. Brumby, P. Humbert, 2008, Oncogene.

Abnormalities in cell proliferation and apico-basal cell polarity are separable in Drosophila lgl mutant clones in the developing eye.

H. Richardson, J. Secombe, A. Brumby, 2007, Developmental biology.

Drosophila Hfp negatively regulates dmyc and stg to inhibit cell proliferation

D. Bowtell, R. Dickins, H. Richardson, 2004, Development.

Drosophila Models of Cell Polarity and Cell Competition in Tumourigenesis.

H. Richardson, John E. La Marca, Marta Portela, 2019, Advances in experimental medicine and biology.

Hfp inhibits Drosophila myc transcription and cell growth in a TFIIH/Hay-dependent manner

R. Hannan, H. Richardson, Naomi C. Mitchell, 2010, Development.

The lethal giant larvae tumour suppressor mutation requires dMyc oncoprotein to promote clonal malignancy

A. Pession, A. Pession, H. Richardson, 2010, BMC Biology.

The Ecdysone-inducible zinc-finger transcription factor Crol regulates Wg transcription and cell cycle progression in Drosophila

H. Richardson, Naomi C. Mitchell, L. Quinn, 2008, Development.

Replication and the Cell Cycle

H. Richardson, J. Secombe, L. Quinn, 2006 .

A Genetic Screen for Dominant Modifiers of a cyclin E Hypomorphic Mutation Identifies Novel Regulators of S-Phase Entry in Drosophila

J. Horsfield, H. Richardson, R. Saint, 2004, Genetics.

Identification of Novel Ras-Cooperating Oncogenes in Drosophila melanogaster: A RhoGEF/Rho-Family/JNK Pathway Is a Central Driver of Tumorigenesis

Jessica E. Bolden, S. Loi, J. Bolden, 2011, Genetics.

A Drosophila in vivo chemical screen reveals that combination drug treatment targeting MEK and DGKα mitigates Ras-driven polarity-impaired tumourigenesis

H. Richardson, John E. La Marca, Peter Burke, 2022, bioRxiv.

TSPAN6 is a suppressor of Ras-driven cancer

T. Meyer, A. Farrell, J. Penninger, 2022, Oncogene.

Src Cooperates with Oncogenic Ras in Tumourigenesis via the JNK and PI3K Pathways in Drosophila epithelial Tissue

H. Richardson, A. Brumby, C. Poon, 2018, International journal of molecular sciences.

In Drosophila, RhoGEF2 cooperates with activated Ras in tumorigenesis through a pathway involving Rho1–Rok–Myosin-II and JNK signalling

H. Richardson, A. Brumby, Lee F. Willoughby, 2013, Disease Models & Mechanisms.

New tricks for old dogs: unexpected roles for cell cycle regulators revealed using animal models.

H. Richardson, L. Quinn, A. Brumby, 2004, Current opinion in cell biology.

The Scribble-Dlg-Lgl polarity module in development and cancer: from flies to man.

H. Richardson, L. Yates, P. Humbert, 2012, Essays in biochemistry.

Ectopic cyclin E expression induces premature entry into S phase and disrupts pattern formation in the Drosophila eye imaginal disc.

T Marty, H. Richardson, R. Saint, 1995, Development.

BTB-Zinc Finger Oncogenes Are Required for Ras and Notch-Driven Tumorigenesis in Drosophila

H. Richardson, M. Murray, Karen Doggett, 2015, PloS one.

Buffy, a Drosophila Bcl‐2 protein, has anti‐apoptotic and cell cycle inhibitory functions

Sharad Kumar, H. Richardson, L. Quinn, 2003, The EMBO journal.

Death to flies: Drosophila as a model system to study programmed cell death.

Sharad Kumar, H. Richardson, 2002, Journal of immunological methods.

Wingless signaling directly regulates cyclin E expression in proliferating embryonic PNS precursor cells

D. Deb, Lynn Jones, W. Du, 2008, Mechanisms of Development.

A Drosophila G1-specific cyclin E homolog exhibits different modes of expression during embryogenesis.

S. Reed, H. Richardson, R. Saint, 1993, Development.

Strip and Cka negatively regulate JNK signalling during Drosophila spermatogenesis

A. Hart, H. Richardson, Hongyan Wang, 2019, Development.

When cell cycle meets development

P. Kaldis, H. Richardson, 2012, Development.

Upstream Regulation of the Hippo Size Control Pathway

K. Harvey, H. Richardson, F. Grusche, 2010, Current Biology.

Debcl, a Proapoptotic Bcl-2 Homologue, Is a Component of the Drosophila melanogaster Cell Death Machinery

Sharad Kumar, H. Richardson, L. Quinn, 2000, The Journal of cell biology.

Geminin and Brahma act antagonistically to regulate EGFR-Ras-MAPK signaling in Drosophila.

B. Sarcevic, M. Sadowski, H. Richardson, 2010, Developmental biology.

Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling

H. Richardson, L. Dow, P. Humbert, 2008, Oncogene.

Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2.

K. Sadhu, P. Russell, S. Reed, 1990, Proceedings of the National Academy of Sciences of the United States of America.

POSH regulates Hippo signaling through ubiquitin-mediated expanded degradation

L. Xue, H. Richardson, Xianjue Ma, 2018, Proceedings of the National Academy of Sciences.

Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling

H. Richardson, Karen Doggett, A. Brumby, 2011, BMC Developmental Biology.

The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster.

K. Harvey, H. Richardson, Joffrey L. Degoutin, 2011, Developmental biology.

DRONC, an ecdysone-inducible Drosophila caspase.

Sharad Kumar, H. Richardson, L. Quinn, 1999, Proceedings of the National Academy of Sciences of the United States of America.

The Drosophila Geminin homolog: roles for Geminin in limiting DNA replication, in anaphase and in neurogenesis.

T. McGarry, H. Richardson, L. Quinn, 2001, Genes & development.

Lgl, the SWH pathway and tumorigenesis: It’s a matter of context and competition!

H. Richardson, L. Parsons, N. Grzeschik, 2010, Cell cycle.

A family of cyclin homologs that control the G1 phase in yeast.

S. Reed, C. Wittenberg, H. Richardson, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe.

P. Russell, S. Reed, H. Richardson, 1990, Genes & development.

Analysis of the Cdc28 protein kinase complex by dosage suppression

S. Reed, C. Wittenberg, H. Richardson, 1989, Journal of Cell Science.

Modelling Cooperative Tumorigenesis in Drosophila

H. Richardson, Marta Portela, 2018, BioMed research international.

DECAY, a Novel Drosophila Caspase Related to Mammalian Caspase-3 and Caspase-7*

Sharad Kumar, H. Richardson, L. Quinn, 1999, The Journal of Biological Chemistry.

Lgl reduces endosomal vesicle acidification and Notch signaling by promoting the interaction between Vap33 and the V-ATPase complex

H. Richardson, A. Veraksa, Marta Portela, 2018, Science Signaling.

Differential regulation of protein tyrosine kinase signalling by Dock and the PTP61F variants

C. Warr, H. Richardson, Marta Portela, 2017, The FEBS journal.

Modelling Cancer in Drosophila

H. Richardson, A. Brumby, 2008 .

scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs

H. Richardson, A. Brumby, K. Goulding, 2009, BMC Biology.

Drosophila cyclin E interacts with components of the Brahma complex

Claudia B. Zraly, A. Dingwall, H. Richardson, 2002, The EMBO journal.

G1 control in yeast and animal cells.

S. Reed, C. Wittenberg, H. Richardson, 1992, Ciba Foundation symposium.

Drosophila melanogaster Guk-holder interacts with the Scribbled PDZ1 domain and regulates epithelial development with Scribbled and Discs Large

H. Richardson, Marta Portela, M. Kvansakul, 2018, The Journal of Biological Chemistry.

Two-Faced: Roles of JNK Signalling During Tumourigenesis in the Drosophila Model

H. Richardson, John E. La Marca, 2020, Frontiers in Cell and Developmental Biology.

PTP61F Mediates Cell Competition and Mitigates Tumorigenesis

H. Richardson, John E. La Marca, Marta Portela, 2021, International journal of molecular sciences.

Basic and Translational Models of Cooperative Oncogenesis

H. Richardson, D. Grifoni, J. Cordero, 2020, International journal of molecular sciences.

hScrib is a functional homologue of the Drosophila tumour suppressor Scribble

J. Trapani, H. Richardson, S. Russell, 2003, Oncogene.

Cooperation of the BTB-Zinc finger protein, Abrupt, with cytoskeletal regulators in Drosophila epithelial tumorigenesis

H. Richardson, Marta Portela, A. Brumby, 2015, Biology Open.

Tissue growth and tumorigenesis in Drosophila: cell polarity and the Hippo pathway.

H. Richardson, Marta Portela, 2017, Current opinion in cell biology.

Modelling Cooperative Tumorigenesis in Drosophila

H. Richardson, Marta Portela, 2018, BioMed research international.

The Drosophila Tumour Suppressor Lgl and Vap33 activate the Hippo pathway by a dual mechanism, involving RtGEF/Git/Arf79F and inhibition of the V-ATPase

H. Richardson, A. Veraksa, John E. La Marca, 2023, bioRxiv.

scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs

H. Richardson, A. Brumby, K. Goulding, 2009, BMC Biology.

Lgl reduces endosomal vesicle acidification and Notch signaling by promoting the interaction between Vap33 and the V-ATPase complex

H. Richardson, A. Veraksa, Marta Portela, 2018, Science Signaling.

A Kinome RNAi Screen in Drosophila Identifies Novel Genes Interacting with Lgl, aPKC, and Crb Cell Polarity Genes in Epithelial Tissues

H. Richardson, Peter Burke, L. Parsons, 2017, G3: Genes, Genomes, Genetics.