Y. Okuno

发表

Clustered Adenine/Thymine Stretches Are Essential for Function of a Fission Yeast Replication Origin

H. Masukata, Y. Okuno, H. Satoh, 1999, Molecular and Cellular Biology.

Stability, chromatin association and functional activity of mammalian pre‐replication complex proteins during the cell cycle

J. Pines, N. den Elzen, D. Gilbert, 2001, The EMBO journal.

Crystal structure of pathogenic Staphylococcus aureus lipase complex with the anti-obesity drug orlistat

Masaki Yamamoto, T. Hikima, Y. Okuno, 2020, Scientific Reports.

Albendazole induces the terminal differentiation of acute myeloid leukaemia cells to monocytes by stimulating the Krüppel‐like factor 4‐dihydropyrimidinase‐like 2A (KLF4‐DPYSL2A) axis

S. Adachi, Y. Okuno, Y. Kamikubo, 2021, British journal of haematology.

A replication-enhancing element with transcriptional silencer activity in autonomously replicating human chromosomal fragments.

C. Obuse, T. Okazaki, H. Masukata, 1996, Molecular biology of the cell.

Physical mapping and identification of interspersed homologous sequences in the Trichoplusia ni granulosis virus genome.

R. R. Granados, Y. Okuno, K. Hayashi, 1996, The Journal of general virology.

RBM24 promotes U1 snRNP recognition of the mutated 5' splice site in the IKBKAP gene of familial dysautonomia.

M. Hagiwara, K. Ohe, N. Kataoka, 2017, RNA.

Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia

M. Hagiwara, Tsutomu Suzuki, K. Ohe, 2015, Proceedings of the National Academy of Sciences.

Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ

M. Hagiwara, T. Hosoya, Y. Okuno, 2015, Scientific Reports.

In vitro expansion of mouse primordial germ cell‐like cells recapitulates an epigenetic blank slate

M. Hagiwara, H. Ohta, I. Okamoto, 2017, The EMBO journal.

Purification and characterization of galactocerebrosidase from human lymphocytes.

A. Iwamatsu, Y. Okuno, K. Inui, 1994, Journal of biochemistry.

A cell-based assay to screen stimulators of the Hippo pathway reveals the inhibitory effect of dobutamine on the YAP-dependent gene transcription.

Y. Hata, H. Nishina, Y. Okuno, 2011, Journal of biochemistry.

Title Development of an orally available inhibitor of CLK 1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy

M. Hagiwara, M. Matsuo, Y. Okuno, 2018 .

Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy

M. Hagiwara, K. Ohe, M. Matsuo, 2017, Scientific Reports.

RB Reversibly Inhibits DNA Replication via Two Temporally Distinct Mechanisms

Steven P. Angus, M. C. Cardoso, D. Gilbert, 2004, Molecular and Cellular Biology.

Identification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice

M. Hagiwara, N. Ito, T. Ikura, 2015, Molecular Pharmacology.

Title Selective inhibition of the kinase DYRK 1 A by targeting itsfolding process

M. Hagiwara, H. Shibuya, N. Ito, 2019 .

Selective inhibition of the kinase DYRK1A by targeting its folding process

M. Hagiwara, H. Shibuya, N. Ito, 2016, Nature Communications.

A novel cell-based assay for the high-throughput screening of epithelial-mesenchymal transition inhibitors: Identification of approved and investigational drugs that inhibit epithelial-mesenchymal transition.

H. Date, T. Menju, Y. Okuno, 2022, Lung cancer.

Establishment of Nephrin Reporter Mice and Use for Chemical Screening

M. Ohtsuka, K. Asanuma, T. Matsusaka, 2016, PloS one.

Establishment of Nephrin Reporter Mice and Use for Chemical Screening

M. Ohtsuka, K. Asanuma, T. Matsusaka, 2016, PloS one.

Structure of a palindromic amplicon junction implicates microhomology-mediated end joining as a mechanism of sister chromatid fusion during gene amplification.

D. Gilbert, Y. Okuno, P. Hahn, 2004, Nucleic acids research.

Chinese hamster ORC subunits dynamically associate with chromatin throughout the cell-cycle.

T. Misteli, D. Gilbert, Y. Okuno, 2005, Experimental cell research.

The DNA polymerase activity of Pol ε holoenzyme is required for rapid and efficient chromosomal DNA replication in Xenopus egg extracts

S. Waga, Y. Okuno, A. Sugino, 2006, BMC Biochemistry.

Title Identification of a DYRK 1 A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC 37 fused with Luciferase nanoKAZ

M. Hagiwara, T. Hosoya, Y. Okuno, 2018 .

The Chinese Hamster Dihydrofolate Reductase Replication Origin Decision Point Follows Activation of Transcription and Suppresses Initiation of Replication within Transcription Units

D. Gilbert, Takayo Sasaki, Y. Okuno, 2006, Molecular and Cellular Biology.

Identification of a predominant replication origin in fission yeast.

T. Okazaki, H. Masukata, Y. Okuno, 1997, Nucleic acids research.

Identification of Novel N-(Morpholine-4-Carbonyloxy) Amidine Compounds as Potent Inhibitors against Hepatitis C Virus Replication

M. Hagiwara, S. Kakinuma, N. Sakamoto, 2011, Antimicrobial Agents and Chemotherapy.

RBM24 promotes U1 snRNP recognition of the mutated 5′ splice site in the IKBKAP gene of familial dysautonomia

M. Hagiwara, K. Ohe, N. Kataoka, 2017, RNA.

Title Identification of a Dual Inhibitor of SRPK1 and CK2 that Attenuates Pathological Angiogenesis of Macular Degeneration

M. Hagiwara, N. Ito, T. Ikura, 2018 .

The Kinase Inhibitor SFV785 Dislocates Dengue Virus Envelope Protein from the Replication Complex and Blocks Virus Assembly

M. Garcia-Blanco, M. Hagiwara, Masaaki Suzuki, 2011, PloS one.

Discovery of Protein Disulfide Isomerase P5 Inhibitors that Reduce the Secretion of MICA from Cancer Cells

T. Horibe, A. Torisawa, K. Kawakami, 2014, Chembiochem : a European journal of chemical biology.

Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice

M. Hagiwara, T. Awaya, T. Hosoya, 2017, Proceedings of the National Academy of Sciences.

M. Hagiwara, T. Awaya, Y. Okuno, 2017 .

Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice

M. Hagiwara, T. Awaya, T. Hosoya, 2017, Proceedings of the National Academy of Sciences.

Retinoid derivative Tp80 exhibits anti‐hepatitis C virus activity through restoration of GI‐GPx expression

M. Hagiwara, N. Sakamoto, H. Kagechika, 2017, Journal of medical virology.

Cryptotanshinone is a candidate therapeutic agent for interstitial lung disease associated with a BRICHOS-domain mutation of SFTPC

T. Awaya, M. Osawa, Y. Okuno, 2023, iScience.