Fenghe Du

发表

R2D2, a Bridge Between the Initiation and Effector Steps of the Drosophila RNAi Pathway

Xiaodong Wang, Xiaodong Wang, Qinghua Liu, 2003, Science.

Direct, noncatalytic mechanism of IKK inhibition by A20.

Jin He, Zhijian J. Chen, Fenghe Du, 2011, Molecular cell.

The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways

Xiaodong Wang, She Chen, Fenghe Du, 2012, Cell.

TNF-α Induces Two Distinct Caspase-8 Activation Pathways

Xiaodong Wang, Xiaodong Wang, Fenghe Du, 2008, Cell.

Computational approach for binding prediction of SARS-CoV-2 with neutralizing antibodies

Zhijian J. Chen, D. Beshnova, Mingjian Du, 2022, Computational and Structural Biotechnology Journal.

Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response.

N. Grishin, L. Kinch, Zhijian J. Chen, 2012, Immunity.

PHAPI, CAS, and Hsp70 promote apoptosome formation by preventing Apaf-1 aggregation and enhancing nucleotide exchange on Apaf-1.

Xiaodong Wang, Xuejun Jiang, Fenghe Du, 2008, Molecular cell.

An antibody that neutralizes SARS-CoV-1 and SARS-CoV-2 by binding to a conserved spike epitope outside the receptor binding motif

Zhijian J. Chen, X. Bai, Xuping Xie, 2022, Science Immunology.

Novel small molecules relieve prothymosin alpha-mediated inhibition of apoptosome formation by blocking its interaction with Apaf-1.

X. Qi, Fenghe Du, Lai Wang, 2010, Biochemistry.

Phosphorylation and Chromatin Tethering Prevent cGAS activation During Mitosis

Zhijian J. Chen, Mingjian Du, Xiang Chen, 2021, Science.

Formation of apoptosome is initiated by cytochrome c-induced dATP hydrolysis and subsequent nucleotide exchange on Apaf-1.

Xiaodong Wang, Xiaodong Wang, M. Fang, 2005, Proceedings of the National Academy of Sciences of the United States of America.

The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop.

Zhijian J. Chen, Hui Xu, Xuewu Zhang, 2014, Cell reports.

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

Zhijian J. Chen, Lijun Sun, Xiang Chen, 2013, Science.

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

Zhijian J. Chen, Lijun Sun, Xiang Chen, 2013, Science.

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

Nan Yan, Zhijian J. Chen, Lijun Sun, 2013, Science.

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

Tao Wang, Xiaodong Wang, Liping Zhao, 2009, Cell.

Mule/ARF-BP1, a BH3-Only E3 Ubiquitin Ligase, Catalyzes the Polyubiquitination of Mcl-1 and Regulates Apoptosis

Xiaodong Wang, Q. Zhong, Fenghe Du, 2005, Cell.

Argonaute2 Cleaves the Anti-Guide Strand of siRNA during RISC Activation

Xiaodong Wang, T. A. Rand, Fenghe Du, 2005, Cell.

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

N. Grishin, Q. Cong, Zhijian J. Chen, 2015, Science.

Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation.

Wenhua Gao, Xiaodong Wang, Xiaodong Wang, 2003, Genes & development.

Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK

Xiaodong Wang, Shen Li, Liping Zhao, 2011, Proceedings of the National Academy of Sciences.

Autophagy Induction via STING Trafficking Is a Primordial Function of the cGAS Pathway

Zhijian J. Chen, Xiaojun Tan, Fenghe Du, 2019, Nature.

Sun the Type I Interferon Pathway Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates

Zhijian J. Chen, Lijun Sun, Xiang Chen, 2013 .

Ubiquitin-like conjugation by bacterial cGAS enhances anti-phage defence

Zhijian J. Chen, Chee-Kwee Ea, Fenghe Du, 2023, Nature.

Mutations in the BRCA1-associated RING domain (BARD1) gene in primary breast, ovarian and uterine cancers.

B. Trask, H. Massa, A. Bowcock, 1998, Human molecular genetics.

Mutational and haplotype analyses of families with familial partial lipodystrophy (Dunnigan variety) reveal recurrent missense mutations in the globular C-terminal domain of lamin A/C.

M. Lovett, A. Bowcock, Simeon I. Taylor, 2000, American journal of human genetics.

Pleomorphic adenoma gene 1 is expressed in cultured benign and malignant salivary gland tumor cells.

M. Lovett, A. Bowcock, J. Soares, 1999, Laboratory investigation; a journal of technical methods and pathology.

Conformational Motions Regulate Phosphoryl Transfer in Related Protein Tyrosine Phosphatases

Nan Yan, Zhijian J. Chen, J. P. Loria, 2013, Science.

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

Xiaodong Wang, Liping Zhao, Fenghe Du, 2009, Cell.