C. Khanna

发表

Osteosarcoma Genetics and Epigenetics: Emerging Biology and Candidate Therapies.

James J. Morrow, C. Khanna, Chand Khanna, 2015, Critical reviews in oncogenesis.

The dog as a cancer model

K. Lindblad-Toh, E. Ostrander, S. Westmoreland, 2006, Nature Biotechnology.

Characterization of the metastatic phenotype of a panel of established osteosarcoma cells

James J. Morrow, P. Meltzer, C. Khanna, 2015, Oncotarget.

Modeling opportunities in comparative oncology for drug development.

C. Khanna, I. Gordon, 2010, ILAR journal.

Defining the Value of a Comparative Approach to Cancer Drug Development

C. Khanna, C. Mazcko, A. LeBlanc, 2015, Clinical Cancer Research.

A Review of Paclitaxel and Novel Formulations Including Those Suitable for Use in Dogs

C. Khanna, D. Vail, M. Rosenberg, 2015, Journal of veterinary internal medicine.

Insulin-like growth factor-I regulates the liver microenvironment in obese mice and promotes liver metastasis.

S. Yakar, P. Brodt, C. Khanna, 2010, Cancer research.

Provocative questions in osteosarcoma basic and translational biology: A report from the Children's Oncology Group

P. Meltzer, P. Sorensen, B. Crompton, 2019, Cancer.

Spontaneous and genetically engineered animal models; use in preclinical cancer drug development.

C. Khanna, K. Hansen, Katherine S. Hansen, 2004, European journal of cancer.

Pretreatment with a monoclonal antibody/interleukin-2 fusion protein directed against DNA enhances the delivery of therapeutic molecules to solid tumors.

L. Khawli, J. Hornick, A. Epstein, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

Merlin/NF2 Tumor Suppressor and Ezrin–Radixin–Moesin (ERM) Proteins in Cancer Development and Progression

C. Khanna, L. Ren, 2010 .

A Compendium of Canine Normal Tissue Gene Expression

J. Khan, Qingrong Chen, Xinyu Wen, 2011, PloS one.

Tumor Expression of 4-1BB Ligand Sustains Tumor Lytic T Cells

C. June, J. Toretsky, L. Helman, 2003, Cancer biology & therapy.

Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33.

William Wheeler, Hideo Tanaka, Jianxin Shi, 2014, Human molecular genetics.

Loss-of-function screen in rhabdomyosarcoma identifies CRKL-YES as a critical signal for tumor growth

L. Staudt, J. Khan, S. Hewitt, 2013, Oncogene.

The Challenge of Cognitive Dissonance in the Delivery of Precision Medicine in Veterinary Oncology

C. Khanna, J. Cawley, 2020 .

Nitric Oxide Synthase and Breast Cancer: Role of TIMP-1 in NO-mediated Akt Activation

S. Ambs, D. Wink, H. Yfantis, 2012, PloS one.

Ezrin mediates growth and survival in Ewing’s sarcoma through the AKT/mTOR, but not the MAPK, signaling pathway

Dafydd G. Thomas, S. Hewitt, L. Helman, 2006, Clinical & Experimental Metastasis.

Response evaluation criteria for peripheral nodal lymphoma in dogs (v1.0)--a Veterinary Cooperative Oncology Group (VCOG) consensus document.

C. Khanna, C. London, D. Vail, 2010, Veterinary and comparative oncology.

Met interacts with EGFR and Ron in canine osteosarcoma.

S. Kulp, C. Khanna, J. McCleese, 2013, Veterinary and comparative oncology.

Role of ezrin in osteosarcoma metastasis.

C. Khanna, L. Ren, 2014, Advances in experimental medicine and biology.

The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC

S. Hewitt, C. Khanna, L. Ren, 2009, Oncogene.

Expression of the cytoskeleton linker protein ezrin in human cancers

P. Meltzer, A. Borczuk, A. Bretscher, 2007, Clinical & Experimental Metastasis.

In vitro and in vivo cytotoxicity of an anti-osteosarcoma immunotoxin containing pokeweed antiviral protein.

P. Anderson, F. Uckun, D. Saltzman, 1995, Cancer research.

A summary of the osteosarcoma banking efforts: A report from the Children's Oncology Group and the QuadW Foundation

T. Fan, C. Khanna, K. Janeway, 2015, Pediatric blood & cancer.

Genomic landscapes of canine splenic angiosarcoma (hemangiosarcoma) contain extensive heterogeneity within and between patients

Rebecca F. Halperin, J. Trent, V. Zismann, 2020, bioRxiv.

Nm23-H1 suppresses metastasis by inhibiting expression of the lysophosphatidic acid receptor EDG2.

S. Steinberg, C. Horak, M. Merino, 2007, Cancer research.

Polymerase chain reaction for antigen receptor rearrangement: Benchmarking performance of a lymphoid clonality assay in diverse canine sample types

V. Zismann, W. Hendricks, C. Khanna, 2019, Journal of Veterinary Internal Medicine.

Immune synapse formation requires ZAP-70 recruitment by ezrin and CD43 removal by moesin

A. Bretscher, T. Veenstra, Ming Zhou, 2007, The Journal of cell biology.

Metabolomics uncovers a link between inositol metabolism and osteosarcoma metastasis

C. Khanna, L. Ren, A. LeBlanc, 2017, Oncotarget.

Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression

S. Ambs, D. Wink, S. Hussain, 2014, Proceedings of the National Academy of Sciences.

Chapter 5 – Cellular Growth/Neoplasia

C. Khanna, A. Sahora, 2013 .

Interleukin‐2 liposome inhalation therapy is safe and effective for dogs with spontaneous pulmonary metastases

P. Anderson, C. Khanna, E. Katsanis, 1997, Cancer.

Disseminated Polyomavirus Infection in Chronic Lymphocytic Leukemia (CLL) Following Salvage Chemo-Immunotherapy

C. Khanna, J. Barstis, W. Clough, 2010 .

Prevalence and clinical features of thoracolumbar intervertebral disc‐associated epidural hemorrhage in dogs

C. Khanna, S. Stewart, R. Windsor, 2022, Journal of veterinary internal medicine.

mTOR Inhibition Mitigates Enhanced mRNA Translation Associated with the Metastatic Phenotype of Osteosarcoma Cells In Vivo

James J. Morrow, Allyson E. Koyen, Ming Zhou, 2016, Clinical Cancer Research.

Tolerability of oral sorafenib in pet dogs with a diagnosis of cancer

C. Khanna, I. Gordon, C. Manley, 2017, Veterinary medicine.

STEALTH liposome-encapsulated cisplatin (SPI-77) versus carboplatin as adjuvant therapy for spontaneously arising osteosarcoma (OSA) in the dog: a randomized multicenter clinical trial

P. Working, C. Khanna, D. Vail, 2002, Cancer Chemotherapy and Pharmacology.

Pharmacokinetic Exposures Associated With Oral Administration of Sorafenib in Dogs With Spontaneous Tumors

J. Mochel, C. Khanna, J. Fenger, 2022, Frontiers in Veterinary Science.

Single agent gemcitabine chemotherapy in dogs with spontaneously occurring lymphoma.

R. M. Gamblin, C. Khanna, K. Hahn, 2006, Journal of veterinary internal medicine.

Single A gent Gemcitabine Chemotherapy i n D ogs with S pontaneously Occurring L ymphoma

R. M. Gamblin, C. Khanna, K. Hahn, 2006 .

Fas-Negative Osteosarcoma Tumor Cells Are Selected during Metastasis to the Lungs: The Role of the Fas Pathway in the Metastatic Process of Osteosarcoma

E. Kleinerman, C. Khanna, A. Mendoza, 2007, Molecular Cancer Research.

Bridging the gap between experimental animals and humans in osteosarcoma.

C. Khanna, S. Withrow, 2009, Cancer treatment and research.

Apoptosis resistance and PKC signaling: distinguishing features of high and low metastatic cells.

C. Khanna, L. Ren, A. Mendoza, 2012, Neoplasia.

Feasibility and promise of circulating tumor DNA analysis in dogs with naturally-occurring sarcoma

J. Trent, M. Murtaza, W. Hendricks, 2020, bioRxiv.

Hypomagnesemia in 188 dogs: a hospital population-based prevalence study.

P. J. Armstrong, C. Khanna, M. Raffe, 1998, Journal of veterinary internal medicine.

Evaluation of the oral antimitotic agent (ABT-751) in dogs with lymphoma.

C. Khanna, A. Krivoshik, E. McKeegan, 2012, Journal of veterinary internal medicine.

Biologically relevant orthotopic neuroblastoma xenograft models: primary adrenal tumor growth and spontaneous distant metastasis.

J. Jaboin, C. Thiele, E. Drakos, 2002, In vivo.

Abstract 3906: Design, synthesis and biological evaluation of 2nd generation ezrin inhibitors for metastatic osteosarcoma

A. Üren, J. Toretsky, M. Paige, 2012 .

Concentration of lipocalin region of collagen XXVII alpha 1 in the serum of dogs with hemangiosarcoma.

C. Khanna, M. A. Hayes, G. Kirby, 2011, Journal of veterinary internal medicine.

Use of single-agent carboplatin as adjuvant or neoadjuvant therapy in conjunction with amputation for appendicular osteosarcoma in dogs.

B. Powers, C. Khanna, D. Vail, 2009, Journal of the American Animal Hospital Association.

Rapamycin Pharmacokinetic and Pharmacodynamic Relationships in Osteosarcoma: A Comparative Oncology Study in Dogs

T. Fan, M. Paoloni, C. Khanna, 2010, PloS one.

Prospective observational study of dogs with splenic mass rupture suggests potentially lower risk of malignancy and more favorable perioperative outcomes.

C. Khanna, S. Stewart, E. Ehrhart, 2020, Veterinary and comparative oncology.

Evaluation of eIF4E Expression in an Osteosarcoma-Specific Tissue Microarray

S. Hewitt, J. Healey, C. Khanna, 2011, Journal of pediatric hematology/oncology.

Phase I clinical evaluation of carboplatin in tumor-bearing cats: a Veterinary Cooperative Oncology Group study.

C. Couto, C. Khanna, W. Kisseberth, 2008, Journal of veterinary internal medicine.

Concepts and Prospects

C. Khanna, Ryane E Englar, S. Stewart, 2021 .

Naturally occurring diseases in animals: contributions to translational medicine.

C. Khanna, M. Lairmore, 2014, ILAR journal.

Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells

A. Üren, S. Dakshanamurthy, J. Toretsky, 2012, Oncogene.

Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators

Javed Khan, Glenn Merlino, Paul S Meltzer, 2004, Nature Medicine.

The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis

Stephen M Hewitt, Richard Gorlick, S. Hewitt, 2004, Nature Medicine.

Metastasis-associated differences in gene expression in a murine model of osteosarcoma.

P. Meltzer, J. Khan, L. Helman, 2001, Cancer research.

Cancers as wounds that do not heal: differences and similarities between renal regeneration/repair and renal cell carcinoma.

A. Rosenwald, J. Powell, Liming Yang, 2006, Cancer research.

Translation of new cancer treatments from pet dogs to humans

M. Paoloni, C. Khanna, Chand Khanna, 2008, Nature Reviews Cancer.

Comparative oncology today.

M. Paoloni, C. Khanna, 2007, The Veterinary clinics of North America. Small animal practice.

Surveillance of Zoonotic Infectious Disease Transmitted by Small Companion Animals

T. Kuiken, S. Cleaveland, J. Kirpensteijn, 2012, Emerging Infectious Diseases.

Results of a phase II clinical trial on the use of ifosfamide for treatment of cats with vaccine-associated sarcomas.

C. Rodriguez, C. Khanna, R. Page, 2006, American journal of veterinary research.

Molecular Diagnostics

M. Paoloni, C. Khanna, A. Avery, 2020, Withrow and MacEwen's Small Animal Clinical Oncology.

Tumor Biology and Metastasis

D. Argyle, C. Khanna, Nicole Giancristofaro, 2020, Withrow and MacEwen's Small Animal Clinical Oncology.

improved cancer drug development with drug disco

D. Warshawsky, C. Khanna, S. Stewart, 2019 .

p53 Loss Increases the Osteogenic Differentiation of Bone Marrow Stromal Cells

Howard H. Yang, A. Lal, G. Merlino, 2015, Stem cells.

Somatic inactivating PTPRJ mutations and dysregulated pathways identified in canine melanoma by integrated comparative genomic analysis

Winnie S. Liang, M. Neff, W. Tembe, 2017, bioRxiv.

Corruption of the Fas Pathway Delays the Pulmonary Clearance of Murine Osteosarcoma Cells, Enhances Their Metastatic Potential, and Reduces the Effect of Aerosol Gemcitabine

E. Kleinerman, S. Jia, L. Worth, 2007, Clinical Cancer Research.

Defining the Pharmacodynamic Profile and Therapeutic Index of NHS-IL12 Immunocytokine in Dogs with Malignant Melanoma

M. Kiupel, M. Paoloni, C. Khanna, 2015, PloS one.

Beta4 integrin promotes osteosarcoma metastasis and interacts with ezrin

L. Helman, R. Tuan, C. Mackall, 2009, Oncogene.

Mitochondrial retrograde signaling induces epithelial–mesenchymal transition and generates breast cancer stem cells

R. Carstens, G. Ruthel, C. Khanna, 2014, Oncogene.

Modeling metastasis in vivo.

K. Hunter, C. Khanna, 2004, Carcinogenesis.

Biology of childhood osteogenic sarcoma and potential targets for therapeutic development: meeting summary.

P. Meltzer, M. Ladanyi, E. Kleinerman, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Effect of modulation of MET with the small molecule inhibitor PF-04217903 on osteosarcoma metastasis in vivo.

J. Christensen, L. Helman, S. Y. Kim, 2010 .

Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models.

L. Staudt, J. Khan, Jun S. Wei, 2009, The Journal of clinical investigation.

Modeling metastasis biology and therapy in real time in the mouse lung.

K. Hunter, L. Wakefield, S. Hewitt, 2010, The Journal of clinical investigation.

Somatic inactivating PTPRJ mutations and dysregulated pathways identified in canine malignant melanoma by integrated comparative genomic analysis

Winnie S. Liang, J. Trent, M. Neff, 2018, PLoS genetics.

8 – Molecular Diagnostics

M. Paoloni, C. Khanna, A. Avery, 2013 .

Germline TP53 variants and susceptibility to osteosarcoma.

S. Chanock, J. Gastier-Foster, M. Yeager, 2015, Journal of the National Cancer Institute.

Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening.

Qing-Rong Chen, Sean Davis, Javed Khan, 2011, Journal of the National Cancer Institute.

Combined SFK/MEK inhibition prevents metastatic outgrowth of dormant tumor cells.

M. Hoenerhoff, Jeffrey E. Green, C. Khanna, 2014, The Journal of clinical investigation.

Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton.

S. Lockett, H. Kleinman, S. Costes, 2008, Cancer research.

CCL9 Induced by TGFβ Signaling in Myeloid Cells Enhances Tumor Cell Survival in the Premetastatic Organ.

K. Hunter, C. Khanna, B. R. Achyut, 2015, Cancer research.

Novel targets with potential therapeutic applications in osteosarcoma

C. Khanna, Chand Khanna, 2008, Current oncology reports.

Genome-wide Association Study Identifies Two Susceptibility Loci for Osteosarcoma

David M. Thomas, Peter Kraft, Dina Halai, 2013, Nature Genetics.

Protein kinase C regulates ezrin-radixin-moesin phosphorylation in canine osteosarcoma cells.

C. Khanna, L. Ren, C. Mazcko, 2011, Veterinary and comparative oncology.

Aerosol delivery of interleukin 2 liposomes is nontoxic and biologically effective: canine studies.

P. Anderson, C. Khanna, D. Hasz, 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

Guiding the Optimal Translation of New Cancer Treatments From Canine to Human Cancer Patients

S. Hirschfeld, C. Khanna, C. London, 2009, Clinical Cancer Research.

Inhibition of Tumor Cell Motility by the Interferon-inducible GTPase MxA*

W. Linehan, P. Nguyen, J. Trepel, 2009, Journal of Biological Chemistry.

A review of the association between osteosarcoma metastasis and protein translation.

C. Khanna, T. Osborne, 2012, Journal of comparative pathology.

The Biology of Metastases in Pediatric Sarcomas

L. Helman, C. Khanna, K. Krishnan, 2005, Cancer journal.

Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma.

L. Helman, X. Wan, C. Khanna, 2005, Cancer research.

Comparative Aspects of Osteosarcoma Pathogenesis in Humans and Dogs

T. Fan, C. Khanna, 2015, Veterinary sciences.

Nebulized Interleukin 2 Liposomes: Aerosol Characteristics and Biodistribution

P. Anderson, J. Waldrep, C. Khanna, 1997, The Journal of pharmacy and pharmacology.

Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression

P. Meltzer, S. Davis, T. Triche, 2009, BMC Genomics.

The current state and a perspective towards the future of osteosarcoma in dogs.

C. Khanna, 2016, Veterinary and comparative oncology.

Perspectives from man’s best friend: National Academy of Medicine’s Workshop on Comparative Oncology

Mark Dewhirst, Daniel L. Gustafson, Deborah W. Knapp, 2016, Science Translational Medicine.

A randomized trial investigating the efficacy and safety of water soluble micellar paclitaxel (Paccal Vet) for treatment of nonresectable grade 2 or 3 mast cell tumors in dogs.

D. Thamm, M. Martano, J. Hirschberger, 2012, Journal of veterinary internal medicine.

Randomized controlled trial of doxorubicin versus dactinomycin in a multiagent protocol for treatment of dogs with malignant lymphoma.

D. W. Hayden, F. W. Bell, C. Khanna, 1998, Journal of the American Veterinary Medical Association.

2 – Tumor Biology and Metastasis

D. Argyle, C. Khanna, 2013 .

An orthotopic model of murine osteosarcoma with clonally related variants differing in pulmonary metastatic potential

L. Helman, M. Tsokos, C. Khanna, 2004, Clinical & Experimental Metastasis.

Targeting the lung: preclinical and comparative evaluation of anticancer aerosols in dogs with naturally occurring cancers.

C. Khanna, D. Vail, 2003, Current cancer drug targets.

Phase I C linical Evaluation of Carb oplatin in Tumor-Bearing C ats: A V eterinary Cooperative O ncology G roup Study

C. Khanna, W. Kisseberth, J. Yaissle, 2008 .

A randomized controlled trial of octreotide pamoate long-acting release and carboplatin versus carboplatin alone in dogs with naturally occurring osteosarcoma: evaluation of insulin-like growth factor suppression and chemotherapy.

S. Hewitt, L. Helman, C. Khanna, 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma.

David M. Thomas, Dina Halai, Sean Davis, 2015, Cancer discovery.

MS-27-275, an inhibitor of histone deacetylase, has marked in vitro and in vivo antitumor activity against pediatric solid tumors.

S. Bates, J. Jaboin, C. Thiele, 2002, Cancer research.

Global Methylation Analysis Identifies PITX2 as an Upstream Regulator of the Androgen Receptor and IGF-I Receptor Genes in Prostate Cancer

H. Schayek, S. Plymate, H. Werner, 2012, Hormone and Metabolic Research.

Addiction to elevated insulin-like growth factor I receptor and initial modulation of the AKT pathway define the responsiveness of rhabdomyosarcoma to the targeting antibody.

L. Helman, X. Wan, C. Khanna, 2008, Cancer research.

A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis

Natalie K. Wolf, Madison T. Weg, D. Largaespada, 2015, Nature Genetics.

Toward a Drug Development Path That Targets Metastatic Progression in Osteosarcoma

P. Meltzer, J. Trent, E. Kleinerman, 2014, Clinical Cancer Research.

Core biopsies can be used to distinguish differences in expression profiling by cDNA microarrays.

C. Sotiriou, A. Jazaeri, E. Liu, 2002, The Journal of molecular diagnostics : JMD.

A novel noninvasive method for evaluating experimental lung metastasis in mice.

J. Webster, C. Khanna, A. Mendoza, 2013, Journal of the American Association for Laboratory Animal Science : JAALAS.

PTEN phosphatase inhibits metastasis by negatively regulating the Entpd5/IGF1R pathway through ATF6

G. Merlino, M. McMahon, M. Bosenberg, 2023, iScience.

Revisiting the seed and soil in cancer metastasis.

C. Khanna, Chand Khanna, Martin Mendoza, 2009, The international journal of biochemistry & cell biology.

Credentialing preclinical pediatric xenograft models using gene expression and tissue microarray analysis.

Peter Houghton, Javed Khan, Sven Bilke, 2007, Cancer research.

Precision medicine: an opportunity for a paradigm shift in veterinary medicine.

J. Trent, W. Hendricks, M. Kotlikoff, 2016, Journal of the American Veterinary Medical Association.

NCI Comparative Oncology Program Testing of Non-Camptothecin Indenoisoquinoline Topoisomerase I Inhibitors in Naturally Occurring Canine Lymphoma

James H. Doroshow, Amy LeBlanc, Yves Pommier, 2018, Clinical Cancer Research.

Nm 23-H 1 Suppresses Metastasis by Inhibiting Expression of the Lysophosphatidic Acid Receptor EDG 2

S. Steinberg, C. Horak, M. Merino, 2007 .

Prospective study of thrombospondin-1 mimetic peptides, ABT-510 and ABT-898, in dogs with soft tissue sarcoma.

J. Henkin, C. Khanna, E. McKeegan, 2012, Journal of veterinary internal medicine.

Preclinical Evaluation of Antiangiogenic Thrombospondin-1 Peptide Mimetics, ABT-526 and ABT-510, in Companion Dogs with Naturally Occurring Cancers

F. Haviv, J. Henkin, C. Khanna, 2006, Clinical Cancer Research.

Current state of pediatric sarcoma biology and opportunities for future discovery: A report from the sarcoma translational research workshop.

C. Bult, P. Meltzer, P. Sorensen, 2016, Cancer genetics.

Pharmacokinetics of orally administered low-dose rapamycin in healthy dogs.

T. Fan, C. Khanna, R. Hansen, 2016, American journal of veterinary research.

Positively selected enhancer elements endow osteosarcoma cells with metastatic competence

James J. Morrow, J. Stamatoyannopoulos, P. Meltzer, 2017, Nature Medicine.

The ezrin metastatic phenotype is associated with the initiation of protein translation.

J. Khan, Jun S. Wei, T. Veenstra, 2012, Neoplasia.

The Comparative Oncology Trials Consortium: Using Spontaneously Occurring Cancers in Dogs to Inform the Cancer Drug Development Pathway

M. Paoloni, C. Khanna, C. Mazcko, 2009, PLoS medicine.

Launching a Novel Preclinical Infrastructure: Comparative Oncology Trials Consortium Directed Therapeutic Targeting of TNFα to Cancer Vasculature

S. Libutti, W. Arap, D. Thamm, 2009, PloS one.

Identification of potential modulators of osteosarcoma metastasis by high‐throughput cellular screening of natural products

L. Jia, E. Goncharova, C. J. Henrich, 2020, Chemical biology & drug design.

Prospective Molecular Profiling of Canine Cancers Provides a Clinically Relevant Comparative Model for Evaluating Personalized Medicine (PMed) Trials

David Cherba, Christopher Kingsley, Christina Mazcko, 2014, PloS one.

Fishing for the origins of cancer.

G. Merlino, C. Khanna, 2007, Genes & Development.

Adjuvant Sirolimus Does Not Improve Outcome in Pet Dogs Receiving Standard-of-Care Therapy for Appendicular Osteosarcoma: A Prospective, Randomized Trial of 324 Dogs

T. Fan, S. Suter, C. Khanna, 2021, Clinical Cancer Research.

Towards the Delivery of Precision Veterinary Cancer Medicine.

C. Khanna, Anna Katogiritis, 2019, The Veterinary clinics of North America. Small animal practice.

Osteosarcoma Metastasis : An Unmet Clinical Need and Unique Drug Development Opportunity

D. Warshawsky, C. Khanna, S. Stewart, 2019 .

A RUNX2-Mediated Epigenetic Regulation of the Survival of p53 Defective Cancer Cells

Yunlong He, Jing Huang, Chengyu Liu, 2016, PLoS genetics.

The molecular biology of pulmonary metastasis.

L. Helman, C. Khanna, K. Krishnan, 2006, Thoracic surgery clinics.

Type III Collagen Directs Stromal Organization and Limits Metastasis in a Murine Model of Breast Cancer.

E. Puré, R. Wells, C. Khanna, 2015, The American journal of pathology.

Ecteinascidin 743 interferes with the activity of EWS-FLI1 in Ewing sarcoma cells.

J. Khan, Y. Pommier, Qingrong Chen, 2011, Neoplasia.

Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases

L. Helman, D. Wong, S. Y. Kim, 2007, Clinical & Experimental Metastasis.

The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation

T. Veenstra, S. Hewitt, A. Weissman, 2007, Nature Medicine.

Positively Selected Enhancer Elements Endow Tumor Cells with Metastatic Competence

James J. Morrow, J. Stamatoyannopoulos, P. Meltzer, 2017, bioRxiv.

Positively Selected Enhancer Elements Endow Tumor Cells with Metastatic Competence

James J. Morrow, J. Stamatoyannopoulos, P. Meltzer, 2017, bioRxiv.

CCI-779 inhibits rhabdomyosarcoma xenograft growth by an antiangiogenic mechanism linked to the targeting of mTOR/Hif-1alpha/VEGF signaling.

L. Helman, N. Shen, X. Wan, 2006, Neoplasia.

Immune reconstitution prevents metastatic recurrence of murine osteosarcoma

L. Helman, C. Mackall, C. Khanna, 2007, Cancer Immunology, Immunotherapy.

CD1d-restricted natural killer T cells can down-regulate tumor immunosurveillance independent of interleukin-4 receptor-signal transducer and activator of transcription 6 or transforming growth factor-beta.

J. Berzofsky, L. Helman, C. Mackall, 2006, Cancer research.

Murine osteosarcoma primary tumour growth and metastatic progression is maintained after marked suppression of serum insulin‐like growth factor I

D. Leroith, L. Helman, S. Yakar, 2009, International journal of cancer.

Leukocyte and cytokine variables in asymptomatic Pugs at genetic risk of necrotizing meningoencephalitis

M. Huentelman, J. Talboom, C. Lewis, 2021, Journal of veterinary internal medicine.

Preclinical studies of treosulfan demonstrate potent activity in Ewing’s sarcoma

C. Niemeyer, U. Kontny, M. Erlacher, 2008, Cancer Chemotherapy and Pharmacology.

Inhibition of AP-1 transcriptional activity blocks the migration, invasion, and experimental metastasis of murine osteosarcoma.

H. Donninger, M. Birrer, C. Khanna, 2009, The American journal of pathology.

Catching Cancer by the Tail: New Perspectives on the Use of Kinase Inhibitors

C. Khanna, I. Gordon, 2009, Clinical Cancer Research.

Correlation between clinical outcome and growth factor pathway expression in osteogenic sarcoma

Mimi Y. Kim, S. Hewitt, J. Healey, 2009, Cancer.

Alterations in Gemin5 expression contribute to alternative mRNA splicing patterns and tumor cell motility.

Zhaojing Meng, Timothy D Veenstra, C. Horak, 2008, Cancer research.

Comparative Gene Expression Analyses Identify Luminal and Basal Subtypes of Canine Invasive Urothelial Carcinoma That Mimic Patterns in Human Invasive Bladder Cancer

B. Craig, D. Dhawan, J. Ramos-Vara, 2015, PloS one.

Upregulation of Glucose-Regulated Protein 78 in Metastatic Cancer Cells Is Necessary for Lung Metastasis Progression12

James J. Morrow, Tyler E. Miller, P. Scacheri, 2016, Neoplasia.

Obesity and Associated Comorbidities in People and Companion Animals: A One Health Perspective.

S. Cunningham, C. Khanna, M. Day, 2017, Journal of comparative pathology.

Activation of the unfolded protein response in sarcoma cells treated with rapamycin or temsirolimus

A. Weissman, J. Dinman, C. Khanna, 2017, PloS one.

Hospital Team Considerations

H. Ballantyne, C. Khanna, S. Stewart, 2021 .

A Comparative Oncology Study of Iniparib Defines Its Pharmacokinetic Profile and Biological Activity in a Naturally-Occurring Canine Cancer Model

Christina Mazcko, Amy K. LeBlanc, Jessica Lawrence, 2016, PloS one.

Cooperative Activity of Cytotoxic Chemotherapy with Antiangiogenic Thrombospondin-I Peptides, ABT-526 in Pet Dogs with Relapsed Lymphoma

J. Henkin, E. Cozzi, C. Khanna, 2006, Clinical Cancer Research.

A potential early clinical phenotype of necrotizing meningoencephalitis in genetically at‐risk pug dogs

M. Huentelman, I. Piras, C. Khanna, 2022, Journal of veterinary internal medicine.

Survivorship Endpoints in Pet Dogs with Naturally Occurring Cancer as Models for Human Cancer

C. Khanna, S. Kahn, A. Mutsaers, 2022, Journal of Oncology Research and Therapy.

Molecular approaches in pediatric oncology.

L. Helman, C. Khanna, 2006, Annual review of medicine.

Osteosarcoma enters a post genomic era with in silico opportunities: Generation of the High Dimensional Database for facilitating sarcoma biology research: A report from the Children's Oncology Group and the QuadW Foundation

J. Toretsky, C. Lau, T. Man, 2017, PloS one.

Correction: Corrigendum: Positively selected enhancer elements endow osteosarcoma cells with metastatic competence

James J. Morrow, J. Stamatoyannopoulos, P. Meltzer, 2018, Nature Medicine.

Dysregulation of ezrin phosphorylation prevents metastasis and alters cellular metabolism in osteosarcoma.

J. Khan, Qingrong Chen, C. Khanna, 2012, Cancer research.

Retrospective evaluation of the impact of hypoxemia during thoracic surgery in dogs on outcome: A multicenter analysis of 94 cases.

C. Khanna, S. Stewart, L. Duffee, 2023, Veterinary anaesthesia and analgesia.

More on cultivating veterinarian-scientists.

M. Barton, C. Khanna, M. Oyama, 2010, Journal of the American Veterinary Medical Association.

Feasibility of circulating tumor DNA analysis in dogs with naturally occurring malignant and benign splenic lesions

J. Trent, M. Murtaza, C. Khanna, 2022, Scientific Reports.

Guiding the Optimal Translation of New Cancer Treatments From Canine to Human Cancer Patients

S. Hirschfeld, C. Khanna, C. London, 2009, Clinical Cancer Research.

CCL9 Induced by TGFβ Signaling in Myeloid Cells Enhances Tumor Cell Survival in the Premetastatic Organ.

K. Hunter, C. Khanna, B. R. Achyut, 2015, Cancer research.

Defining the Value of a Comparative Approach to Cancer Drug Development

C. Khanna, C. Mazcko, A. LeBlanc, 2015, Clinical Cancer Research.

Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton.

S. Lockett, H. Kleinman, S. Costes, 2008, Cancer research.

Addiction to elevated insulin-like growth factor I receptor and initial modulation of the AKT pathway define the responsiveness of rhabdomyosarcoma to the targeting antibody.

L. Helman, X. Wan, C. Khanna, 2008, Cancer research.

A survey of evidence in the Journal of Veterinary Internal Medicine oncology manuscripts from 1999 to 2007.

C. Khanna, A. Sahora, 2010, Journal of veterinary internal medicine.

Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33.

David M. Thomas, Krista A. Zanetti, Geoffrey S. Tobias, 2014, Human molecular genetics.

Modeling metastasis biology and therapy in real time in the mouse lung.

K. Hunter, L. Wakefield, S. Hewitt, 2010, Journal of Clinical Investigation.

Assessing a Novel 3D Assay System for Drug Screening against OS Metastasis

D. Warshawsky, C. Khanna, D. Barkan, 2021, Pharmaceuticals.

The role of clinical trials in veterinary oncology.

C. Khanna, J. Burton, 2014, The Veterinary clinics of North America. Small animal practice.

Comparative Gene Expression Analyses Identify Luminal and Basal Subtypes of Canine Invasive Urothelial Carcinoma That Mimic Patterns in Human Invasive Bladder Cancer

B. Craig, D. Dhawan, J. Ramos-Vara, 2015, PloS one.