Xiaolin Wu

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Enhancers Are Major Targets for Murine Leukemia Virus Vector Integration

Michael Poidinger, Stephen H. Hughes, Janet L. Macpherson, 2014, Journal of Virology.

Weak Palindromic Consensus Sequences Are a Common Feature Found at the Integration Target Sites of Many Retroviruses

S. Burgess, B. Crise, Xiaolin Wu, 2005, Journal of Virology.

Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions

Bo Zhang, Zuoyan Zhu, Shuo Lin, 2007, Proceedings of the National Academy of Sciences.

LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes

Stephen H Hughes, Brian T Luke, Henry L Levin, 2015, Genes & development.

13. Hot Spots for rAAV2 Vector Integration in Mice

M. Kay, S. Burgess, M. Grompe, 2004 .

Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration.

A. Brass, A. Engelman, S. Sarafianos, 2018, Cell host & microbe.

Distinct genome‐wide methylation patterns in sporadic and hereditary nonfunctioning pancreatic neuroendocrine tumors

J. Lack, E. Kebebew, A. Tirosh, 2019, Cancer.

B-108 Specific HIV integration sites are linked to clonal expansion and persistence of infected cells

S. Hughes, J. Mellors, J. Coffin, 2016 .

Gene-edited pseudogene resurrection corrects p47phox-deficient chronic granulomatous disease.

J. Chiorini, D. Kuhns, S. Afione, 2017, Blood advances.

Diagnostic approach to the evaluation of myeloid malignancies following CAR T-cell therapy in B-cell acute lymphoblastic leukemia

J. Khan, T. Fry, K. Calvo, 2020, Journal for ImmunoTherapy of Cancer.

Clonal expansion of CAR T cells harboring lentivector integration in the CBL gene following anti-CD22 CAR T-cell therapy.

M. Raffeld, S. Hughes, M. Stetler-Stevenson, 2019, Blood advances.

High-Resolution Genome-Wide Mapping of Transposon Integration in Mammals

Shawn M. Burgess, Brian Garrison, Mark A. Kay, 2005, Molecular and Cellular Biology.

Early Emergence and Long-Term Persistence of HIV-Infected T-Cell Clones in Children

S. Hughes, J. Mellors, J. Coffin, 2021, mBio.

Early Emergence and Long-Term Persistence of HIV-Infected T Cell Clones in Children

S. Hughes, J. Mellors, J. Coffin, 2020, bioRxiv.

HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor

A. Engelman, S. Hughes, Steven J Smith, 2012, Nucleic acids research.

Combined HIV-1 sequence and integration site analysis informs viral dynamics and allows reconstruction of replicating viral ancestors

Michele D. Sobolewski, Wei-Shau Hu, S. Hughes, 2019, Proceedings of the National Academy of Sciences.

Germline SUCLG2 Variants in Patients with Pheochromocytoma and Paraganglioma.

Jun Zhu, J. Černý, J. Neuzil, 2021, Journal of the National Cancer Institute.

Lentivector cryptic splicing mediates increase in CD34+ clones expressing truncated HMGA2 in human X-linked severe combined immunodeficiency

L. Notarangelo, J. Puck, S. S. De Ravin, 2022, Nature Communications.

Radiation-inducible promoter mediated PUMA gene in the the treatment of Tca8113

Bing Liu, Xiaolin Wu, Wei Zhao, 2011 .

Redefining the common insertion site.

Brian T Luke, B. Luke, S. Burgess, 2006, Virology.

Large-Scale Molecular Characterization of Adeno-Associated Virus Vector Integration in Mouse Liver

Theresa A. Storm, Shawn M. Burgess, Eugenio Montini, 2005, Journal of Virology.

Transcription Start Regions in the Human Genome Are Favored Targets for MLV Integration

Shawn M. Burgess, S. Burgess, B. Crise, 2003, Science.

CRISPR-Cas9-AAV versus lentivector transduction for genome modification of X-linked severe combined immunodeficiency hematopoietic stem cells

L. Notarangelo, S. Tsai, M. Porteus, 2023, Frontiers in Immunology.

Lentiviral hematopoietic stem cell gene therapy for X-linked severe combined immunodeficiency

L. Notarangelo, J. Gray, D. Kuhns, 2016, Science Translational Medicine.

CRISPR-Cas9 gene repair of hematopoietic stem cells from patients with X-linked chronic granulomatous disease

Pachai Natarajan, Angelia Viley, Susan Moir, 2017, Science Translational Medicine.

CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice

Mitchell Ho, J. Khan, S. Hewitt, 2021, Cell reports. Medicine.

The olfactory bulb provides a radioresistant niche for glioblastoma cells.

K. Camphausen, P. Tofilon, Xiaolin Wu, 2020, International journal of radiation oncology, biology, physics.

Radiation drives the evolution of orthotopic xenografts initiated from glioblastoma stem-like cells.

K. Camphausen, U. Shankavaram, P. Tofilon, 2019, Cancer research.

Real-time PCR analysis of candidate imprinted genes on mouse chromosome 11 shows balanced expression from the maternal and paternal chromosomes and strain-specific variation in expression levels

Karlyne M. Reilly, K. Reilly, E. Rozenblum, 2008, Epigenetics.

Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration

A. Engelman, C. Allis, S. Hughes, 2010, Proceedings of the National Academy of Sciences.

The NCI Transcriptional Pharmacodynamics Workbench: A Tool to Examine Dynamic Expression Profiling of Therapeutic Response in the NCI-60 Cell Line Panel.

Dmitriy Sonkin, Yingdong Zhao, Jianwen Fang, 2018, Cancer research.

The Integrator complex controls the termination of transcription at diverse classes of gene targets

M. Pagano, M. Washburn, S. Hughes, 2015, Cell Research.

An analytical pipeline for identifying and mapping the integration sites of HIV and other retroviruses

S. Hughes, J. Coffin, Xiaolin Wu, 2020, BMC Genomics.

Retroviral Integration Sites Correlate with Expressed Genes in Hematopoietic Stem Cells

C. Schwager, A. Ho, Jonathon Blake, 2005, Stem cells.

Integration in oncogenes plays only a minor role in determining the in vivo distribution of HIV integration sites before or during suppressive antiretroviral therapy

S. Hughes, J. Mellors, B. Luke, 2021, PLoS pathogens.

Integration in or Near Oncogenes Plays Only a Minor Role in Determining the in Vivo Distribution of HIV Integration Sites Before or During Suppressive Antiretroviral Therapy

S. Hughes, J. Mellors, B. Luke, 2020, bioRxiv.

Human T-Cell Leukemia Virus Type 1 Integration Target Sites in the Human Genome: Comparison with Those of Other Retroviruses

S. Hughes, B. Crise, Xiaolin Wu, 2007, Journal of Virology.

Simian Immunodeficiency Virus Integration Preference Is Similar to That of Human Immunodeficiency Virus Type 1

L. Arthur, D. Whitby, B. Crise, 2005, Journal of Virology.

DNA Palindromes with a Modest Arm Length of ≳20 Base Pairs Are a Significant Target for Recombinant Adeno-Associated Virus Vector Integration in the Liver, Muscles, and Heart in Mice

Theresa A. Storm, M. Kay, S. Lewis, 2007, Journal of Virology.

Genes affected by mouse mammary tumor virus (MMTV) proviral insertions in mouse mammary tumors are deregulated or mutated in primary human mammary tumors

R. Stephens, U. Mudunuri, B. Luke, 2012, Oncotarget.

Retrovirus Integration Database (RID): a public database for retroviral insertion sites into host genomes

John W. Mellors, John M. Coffin, Wei Shao, 2016, Retrovirology.

Rapid Communication Redefining the common insertion site

B. Luke, S. Burgess, Xiaolin Wu, 2006 .

CRISPR-targeted MAGT1 insertion restores XMEN patient hematopoietic stem cells and lymphocytes.

L. Notarangelo, S. Tsai, B. Kleinstiver, 2021, Blood.

Correction of X-CGD patient HSPCs by targeted CYBB cDNA insertion using CRISPR/Cas9 with 53BP1 inhibition for enhanced homology-directed repair

Linhong Li, M. Porteus, N. Theobald, 2021, Gene therapy.

Enhanced Homology-directed Repair for Highly Efficient Gene Editing in Hematopoietic Stem/Progenitor Cells.

Linhong Li, S. Tsai, M. Porteus, 2021, Blood.

Dynamic Shifts in the HIV Proviral Landscape During Long Term Combination Antiretroviral Therapy: Implications for Persistence and Control of HIV Infections

S. Hughes, E. Boritz, J. Coffin, 2020, Viruses.

CRISPR/Cas9-mediated gene knockout is insensitive to target copy number but is dependent on guide RNA potency and Cas9/sgRNA threshold expression level

Ji Luo, Eric Batchelor, Eric Batchelor, 2017, Nucleic acids research.

Clones of infected cells arise early in HIV-infected individuals.

S. Hughes, J. Mellors, B. Luke, 2019, JCI insight.

Multiple Origins of Virus Persistence during Natural Control of HIV Infection

S. Hughes, E. Boritz, S. Migueles, 2016, Cell.

Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivo

S. Hughes, J. Kovacs, M. Polis, 2016, Proceedings of the National Academy of Sciences.

Construction and next-generation sequencing analysis of a large phage-displayed VNAR single-domain antibody library from six naïve nurse sharks

Mitchell Ho, M. Flajnik, Xiaolin Wu, 2018, Antibody therapeutics.

Pharmacogenomics Implementation at the National Institutes of Health Clinical Center

Ellen J. Eckes, M. Barcus, D. Soppet, 2017, Journal of clinical pharmacology.

H3K4me3 Interactions with TAF3 Regulate Preinitiation Complex Assembly and Selective Gene Activation

Stephen H. Hughes, Takahiro Nakayama, S. Hughes, 2013, Cell.

Insertional activation of STAT3 and LCK by HIV-1 proviruses in T cell lymphomas

Beth A. Scott, S. Hughes, J. Mellors, 2021, Science advances.

Correction of X-CGD patient HSPCs by targeted CYBB cDNA insertion using CRISPR/Cas9 with 53BP1 inhibition for enhanced homology-directed repair

Linhong Li, M. Porteus, N. Theobald, 2021, Gene Therapy.

Targeted Gene Addition to a Safe Harbor locus in human CD34+ Hematopoietic Stem Cells for Correction of X-linked Chronic Granulomatous Disease

Castle Raley, Pei-Qi Liu, Fyodor D Urnov, 2016, Nature Biotechnology.

Clonal expansion of SIV-infected cells in macaques on antiretroviral therapy is similar to that of HIV-infected cells in humans

S. Hughes, J. Lifson, J. Coffin, 2019, PLoS pathogens.

HIV-1 in lymph nodes is maintained by cellular proliferation during antiretroviral therapy.

S. Hughes, J. Mellors, J. Coffin, 2019, The Journal of clinical investigation.

HIV-1 in Lymph Nodes is Maintained by Cellular Proliferation During Antiretroviral 1 Therapy 2 3

Patro, S. Hughes, J. Mellors, 2019 .

Preferential selection of human T-cell leukemia virus type I provirus integration sites in leukemic versus carrier states.

M. Matsuoka, J. Yasunaga, Xiaolin Wu, 2005, Blood.

HIV-1 Viremia Not Suppressible By Antiretroviral Therapy Can Originate from Large T-Cell Clones Producing Infectious Virus

S. Hughes, J. Mellors, J. Coffin, 2020, bioRxiv.

Mutant IL-7Rα and mutant NRas are sufficient to induce murine T cell acute lymphoblastic leukemia

D. Esposito, S. Durum, Wenqing Li, 2018, Leukemia.

Aberrant Clonal Hematopoiesis following Lentiviral Vector Transduction of HSPCs in a Rhesus Macaque.

Chuanfeng Wu, J. Tisdale, K. Calvo, 2019, Molecular therapy : the journal of the American Society of Gene Therapy.

Frequency and Spectrum of Genomic Integration of Recombinant Adeno-Associated Virus Serotype 8 Vector in Neonatal Mouse Liver

H. Nakai, Xiaolin Wu, Xiaolin Wu, 2008, Journal of Virology.

Differential Effects of Human Immunodeficiency Virus Type 1 Capsid and Cellular Factors Nucleoporin 153 and LEDGF/p75 on the Efficiency and Specificity of Viral DNA Integration

Kenneth A. Matreyek, A. Engelman, S. Hughes, 2012, Journal of Virology.

NCF1 (p47phox)-deficient chronic granulomatous disease: comprehensive genetic and flow cytometric analysis.

S. Holland, A. Hsu, D. Kuhns, 2019, Blood advances.

Tracking HIV-1-Infected Cell Clones Using Integration Site-Specific qPCR

S. Hughes, J. Mellors, J. Coffin, 2021, Viruses.

False-positive HIV PCR test following ex vivo lentiviral gene transfer treatment of X-linked severe combined immunodeficiency vector.

S. Hughes, J. Coffin, J. Gray, 2014, Molecular therapy : the journal of the American Society of Gene Therapy.

An analytical pipeline for identifying and mapping the integration sites of HIV and other retroviruses

S. Hughes, J. Coffin, Xiaolin Wu, 2020, BMC Genomics.

Correction to: An analytical pipeline for identifying and mapping the integration sites of HIV and other retroviruses

S. Hughes, J. Coffin, Xiaolin Wu, 2020, BMC Genomics.

Retrovirus Integration Database (RID): a public database for retroviral insertion sites into host genomes

S. Hughes, J. Mellors, B. Luke, 2016, Retrovirology.

Proceedings of the Frontiers of Retrovirology Conference 2016

Sebastian A. Wagner, R. König, D. Elleder, 2016, Retrovirology.

Specific HIV integration sites are linked to clonal expansion and persistence of infected cells

S. Hughes, J. Mellors, J. Coffin, 2014, Science.

The largest HIV-1-infected T cell clones in children on long-term combination antiretroviral therapy contain solo LTRs

S. Hughes, J. Mellors, M. Cotton, 2023, mBio.

DNA palindromes with a modest arm length of greater, similar 20 base pairs are a significant target for recombinant adeno-associated virus vector integration in the liver, muscles, and heart in mice.

Theresa A. Storm, M. Kay, S. Lewis, 2007, Journal of virology.

Aberrant Clonal Hematopoiesis Following Lentiviral Transduction of HSPC in a Rhesus Macaque

Chuanfeng Wu, J. Tisdale, K. Calvo, 2019, bioRxiv.

Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration

A. Engelman, C. Allis, S. Hughes, 2010, Proceedings of the National Academy of Sciences.