A. Chabes

发表

A mechanism for preventing asymmetric histone segregation onto replicating DNA strands

R. Xu, H. Gan, Zhiguo Zhang, 2018, Science.

High density of unrepaired genomic ribonucleotides leads to Topoisomerase 1-mediated severe growth defects in absence of ribonucleotide reductase

D. Tollervey, R. Crouch, J. Iranzo, 2020, Nucleic acids research.

Topoisomerase 1-mediated removal of ribonucleotides from nascent leading-strand DNA.

T. Kunkel, S. Lujan, A. Chabes, 2013, Molecular cell.

Lesion bypass by S. cerevisiae Pol ζ alone.

T. Kunkel, Sara K. Binz, S. Iwai, 2011, DNA repair.

Trypanosoma brucei CTP synthetase: A target for the treatment of African sleeping sickness

A. Chabes, R. Brun, D. Steverding, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Rnr4p, a novel ribonucleotide reductase small-subunit protein

A. Chabes, T. Huffaker, L. Thelander, 1997, Molecular and cellular biology.

Yeast Sml1, a Protein Inhibitor of Ribonucleotide Reductase*

A. Chabes, L. Thelander, V. Domkin, 1999, The Journal of Biological Chemistry.

Yeast ribonucleotide reductase has a heterodimeric iron-radical-containing subunit.

S. Wijmenga, A. Chabes, L. Thelander, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Yeast DNA Damage-inducible Rnr3 Has a Very Low Catalytic Activity Strongly Stimulated after the Formation of a Cross-talking Rnr1/Rnr3 Complex*

A. Chabes, L. Thelander, V. Domkin, 2002, The Journal of Biological Chemistry.

H2B Mono-ubiquitylation Facilitates Fork Stalling and Recovery during Replication Stress by Coordinating Rad53 Activation and Chromatin Assembly

A. Chabes, Lisette Marjavaara, C. Kao, 2014, PLoS genetics.

Inactivation of folylpolyglutamate synthetase Met7 results in genome instability driven by an increased dUTP/dTTP ratio

Sushma Sharma, A. Chabes, B. Luke, 2019, Nucleic acids research.

Controlled Protein Degradation Regulates Ribonucleotide Reductase Activity in Proliferating Mammalian Cells during the Normal Cell Cycle and in Response to DNA Damage and Replication Blocks*

A. Chabes, L. Thelander, Lars Thelander, 2000, The Journal of Biological Chemistry.

A common telomeric gene silencing assay is affected by nucleotide metabolism.

B. Stillman, A. Chabes, Weijun Luo, 2011, Molecules and Cells.

Elimination of rNMPs from mitochondrial DNA has no effect on its stability

Danielle L. Watt, M. Engqvist, Sushma Sharma, 2020, Proceedings of the National Academy of Sciences.

The physiological level of rNMPs present in mtDNA does not compromise its stability

Danielle L. Watt, M. Engqvist, Sushma Sharma, 2019 .

Age-dependent loss of mitochondrial DNA integrity in mammalian muscle

Danielle L. Watt, M. Engqvist, Sushma Sharma, 2019, bioRxiv.

Replication Fork Collapse and Genome Instability in a Deoxycytidylate Deaminase Mutant

N. Krogan, P. Russell, A. Roguev, 2012, Molecular and Cellular Biology.

Mrc1 and Rad9 cooperate to regulate initiation and elongation of DNA replication in response to DNA damage

A. Lengronne, P. Pasero, Sushma Sharma, 2018, The EMBO journal.

Phosphines are ribonucleotide reductase reductants that act via C-terminal cysteines similar to thioredoxins and glutaredoxins

A. Chabes, V. Domkin, 2014, Scientific Reports.

Mec1 Is Activated at the Onset of Normal S Phase by Low-dNTP Pools Impeding DNA Replication.

M. Skrzypczak, K. Ginalski, Ismael Padioleau, 2020, Molecular cell.

Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype

Grant W. Brown, C. Myers, K. Shirahige, 2012, The EMBO journal.

Constitutively high dNTP concentration inhibits cell cycle progression and the DNA damage checkpoint in yeast Saccharomyces cerevisiae

B. Stillman, A. Chabes, 2007, Proceedings of the National Academy of Sciences of the United States of America.

S phase block following MEC1ATR inactivation occurs without severe dNTP depletion

A. Chabes, S. Rowbotham, R. Cha, 2015, Biology Open.

BIO015347 1739..1743

A. Chabes, S. Rowbotham, R. Cha, 2015 .

Evidence that processing of ribonucleotides in DNA by topoisomerase 1 is leading-strand specific

T. Kunkel, S. Lujan, A. Chabes, 2015, Nature Structural &Molecular Biology.

Genome instability due to ribonucleotide incorporation into DNA

Danielle L. Watt, T. Kunkel, S. A. Nick McElhinny, 2010, Nature chemical biology.

Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations

A. Chabes, P. Burgers, P. V. Shcherbakova, 2016, Nucleic acids research.

Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations.

A. Chabes, P. Burgers, P. V. Shcherbakova, 2016, Nucleic acids research.

DNA Building Blocks at the Foundation of Better Survival

A. Chabes, L. Thelander, 2003, Cell cycle.

SAMHD1 acts at stalled replication forks to prevent interferon induction

V. Costanzo, M. Benkirane, P. Pasero, 2018, Nature.

Shortage of dNTPs underlies altered replication dynamics and DNA breakage in the absence of the APC/C cofactor Cdh1

S. Moreno, I. Garcı́a-Higuera, J. Méndez, 2017, Oncogene.

Acute Smc5/6 depletion reveals its primary role in rDNA replication by restraining recombination at fork pausing sites

Xiaolan Zhao, A. Chabes, Lisette Marjavaara, 2018, PLoS genetics.

dNTP concentrations do not increase in mammalian cells in response to DNA damage

Sushma Sharma, A. Chabes, P. Mishra, 2022, Cell Metabolism.

Simultaneous determination of ribonucleoside and deoxyribonucleoside triphosphates in biological samples by hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry

T. Moritz, A. Chabes, R. Lundmark, 2018, Nucleic acids research.

Determination of deoxyribonucleoside triphosphate concentrations in yeast cells by strong anion-exchange high-performance liquid chromatography coupled with ultraviolet detection.

Sushma Sharma, A. Chabes, Lisette Marjavaara, 2015, Methods in molecular biology.

Elevated dNTP levels suppress hyper-recombination in Saccharomyces cerevisiae S-phase checkpoint mutants

A. Chabes, Mingzeng Sun, M. Fasullo, 2009, Nucleic acids research.

Survival of DNA Damage in Yeast Directly Depends on Increased dNTP Levels Allowed by Relaxed Feedback Inhibition of Ribonucleotide Reductase

R. Rothstein, Xiaolan Zhao, A. Chabes, 2003, Cell.

SAMHD1 acts at stalled replication forks to prevent interferon induction

V. Costanzo, M. Benkirane, P. Pasero, 2018, Nature.

Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases

Danielle L. Watt, T. Kunkel, S. A. Nick McElhinny, 2010, Proceedings of the National Academy of Sciences.

SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP

A. Schuh, J. Rehwinkel, Sushma Sharma, 2020, Cell reports.

SAMHD1 limits the efficacy of forodesine in leukaemia by protecting cells against cytotoxicity of dGTP

A. Schuh, J. Rehwinkel, Sushma Sharma, 2020, bioRxiv.

De novo dNTP production is essential for normal postnatal murine heart development

Sushma Sharma, A. Chabes, P. Medini, 2019, The Journal of Biological Chemistry.

Ribonucleotides incorporated by the yeast mitochondrial DNA polymerase are not repaired

M. Engqvist, A. Chabes, Clara Navarrete, 2017, Proceedings of the National Academy of Sciences.

Checkpoint Kinase Rad53 Couples Leading- and Lagging-Strand DNA Synthesis under Replication Stress.

Junhong Han, D. Remus, H. Gan, 2017, Molecular cell.

dNTP pools determine fork progression and origin usage under replication stress

Philippe Pasero, Véronique Pantesco, V. Pantesco, 2012, The EMBO journal.

Genome-wide analysis of the specificity and mechanisms of replication infidelity driven by imbalanced dNTP pools

Danielle L. Watt, T. Kunkel, S. Lujan, 2015, Nucleic acids research.

Increased and Imbalanced dNTP Pools Symmetrically Promote Both Leading and Lagging Strand Replication Infidelity

Danielle L. Watt, T. Kunkel, A. Chabes, 2014, PLoS genetics.

Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools

T. Kunkel, A. Chabes, Dinesh Kumar, 2010, Nucleic acids research.

The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage

R. Rothstein, Xiaolan Zhao, A. Chabes, 2001, The EMBO journal.

Strand-specific analysis shows protein binding at replication forks and PCNA unloading from lagging strands when forks stall.

Junhong Han, Zhiguo Zhang, G. Farrugia, 2014, Molecular cell.

Break-Induced Replication Is Highly Inaccurate

A. Malkova, A. Chabes, A. Keszthelyi, 2011, PLoS biology.

The mutation spectrum in genomic late replication domains shapes mammalian GC content

I. Simon, A. Tanay, E. Kenigsberg, 2016, Nucleic acids research.

A genetic screen pinpoints ribonucleotide reductase residues that sustain dNTP homeostasis and specifies a highly mutagenic type of dNTP imbalance

R. Wade, Sushma Sharma, A. Chabes, 2018, Nucleic acids research.

Alterations in cellular metabolism triggered by URA7 or GLN3 inactivation cause imbalanced dNTP pools and increased mutagenesis

M. Knop, Sushma Sharma, A. Chabes, 2017, Proceedings of the National Academy of Sciences.

Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint

A. Chabes, Dinesh Kumar, A. K. Nilsson, 2010, Nucleic acids research.

Cid13 Is a Cytoplasmic Poly(A) Polymerase that Regulates Ribonucleotide Reductase mRNA

J. Yates, P. Russell, W. McDonald, 2002, Cell.

Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance

Danielle L. Watt, J. Trygg, A. Chabes, 2016, Proceedings of the National Academy of Sciences.

dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants

A. Chabes, A. Herr, E. Fox, 2015, Proceedings of the National Academy of Sciences.

Pre-activation of the genome integrity checkpoint increases DNA damage tolerance

A. Chabes, O. Tsaponina, 2013, Nucleic acids research.

Myc-dependent purine biosynthesis affects nucleolar stress and therapy response in prostate cancer

Stefan J. Barfeld, I. Mills, L. Fazli, 2015, Oncotarget.

Telomere length kinetics assay (TELKA) sorts the telomere length maintenance (tlm) mutants into functional groups

M. Kupiec, L. Ungar, A. Chabes, 2014, Nucleic acids research.

Telomere Length Homeostasis Responds to Changes in Intracellular dNTP Pools

Michael Chang, J. Lingner, R. Rothstein, 2013, Genetics.

Upregulation of dNTP Levels After Telomerase Inactivation Influences Telomerase-Independent Telomere Maintenance Pathway Choice in Saccharomyces cerevisiae

Michael Chang, Sushma Sharma, A. Chabes, 2018, G3: Genes, Genomes, Genetics.

Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage

D. Goyal, E. Johansson, A. Chabes, 2008, Nucleic acids research.

Rnr1, but not Rnr3, facilitates the sustained telomerase-dependent elongation of telomeres

M. Kupiec, K. Shemesh, Sushma Sharma, 2017, PLoS Genetics.

Function of the Rad53 Checkpoint Kinase Molecular Basis of the Essential S Phase

M. Tsai, A. Fazio, A. Chabes, 2014 .

Molecular Basis of the Essential S Phase Function of the Rad53 Checkpoint Kinase

M. Tsai, A. Fazio, J. Heierhorst, 2013, Molecular and Cellular Biology.

Ixr1 Is Required for the Expression of the Ribonucleotide Reductase Rnr1 and Maintenance of dNTP Pools

A. Chabes, S. Åström, E. Barsoum, 2011, PLoS genetics.

Mutational and Structural Analyses of the Ribonucleotide Reductase Inhibitor Sml1 Define Its Rnr1 Interaction Domain Whose Inactivation Allows Suppression of mec1 andrad53 Lethality

S. Wijmenga, R. Rothstein, J. H. Ippel, 2000, Molecular and Cellular Biology.

Rtt105 functions as a chaperone for replication protein A to preserve genome stability

Junhong Han, Yujie Sun, H. Gan, 2018, The EMBO journal.

Chl1 helicase controls replication fork progression by regulating dNTP pools

S. Sun, H. van Attikum, Sushma Sharma, 2022, Life Science Alliance.

Separable roles for Mec1/ATR in genome maintenance, DNA replication, and checkpoint signaling

Ethan J. Sanford, M. Smolka, Sushma Sharma, 2018, Genes & development.

A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme

Sushma Sharma, A. Chabes, Daniel P. Kane, 2019, Nature Communications.

Ribonucleotides in mitochondrial DNA

A. Chabes, Paulina H. Wanrooij, 2019, FEBS letters.

Proofreading deficiency in mitochondrial DNA polymerase does not affect total dNTP pools in mouse embryos

Sushma Sharma, A. Chabes, N. Larsson, 2020, Nature Metabolism.

dNTPs and maintenance of genome stability

A. Chabes, 2019 .

A geographically matched control population efficiently limits the number of candidate disease-causing variants in an unbiased whole-genome analysis

Pall I. Olason, E. Johansson, P. Olason, 2019, PloS one.

A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme

Sushma Sharma, A. Chabes, Daniel P. Kane, 2019, Nature Communications.

The histone deacetylases sir2 and rpd3 act on ribosomal DNA to control the replication program in budding yeast.

Kazumasa Yoshida, Hugues Parrinello, Krzysztof Ginalski, 2014, Molecular cell.

Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity

Sushma Sharma, A. Chabes, Tony M Mertz, 2015, Proceedings of the National Academy of Sciences.

The absence of the catalytic domains of Saccharomyces cerevisiae DNA polymerase ϵ strongly reduces DNA replication fidelity.

T. Kunkel, S. Lujan, Sushma Sharma, 2019, Nucleic acids research.

Hydroxyurea-Mediated Cytotoxicity Without Inhibition of Ribonucleotide Reductase

S. Bell, A. Chabes, Lisette Marjavaara, 2016, Cell reports.

Impairment of the non-catalytic subunit Dpb2 of DNA Pol ɛ results in increased involvement of Pol δ on the leading strand.

Sushma Sharma, A. Chabes, I. Fijalkowska, 2023, DNA repair.

Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria

Stefan J. Siira, C. Gustafsson, M. Falkenberg, 2019, Molecular cell.

[SAMHD1 acts at stalled replication forks to prevent interferon induction].

V. Costanzo, M. Benkirane, P. Pasero, 2020, Comptes rendus biologies.

Abnormal Rebuck skin window response in kwashiorkor.

A. Chabes, E. Freyre, O. Poémape, 1973, Jornal de Pediatria.

Pulmonary chemodectomatosis.

A. Chabes, F. Zak, 1963, JAMA.

Isocratic HPLC analysis for the simultaneous determination of dNTPs, rNTPs and ADP in biological samples

Sushma Sharma, A. Chabes, A. Hofer, 2021, Nucleic Acids Research.

NME6: ribonucleotide salvage sustains mitochondrial transcription

A. Chabes, Paulina H. Wanrooij, 2023, The EMBO journal.

A common telomeric gene silencing assay is affected by nucleotide metabolism.

B. Stillman, A. Chabes, Weijun Luo, 2011, Molecular cell.

Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity

Sushma Sharma, A. Chabes, Tony M Mertz, 2015, Proceedings of the National Academy of Sciences.

Myc-dependent purine biosynthesis affects nucleolar stress and therapy response in prostate cancer

Stefan J. Barfeld, I. Mills, L. Fazli, 2015, Oncotarget.

Ribonucleotides incorporated by the yeast mitochondrial DNA polymerase are not repaired

M. Engqvist, A. Chabes, Clara Navarrete, 2017, Proceedings of the National Academy of Sciences.

Topoisomerase 1-mediated removal of ribonucleotides from nascent leading-strand DNA.

T. Kunkel, S. Lujan, A. Chabes, 2013, Molecular cell.

Increased contribution of DNA polymerase delta to the leading strand replication in yeast with an impaired CMG helicase complex.

H. Araki, Sushma Sharma, A. Chabes, 2022, DNA repair.

Developmental signals control chromosome segregation fidelity during pluripotency and neurogenesis by modulating replicative stress

B. Schoell, R. Sotillo, M. Shahbazi, 2024, Nature communications.