Hakim Djaballah

发表

Systematic analysis of RNAi reports identifies dismal commonality at gene-level and reveals an unprecedented enrichment in pooled shRNA screens.

Bhavneet Bhinder, Hakim Djaballah, B. Bhinder, 2013, Combinatorial chemistry & high throughput screening.

An arrayed RNA interference genome-wide screen identifies candidate genes involved in the MicroRNA 21 biogenesis pathway.

M. Landthaler, T. Farazi, S. Magdaleno, 2013, Assay and drug development technologies.

Death induced by CD95 or CD95 ligand elimination.

M. Peter, N. Chandel, J. Richards, 2014, Cell reports.

High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells.

N. Socci, L. Studer, Hakim Djaballah, 2008, Cell stem cell.

Identification of Compounds that Rescue IKBKAP Expression in Familial Dysautonomia-iPS Cells

L. Studer, B. Bhinder, Hakim Djaballah, 2012, Nature Biotechnology.

A high-content assay strategy for the identification and profiling of ABCG2 modulators in live cells.

E. Holland, C. Antczak, B. Bhinder, 2014, Assay and drug development technologies.

Peptidylglutamyl-peptide hydrolase activity of the multicatalytic proteinase complex: evidence for a new high-affinity site, analysis of cooperative kinetics, and the effect of manganese ions.

A. Rivett, Hakim Djaballah, 1992, Biochemistry.

A Multiplexed Cell-Based Assay for the Identification of Modulators of Pre-Membrane Processing as a Target against Dengue Virus

R. Wolkowicz, Cameron A. Smurthwaite, Zachary D Stolp, 2015, Journal of biomolecular screening.

ABCG2 regulates self-renewal and stem cell marker expression but not tumorigenicity or radiation resistance of glioma cells

S. Nelander, O. Podlaha, E. Holland, 2016, Scientific Reports.

Editorial. Random RNAi screening data analysis: a call for standardization.

Hakim Djaballah, 2012, Combinatorial chemistry & high throughput screening.

Time-Resolved Fluorescence Energy Transfer DNA Helicase Assays for High Throughput Screening

D. Earnshaw, Hakim Djaballah, A. Pope, 1999, Journal of biomolecular screening.

Novel Imidazoline Antimicrobial Scaffold That Inhibits DNA Replication with Activity against Mycobacteria and Drug Resistant Gram-Positive Cocci

N. Socci, M. Glickman, Hakim Djaballah, 2014, ACS chemical biology.

A high-throughput scintillation proximity-based assay for human DNA ligase IV.

A. Tomkinson, D. Scheinberg, David Shum, 2012, Assay and drug development technologies.

A high density assay format for the detection of novel cytotoxic agents in large chemical libraries

V. Seshan, David Shum, Hakim Djaballah, 2008, Journal of enzyme inhibition and medicinal chemistry.

Comparison of luminescence ADP production assay and radiometric scintillation proximity assay for Cdc7 kinase.

David Shum, Ruth E Santos, M. Frattini, 2011, Combinatorial chemistry & high throughput screening.

A Miniaturized 1536-Well Format γ -Secretase Assay

David Shum, Hakim Djaballah, C. Radu, 2009 .

A miniaturized 1536-well format gamma-secretase assay.

David Shum, Hakim Djaballah, C. Radu, 2009, Assay and drug development technologies.

Flaviviruses Are Sensitive to Inhibition of Thymidine Synthesis Pathways

D. A. Stein, K. Früh, David Shum, 2013, Journal of Virology.

Synthesis of antiproliferative Cephalotaxus esters and their evaluation against several human hematopoietic and solid tumor cell lines: uncovering differential susceptibilities to multidrug resistance.

C. Antczak, Matthew T. Epperson, David Shum, 2008, Chemistry.

Identiﬁcation of Novel Antipoxviral Agents: Mitoxantrone Inhibits Vaccinia Virus Replication by Blocking Virion Assembly (cid:1)

D. Smee, S. Shuman, Hakim Djaballah, 2007 .

A High-Content Assay to Screen for Modulators of EGFR Function.

C. Antczak, Hakim Djaballah, 2016, Methods in molecular biology.

Synthesis, antileukemic and antiplatelet activities of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines.

David Shum, R. Giridhar, M. Yadav, 2008, European journal of medicinal chemistry.

The multicatalytic proteinase complex (proteasome): structure and conformational changes associated with changes in proteolytic activity.

S. Harding, A. Rivett, Hakim Djaballah, 1993, The Biochemical journal.

High-content assay to identify inhibitors of dengue virus infection.

D. A. Stein, K. Früh, David Shum, 2010, Assay and drug development technologies.

A Preliminary Study of the Activation of Endogenous Pancreatic Exocrine Enzymes during Automated Porcine Islet Isolation 1

S. White, Hakim Djaballah, N. London, 1999, Cell transplantation.

Azaphilones from an Acid Mine Extremophile Strain of a Pleurostomophora sp.

A. Stierle, D. Stierle, T. Mou, 2015, Journal of natural products.

Inhibition of Dengue Virus Replication by a Class of Small-Molecule Compounds That Antagonize Dopamine Receptor D4 and Downstream Mitogen-Activated Protein Kinase Signaling

D. A. Stein, K. Früh, David Shum, 2014, Journal of Virology.

Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion.

E. Cheng, J. Baggs, J. Rabinowitz, 2014, Molecular cell.

Intra-arterial and Oral Digoxin Therapy for Retinoblastoma

S. Brodie, R. Folberg, C. Antczak, 2011, Ophthalmic genetics.

A viral inhibitor of peptide transporters for antigen presentation

P. A. Peterson, R. Tampé, K. Früh, 1995, Nature.

Identification of Compounds that Rescue IKBKAP Expression in Familial Dysautonomia-iPS Cells

L. Studer, B. Bhinder, Hakim Djaballah, 2012, Nature biotechnology.

Identification of Novel Antipoxviral Agents: Mitoxantrone Inhibits Vaccinia Virus Replication by Blocking Virion Assembly

D. Smee, S. Shuman, Hakim Djaballah, 2007, Journal of Virology.

Identification of novel antipoxviral agents : Mitoxantrone inhibits vaccinia virus 10 replication by blocking virion assembly 11 12 13 14

D. Smee, S. Shuman, Hakim Djaballah, 2007 .

A Profiling Platform for the Identification of Selective Metalloprotease Inhibitors

C. Antczak, Hakim Djaballah, C. Radu, 2008, Journal of biomolecular screening.

Modulators of the microRNA biogenesis pathway via arrayed lentiviral enabled RNAi screening for drug and biomarker discovery.

David Shum, B. Bhinder, Hakim Djaballah, 2013, Combinatorial chemistry & high throughput screening.

An image-based biosensor assay strategy to screen for modulators of the microRNA 21 biogenesis pathway.

T. Tuschl, M. Landthaler, T. Farazi, 2012, Combinatorial chemistry & high throughput screening.

Live-Cell Imaging of Caspase Activation for High-Content Screening

Christophe Antczak, Constantin Radu, Hakim Djaballah, 2009, Journal of biomolecular screening.

Discovery of a Dicer-Independent, Cell-Type Dependent Alternate Targeting Sequence Generator: Implications in Gene Silencing & Pooled RNAi Screens

S. Magdaleno, David Shum, B. Bhinder, 2014, PloS one.

Comparative analysis of RNAi screening technologies at genome-scale reveals an inherent processing inefficiency of the plasmid-based shRNA hairpin.

David Shum, B. Bhinder, Hakim Djaballah, 2014, Combinatorial chemistry & high throughput screening.

A 1536-well fluorescence polarization assay to screen for modulators of the MUSASHI family of RNA-binding proteins.

M. Kharas, C. Antczak, David Shum, 2014, Combinatorial chemistry & high throughput screening.

Validation of a high-content screening assay using whole-well imaging of transformed phenotypes.

E. Holland, C. Antczak, David Shum, 2011, Assay and drug development technologies.

BET Inhibition-Induced GSK3β Feedback Enhances Lymphoma Vulnerability to PI3K Inhibitors.

V. Seshan, J. Philip, E. de Stanchina, 2018, Cell reports.

A high throughput scintillation proximity imaging assay for protein methyltransferases.

C. Antczak, David Shum, M. Luo, 2012, Combinatorial chemistry & high throughput screening.

Combining integrated genomics and functional genomics to dissect the biology of a cancer‐associated, aberrant transcription factor, the ASPSCR1–TFE3 fusion oncoprotein

C. Leslie, A. Olshen, M. Ladanyi, 2013, The Journal of pathology.

A simple method for analyzing actives in random RNAi screens: introducing the "H Score" for hit nomination & gene prioritization.

B. Bhinder, Hakim Djaballah, 2012, Combinatorial chemistry & high throughput screening.

An arrayed genome-scale lentiviral-enabled short hairpin RNA screen identifies lethal and rescuer gene candidates.

C. Antczak, David Shum, M. Frattini, 2013, Assay and drug development technologies.

Identification and Preliminary Characterization of Novel Small Molecules That Inhibit Growth of Human Lung Adenocarcinoma Cells

H. Varmus, R. Somwar, David Shum, 2009, Journal of biomolecular screening.

Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47.

P. A. Peterson, R. Tampé, T. Meyer, 1996, The EMBO journal.

Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines

Chris Sander, Erik Larsson, David Shum, 2011, Proceedings of the National Academy of Sciences.

Cell viability assessment: toward content-rich platforms

C. Antczak, Hakim Djaballah, Christina N. Ramirez, 2010, Expert opinion on drug discovery.

Small-Molecule Inhibitors of SETD8 with Cellular Activity

David Shum, M. Luo, J. Rice, 2014, ACS chemical biology.

Maturation of Qa-1b class I molecules requires beta 2-microglobulin but is TAP independent.

P. Travers, Hakim Djaballah, P. Robinson, 1998, Journal of immunology.

Revisiting old drugs as novel agents for retinoblastoma: in vitro and in vivo antitumor activity of cardenolides.

L. Mueller-Kuhrt, E. de Stanchina, C. Antczak, 2009, Investigative ophthalmology & visual science.

Proteasome Addiction Defined in Ewing Sarcoma Is Effectively Targeted by a Novel Class of 19S Proteasome Inhibitors.

B. Taylor, M. Ladanyi, J. Reis-Filho, 2016, Cancer research.

Drug Discovery and Repurposing for Retinoblastoma

Bhavneet Bhinder, Christophe Antczak, Hakim Djaballah, 2015 .

Domain-based biosensor assay to screen for epidermal growth factor receptor modulators in live cells.

C. Antczak, Dmitry Malkov, Hakim Djaballah, 2012, Assay and drug development technologies.

Antigen processing by proteasomes: insights into the molecular basis of crypticity

Hakim Djaballah, 1997, Molecular Biology Reports.

The King Is Dead, Long Live the King! JBS Special Issue on Screening by RNAi and Precise Genome Editing Technologies

M. Bickle, Hakim Djaballah, L. Mayr, 2015, Journal of biomolecular screening.

Evaluation of Compound Optical Interference in High-Content Screening

C. Antczak, David Shum, B. Bhinder, 2018, SLAS discovery : advancing life sciences R & D.

Chemical & RNAi screening at MSKCC: a collaborative platform to discover & repurpose drugs to fight disease.

Bhavneet Bhinder, Christophe Antczak, David Shum, 2014, Combinatorial chemistry & high throughput screening.

Designs and Concept Reliance of a Fully Automated High-Content Screening Platform

Constantin Radu, Hakim Djaballah, Hosna Sana Adrar, 2012, Journal of laboratory automation.

A High-Content Biosensor-Based Screen Identifies Cell-Permeable Activators and Inhibitors of EGFR Function

Jeni P. Mahida, C. Antczak, B. Bhinder, 2012, Journal of biomolecular screening.

A Synergetic Screening Approach with Companion Effector for Combination Therapy: Application to Retinoblastoma

Jeni P. Mahida, D. Albert, C. Antczak, 2013, PloS one.

Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells.

H. Varmus, G. Morin, S. Dixon, 2022, Cell reports.

A novel small molecule that induces cytotoxicity in lung cancer cells inhibits disulfide reductases GSR and TXNRD1

H. Varmus, G. Morin, S. Dixon, 2021, bioRxiv.

Development and validation of a high-density fluorescence polarization-based assay for the trypanosoma RNA triphosphatase TbCet1.

V. Seshan, C. Antczak, David Shum, 2009, Combinatorial chemistry & high throughput screening.

Pharmacokinetics, Safety, and Efficacy of Intravitreal Digoxin in Preclinical Models for Retinoblastoma.

Hakim Djaballah, S. Negrotto, D. Abramson, 2015 .

Nanomolar Inhibitors of Trypanosoma brucei RNA Triphosphatase

C. Ho, S. Shuman, Y. Takagi, 2016, mBio.

A high content assay to assess cellular fitness.

Jeni P. Mahida, C. Antczak, Chanpreet Singh, 2014, Combinatorial chemistry & high throughput screening.

Modulation of γ-secretase specificity using small molecule allosteric inhibitors

Li Yang, Rong Wang, Hakim Djaballah, 2009, Proceedings of the National Academy of Sciences.

A high-throughput screen for alpha particle radiation protectants.

D. Scheinberg, David Shum, Hakim Djaballah, 2010, Assay and drug development technologies.

High-Throughput Identification of Inhibitors of Human Mitochondrial Peptide Deformylase

V. Seshan, D. Scheinberg, C. Antczak, 2007, Journal of biomolecular screening.

A Genome-Wide RNAi Screen Reveals Common Host–Virus Gene Signatures: Implication for Dengue Antiviral Drug Discovery

Jeni P. Mahida, David Shum, B. Bhinder, 2023, GEN Biotechnology.

An RNAi screen reveals common host-virus gene signatures: implication for anti-viral drug discovery

Jeni P. Mahida, David Shum, B. Bhinder, 2022, bioRxiv.

A class of allosteric caspase inhibitors identified by high-throughput screening.

Xuejun Jiang, Christophe Antczak, Hakim Djaballah, 2012, Molecular cell.

A novel high throughput 1536-well Notch1 γ -secretase AlphaLISA assay.

David Shum, B. Bhinder, Hakim Djaballah, 2013, Combinatorial chemistry & high throughput screening.

Drug discovery and repurposing at Memorial Sloan Kettering Cancer Center: chemical biology drives translational medicine.

B. Bhinder, Hakim Djaballah, 2014, ACS Chemical Biology.

Abstract LB-273: Preclinical assesment of a novel CDC7 inhibitor: Genomewide RNAi screening identifies unique synergetic and resistance genes

David Shum, M. Frattini, B. Bhinder, 2011 .

Discovery and Validation of a Novel Class of Small Molecule Inhibitors of the CDC7 Kinase: Modulation of Tumor Cell Growth in Vitro and In Vivo.

P. Maslak, T. Kelly, David Shum, 2009 .

An arrayed RNA interference genome-wide screen identifies candidate genes involved in the MicroRNA 21 biogenesis pathway.

M. Landthaler, T. Farazi, S. Magdaleno, 2013, Assay and drug development technologies.

Flaviviruses Are Sensitive to Inhibition of Thymidine Synthesis Pathways

D. A. Stein, K. Früh, David Shum, 2013, Journal of Virology.

Drug discovery and repurposing at Memorial Sloan Kettering Cancer Center: chemical biology drives translational medicine.

B. Bhinder, Hakim Djaballah, 2014, ACS chemical biology.