J. Hitomi

发表

Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway

Alexei Degterev, Junying Yuan, Ramnik J. Xavier, 2008, Cell.

Identification of RIP1 kinase as a specific cellular target of necrostatins.

Alexei Degterev, Chengye Yuan, Junying Yuan, 2008, Nature chemical biology.

Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

Y. Itoyama, T. Kudo, P. George-Hyslop, 1999, Nature Cell Biology.

Increased Production of β-Amyloid and Vulnerability to Endoplasmic Reticulum Stress by an Aberrant Spliced Form of Presenilin 2*

P. S. St George-Hyslop, Y. Itoyama, T. Kudo, 2001, The Journal of Biological Chemistry.

An In Vitro Model for Lewy Body-Like Hyaline Inclusion/Astrocytic Hyaline Inclusion: Induction by ER Stress with an ALS-Linked SOD1 Mutation

Y. Itoyama, M. Tohyama, Y. Koyama, 2007, PloS one.

Apoptosis induced by endoplasmic reticulum stress depends on activation of caspase-3 via caspase-12

M. Tohyama, J. Hitomi, M. Taniguchi, 2004, Neuroscience Letters.

JAB1 participates in unfolded protein responses by association and dissociation with IRE1

M. Tohyama, S. Matsuda, T. Manabe, 2004, Neurochemistry International.

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS

Junying Yuan, M. Pasparakis, M. Kelliher, 2016, Science.

Absence of endoproteolysis but no effects on amyloid beta production by alternative splicing forms of presenilin-1, which lack exon 8 and replace D257A.

M. Tohyama, T. Morihara, T. Manabe, 2000, Brain research. Molecular brain research.

Presenilin-1 mutation activates the signaling pathway of caspase-4 in endoplasmic reticulum stress-induced apoptosis

M. Tohyama, Y. Koyama, J. Hitomi, 2008, Neurochemistry International.

Alzheimer pathology and endoplasmic reticulum stress

T. Kudo, M. Takeda, M. Tohyama, 2005 .

Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Aβ-induced cell death

T. Kudo, M. Tohyama, Y. Koyama, 2004, The Journal of cell biology.

Characterization of mouse Ire1 alpha: cloning, mRNA localization in the brain and functional analysis in a neural cell line.

M. Tohyama, T. Manabe, J. Hitomi, 2000, Brain research. Molecular brain research.

A novel role for RIP1 kinase in mediating TNFα production

S. Gygi, Junying Yuan, S. Gerber, 2012, Cell Death and Disease.

Induction of neuronal death by ER stress in Alzheimer’s disease

Takashi Kudo, Takayuki Manabe, T. Kudo, 2004, Journal of Chemical Neuroanatomy.

Induced HMGA1a expression causes aberrant splicing of Presenilin-2 pre-mRNA in sporadic Alzheimer's disease

T. Kudo, A. Mayeda, M. Tohyama, 2003, Cell Death and Differentiation.

Molecular Cloning of a Novel Membrane Glycoprotein, Pal, Specifically Expressed in Photoreceptor Cells of the Retina and Containing Leucine-Rich Repeat

Takashi Fujikado, Yasuo Tano, Y. Tano, 2000, The Journal of Neuroscience.

Role of ARF4L in Recycling Between Endosomes and the Plasma Membrane

M. Tohyama, T. Manabe, J. Hitomi, 2004, Cellular and Molecular Neurobiology.

APOE genotypes modify the obesity paradox in dementia

N. Sato, J. Hitomi, Ghupurjan Gheni, 2023, Journal of Neurology, Neurosurgery, and Psychiatry.

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS

Junying Yuan, M. Pasparakis, M. Kelliher, 2016, Science.

Apoptosis induced by endoplasmic reticulum stress depends on activation of caspase-3 via caspase-12

M. Tohyama, J. Hitomi, M. Taniguchi, 2004, Neuroscience Letters.

Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Aβ-induced cell death

T. Kudo, M. Tohyama, Y. Koyama, 2004, The Journal of cell biology.