L. Fong

发表

Modeling Insertional Mutagenesis Using Gene Length and Expression in Murine Embryonic Stem Cells

W. Tingley, K. Vranizan, P. Babbitt, 2007, PloS one.

Prelamin A and lamin A appear to be dispensable in the nuclear lamina.

Richard T. Lee, M. Bergo, S. Young, 2006, The Journal of clinical investigation.

Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons.

S. Young, F. Peale, Z. Ding, 2007, Cell metabolism.

Chylomicronemia With a Mutant GPIHBP1 (Q115P) That Cannot Bind Lipoprotein Lipase

S. Young, J. Kastelein, R. Walzem, 2009, Arteriosclerosis, thrombosis, and vascular biology.

Chylomicronemia With Low Postheparin Lipoprotein Lipase Levels in the Setting of GPIHBP1 Defects

S. Young, J. Kastelein, A. Beigneux, 2010, Circulation. Cardiovascular genetics.

Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia

M. Hayden, S. Young, A. Beigneux, 2010, Journal of Lipid Research.

GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries.

S. Young, I. Goldberg, A. Beigneux, 2010, Cell metabolism.

New wrinkles in lipoprotein lipase biology

Stephen G. Young, S. Young, A. Beigneux, 2012, Current opinion in lipidology.

New Developments in the Lipolytic Processing of Triglyceride‐Rich Lipoproteins

S. Young, A. Beigneux, L. Fong, 2010 .

GPIHBP1: a new chylomicronemia gene

S. Young, A. Beigneux, Brandon S. J. Davies, 2008 .

The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma.

S. Young, R. Evans, H. Waki, 2008, Molecular endocrinology.

Targeting Protein Prenylation in Progeria

S. Young, Brandon S. J. Davies, L. Fong, 2013, Science Translational Medicine.

Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24

S. Young, Sandy Chang, D. Andres, 2012, Journal of Lipid Research.

Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes.

M. Bergo, S. Young, Sandy Chang, 2010, Human molecular genetics.

Caution! Analyze transcripts from conditional knockout alleles

M. Bergo, S. Young, Xin Qiao, 2009, Transgenic Research.

Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling.

S. Young, P. Tontonoz, K. Reue, 2013, Progress in lipid research.

Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis.

D. Steinberg, L. Fong, S. Parthasarathy, 1987, Proceedings of the National Academy of Sciences of the United States of America.

High-density lipoprotein inhibits the oxidative modification of low-density lipoprotein.

L. Fong, S. Parthasarathy, J. Barnett, 1990, Biochimica et biophysica acta.

Nuclear membrane ruptures, cell death, and tissue damage in the setting of nuclear lamin deficiencies

S. Young, L. Fong, Natalie Y. Chen, 2020, Nucleus.

Disrupting the LINC complex in smooth muscle cells reduces aortic disease in a mouse model of Hutchinson-Gilford progeria syndrome

S. Young, D. Hodzic, J. Dunn, 2018, Science Translational Medicine.

Investigating the purpose of prelamin A processing.

S. Young, C. Coffinier, Brandon S. J. Davies, 2011, Nucleus.

Investigating the purpose of prelamin A processing

S. Young, C. Coffinier, Brandon S. J. Davies, 2011 .

Posttranslational Processing of Nuclear Lamins

S. Young, C. Coffinier, Brandon S. J. Davies, 2011 .

Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria

S. Young, Sandy Chang, D. Andres, 2010, Journal of Lipid Research.

Eliminating the Synthesis of Mature Lamin A Reduces Disease Phenotypes in Mice Carrying a Hutchinson-Gilford Progeria Syndrome Allele*

S. Young, Sandy Chang, Xin Qiao, 2008, Journal of Biological Chemistry.

Increased progerin expression associated with unusual LMNA mutations causes severe progeroid syndromes

S. Young, Jennifer M. Gardner, L. Fong, 2007, Human mutation.

Prelamin A Farnesylation and Progeroid Syndromes*

S. Young, L. Fong, M. Meta, 2006, Journal of Biological Chemistry.

Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes.

M. Gelb, S. Young, J. Toth, 2005, Proceedings of the National Academy of Sciences of the United States of America.

A new monoclonal antibody, 4-1a, that binds to the amino terminus of human lipoprotein lipase.

S. Young, A. Beigneux, L. Fong, 2014, Biochimica et biophysica acta.

Binding Preferences for GPIHBP1, a Glycosylphosphatidylinositol-Anchored Protein of Capillary Endothelial Cells

S. Young, A. Beigneux, Brandon S. J. Davies, 2010, Arteriosclerosis, thrombosis, and vascular biology.

Recognition of solubilized apoproteins from delipidated, oxidized low density lipoprotein (LDL) by the acetyl-LDL receptor.

D. Steinberg, L. Fong, S. Parthasarathy, 1987, Proceedings of the National Academy of Sciences of the United States of America.

The LXR-Idol axis differentially regulates plasma LDL levels in primates and mice.

Richard G. Lee, S. Young, P. Tontonoz, 2014, Cell metabolism.

A Potent HIV Protease Inhibitor, Darunavir, Does Not Inhibit ZMPSTE24 or Lead to an Accumulation of Farnesyl-prelamin A in Cells*

S. Young, C. Coffinier, D. Andres, 2008, Journal of Biological Chemistry.

LINCing lamin B2 to neuronal migration

S. Young, C. Coffinier, L. Fong, 2010, Nucleus.

High-resolution imaging of dietary lipids in cells and tissues by NanoSIMS analysis[S]

S. Young, A. Beigneux, C. Grovenor, 2014, Journal of Lipid Research.

An absence of both lamin B1 and lamin B2 in keratinocytes has no effect on cell proliferation or the development of skin and hair.

P. D. de Jong, Y. Yoshinaga, S. Young, 2011, Human molecular genetics.

Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons

P. D. de Jong, Y. Yoshinaga, S. Young, 2011, Molecular biology of the cell.

Apolipoprotein C-III inhibits triglyceride hydrolysis by GPIHBP1-bound LPL[S]

S. Young, A. Beigneux, L. Fong, 2017, Journal of Lipid Research.

Quantitative measurement of 4-hydroxyalkenals in oxidized low-density lipoprotein by gas chromatography-mass spectrometry.

R. J. Stephens, F. V. van Kuijk, L. Fong, 1995, Analytical biochemistry.

High-resolution visualization and quantification of nucleic acid–based therapeutics in cells and tissues using Nanoscale secondary ion mass spectrometry (NanoSIMS)

S. Young, K. Iyer, C. Bennett, 2020, Nucleic acids research.

Nonenzymatic oxidative cleavage of peptide bonds in apoprotein B-100.

S. Parthasarathy, D. Steinberg, J. Witztum, 1987, Journal of lipid research.

SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression[S]

S. Young, T. Osborne, K. Reue, 2016, Journal of Lipid Research.

The Acidic Domain of GPIHBP1 Is Important for the Binding of Lipoprotein Lipase and Chylomicrons*

S. Young, A. Beigneux, Brandon S. J. Davies, 2008, Journal of Biological Chemistry.

Abnormal Patterns of Lipoprotein Lipase Release into the Plasma in GPIHBP1-deficient Mice*

S. Young, J. Esko, A. Beigneux, 2008, Journal of Biological Chemistry.

Inhibition of lipopolysaccharide-induced interleukin-1 beta mRNA expression in mouse macrophages by oxidized low density lipoprotein.

T. Annie, L. Fong, A. Cooper, 1991, Journal of lipid research.

Chylomicronemia from GPIHBP1 autoantibodies

S. Young, M. Ploug, J. Lutz, 2020, Journal of Lipid Research.

Mouse models of the laminopathies.

S. Young, C. Stewart, L. Fong, 2007, Experimental cell research.

Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin.

S. Young, Sandy Chang, Yibin Wang, 2011, Human molecular genetics.

Lipin-1 and lipin-3 together determine adiposity in vivo.

P. D. de Jong, Y. Yoshinaga, S. Young, 2014, Molecular metabolism.

Reciprocal Metabolic Perturbations in the Adipose Tissue and Liver of GPIHBP1-Deficient Mice

S. Young, S. Watkins, P. Tontonoz, 2012, Arteriosclerosis, thrombosis, and vascular biology.

GPIHBP1, an endothelial cell transporter for lipoprotein lipase

S. Young, P. Tontonoz, K. Reue, 2011, Journal of Lipid Research.

Acceleration of uptake of LDL but not chylomicrons or chylomicron remnants by cells that secrete apoE and hepatic lipase.

M. Komaromy, L. Fong, S. Choi, 1994, Journal of lipid research.

Immunohistochemical localization of low density lipoprotein receptors in adrenal gland, liver, and intestine.

L. Fong, J. Kosek, A. Cooper, 1989, The Journal of clinical investigation.

Impaired thermogenesis and sharp increases in plasma triglyceride levels in GPIHBP1-deficient mice during cold exposure[S]

S. Young, R. Walzem, A. Beigneux, 2018, Journal of Lipid Research.

A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase

S. Young, B. Kragelund, M. Ploug, 2018, Proceedings of the National Academy of Sciences.

Chylomicronemia mutations yield new insights into interactions between lipoprotein lipase and GPIHBP1.

S. Young, A. Beigneux, Brandon S. J. Davies, 2012, Human molecular genetics.

Cultured macrophages transfer surplus cholesterol into adjacent cells in the absence of serum or high-density lipoproteins

S. Young, H. Riezman, P. Tontonoz, 2020, Proceedings of the National Academy of Sciences.

Cholesterol Intake Modulates Plasma Triglyceride Levels in Glycosylphosphatidylinositol HDL-Binding Protein 1-Deficient Mice

S. Young, R. Walzem, P. Tontonoz, 2010, Arteriosclerosis, thrombosis, and vascular biology.

Differences in the processing of chylomicron remnants and beta-VLDL by macrophages.

J. Ellsworth, F. Kraemer, L. Fong, 1990, Journal of lipid research.

Targeting Isoprenylcysteine Methylation Ameliorates Disease in a Mouse Model of Progeria

M. Bergo, S. Young, L. Fong, 2013, Science.

Inhibition of the macrophage-induced oxidation of low density lipoprotein by interferon-gamma.

L. Fong, S. Hom, T. S. Albert, 1994, Journal of lipid research.

A mouse monoclonal antibody specific for mouse apoB48 and apoB100 produced by immunizing "apoB39-only" mice with mouse apoB48.

S. Young, M. Graham, R. Crooke, 2006, Biochimica et biophysica acta.

Lowering plasma cholesterol by raising LDL receptors--revisited.

S. Young, L. Fong, 2012, The New England journal of medicine.

PCSK9 function and physiology 1

S. Young, A. Peterson, L. Fong, 2008 .

Lipoprotein size and susceptibility to atherosclerosis--insights from genetically modified mouse models.

S. Young, A. Beigneux, M. Véniant, 2008, Current drug targets.

Relative roles of the LDL receptor, the LDL receptor-like protein, and hepatic lipase in chylomicron remnant removal by the liver.

M. Komaromy, L. Fong, A. Cooper, 1996, Journal of lipid research.

Deletion of the Basement Membrane Heparan Sulfate Proteoglycan Type XVIII Collagen Causes Hypertriglyceridemia in Mice and Humans

S. Young, M. Passos-Bueno, J. Esko, 2010, PloS one.

NanoSIMS Analysis of Intravascular Lipolysis and Lipid Movement across Capillaries and into Cardiomyocytes.

S. Young, D. Ford, P. Tontonoz, 2018, Cell metabolism.

Glycosylphosphatidylinositol‐anchored high‐density lipoprotein‐binding protein 1 and the intravascular processing of triglyceride‐rich lipoproteins

S. Young, A. Beigneux, L. Fong, 2012, Journal of internal medicine.

Integrative Physiology/Experimental Medicine Chylomicronemia Elicits Atherosclerosis in Mice—Brief Report

S. Young, A. Lusis, L. Castellani, 2009 .

Use of an anti-low density lipoprotein receptor antibody to quantify the role of the LDL receptor in the removal of chylomicron remnants in the mouse in vivo.

L. Fong, S. Choi, A. Cooper, 1991, The Journal of clinical investigation.

NanoSIMS imaging: an approach for visualizing and quantifying lipids in cells and tissues

S. Young, L. Fong, Cuiwen He, 2016, Journal of Investigative Medicine.

SREBP-2-defi cient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1 c expression

S. Young, T. Osborne, K. Reue, 2016 .

LDL and cAMP cooperate to regulate the functional expression of the LRP in rat ovarian granulosa cells Published, JLR Papers in Press, August 23, 2006.

L. Fong, W. Shen, S. Medicherla, 2006, Journal of Lipid Research.

Enhancement of fatty acid and cholesterol synthesis accompanied by enhanced biliary but not very-low-density lipoprotein lipid secretion following sustained pravastatin blockade of hydroxymethyl glutaryl coenzyme A reductase in rat liver.

C. Loguercio, L. Fong, M. Carrella, 1999, Metabolism: clinical and experimental.

Macrophages release plasma membrane-derived particles rich in accessible cholesterol

S. Young, H. Riezman, P. Tontonoz, 2018, Proceedings of the National Academy of Sciences.

An Absence of Nuclear Lamins in Keratinocytes Leads to Ichthyosis, Defective Epidermal Barrier Function, and Intrusion of Nuclear Membranes and Endoplasmic Reticulum into the Nuclear Chromatin

S. Young, L. Fong, H. Herrmann, 2014, Molecular and Cellular Biology.

Mutating a conserved cysteine in GPIHBP1 reduces amounts of GPIHBP1 in capillaries and abolishes LPL binding[S]

P. D. de Jong, S. Young, A. Beigneux, 2017, Journal of Lipid Research.

Lipoprotein lipase reaches the capillary lumen in chickens despite an apparent absence of GPIHBP1.

B. Raney, S. Young, R. Walzem, 2017, JCI insight.

An LPL–specific monoclonal antibody, 88B8, that abolishes the binding of LPL to GPIHBP1[S]

S. Young, M. Ploug, A. Beigneux, 2016, Journal of Lipid Research.

Mobility of “HSPG-bound” LPL explains how LPL is able to reach GPIHBP1 on capillaries[S]

S. Young, M. Ploug, A. Beigneux, 2016, Journal of Lipid Research.

Heterogeneity in the properties of mutant secreted lymphocyte antigen 6/urokinase receptor‐related protein 1 (SLURP1) in Mal de Meleda

S. Young, M. Oberer, M. Ploug, 2015, The British journal of dermatology.

Multimerization of Glycosylphosphatidylinositol-anchored High Density Lipoprotein-binding Protein 1 (GPIHBP1) and Familial Chylomicronemia from a Serine-to-Cysteine Substitution in GPIHBP1 Ly6 Domain*

S. Young, M. Ploug, H. Gårdsvoll, 2014, The Journal of Biological Chemistry.

Mutations in lipoprotein lipase that block binding to the endothelial cell transporter GPIHBP1

S. Young, A. Beigneux, Brandon S. J. Davies, 2011, Proceedings of the National Academy of Sciences.

Assessing the Role of the Glycosylphosphatidylinositol-anchored High Density Lipoprotein-binding Protein 1 (GPIHBP1) Three-finger Domain in Binding Lipoprotein Lipase*

S. Young, C. Pullinger, A. Beigneux, 2011, The Journal of Biological Chemistry.

Binding Preferences for GPIHBP 1 , a Glycosylphosphatidylinositol-Anchored Protein of Capillary Endothelial Cells

S. Young, A. Beigneux, Brandon S. J. Davies, 2010 .

Highly Conserved Cysteines within the Ly6 Domain of GPIHBP1 Are Crucial for the Binding of Lipoprotein Lipase*

S. Young, A. Beigneux, Brandon S. J. Davies, 2009, The Journal of Biological Chemistry.

Normal binding of lipoprotein lipase, chylomicrons, and apo-AV to GPIHBP1 containing a G56R amino acid substitution.

S. Young, A. Beigneux, Brandon S. J. Davies, 2007, Biochimica et biophysica acta.

Modulation of LMNA splicing as a strategy to treat prelamin A diseases.

S. Young, C. F. Bennett, F. Rigo, 2016, The Journal of clinical investigation.

Equivalent binding of wild-type lipoprotein lipase (LPL) and S447X-LPL to GPIHBP1, the endothelial cell LPL transporter.

S. Young, A. Beigneux, L. Fong, 2014, Biochimica et biophysica acta.

r receptor transport by protein phos pCw>ryktion'

L. Fong, 1996 .

Monoclonal antibodies that bind to the Ly6 domain of GPIHBP1 abolish the binding of LPL[S]

S. Young, M. Sleeman, M. Linton, 2016, Journal of Lipid Research.

Palmoplantar keratoderma in Slurp2-deficient mice

S. Young, P. Tontonoz, A. Beigneux, 2015, The Journal of investigative dermatology.

Unexpected Expression Pattern for Glycosylphosphatidylinositol-anchored HDL-binding Protein 1 (GPIHBP1) in Mouse Tissues Revealed by Positron Emission Tomography Scanning*

Sung-Cheng Huang, S. Young, Koon-Pong Wong, 2010, The Journal of Biological Chemistry.

GPIHBP1 and lipolysis: an update

S. Young, A. Beigneux, Brandon S. J. Davies, 2009, Current opinion in lipidology.

Inhibition of mouse macrophage degradation of acetyl-low density lipoprotein by interferon-gamma.

L. Fong, A. Cooper, T. Fong, 1990, The Journal of biological chemistry.

GPIHBP1 autoantibodies in a patient with unexplained chylomicronemia.

S. Young, Sandy Chang, M. Ploug, 2017, Journal of clinical lipidology.

Nuclear membrane ruptures underlie the vascular pathology in a mouse model of Hutchinson-Gilford progeria syndrome

S. Young, A. Rowat, L. Fong, 2021, JCI insight.

Treatment with a farnesyltransferase inhibitor improves survival in mice with a Hutchinson-Gilford progeria syndrome mutation.

S. Young, Xin Qiao, L. Fong, 2008, Biochimica et biophysica acta.

Lamin B1 and lamin B2 are long-lived proteins with distinct functions in retinal development

S. Young, D. Hodzic, L. Fong, 2016, Molecular biology of the cell.

Investigating the purpose of prelamin A processing.

S. Young, J. Lammerding, C. Coffinier, 2010, Nucleus.

NanoSIMS imaging reveals unexpected heterogeneity in nutrient uptake by brown adipocytes.

S. Young, H. Gerhardt, P. Tontonoz, 2018, Biochemical and biophysical research communications.

Electrostatic sheathing of lipoprotein lipase is essential for its movement across capillary endothelial cells

S. Young, P. Tontonoz, M. Ploug, 2022, The Journal of clinical investigation.

A novel approach to tag and identify geranylgeranylated proteins

F. Tamanoi, S. Young, Brandon S. J. Davies, 2009, Electrophoresis.

Genetic analyses of the role of RCE1 in RAS membrane association and transformation.

M. Bergo, S. Young, L. Fong, 2008, Methods in enzymology.

Are B-type lamins essential in all mammalian cells?

S. Young, C. Coffinier, L. Fong, 2011, Nucleus.

Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia

S. Young, C. Pullinger, D. Blom, 2017, The New England journal of medicine.

Deficiency in ZMPSTE24 and resulting farnesyl–prelamin A accumulation only modestly affect mouse adipose tissue stores[S]

P. D. de Jong, Y. Yoshinaga, S. Young, 2020, Journal of Lipid Research.

Reciprocal knock-in mice to investigate the functional redundancy of lamin B1 and lamin B2

P. D. de Jong, Y. Yoshinaga, S. Young, 2014, Molecular biology of the cell.

Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration

P. D. de Jong, Y. Yoshinaga, S. Young, 2013, Proceedings of the National Academy of Sciences.

GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients

L. Liau, H. Vinters, S. Young, 2019, eLife.

IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure

Brandon J Thomas, S. Young, A. Lusis, 2018, Cell.

Lamins A and C but Not Lamin B1 Regulate Nuclear Mechanics*

Richard T. Lee, S. Young, C. Stewart, 2006, Journal of Biological Chemistry.

A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation.

M. Bergo, S. Young, C. Coffinier, 2006, The Journal of clinical investigation.

A Protein Farnesyltransferase Inhibitor Ameliorates Disease in a Mouse Model of Progeria

Stephen G Young, S. Young, C. Coffinier, 2006, Science.

Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation.

M. Gelb, M. Bergo, S. Young, 2005, Proceedings of the National Academy of Sciences of the United States of America.

commentary PCSK 9 function and physiology 1

S. Young, A. Peterson, L. Fong, 2008 .

10 Genetic approaches to understanding the physiologic importance of the carboxyl methylation of isoprenylated proteins.

S. Young, S. Clarke, L. Fong, 2006, The Enzymes.

Thematic Review Series: Lipid Posttranslational Modifications. Prelamin A, Zmpste24, misshapen cell nuclei, and progeria—new evidence suggesting that protein farnesylation could be important for disease pathogenesis Published, JLR Papers in Press, October 5, 2005. DOI 10.1194/jlr.R500011-JLR200

S. Young, L. Fong, S. Michaelis, 2005, Journal of Lipid Research.

Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues

P. D. de Jong, M. Nefedov, Y. Yoshinaga, 2012, Journal of Lipid Research.

Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA

S. Young, T. Sun, C. Coffinier, 2012, Proceedings of the National Academy of Sciences.

Nuclear Lamins in the Brain — New Insights into Function and Regulation

S. Young, L. Fong, John M. Lee, 2012, Molecular Neurobiology.

Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs.

A. Hevener, S. Young, P. Tontonoz, 2013, Cell metabolism.

Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs.

P. D. de Jong, M. Nefedov, Y. Yoshinaga, 2014, The Journal of clinical investigation.

The arrestin domain-containing 3 protein regulates body mass and energy expenditure.

Richard T. Lee, Radu Dobrin, E. Schadt, 2011, Cell metabolism.

Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum

Jessica M. Lee, P. D. de Jong, Y. Yoshinaga, 2012, Proceedings of the National Academy of Sciences.

Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis

S. Young, P. Tontonoz, K. Reue, 2018, The Journal of clinical investigation.

Understanding the Roles of Nuclear A- and B-type Lamins in Brain Development*

S. Young, C. Coffinier, L. Fong, 2012, The Journal of Biological Chemistry.

Severe hepatocellular disease in mice lacking one or both CaaX prenyltransferases[S]

M. Bergo, S. Young, Sandy Chang, 2012, Journal of Lipid Research.

DYT1 Dystonia Patient-Derived Fibroblasts Have Increased Deformability and Susceptibility to Damage by Mechanical Forces

S. Young, A. Rowat, L. Fong, 2018, bioRxiv.

GPIHBP1: an endothelial cell molecule important for the lipolytic processing of chylomicrons

S. Young, A. Beigneux, Brandon S. J. Davies, 2007, Current opinion in lipidology.

An upstream enhancer regulates Gpihbp1 expression in a tissue-specific manner[S]

D. Cusanovich, S. Young, A. Beigneux, 2018, Journal of Lipid Research.

Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice

M. Bergo, S. Young, C. Stewart, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Nuclear lamins and brain development*

C. Coffinier, L. Fong, Hea-Jin Jung, 2012 .

Laminopathies and the long strange trip from basic cell biology to therapy.

S. Young, H. Worman, L. Fong, 2009, The Journal of clinical investigation.

GPIHBP1 and Plasma Triglyceride Metabolism

S. Young, M. Oberer, M. Ploug, 2016, Trends in Endocrinology & Metabolism.

Cell Nuclei Spin in the Absence of Lamin B1*

Richard T. Lee, S. Young, C. Stewart, 2007, Journal of Biological Chemistry.

The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain

S. Young, M. Ploug, H. Gårdsvoll, 2016, eLife.

University of Southern Denmark The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain Mysling,

S. Young, M. Ploug, H. Gårdsvoll, 2016 .

Syddansk Universitet The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain Mysling,

S. Young, M. Ploug, H. Gårdsvoll, 2016 .

Sterol Regulatory Element Binding Protein 1a Regulates Hepatic Fatty Acid Partitioning by Activating Acetyl Coenzyme A Carboxylase 2

L. E. Hammond, S. Young, T. Osborne, 2009, Molecular and Cellular Biology.

Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated.

S. Young, D. Andres, L. Fong, 2008, The Journal of clinical investigation.

Fibroblasts lacking nuclear lamins do not have nuclear blebs or protrusions but nevertheless have frequent nuclear membrane ruptures

Stephen G. Young, S. Young, L. Fong, 2018, Proceedings of the National Academy of Sciences.

New Lmna knock-in mice provide a molecular mechanism for the 'segmental aging' in Hutchinson-Gilford progeria syndrome.

S. Young, L. Fong, Shao H. Yang, 2014, Human molecular genetics.

GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride Metabolism.

S. Young, M. Ploug, A. Beigneux, 2019, Cell metabolism.

Nuclear Envelope Protein Lem2 is Required for Mouse Development and Regulates MAP and AKT Kinases

S. Young, L. Gerace, L. Fong, 2015, PLoS ONE.

HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells

S. Young, C. Coffinier, Sandy Chang, 2007, Proceedings of the National Academy of Sciences.

LMNA missense mutations causing familial partial lipodystrophy do not lead to an accumulation of prelamin A

S. Young, L. Fong, Yiping Tu, 2016, Nucleus.

Direct Synthesis of Lamin A, Bypassing Prelamin A Processing, Causes Misshapen Nuclei in Fibroblasts but No Detectable Pathology in Mice*

S. Young, J. Lammerding, C. Coffinier, 2010, The Journal of Biological Chemistry.

The posttranslational processing of prelamin A and disease.

S. Young, C. Coffinier, Brandon S. J. Davies, 2009, Annual review of genomics and human genetics.

HIV-protease inhibitors block the enzymatic activity of purified Ste24p.

S. Young, C. Coffinier, L. Fong, 2008, Biochemical and biophysical research communications.

Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect

F. Collins, E. Nabel, S. Young, 2011, Proceedings of the National Academy of Sciences.

An absence of lamin B1 in migrating neurons causes nuclear membrane ruptures and cell death

Stephen G. Young, Paul S. Weiss, Steven J. Jonas, 2019, Proceedings of the National Academy of Sciences.

Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency

S. Young, C. Coffinier, J. Toth, 2010, Proceedings of the National Academy of Sciences.

Protein farnesyltransferase inhibitors and progeria.

M. Bergo, S. Young, L. Fong, 2006, Trends in molecular medicine.

Nuclear Lamins and Neurobiology

S. Young, L. Fong, John M. Lee, 2014, Molecular and Cellular Biology.

Activating the synthesis of progerin, the mutant prelamin A in Hutchinson–Gilford progeria syndrome, with antisense oligonucleotides

S. Young, C. Coffinier, C. F. Bennett, 2009, Human molecular genetics.

GPIHBP1 Missense Mutations Often Cause Multimerization of GPIHBP1 and Thereby Prevent Lipoprotein Lipase Binding

S. Young, M. Oberer, M. Ploug, 2015, Circulation research.

Palmoplantar keratoderma along with neuromuscular and metabolic phenotypes in Slurp1-deficient mice

S. Young, P. Tontonoz, A. Beigneux, 2014, The Journal of investigative dermatology.

Nuclear Lamins in the Brain — New Insights into Function and Regulation

S. Young, L. Fong, John M. Lee, 2013, Molecular Neurobiology.

Feedback regulation of cholesterol uptake by the LXR-IDOL-LDLR axis.

S. Young, P. Tontonoz, K. Reue, 2012, Arteriosclerosis, thrombosis, and vascular biology.

Multiple processes are involved in the uptake of chylomicron remnants by mouse peritoneal macrophages.

L. Fong, Y. Fujioka, A. Cooper, 1998, Journal of lipid research.

Intermittent chylomicronemia caused by intermittent GPIHBP1 autoantibodies.

R. Hegele, S. Young, M. Ploug, 2020, Journal of clinical lipidology.

The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries.

S. Young, A. Hoenger, J. Esko, 2014, Cell metabolism.

High-resolution imaging and quantification of plasma membrane cholesterol by NanoSIMS

Peter Tontonoz, Haibo Jiang, S. Young, 2017, Proceedings of the National Academy of Sciences.

A hypomorphic Egfr allele does not ameliorate the palmoplantar keratoderma caused by SLURP1 deficiency

S. Young, A. Beigneux, L. Fong, 2017, Experimental Dermatology.

Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT 3-activated microRNAs

M. Nefedov, Y. Yoshinaga, P. Jong, 2019 .

Mice that express farnesylated versions of prelamin A in neurons develop achalasia.

S. Young, S. Ward, S. Procaccia, 2015, Human molecular genetics.

Compromised Mitochondrial Fatty Acid Synthesis in Transgenic Mice Results in Defective Protein Lipoylation and Energy Disequilibrium

Y. Yoshinaga, S. Griffey, S. Young, 2012, PloS one.

IDOL Stimulates Clathrin-Independent Endocytosis and Multivesicular Body-Mediated Lysosomal Degradation of the Low-Density Lipoprotein Receptor

S. Young, A. Ting, P. Pilch, 2013, Molecular and Cellular Biology.

Targeted Disruption of the Idol Gene Alters Cellular Regulation of the Low-Density Lipoprotein Receptor by Sterols and Liver X Receptor Agonists

P. D. de Jong, Y. Yoshinaga, S. Young, 2011, Molecular and Cellular Biology.

Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia

S. Young, J. Wohlschlegel, P. Tontonoz, 2019, eLife.

A protein of capillary endothelial cells, GPIHBP1, is crucial for plasma triglyceride metabolism

S. Young, M. Ploug, A. Beigneux, 2022, Proceedings of the National Academy of Sciences of the United States of America.

The Processing of Ligands by the Class A Scavenger Receptor Is Dependent on Signal Information Located in the Cytoplasmic Domain*

L. Fong, Dinh Le, 1999, The Journal of Biological Chemistry.

Chylomicronemia From GPIHBP1 Autoantibodies Successfully Treated With Rituximab: A Case Report

S. Young, M. Ploug, J. Lutz, 2020, Annals of Internal Medicine.

The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase

J. Luz, S. Young, M. Ploug, 2020, Journal of Lipid Research.

GPIHBP1, a partner protein for lipoprotein lipase, is expressed only in capillary endothelial cells

S. Young, L. Fong, W. Zeng, 2020, Journal of Lipid Research.

Lipoprotein lipase is active as a monomer

S. Young, M. Ploug, A. Beigneux, 2019, Proceedings of the National Academy of Sciences.

Structure of the lipoprotein lipase–GPIHBP1 complex that mediates plasma triglyceride hydrolysis

S. Young, H. Mertens, M. Ploug, 2018, Proceedings of the National Academy of Sciences.

Assessing mechanisms of GPIHBP1 and lipoprotein lipase movement across endothelial cells[S]

S. Young, A. Beigneux, Brandon S. J. Davies, 2012, Journal of Lipid Research.

Overexpression of hormone-sensitive lipase in Chinese hamster ovary cells leads to abnormalities in cholesterol homeostasis.

M. Komaromy, S. Patel, F. Kraemer, 1997, Journal of lipid research.

Prelamin A causes aberrant myonuclear arrangement and results in muscle fiber weakness

Chen-Yu Liao, B. Kennedy, C. López-Otín, 2018, JCI insight.

Genetic analyses of Rce1 function in Ras membrane association and function

M. Bergo, S. Young, L. Fong, 2008 .

Peroxidasin-mediated bromine enrichment of basement membranes

J. Zuckerman, S. Young, B. Hudson, 2020, Proceedings of the National Academy of Sciences.

Oxidative modification of LDL: comparison between cell-mediated and copper-mediated modification.

D. Steinberg, L. Fong, S. Parthasarathy, 1990, European heart journal.

Do lamin B1 and lamin B2 have redundant functions?

S. Young, L. Fong, John M. Lee, 2014, Nucleus.

Increased expression of LAP2β eliminates nuclear membrane ruptures in nuclear lamin–deficient neurons and fibroblasts

S. Young, L. Fong, Yiping Tu, 2021, Proceedings of the National Academy of Sciences.

Structure of the lipoprotein lipase GPIHBP1 complex that mediates plasma triglyceride hydrolysis

S. Young, H. Mertens, M. Ploug, 2018 .

Intracapillary LPL levels in brown adipose tissue, visualized with an antibody-based approach, are regulated by ANGPTL4 at thermoneutral temperatures

S. Young, M. Ploug, A. Beigneux, 2023, Proceedings of the National Academy of Sciences of the United States of America.

The fatty acids from LPL-mediated processing of triglyceride-rich lipoproteins are taken up rapidly by cardiomyocytes

S. Young, L. Fong, Cuiwen He, 2020, Journal of Lipid Research.

Stable isotope imaging of biological samples with high resolution secondary ion mass spectrometry and complementary techniques.

A. Harris, S. Young, D. Ferguson, 2014, Methods.