Wanli W. Smith

发表

The Drosophila hep pathway mediates Lrrk2-induced neurodegeneration.

Dejun Yang, Joseph M. Thomas, Tianxia Li, 2018, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Controversy of TMEM230 Associated with Parkinson’s Disease

E. Whelan, Zhaohui Liu, Wanli W. Smith, 2020, Neuroscience.

Parkin Mediates Nonclassical, Proteasomal-Independent Ubiquitination of Synphilin-1: Implications for Lewy Body Formation

C. Ross, K. Lim, T. Dawson, 2005, The Journal of Neuroscience.

Overview of RAW264.7 for osteoclastogensis study: Phenotype and stimuli

Wanli W. Smith, D. Hao, Lingbo Kong, 2019, Journal of cellular and molecular medicine.

Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells.

C. Ross, J. Troncoso, X. Li, 2005, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Cell cytoskeleton and proliferation study for the RANKL‐induced RAW264.7 differentiation

Wanli W. Smith, Lingbo Kong, Rui Ma, 2021, Journal of cellular and molecular medicine.

Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model.

D. Borchelt, C. Ross, N. Jenkins, 2010, Human molecular genetics.

Evaluation of efficacy on RANKL induced osteoclast from RAW264.7 cells

Wanli W. Smith, Jinglong Yan, Lingbo Kong, 2018, Journal of cellular physiology.

AMPK signaling mediates synphilin-1-induced hyperphagia and obesity in Drosophila

Tianxia Li, Wanli W. Smith, T. Moran, 2020, Journal of Cell Science.

Synphilin-1 Interacts with AMPK and Increases AMPK Phosphorylation

Dejun Yang, Tianxia Li, Wanli W. Smith, 2020, International journal of molecular sciences.

Synphilin-1 attenuates mutant LRRK2-induced neurodegeneration in Parkinson's disease models.

C. Ross, Joseph M. Thomas, Tianxia Li, 2016, Human molecular genetics.

Synphilin-1 Binds ATP and Regulates Intracellular Energy Status

Tianxia Li, Wanli W. Smith, Jingnan Liu, 2014, PloS one.

Behavioral Characterization of the Hyperphagia Synphilin-1 Overexpressing Mice

Y. Treesukosol, Dejun Yang, Tianxia Li, 2014, PloS one.

A novel obesity model: Synphilin-1 induced hyperphagia and obesity in mice

C. Ross, Zhaohui Liu, Wanli W. Smith, 2011, International Journal of Obesity.

CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

L. Petrucelli, C. Ross, T. Dawson, 2009, Proceedings of the National Academy of Sciences.

Novel LRRK 2 GTP-binding inhibitors reduced degeneration in Parkinson ’ s disease cell and mouse models

Alexander D. MacKerell, Dejun Yang, Joseph M. Thomas, 2014 .

Novel LRRK2 GTP-binding inhibitors reduced degeneration in Parkinson's disease cell and mouse models.

Alexander D. MacKerell, Dejun Yang, Joseph M. Thomas, 2014, Human molecular genetics.

68 and FX2149 Attenuate Mutant LRRK2-R1441C-Induced Neural Transport Impairment

P. Fishman, Joseph M. Thomas, Tianxia Li, 2017, Front. Aging Neurosci..

LRRK2 kinase activity mediates toxic interactions between genetic mutation and oxidative stress in a Drosophila model: Suppression by curcumin

C. Ross, Dejun Yang, Tianxia Li, 2012, Neurobiology of Disease.

LDN-73794 Attenuated LRRK2-Induced Degeneration in a Drosophila Parkinson's Disease Model

Dejun Yang, Tianxia Li, Wanli W. Smith, 2015 .

Curcumin protects against rotenone-induced neurotoxicity in cell and drosophila models of Parkinson’s disease

Dejun Yang, Tianxia Li, Zhaohui Liu, 2013 .

ATF3 plays a protective role against toxicity by N-terminal fragment of mutant huntingtin in stable PC12 cell line

C. Ross, Tsonwin Hai, M. Poirier, 2009, Brain Research.

Depletion of CBP is directly linked with cellular toxicity caused by mutant huntingtin

C. Ross, D. DeFranco, M. Poirier, 2006, Neurobiology of Disease.

Curcumin Reduced H2O2- and G2385R-LRRK2-Induced Neurodegeneration

C. Ross, Zhaohui Liu, Wanli W. Smith, 2021, Frontiers in Aging Neuroscience.

An MRI study: Mutant G2019S-LRRK2 induces abnormalities in arteriolar cerebral blood volume in mouse brains

C. Ross, J. Hua, Jiadi Xu, 2021 .

From fat fruitfly to human obesity

Joseph M. Thomas, Tianxia Li, Wanli W. Smith, 2014 .

Exendin-4 reduces food intake via the PI3K/AKT signaling pathway in the hypothalamus

Wanli W. Smith, Nu-Chu Liang, T. Moran, 2017, Scientific Reports.

Parkinson's disease genetic mutations increase cell susceptibility to stress: mutant alpha-synuclein enhances H2O2- and Sin-1-induced cell death.

C. Ross, T. Dawson, V. Dawson, 2007, Neurobiology of aging.

Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model.

D. Borchelt, C. Ross, N. Jenkins, 2010, Human molecular genetics.

Pyrroloquinoline Quinine Inhibits RANKL-Mediated Expression of NFATc1 in Part via Suppression of c-Fos in Mouse Bone Marrow Cells and Inhibits Wear Particle-Induced Osteolysis in Mice

Wanli W. Smith, Shu Zhu, Jinyu Zhu, 2013, PloS one.

VPS35 Protects Against TMEM230-mutation-induced Progressive Locomotor Deficits in Drosophila.

Zhaohui Liu, Wanli W. Smith, Xiaobo Wang, 2022, Neuroscience bulletin.

M1 and M2 macrophage polarization and potentially therapeutic naturally occurring compounds

Wanli W. Smith, B. He, D. Hao, 2019, International immunopharmacology.

Parkinson's disease genetic mutations increase cell susceptibility to stress: Mutant α-synuclein enhances H2O2- and Sin-1-induced cell death

C. Ross, T. Dawson, V. Dawson, 2007, Neurobiology of Aging.

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration.

Andrew B West, Christopher A Ross, Haibing Jiang, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Gene-environment interactions in Parkinson's disease.

Christopher A Ross, C. Ross, Wanli W. Smith, 2007, Parkinsonism & related disorders.

Preserve Common Limb in Duodenal–Jejunal Bypass Surgery Benefits Rats with Type 2-Like Diabetes

Dong Liu, Wei Wang, Wanli W. Smith, 2014, Obesity Surgery.

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity.

C. Ross, T. Dawson, V. Dawson, 2005, Proceedings of the National Academy of Sciences of the United States of America.

A Drosophila model for LRRK2-linked parkinsonism

C. Ross, A. Sawa, C. Montell, 2008, Proceedings of the National Academy of Sciences.

Signaling mechanisms underlying Abeta toxicity: potential therapeutic targets for Alzheimer's disease.

M. Gorospe, Wanli W. Smith, J. Kusiak, 2006, CNS & neurological disorders drug targets.

Overview of cellular mechanisms and signaling pathways of Piceatannol.

Wanli W. Smith, Lingbo Kong, Yang Cao, 2019, Current stem cell research & therapy.

Kinase activity of mutant LRRK2 mediates neuronal toxicity

C. Ross, T. Dawson, V. Dawson, 2006, Nature Neuroscience.

Regulation effects of melatonin on bone marrow mesenchymal stem cell differentiation

Wanli W. Smith, B. He, Biao Wang, 2018, Journal of cellular physiology.

A Novel Taspine Derivative, HMQ1611, Inhibits Breast Cancer Cell Growth via Estrogen Receptor α and EGF Receptor Signaling Pathways

Y. Zhan, Yanmin Zhang, Yinnan Chen, 2012, Cancer Prevention Research.

ANovelTaspineDerivative,HMQ1611,InhibitsBreastCancer Cell Growth via Estrogen Receptor a and EGF Receptor Signaling Pathways

Y. Zhan, Yanmin Zhang, Yinnan Chen, 2012 .

From fat fruit fly to human obesity

Joseph M. Thomas, Tianxia Li, Wanli W. Smith, 2014, Physiology & Behavior.

Identification of Glyceraldehyde 3-Phosphate Dehydrogenase Sequence and Expression Profiles in Tree Shrew (Tupaia belangeri)

Wanli W. Smith, Yingjun Wang, Jing Leng, 2014, PloS one.

Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1

C. Ross, K. Lim, C. Ng, 2016, Nature Communications.

Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models.

T. Dawson, V. Dawson, K. Caldwell, 2011, Human molecular genetics.

α-Synuclein Phosphorylation Enhances Eosinophilic Cytoplasmic Inclusion Formation in SH-SY5Y Cells

C. Ross, J. Troncoso, X. Li, 2005, The Journal of Neuroscience.

Phosphorylation of p66Shc and forkhead proteins mediates Aβ toxicity

M. Gorospe, N. Holbrook, S. Nemoto, 2005, The Journal of cell biology.

G2019S-LRRK2 mutation enhances MPTP-linked Parkinsonism in mice.

C. Ross, F. Nucifora, Wanli W. Smith, 2019, Human molecular genetics.

VPS35 Protects Against TMEM230-mutation-induced Progressive Locomotor Deficits in Drosophila

Zhaohui Liu, Wanli W. Smith, Xiaobo Wang, 2021, Neuroscience Bulletin.

The role of Rho GTPases’ substrates Rac and Cdc42 in osteoclastogenesis and relevant natural medicinal products study

Wanli W. Smith, B. He, Lingbo Kong, 2020, Bioscience reports.

Enhanced Aβ1–40 Production in Endothelial Cells Stimulated with Fibrillar Aβ1–42

D. Taub, Aaron Tan, M. Inayathullah, 2013, PloS one.

Mitochondrial-Derived Peptide MOTS-c Attenuates Vascular Calcification and Secondary Myocardial Remodeling via Adenosine Monophosphate-Activated Protein Kinase Signaling Pathway

Wanli W. Smith, H. Cao, Jin-rui Chang, 2019, Cardiorenal Medicine.

GTP‐binding inhibitors increase LRRK2‐linked ubiquitination and Lewy body‐like inclusions

C. Ross, F. Nucifora, Joseph M. Thomas, 2020, Journal of cellular physiology.

Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake

M. Birnbaum, G. Ronnett, Wendy Keung, 2007, Proceedings of the National Academy of Sciences.

Exendin-4 reduces food intake via the PI3K/AKT signaling pathway in the hypothalamus

Wanli W. Smith, Nu-Chu Liang, T. Moran, 2017, Scientific Reports.

Identification of the full-length β-actin sequence and expression profiles in the tree shrew (Tupaia belangeri).

Wanli W. Smith, Jing Leng, Qihui Wang, 2015, International journal of molecular medicine.

Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity.

C. Ross, A. Sawa, T. Dawson, 2005, Human molecular genetics.

Inhibitors of LRRK 2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson ’ s disease models

T. Dawson, V. Dawson, K. Caldwell, 2011 .

Natural products for regulating macrophages M2 polarization.

Wanli W. Smith, Lingbo Kong, Youhan Wang, 2019, Current stem cell research & therapy.

Roles of dorsomedial hypothalamic cholecystokinin signaling in the controls of meal patterns and glucose homeostasis

Wanli W. Smith, T. Moran, Jian-qun Yan, 2012, Physiology & Behavior.

Models for LRRK2-Linked Parkinsonism

Dejun Yang, Tianxia Li, Zhaohui Liu, 2011, Parkinson's disease.

Activation of Nrf2 in Astrocytes Suppressed PD-Like Phenotypes via Antioxidant and Autophagy Pathways in Rat and Drosophila Models

Zhaohui Liu, Wanli W. Smith, Xiaobo Wang, 2021, Cells.

Mutant TMEM230 induced neurodegeneration and impaired axonal mitochondrial transport.

C. Ross, Zhaohui Liu, Wanli W. Smith, 2021, Human molecular genetics.

Curcumin protects against A53T alpha-synuclein-induced toxicity in a PC12 inducible cell model for Parkinsonism.

C. Ross, Zhaohui Liu, Wanli W. Smith, 2011, Pharmacological research.

Transmembrane Protein 230 Mediates a Poly(ADP-ribose) Polymerase-1-Linked Apoptosis

C. Ross, Zhaohui Liu, Wanli W. Smith, 2020, Frontiers in Aging Neuroscience.

A LRRK2 GTP Binding Inhibitor, 68, Reduces LPS-Induced Signaling Events and TNF-α Release in Human Lymphoblasts

C. Ross, A. Sawa, Joseph M. Thomas, 2021, Cells.

CCK Response Deficiency in Synphilin-1 Transgenic Mice

Dejun Yang, Tianxia Li, Wanli W. Smith, 2015, PloS one.

Macrophages on Bone Homeostasis.

Wanli W. Smith, D. Hao, Lingbo Kong, 2019, Current stem cell research & therapy.

Baicalein reduces E46K α‐synuclein aggregation in vitro and protects cells against E46K α‐synuclein toxicity in cell models of familiar Parkinsonism

D. Zack, C. Ross, C. Berlinicke, 2010, Journal of neurochemistry.

Inhibitors of Lrrk2 Kinase Attenuate Neurodegeneration and Parkinson-like Phenotypes in C. Elegans and Drosophila Parkinson's Disease Models

T. Dawson, V. Dawson, K. Caldwell, 2022 .

A Novel GTP-Binding Inhibitor, FX2149, Attenuates LRRK2 Toxicity in Parkinson’s Disease Models

Xinhua He, Dejun Yang, Joseph M. Thomas, 2015, PloS one.