Jay L. Patel

Genetic Inactivation of the PRC2 Complex in T-Cell Acute Lymphoblastic Leukemia

A. Ferrando, R. Rabadán, T. Huynh, 2011, Nature Medicine.

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.

J. Licht, O. Abdel-Wahab, A. Melnick, 2010, Cancer cell.

Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia

Francine E. Garrett-Bakelman, Anna L. Brown, C. Mason, 2016, Nature Medicine.

Clinical implications of novel mutations in epigenetic modifiers in AML.

O. Abdel-Wahab, R. Levine, Jay L. Patel, 2011, Hematology/oncology clinics of North America.

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate.

Omar Abdel-Wahab, Joshua D Rabinowitz, Hilary A Coller, 2010, Cancer cell.