N. Clark

发表

Metal dependence and branched RNA cocrystal structures of the RNA lariat debranching enzyme Dbr1

P. Hart, Alexander B. Taylor, P. F. Fitzpatrick, 2016, Proceedings of the National Academy of Sciences.

Design, Synthesis, and Properties of Phosphoramidate 2',5'-Linked Branched RNA: Toward the Rational Design of Inhibitors of the RNA Lariat Debranching Enzyme.

M. Sekine, P. Hart, M. Damha, 2015, The Journal of organic chemistry.

The molecular basis of pharmacological chaperoning in human α-galactosidase.

N. Clark, S. Garman, A. Guce, 2011, Chemistry & biology.

Adaptor-dependent degradation of a cell-cycle regulator uses a unique substrate architecture.

N. Clark, Peter Chien, S. Garman, 2012, Structure.

Pharmacological chaperones for human α-N-acetylgalactosaminidase

N. Clark, S. Garman, G. Fleet, 2012, Proceedings of the National Academy of Sciences.

Fluorescent Branched RNAs for High-Throughput Analysis of Dbr1 Enzyme Kinetics and Inhibition.

P. Hart, M. Damha, N. Clark, 2017, ACS chemical biology.

Catalytic Mechanism of Human α-Galactosidase*

H. Brumer, E. N. Salgado, N. Clark, 2009, The Journal of Biological Chemistry.

The 1.9 a structure of human alpha-N-acetylgalactosaminidase: The molecular basis of Schindler and Kanzaki diseases.

N. Clark, S. Garman, 2009, Journal of molecular biology.

Interconversion of the Specificities of Human Lysosomal Enzymes Associated with Fabry and Schindler Diseases*

N. Clark, S. Garman, A. Guce, 2010, The Journal of Biological Chemistry.

Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection

Allison J. Taggart, J. Casanova, J. Boeke, 2018, Cell.

Structural basis of lariat RNA recognition by the intron debranching enzyme Dbr1

P. Hart, Alexander B. Taylor, M. Damha, 2014, Nucleic acids research.

Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy

P. Hart, Alexander B. Taylor, N. Clark, 2017, The Journal of Biological Chemistry.

The molecular basis of pharmacological chaperoning in human alpha-galactosidase

N. Clark, S. Garman, A. Guce, 2013 .

The debranching enzyme Dbr1 regulates lariat turnover and intron splicing

Allison J. Taggart, W. Fairbrother, N. Mosammaparast, 2023, Research square.

Crystal Structure of the RNA Lariat Debranching Enzyme Dbr1 with Hydrolyzed Phosphorothioate RNA Product.

W. Fairbrother, P. Hart, Alexander B. Taylor, 2022, Biochemistry.

Activation of human RNA lariat debranching enzyme Dbr1 by binding protein TTDN1 occurs though an intrinsically disordered C-terminal domain

W. Fairbrother, P. Hart, M. Damha, 2023, The Journal of biological chemistry.