D. C. Schultz

发表

Dynamics of histone H3 deposition in vivo reveal a nucleosome gap-filling mechanism for H3.3 to maintain chromatin integrity.

G. Almouzni, P. Adams, D. Ray-Gallet, 2011, Molecular cell.

SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.

G. Maul, D. C. Schultz, K. Ayyanathan, 2002, Genes & development.

BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression

Keith D Wilkinson, Niels Tommerup, H. Gardner, 1998, Oncogene.

Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal stem cell niche

John P. Lynch, Geetha Jagannathan, C. Lengner, 2017, Nature Communications.

Identification of a gene containing zinc-finger motifs based on lost expression in malignantly transformed rat ovarian surface epithelial cells.

A. Godwin, J. Testa, T. Hamilton, 1997, Cancer research.

Discovery of Selective Inhibitors Against EBNA1 via High Throughput In Silico Virtual Screening

Weiliang Zhu, Hualiang Jiang, P. Lieberman, 2010, PloS one.

Mycobacterium tuberculosis 19-kDa Lipoprotein Inhibits IFN-γ-Induced Chromatin Remodeling of MHC2TA by TLR2 and MAPK Signaling1

C. Harding, W. Boom, D. C. Schultz, 2006, The Journal of Immunology.

TLR 2 and MAPK Signaling by MHC 2 TA Chromatin Remodeling of-Induced γ Lipoprotein Inhibits IFN-19-kDa Mycobacterium tuberculosis Boom and

C. Harding, W. Boom, D. C. Schultz, 2006 .

Identification of a zinc-finger gene at 6q25: a chromosomal region implicated in development of many solid tumors

A. Godwin, J. Testa, T. Hamilton, 1997, Oncogene.

Rudimentary G-quadruplex–based telomere capping in Saccharomyces cerevisiae

S. Balasubramanian, F. Johnson, J. M. Nicoludis, 2011, Nature Structural &Molecular Biology.

High-throughput identification of post-transcriptional utrophin up-regulators for Duchenne muscle dystrophy (DMD) therapy

D. Huryn, D. C. Schultz, T. Khurana, 2020, Scientific Reports.

Structure-Function Studies of the BTB / POZ Transcriptional Repression Domain from the Promyelocytic Leukemia Zinc Finger Oncoprotein 1

R. Marmorstein, D. C. Schultz, F. Rauscher, 1999 .

Structure-function studies of the BTB/POZ transcriptional repression domain from the promyelocytic leukemia zinc finger oncoprotein.

R. Marmorstein, X. Li, D. C. Schultz, 1999, Cancer research.

Two distinct origins of a common BRCA1 mutation in breast-ovarian cancer families: a genetic study of 15 185delAG-mutation kindreds.

D. B. Berman, A. Godwin, H. Lynch, 1996, American journal of human genetics.

R-spondin 1 promotes vibration-induced bone formation in mouse models of osteoporosis

F. Johnson, R. Pignolo, D. C. Schultz, 2013, Journal of Molecular Medicine.

Cdc13 OB2 dimerization required for productive Stn1 binding and efficient telomere maintenance.

E. Skordalakes, F. Johnson, D. Speicher, 2013, Structure.

Western blotting and enzymatic activity analysis of cathepsin D in breast tissue and sera of patients with breast cancer and benign breast disease and of normal controls.

D. C. Schultz, J. Alhadeff, S. Niedbala, 1994, Cancer research.

A common mutation in BRCA2 that predisposes to a variety of cancers is found in both Jewish Ashkenazi and non-Jewish individuals.

D. B. Berman, A. Godwin, M. Daly, 1996, Cancer research.

Deacetylation of the DNA-binding Domain Regulates p53-mediated Apoptosis*

S. Sykes, T. Stanek, S. McMahon, 2010, The Journal of Biological Chemistry.

SOLUTION STRUCTURE OF THE PHD DOMAIN FROM THE KAP-1 COREPRESSOR

K. Borden, D. C. Schultz, F. Rauscher, 2001 .

Identification of an ubinuclein 1 region required for stability and function of the human HIRA/UBN1/CABIN1/ASF1a histone H3.3 chaperone complex.

R. Marmorstein, P. Adams, T. S. Rai, 2012, Biochemistry.

Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers

Benjamin G. Bitler, I. Shih, D. Speicher, 2015, Nature Medicine.

A common region of deletion on chromosome 17q in both sporadic and familial epithelial ovarian tumors distal to BRCA1.

K. Buetow, R. Ozols, A. Godwin, 1994, American journal of human genetics.

Characterization of chromosome 9 in human ovarian neoplasia identifies frequent genetic imbalance on 9q and rare alterations involving 9p, including CDKN2.

K. Buetow, R. Ozols, A. Godwin, 1995, Cancer research.

Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway

Y. Shiloh, S. Bekker-Jensen, J. Bartek, 2006, Nature Cell Biology.

Histone H3 K4 Demethylation during Activation and Attenuation of GAL1 Transcription in Saccharomyces cerevisiae

Min Gyu Lee, A. Shilatifard, S. Berger, 2007, Molecular and Cellular Biology.

Comprehensive pharmacological profiling of neurofibromatosis cell lines.

J. Field, D. C. Schultz, S. Berritt, 2017, American journal of cancer research.

Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation.

G. Maul, M. Lechner, D. C. Schultz, 2003, Genes & development.

Targeting EZH2 methyltransferase activity in ARID1A mutated cancer cells is synthetic lethal

I. Shih, D. Speicher, Hua Li, 2015, Nature medicine.

The KAP1 Corepressor Functions To Coordinate the Assembly of De Novo HP1-Demarcated Microenvironments of Heterochromatin Required for KRAB Zinc Finger Protein-Mediated Transcriptional Repression

D. C. Schultz, J. Stevens, S. Sripathy, 2006, Molecular and Cellular Biology.

Adaptive mitochondrial reprogramming and resistance to PI3K therapy.

J. C. Ghosh, R. Michalek, V. Vaira, 2015, Journal of the National Cancer Institute.

KAP-1 Corepressor Protein Interacts and Colocalizes with Heterochromatic and Euchromatic HP1 Proteins: a Potential Role for Krüppel-Associated Box–Zinc Finger Proteins in Heterochromatin-Mediated Gene Silencing

Prim B. Singh, D. C. Schultz, K. Ayyanathan, 1999, Molecular and Cellular Biology.

Identification of two candidate tumor suppressor genes on chromosome 17p13.3.

A. Godwin, T. Hamilton, D. C. Schultz, 1996, Cancer research.

SETDB 1 : a novel KAP-1-associated histone H 3 , lysine 9-specific methyltransferase that contributes to HP 1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins

G. Maul, D. C. Schultz, K. Ayyanathan, 2002 .

Identification of a splice acceptor site mutation in p16INK4A/p14ARF within a breast cancer, melanoma, neurofibroma prone kindred

A. Godwin, P. Cairns, M. Daly, 2003, Journal of medical genetics.

Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence.

B. Garcia, S. Berger, P. Adams, 2019, Molecular cell.

Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD.

J. Friedman, D. C. Schultz, F. Rauscher, 2001, Genes & development.

PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing.

Ming-Ming Zhou, K. Yap, A. Ivanov, 2007, Molecular cell.

Reconstitution of the KRAB-KAP-1 repressor complex: a model system for defining the molecular anatomy of RING-B box-coiled-coil domain-mediated protein-protein interactions.

D. Speicher, J. Friedman, D. C. Schultz, 2000, Journal of molecular biology.

Identification of a splice acceptor site mutation in p16/p14 within a breast cancer, melanoma, neurofibroma prone kindred

P. Cairns, M. Daly, D. C. Schultz, 2003 .

Role for KAP1 Serine 824 Phosphorylation and Sumoylation/Desumoylation Switch in Regulating KAP1-mediated Transcriptional Repression*

Y. Yen, H. Shih, D. Ann, 2007, Journal of Biological Chemistry.

The KRAB Zinc Finger Protein RSL1 Regulates Sex- and Tissue-Specific Promoter Methylation and Dynamic Hormone-Responsive Chromatin Configuration

D. C. Schultz, D. Robins, C. Krebs, 2012, Molecular and Cellular Biology.

Expression of OVCA1, a candidate tumor suppressor, is reduced in tumors and inhibits growth of ovarian cancer cells.

A. Godwin, W. Bruening, D. C. Schultz, 1999, Cancer research.

Solution structure of the PHD domain from the KAP‐1 corepressor: structural determinants for PHD, RING and LIM zinc‐binding domains

K. Borden, D. C. Schultz, F. Rauscher, 2001, The EMBO journal.

Configuration Hormone-Responsive Chromatin Promoter Methylation and Dynamic Regulates Sex-and Tissue-Specific The KRAB Zinc Finger Protein RSL 1

D. C. Schultz, D. Robins, C. Krebs, 2012 .

Expression of OVCA 1 , a Candidate Tumor Suppressor , Is Reduced in Tumors and Inhibits Growth of Ovarian Cancer Cells 1

A. Godwin, W. Bruening, D. C. Schultz, 1999 .

Survivin family proteins as novel molecular determinants of doxorubicin resistance in organotypic human breast tumors

V. Vaira, S. Bosari, D. Altieri, 2014, Breast Cancer Research.

Ubinuclein-1 confers histone H3.3-specific-binding by the HIRA histone chaperone complex

R. Marmorstein, P. Adams, T. S. Rai, 2015, Nature Communications.

Human CABIN1 Is a Functional Member of the Human HIRA/UBN1/ASF1a Histone H3.3 Chaperone Complex

R. Marmorstein, P. Adams, T. S. Rai, 2011, Molecular and Cellular Biology.

Structure of the Human Telomeric Stn1-Ten1 Capping Complex

E. Skordalakes, D. C. Schultz, C. Rice, 2013, PloS one.

Identification of a new class of small molecules that efficiently reactivate latent Epstein-Barr Virus.

P. Lieberman, J. Salvino, N. Tikhmyanova, 2014, ACS chemical biology.

The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain.

G. Maul, M. Lechner, D. C. Schultz, 2005, Biochemical and biophysical research communications.

Identification and characterization of small molecule antagonists of pRb inactivation by viral oncoproteins.

J. Kissil, D. Huryn, D. Fera, 2012, Chemistry & biology.

Concurrent MEK2 mutation and BRAF amplification confer resistance to BRAF and MEK inhibitors in melanoma.

Wei Xu, M. Herlyn, K. Nathanson, 2013, Cell reports.

High-throughput identification of post-transcriptional utrophin up-regulators for Duchenne muscle dystrophy (DMD) therapy

D. Huryn, D. C. Schultz, T. Khurana, 2020, Scientific Reports.

Development of a High-Throughput Screen for Inhibitors of Epstein-Barr Virus EBNA1

P. Lieberman, D. C. Schultz, M. Reichman, 2010, Journal of biomolecular screening.

A cell-based high-content screen identifies isocotoin as a small molecule inhibitor of the meiosis-specific MEIOB–SPATA22 complex†

N. A. Leu, D. C. Schultz, Yang Xu, 2020, Biology of Reproduction.

Polo-like kinase 1 as a therapeutic target for malignant peripheral nerve sheath tumors (MPNST) and schwannomas.

N. Ratner, J. Field, D. C. Schultz, 2020, American journal of cancer research.

Identification and Characterization of Small Molecule Human Papillomavirus E6 Inhibitors

D. Fera, K. Malecka, R. Marmorstein, 2014, ACS chemical biology.

Identi fi cation and Characterization of Small Molecule Human Papillomavirus E 6 Inhibitors

D. Fera, K. Malecka, R. Marmorstein, 2014 .

Spurious intragenic transcription is a feature of mammalian cellular senescence and tissue aging

S. Berger, G. Donahue, D. C. Schultz, 2023, Nature Aging.

R-spondin 1 promotes vibration-induced bone formation in mouse models of osteoporosis

F. Johnson, R. Pignolo, D. C. Schultz, 2013, Journal of Molecular Medicine.

Histone chaperone HIRA, Promyelocytic Leukemia (PML) protein and p62/SQSTM1 coordinate to regulate inflammation during cell senescence and aging

S. Berger, Valesca Anschau, J. Proulx, 2023 .

Rudimentary G-quadruplex–based telomere capping in Saccharomyces cerevisiae

S. Balasubramanian, F. Johnson, M. Teulade‐Fichou, 2011, Nature Structural &Molecular Biology.

Cloning and localization of a human diphthamide biosynthesis-like protein-2 gene, DPH2L2.

A. Godwin, J. Testa, D. C. Schultz, 1998, Genomics.

Deacetylation of the DNA-binding Domain Regulates p53-mediated Apoptosis*

S. Sykes, T. Stanek, S. McMahon, 2010, The Journal of Biological Chemistry.

Histone chaperone HIRA, Promyelocytic Leukemia (PML) protein and p62/SQSTM1 coordinate to regulate inflammation during cell senescence

Christina Huan Shi, S. Berger, Valesca Anschau, 2024, bioRxiv.