D. Cooper

D. Cooper, J. Teuteberg, 2010, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

The impact of serum incubation time on IgM/IgG binding to porcine aortic endothelial cells

D. Cooper, M. Ezzelarab, H. Hara, 2017, Xenotransplantation.

CARBOHYDRATE ANTIGENS OF PIG TISSUES REACTING WITH HUMAN NATURAL ANTIBODIES AS POTENTIAL TARGETS FOR HYPERACUTE VASCULAR REJECTION IN PIG‐TO‐MAN ORGAN XENOTRANSPLANTATION1

R. Oriol, D. Cooper, Y. Ye, 1993, Transplantation.

Identification of alpha-galactosyl and other carbohydrate epitopes that are bound by human anti-pig antibodies: relevance to discordant xenografting in man.

R. Oriol, D. Cooper, Y. Ye, 1993, Transplant immunology.

Suppression of Natural and Elicited Antibodies in Pig‐to‐Baboon Heart Transplantation Using a Human Anti‐Human CD154 mAb‐Based Regimen

N. Mueller, D. Sachs, K. Kuwaki, 2004, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Marked prolongation of porcine renal xenograft survival in baboons through the use of α1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue

D. Sachs, M. Sykes, R. Hawley, 2005, Nature Medicine.

Heart transplantation in baboons using α1,3-galactosyltransferase gene-knockout pigs as donors: initial experience

N. Mueller, D. Sachs, K. Kuwaki, 2005, Nature Medicine.

Pig-to-Nonhuman Primate Islet Xenotransplantation: A Review of Current Problems

R. Bottino, M. Trucco, D. Cooper, 2006, Cell transplantation.

Alpha1,3-galactosyltransferase gene-knockout pigs for xenotransplantation: where do we go from here?

R. Pierson, H. Ohdan, D. Cooper, 2007, Transplantation.

Immunological and physiological observations in baboons with life‐supporting genetically engineered pig kidney grafts

E. Klein, M. Wijkstrom, A. Humar, 2017, Xenotransplantation.

Regulation of Clinical Xenotransplantation-Time for a Reappraisal.

R. Pierson, C. Ahn, B. Hering, 2017, Transplantation.

The pathobiology of pig‐to‐primate xenotransplantation: a historical review

R. Bottino, M. Wijkstrom, D. Cooper, 2016, Xenotransplantation.

KIDNEY XENOTRANSPLANTATION

D. Cooper, A. D'apice, P. Cowan, 2013, Kidney international.

New Concepts of Immune Modulation in Xenotransplantation

D. Cooper, M. Ezzelarab, H. Hara, 2013, Transplantation.

Porcine alanine transaminase after liver allo‐and xenotransplantation

D. Cooper, B. Gridelli, B. Ekser, 2012, Xenotransplantation.

Update: cardiac xenotransplantation

D. Cooper, B. Ekser, 2008, Current opinion in organ transplantation.

The pig‐to‐primate immune response: relevance for xenotransplantation

H. Tai, D. Cooper, M. Ezzelarab, 2007, Xenotransplantation.

Measurement of anti‐CD154 monoclonal antibody in primate sera by competitive inhibition ELISA

H. Tai, D. Cooper, M. Ezzelarab, 2006, Xenotransplantation.

A review of studies relating to thyroid hormone therapy in brain-dead organ donors.

D. Cooper, W. Wicomb, D. Novitzky, 2009, Frontiers in bioscience.

The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes-- executive summary.

R. Pierson, B. Hering, G. Korbutt, 2009, Xenotransplantation.

Pig Liver Xenotransplantation as a Bridge to Allotransplantation: Which Patients Might Benefit?

D. Cooper, B. Gridelli, B. Ekser, 2009, Transplantation.

Giant gallstone: A case report.

D. Cooper, P. Becerra, Valentina Becerra, 2011, International journal of surgery case reports.

Altered expression of eNOS, prostacyclin synthase, prostaglandin G/H synthase, and thromboxane synthase in porcine aortic endothelial cells after exposure to human serum—relevance to xenotransplantation

Z. Cai, A. Tang, Yifan Dai, 2017, Cell biology international.

Safe use of anti‐CD154 monoclonal antibody in pig islet xenotransplantation in monkeys

R. Bottino, E. Klein, M. Trucco, 2017, Xenotransplantation.

Major carbohydrate epitopes in tissues of domestic and African wild animals of potential interest for xenotransplantation research

R. Oriol, D. Cooper, M. Niekrasz, 1999, Xenotransplantation.

Effect of the alphaGal epitope on the response to small intestinal submucosa extracellular matrix in a nonhuman primate model.

Kerry A. Daly, S. Badylak, D. Cooper, 2009, Tissue engineering. Part A.

JOINT FDA‐IXA SYMPOSIUM, SEPTEMBER 20, 2017

R. Pierson, B. Hering, D. Sachs, 2017, Xenotransplantation.

Disordered regulation of coagulation and platelet activation in xenotransplantation

S. Robson, D. Cooper, A. D'apice, 2000, Xenotransplantation.

An approach to the control of disease transmission in pig‐to‐human xenotransplantation

A. Osterhaus, D. Onions, D. Cooper, 2000, Xenotransplantation.

Selective inhibition of cyclooxygenase‐2 protects porcine aortic endothelial cells from human antibody‐mediated complement‐dependent cytotoxicity

D. Cooper, Lisha Mou, Hanchao Gao, 2019, Xenotransplantation.

α1,3-Galactosyltransferase Gene-Knockout Pig Heart Transplantation in Baboons with Survival Approaching 6 Months

D. Sachs, K. Kuwaki, S. Robson, 2005, Transplantation.

Regulation of human platelet aggregation by genetically modified pig endothelial cells and thrombin inhibition

D. Cooper, M. Ezzelarab, H. Hara, 2014, Xenotransplantation.

Xenotransplantation-the current status and prospects.

D. Eckhoff, M. Tector, D. Cooper, 2018, British medical bulletin.

Anti-Gal, alpha-Gal epitopes, and xenotransplantation.

D. Cooper, T. Kobayashi, 1999, Sub-cellular biochemistry.

Eomesoderminlo CTLA4hi Alloreactive CD8+ Memory T Cells Are Associated With Prolonged Renal Transplant Survival Induced by Regulatory Dendritic Cell Infusion in CTLA4 Immunoglobulin–Treated Nonhuman Primates

A. Thomson, A. Zahorchak, D. Cooper, 2016, Transplantation.

Safe Induction of Diabetes by High-Dose Streptozotocin in Pigs

H. Tai, R. Bottino, D. Cooper, 2008, Pancreas.

Impact of Thrombocytopenia on Survival of Baboons with Genetically Modified Pig Liver Transplants: Clinical Relevance

E. Klein, R. Wolf, D. Cooper, 2010, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Hepatic Function After Genetically Engineered Pig Liver Transplantation in Baboons

D. Cooper, B. Gridelli, M. Ezzelarab, 2010, Transplantation.

Platelet aggregation in humans and nonhuman primates: relevance to xenotransplantation

D. Cooper, M. Ezzelarab, B. Ekser, 2012, Xenotransplantation.

Pig-to-Primate Islet Xenotransplantation: Past, Present, and Future

Z. Cai, Yifan Dai, R. Bottino, 2017, Cell transplantation.

First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes—Chapter 4: pre‐clinical efficacy and complication data required to justify a clinical trial

A. Kirk, O. Korsgren, R. Bottino, 2016, Xenotransplantation.

Induction of Diabetes in Cynomolgus Monkeys With High-dose Streptozotocin: Adverse Effects and Early Responses

R. Bottino, M. Trucco, D. Cooper, 2006, Pancreas.

Chapter 4: Pre‐clinical efficacy and complication data required to justify a clinical trial

D. Cooper, A. Casu, D. K. Cooper, 2009, Xenotransplantation.

Identification of carbohydrate structures that bind human antiporcine antibodies: implications for discordant xenografting in humans.

D. Cooper, Y. Ye, N. Zuhdi, 1992, Transplantation proceedings.

Intravenous infusion of Galalpha1-3Gal oligosaccharides in baboons delays hyperacute rejection of porcine heart xenografts.

D. Zopf, D. Cooper, W. Hancock, 1998, Transplantation.

Is the renal subcapsular space the preferred site for clinical porcine islet xenotransplantation? Review article.

R. Bottino, D. Cooper, H. Hara, 2019, International journal of surgery.

Further evidence for sustained systemic inflammation in xenograft recipients (SIXR)

M. Wijkstrom, D. Cooper, M. Ezzelarab, 2015, Xenotransplantation.

Xenotransplantation of the endocrine pancreas

R. Bottino, D. Cooper, B. Smood, 2020 .

Metabolic aspects of pig-to-monkey (Macaca fascicularis) islet transplantation: implications for translation into clinical practice

R. Bottino, M. Trucco, D. Cooper, 2007, Diabetologia.

The role of platelets in coagulation dysfunction in xenotransplantation, and therapeutic options

D. Cooper, M. Ezzelarab, B. Ekser, 2014, Xenotransplantation.

Atorvastatin or transgenic expression of TFPI inhibits coagulation initiated by anti‐nonGal IgG binding to porcine aortic endothelial cells

D. Cooper, M. Ezzelarab, H. Hara, 2010, Journal of thrombosis and haemostasis : JTH.

Coagulation dysregulation as a barrier to xenotransplantation in the primate.

D. Cooper, A. Dorling, C. C. Lin, 2009, Transplant immunology.

The potential of statins in xenotransplantation

D. Cooper, M. Ezzelarab, D. Cooper, 2007, Xenotransplantation.

Xenotransplantation of the Heart

D. Cooper, 1996 .

Selection of Patients for the Initial Clinical Trials of Kidney Xenotransplantation

D. Eckhoff, D. Cooper, R. Mannon, 2020 .

Chronic dialysis in patients with end‐stage renal disease: Relevance to kidney xenotransplantation

D. Cooper, R. Gaston, H. Iwase, 2018, Xenotransplantation.

Racial differences in attitudes to clinical pig organ Xenotransplantation

Luz A. Padilla, Kyeonghee Jang, D. Cooper, 2020, Xenotransplantation.

The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of xenocorneal transplantation

R. Pierson, Y. Takeuchi, L. Scobie, 2014, Xenotransplantation.

Deceased humans and living pigs as sources of kidneys for clinical transplantation—Can they be compared?

D. Cooper, Abhijit Jagdale, 2021, Xenotransplantation.

Recipient Tissue Factor Expression Is Associated With Consumptive Coagulopathy in Pig‐to‐Primate Kidney Xenotransplantation

D. Cooper, M. Ezzelarab, H. Hara, 2010, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Genetically-engineered pigs as sources for clinical red blood cell transfusion: What pathobiological barriers need to be overcome?

D. Cooper, H. Hara, B. Smood, 2019, Blood reviews.

Justification of specific genetic modifications in pigs for clinical organ xenotransplantation

D. Cooper, M. Ezzelarab, H. Hara, 2019, Xenotransplantation.

Genetically engineered pigs as a source for clinical red blood cell transfusion.

D. Cooper, H. Hara, M. Yazer, 2010, Clinics in laboratory medicine.

Genetically engineered pig red blood cells for clinical transfusion: initial in vitro studies

D. Cooper, M. Ezzelarab, H. Hara, 2009, Transfusion.

The Pathobiology of Pig-to-Primate Xeno.: A Historical Review

R. Bottino, M. Wijkstrom, D. Cooper, 2020 .

Recent advances in understanding xenotransplantation: implications for the clinic

R. Bottino, D. Cooper, 2015, Expert review of clinical immunology.

Report from IPITA-TTS Opinion Leaders Meeting on the Future of β-Cell Replacement

M. Rickels, B. Kovatchev, B. Ludwig, 2016, Transplantation.

Monoclonal antiidiotypic antibodies neutralize cytotoxic effects of anti-alphaGal antibodies.

D. Cooper, T. Kobayashi, D. Fei, 1996, Transplantation.

Effects of specific anti‐B and/or anti‐plasma cell immunotherapy on antibody production in baboons: depletion of CD20‐ and CD22‐positive B cells does not result in significantly decreased production of  anti‐αGal antibody

D. Sachs, H. Kitamura, D. Cooper, 2001, Xenotransplantation.

An exploratory investigation of the effect of arsenic trioxide on anti‐Gal antibody production in baboons

D. Cooper, A. Thall, C. Knosalla, 2003, Xenotransplantation.

Immunomodulation Strategies in Xenotransplantation

D. Cooper, L. Buhler, M. Basker, 2001 .

The problem of anti‐pig antibodies in pig‐to‐primate xenografting: current and novel methods of depletion and/or suppression of production of anti‐pig antibodies

D. Cooper, L. Buhler, M. Basker, 1999, Xenotransplantation.

High-throughput screening of glycan-binding proteins using miniature pig kidney N-glycan-immobilized beads.

R. Dwek, G. Gil, Yung-Hun Yang, 2008, Chemistry & biology.

The Sda and Cad glycan antigens and their glycosyltransferase, β1,4GalNAcT‐II, in xenotransplantation

Z. Cai, Yifan Dai, D. Cooper, 2018, Xenotransplantation.

Oligosaccharides and Discordant Xenotransplantation

R. Oriol, D. Cooper, E. Koren, 1994, Immunological reviews.

Gal alpha 1,3Gal expression on porcine pancreatic islets, testis, spleen, and thymus.

D. Cooper, H. Schuurman, F. Dor, 2004, Xenotransplantation.

Xenoantigens and xenoantibodies

D. Cooper, 1998, Xenotransplantation.

Galα1,3Gal expression on porcine pancreatic islets, testis, spleen, and thymus

D. Cooper, H. Schuurman, F. Dor, 2004 .

Potential for clinical pancreatic islet xenotransplantation

R. Bottino, M. Wijkstrom, M. Trucco, 2014 .

LIFE-SUPPORTING KIDNEY XENOTRANSPLANTATION FROM GENETICALLY-ENGINEERED PIGS IN BABOONS: A COMPARISON OF TWO IMMUNOSUPPRESSIVE REGIMENS.

D. Eckhoff, E. Klein, D. Cooper, 2019, Transplantation.

Gene therapy--its potential in surgery.

S. Gojo, D. Cooper, C. Patience, 2002, Annals of the Royal College of Surgeons of England.

The need for xenotransplantation as a source of organs and cells for clinical transplantation.

D. Cooper, B. Ekser, A. Tector, 2015, International journal of surgery.

Absence of Replication of Porcine Endogenous Retrovirus and Porcine Lymphotropic Herpesvirus Type 1 with Prolonged Pig Cell Microchimerism after Pig-to-Baboon Xenotransplantation

D. Sachs, D. Cooper, A. Griesemer, 2008, Journal of Virology.

Report of the Xenotransplantation Advisory Committee of the International Society for Heart and Lung Transplantation: the present status of xenotransplantation and its potential role in the treatment of end-stage cardiac and pulmonary diseases.

R. Pierson, P. Corris, L. Stevenson, 2000, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Serum cytotoxicity to pig cells and anti-alphaGal antibody level and specificity in humans and baboons.

D. Cooper, F. Neethling, 1999, Transplantation.

Growth hormone receptor knockout: Relevance to xenotransplantation

D. Cooper, H. Iwase, S. Ball, 2020, Xenotransplantation.

Systemic inflammation in xenograft recipients (SIXR): A new paradigm in pig-to-primate xenotransplantation?

D. Cooper, M. Ezzelarab, 2015, International journal of surgery.

Xenotransplantation of cells and tissues: application to a range of diseases, from diabetes to Alzheimer's.

R. Lanza, D. Cooper, 1998, Molecular medicine today.

Hormonal resuscitation therapy in the management of the brain-dead potential organ donor.

D. Cooper, 2008, International journal of surgery.

A Syndrome of Severe Hypoglycemia and Acidosis in Young Immunosuppressed Diabetic Monkeys and Pigs—Association With Sepsis

L. Rigatti, R. Bottino, M. Wijkstrom, 2012, Transplantation.

Extracellular histones and xenotransplantation

D. Cooper, Tao Li, Houqin Liu, 2020, Xenotransplantation.

The effect of Gal expression on pig cells on the human T‐cell xenoresponse

D. Cooper, M. Ezzelarab, H. Hara, 2012, Xenotransplantation.

Inhibition of platelet aggregation in baboons: therapeutic implications for xenotransplantation

S. Robson, D. Cooper, L. Buhler, 2000, Xenotransplantation.

Acute gastric dilatation after porcine islet transplantation in a cynomolgus monkey – case history and review of the literature

R. Bottino, D. Cooper, P. Rood, 2007, Xenotransplantation.

Which patients first? Planning the first clinical trial of xenotransplantation: a case for cardiac bridging

D. Cooper, R. Kormos, M. Ezzelarab, 2005, Xenotransplantation.

Non-human primate regulatory T cells: current biology and implications for transplantation.

A. Thomson, G. Raimondi, D. Cooper, 2010, Transplantation.

Transplant Tolerance: Current Insights and Strategies for Long-Term Survival of Xenografts

Z. Cai, Yifan Dai, D. Cooper, 2018, Archivum Immunologiae et Therapiae Experimentalis.

Klotho attenuated antibody‐mediated porcine endothelial cell activation and injury

Z. Cai, Zesong Li, Yifan Dai, 2017, Xenotransplantation.

Potential roles of mesenchymal stromal cells in islet allo‐ and xenotransplantation for type 1 diabetes mellitus

Z. Cai, Yifan Dai, D. Cooper, 2021, Xenotransplantation.

Comparison of Proliferative Capacity of Genetically-Engineered Pig and Human Corneal Endothelial Cells

D. Cooper, H. Hara, D. Ayares, 2012, Ophthalmic Research.

Promotion of xenogeneic hematopoietic chimerism in rodents by mononuclear phagocyte depletion

D. Cooper, A. Thall, J. Cheng, 2002, Xenotransplantation.

Investigation of Lymphocyte Depletion and Repopulation Using Alemtuzumab (Campath‐1H) in Cynomolgus Monkeys

J. Ijzermans, C. Macedo, D. Metes, 2010, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Current status of xenotransplantation and prospects for clinical application

R. Pierson, B. Hering, D. Cooper, 2009, Xenotransplantation.

Indicators of impending pig kidney and heart xenograft failure: Relevance to clinical organ xenotransplantation - Review article.

D. Cooper, H. Hara, D. Ayares, 2019, International journal of surgery.

Executive Summary of IPITA-TTS Opinion Leaders Report on the Future of β-Cell Replacement.

M. Rickels, B. Ludwig, G. Weir, 2016, Transplantation.

Gene therapy and transplantation.

J. Iacomini, S. Gojo, D. Cooper, 2000, Transplantation.

Long-term discordant xenogeneic (porcine-to-primate) bone marrow engraftment in a monkey treated with porcine-specific growth factors.

T. Sablinski, D. Sachs, A. Cosimi, 1999, Transplantation.

Effect of pig‐specific cytokines on mobilization of hematopoietic progenitor cells in pigs and on pig bone marrow engraftment in baboons

D. Sachs, T. Spitzer, R. Hawley, 1999, Xenotransplantation.

Removal of anti-porcine natural antibodies from human and nonhuman primate plasma in vitro and in vivo by a Galalpha1-3Galbeta1-4betaGlc-X immunoaffinity column.

T. Sablinski, D. Sachs, P. Gianello, 1998, Transplantation.

Islet xenotransplantation: what is the optimal age of the islet‐source pig?

R. Bottino, M. Wijkstrom, M. Trucco, 2015, Xenotransplantation.

The Choice of Anatomical Site for Islet Transplantation

J. Ijzermans, D. Cooper, G. Echeverri, 2008, Cell transplantation.

Pig-to-Macaque Islet Xenotransplantation.

R. Bottino, M. Trucco, D. Cooper, 2020, Methods in molecular biology.

Transplantation of islets of Langerhans: new developments.

C. Ricordi, T. Berney, R. Alejandro, 2001, Swiss medical weekly.

Human Hemangioblast-Derived Mesenchymal Stem Cells Promote Islet Engraftment in a Minimal Islet Mass Transplantation Model in Mice

R. Bottino, M. Trucco, R. Lanza, 2021, Frontiers in Medicine.

Isolation outcome and functional characteristics of young and adult pig pancreatic islets for transplantation studies

R. Bottino, M. Trucco, D. Cooper, 2007, Xenotransplantation.

Endoscopic biopsy of islet transplants in the gastric submucosal space provides evidence of islet graft rejection in diabetic pigs

K. Haruma, R. Bottino, M. Wijkstrom, 2016, Islets.

Pig‐to‐baboon heterotopic heart transplantation – exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade‐based regimens

E. Wolf, E. Klein, M. Wijkstrom, 2015, Xenotransplantation.

Clinical potential of xenotransplantation.

R. Oriol, D. Cooper, E. Koren, 1994, Transplantation proceedings.

Xenogeneic thymus transplantation in a pig-to-baboon model1

R. Colvin, J. Wain, D. Sachs, 2003, Transplantation.

Pig kidney transplantation in baboons: anti-Gal(alpha)1-3Gal IgM alone is associated with acute humoral xenograft rejection and disseminated intravascular coagulation.

R. Colvin, D. Sachs, S. Robson, 2001, Transplantation.

Sequential Monitoring and Stability of Ex Vivo–Expanded Autologous and Nonautologous Regulatory T Cells Following Infusion in Nonhuman Primates

R. Wiseman, L. Lu, A. Thomson, 2015, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Physiologic Aspects of Pig Kidney Transplantation in Nonhuman Primates.

E. Klein, D. Cooper, H. Iwase, 2018, Comparative medicine.

Xenotransplantation: past, present, and future

D. Cooper, B. Ekser, Ping Li, 2017, Current opinion in organ transplantation.

Suppressive Efficacy and Proliferative Capacity of Human Regulatory T Cells in Allogeneic and Xenogeneic Responses

H. Tai, D. Cooper, H. Hara, 2008, Transplantation.

MECHANISMS OF THROMBOTIC MICROANGIOPATHY FOLLOWING XENOGENEIC HEMATOPOIETIC PROGENITOR CELL TRANSPLANTATION1

S. Robson, E. Csizmadia, H. Kitamura, 2001, Transplantation.

Clinical Islet Xenotransplantation: A Step Forward

R. Bottino, D. Cooper, B. Ekser, 2016, EBioMedicine.

Xenotransplantation and tolerance.

D. Cooper, C. Knosalla, 2002, Frontiers in bioscience : a journal and virtual library.

ACUTE VASCULAR REJECTION OF XENOGRAFTS: ROLES OF NATURAL AND ELICITED XENOREACTIVE ANTIBODIES IN ACTIVATION OF VASCULAR ENDOTHELIAL CELLS AND INDUCTION OF PROCOAGULANT ACTIVITY

S. Robson, D. Cooper, L. Buhler, 2004, Transplantation.

Regulatory Dendritic Cell Infusion Prolongs Kidney Allograft Survival in Nonhuman Primates

A. Demetris, L. Lu, A. Thomson, 2013, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Overcoming Coagulation Dysregulation in Pig Solid Organ Transplantation in Nonhuman Primates: Recent Progress.

D. Cooper, H. Iwase, Yi Wang, 2018, Transplantation.

Incidence of Neoplasia in Pigs and Its Relevance to Clinical Organ Xenotransplantation.

E. Klein, D. Cooper, H. Iwase, 2019, Comparative medicine.

Regulatory T Cell Infusion Can Enhance Memory T Cell and Alloantibody Responses in Lymphodepleted Nonhuman Primate Heart Allograft Recipients

R. Wiseman, L. Lu, A. Thomson, 2016, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Recent advances in pig-to-human organ and cell transplantation

D. Cooper, M. Ezzelarab, H. Hara, 2008, Expert opinion on biological therapy.

Pig-to-non-human primate heart transplantation: immunologic progress over 20 years.

D. Cooper, F. Dor, Xiaocheng Zhu, 2007, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Post-transplant repopulation of naïve and memory T cells in blood and lymphoid tissue after alemtuzumab-mediated depletion in heart-transplanted cynomolgus monkeys.

L. Lu, A. Thomson, A. Zahorchak, 2013, Transplant immunology.

T‐lymphocyte homeostasis and function in infant baboons: implications for transplantation

J. Ijzermans, R. Wolf, D. Cooper, 2012, Transplant international : official journal of the European Society for Organ Transplantation.

Comparison of bile chemistry between humans, baboons, and pigs: implications for clinical and experimental liver xenotransplantation.

D. Cooper, Y. Ye, T. Kobayashi, 1998, Laboratory animal science.

Renal and Cardiac Endothelial Heterogeneity Impact Acute Vascular Rejection in Pig‐to‐Baboon Xenotransplantation

N. Bodyak, A. Usheva, D. Sachs, 2009, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Effect of Rho-kinase Inhibitor, Y27632, on Porcine Corneal Endothelial Cell Culture, Inflammation and Immune Regulation

D. Cooper, H. Hara, Matthew Zhang, 2016, Ocular immunology and inflammation.

Outwitting Evolution - Progress Towards Clinical Xenotransplantation

D. Cooper, 2003 .

Increased Soluble CD154 (CD40 Ligand) Levels in Xenograft Recipients Correlate With the Development of De Novo Anti-Pig IgG Antibodies

K. Isse, D. Cooper, M. Ezzelarab, 2014, Transplantation.

Roles of Anti-αGal Antibody and Oligosaccharide Therapy in Xenotransplantation

R. Cummings, R. Oriol, D. Cooper, 1997 .

Enzyme‐linked immunosorbent assay for the detection of substances that carry blood group A specificity

E. Moase, D. Cooper, E. Romano, 1992, Transfusion.

Anti-Pig IGE and IGA Antibodies in Naive Primates and Nonhuman Primates With Pig Xenografts.

D. Cooper, H. Hara, D. Ayares, 2020, Transplantation.

Outcomes Following Extrahepatic and Intraportal Pancreatic Islet Transplantation: A Comparative Cohort Study

C. Ricordi, A. M. Shapiro, D. Cooper, 2022, Transplantation.

Experimental hepatocyte xenotransplantation—a comprehensive review of the literature

J. Gerlach, D. Cooper, B. Gridelli, 2015, Xenotransplantation.

Thyroid Hormone Therapy to the Recipient of a Heart from a Brain-Dead Donor

D. Cooper, D. Novitzky, 2013 .

Therapeutic Strategies for Xenotransplantation

D. Sachs, D. Cooper, L. Buhler, 2001 .

Different responses of human anti‐HLA and anti‐αgal antibody to long‐term intravenous immunoglobulin therapy

R. Dowling, L. Bühler, D. Cooper, 1999, Xenotransplantation.

A perspective on the potential detrimental role of inflammation in pig orthotopic heart xenotransplantation

G. Walcott, D. Cooper, H. Hara, 2021, Xenotransplantation.

Immunobiology of liver xenotransplantation

M. Rees, S. Robson, D. Cooper, 2012, Expert review of clinical immunology.

Potential factors influencing the development of thrombocytopenia and consumptive coagulopathy after genetically modified pig liver xenotransplantation

D. Stolz, S. Robson, D. Cooper, 2012, Transplant international : official journal of the European Society for Organ Transplantation.

Glucose metabolism in pigs expressing human genes under an insulin promoter

F. Toledo, R. Bottino, M. Wijkstrom, 2015, Xenotransplantation.

Modifying the sugar icing on the transplantation cake.

D. Cooper, 2016, Glycobiology.

Histopathologic insights into the mechanism of anti-non-Gal antibody-mediated pig cardiac xenograft rejection

R. Pierson, S. Robson, H. Tazelaar, 2013, Xenotransplantation.

Identification of αGal as the major target for human anti‐pig antibodies

D. Cooper, D. Cooper, 2009, Xenotransplantation.

Allosensitization Does Not Increase the Risk of Xenoreactivity to α1,3-Galactosyltransferase Gene-Knockout Miniature Swine in Patients on Transplantation Waiting Lists

S. Saidman, D. Sachs, D. Cooper, 2006, Transplantation.

Pig kidney transplantation in baboons treated intravenously with a bovine serum albumin‐Galα1‐3Gal conjugate

D. Sachs, T. Kawai, D. Cooper, 2003, Xenotransplantation.

Depletion of anti‐Gal antibodies by the intravenous infusion of Gal type 2 and 6 glycoconjugates in baboons

D. Sachs, L. Bühler, D. Cooper, 2003, Xenotransplantation.

Anti‐Galα1‐3Gal IgM and IgG antibody levels in sera of humans and old world non‐human primates

D. Cooper, M. Awwad, R. Mañez, 2002 .

Modulation of the in vivo primate anti‐Gal response through administration of anti‐idiotypic antibodies

D. Sachs, H. Kitamura, D. Cooper, 2002, Xenotransplantation.

Depletion of anti-gal antibodies in baboons by intravenous therapy with bovine serum albumin conjugated to gal oligosaccharides.

D. Sachs, L. Bühler, D. Cooper, 2002, Transplantation.

Plasma perfusion by apheresis through a Gal immunoaffinity column successfully depletes anti‐Gal antibody: experience with 320 aphereses in baboons

D. Sachs, S. Gojo, D. Cooper, 2000, Xenotransplantation.

Xenoreactive natural antibodies

J. Iacomini, D. Cooper, N. Cretin, 1999, Cellular and Molecular Life Sciences CMLS.

Lack of variation in αgal expression on lymphocytes in miniature swine of different genotypes

D. Sachs, D. Cooper, S. Arn, 1999, Xenotransplantation.

Pharmacologic immunosuppressive therapy and extracorporeal immunoadsorption in the suppression of anti‐αGal antibody in the baboon

D. Sachs, D. Cooper, J. Fishman, 1998, Xenotransplantation.

Discordant organ xenotransplantation in primates: world experience and current status.

D. Sachs, D. Cooper, D. Lambrigts, 1998, Transplantation.

Xenoantigens and Xenoantibodies: Their Modification

D. Cooper, A. Thall, 1997, World Journal of Surgery.

Major Carbohydrate Xenotransplantation Antigens

D. Cooper, R. Oriol, 1997 .

The reducing end of αGal oligosaccharides contributes to their efficiency in blocking natural antibodies of human and baboon sera

R. Oriol, D. Cooper, D. Joziasse, 1996, Transplant international : official journal of the European Society for Organ Transplantation.

Inhibition of human anti‐αGal IgG by oligosaccharides derived from porcine stomach mucin

R. Cummings, Shifeng Li, D. Cooper, 1995 .

Detection, immunoabsorption, and inhibition of cytotoxic activity of anti‐αGal antibodies using newly developed substances with synthetic Gal α1–3Gal disaccharide epitopes

R. Rieben, E. Korchagina, N. Bovin, 1995 .

Monomorphic and polymorphic carbohydrate antigens on pig tissues: implications for organ xenotransplantation in the pig-to-human model

R. Oriol, D. Cooper, Y. Ye, 1994 .

Variability of anti‐αGal antibodies in human serum and their relation to serum cytotoxicity against pig cells

D. Cooper, E. Koren, F. Neethling, 1994 .

Does expression of a human complement-regulatory protein on xenograft cells protect them from systemic complement activation?

Juan Li, D. Cooper, H. Hara, 2020, International journal of surgery.

MODULATION OF PLATELET AGGREGATION IN BABOONS: IMPLICATIONS FOR MIXED CHIMERISM IN XENOTRANSPLANTATION. I. THE ROLES OF INDIVIDUAL COMPONENTS OF A TRANSPLANTATION CONDITIONING REGIMEN AND OF PIG PERIPHERAL BLOOD PROGENITOR CELLS

S. Robson, D. Cooper, L. Buhler, 2001, Transplantation.

Cryopreservation and mycophenolate therapy are detrimental to hematopoietic progenitor cells.

D. Sachs, L. Bühler, D. Cooper, 2002 .

Cryopreservation and mycophenolate therapy are detrimental to hematopoietic progenitor cells

D. Sachs, L. Bühler, D. Cooper, 2002, Transplantation.

Porcine hematopoietic progenitor cell transplantation in nonhuman primates: a review of progress.

D. Sachs, D. Cooper, Y. Tseng, 2005, Transplantation.

Differential expression of Galα1,3Gal epitopes on fetal and adult porcine hematopoietic cells

S. Gojo, D. Cooper, M. Awwad, 2002, Xenotransplantation.

Pig hematopoietic cell chimerism in baboons conditioned with a nonmyeloablative regimen and CD154 blockade.

D. Sachs, M. Sykes, L. Bühler, 2002, Transplantation.

CLEARANCE OF MOBILIZED PORCINE PERIPHERAL BLOOD PROGENITOR CELLS IS DELAYED BY DEPLETION OF THE PHAGOCYTIC RETICULOENDOTHELIAL SYSTEM IN BABOONS1

D. Sachs, R. Rieben, D. Cooper, 2001, Transplantation.

Immunosuppression for pig-to-nonhuman primate organ grafting

D. Cooper, I. Alwayn, K. Teranishi, 2001 .

Inducing Tolerance by Mixed Hematopoietic Cell Chimerism

D. Sachs, D. Cooper, L. Buhler, 2001 .

Developments in methods of immunomodulation of nonhuman primates undergoing pig organ transplantation during the past

D. Cooper, I. Alwayn, K. Teranishi, 2001 .

Anti-Gal(alpha)1-3Gal antibody response to porcine bone marrow in unmodified baboons and baboons conditioned for tolerance induction.

D. Sachs, D. Cooper, T. Kozłowski, 1998, Transplantation.

Xenotransplantation: The Transplantation of Organs and Tissues Between Species

J. Platt, D. Cooper, D. White, 1991 .

CD40-CD154 pathway blockade requires host macrophages to induce humoral unresponsiveness to pig hematopoietic cells in baboons.

D. Sachs, L. Bühler, D. Cooper, 2001, Transplantation.

Models of xenotransplantation tolerance

D. Cooper, L. Buehler, 2003 .

High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response.

D. Sachs, M. Sykes, L. Bühler, 2000, Transplantation.

Transfer of swine major histocompatibility complex class II genes into autologous bone marrow cells of baboons for the induction of tolerance across xenogeneic barriers.

D. Sachs, A. Cosimi, S. Gojo, 1999, Transplantation.

The Immunology of Xenotransplantation

D. Cooper, C. Knosalla, 2002 .

Evidence that intravenously administered alpha-galactosyl carbohydrates reduce baboon serum cytotoxicity to pig kidney cells (PK15) and transplanted pig hearts.

R. Oriol, S. Kosanke, D. Cooper, 1994, Transplantation.

Assessment of methotrexate as a potential immunosuppressive agent in baboons.

D. Cooper, L. Buhler, M. Awwad, 2001, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Atorvastatin Down-Regulates the Primate Cellular Response to Porcine Aortic Endothelial Cells In Vitro

D. Cooper, M. Ezzelarab, H. Hara, 2008, Transplantation.

Attitudes to Cardiac Xenotransplantation by Pediatric Heart Surgeons and Physicians

Luz A. Padilla, D. Cooper, W. Carlo, 2020, World journal for pediatric & congenital heart surgery.

T Cells from Presensitized Donors Fail to Cause Graft-versus-Host Disease in a Pig-to-Mouse Xenotransplantation Model

D. Sachs, Lan Wang, M. Sykes, 2004, Transplantation.

In vivo immunoadsorption of antipig antibodies in baboons using a specific Gal(alpha)1-3Gal column.

E. Korchagina, N. Bovin, R. Oriol, 1996, Transplantation.

Progress in pig‐to‐non‐human primate transplantation models (1998–2013): a comprehensive review of the literature

D. Cooper, M. Ezzelarab, H. Hara, 2014, Xenotransplantation.

Genetically‐modified pig mesenchymal stromal cells: xenoantigenicity and effect on human T‐cell xenoresponses

D. Cooper, M. Ezzelarab, H. Hara, 2011, Xenotransplantation.

Adult porcine islet transplantation in baboons treated with conventional immunosuppression or a non‐myeloablative regimen and CD154 blockade

J. Squifflet, G. Weir, P. Morel, 2002, Xenotransplantation.

The Innate Immune Response and Activation of Coagulation in α1,3-Galactosyltransferase Gene-Knockout Xenograft Recipients

R. Pierson, H. Tai, D. Cooper, 2009, Transplantation.

Anti‐gal antibodies in α1,3‐galactosyltransferase gene‐knockout pigs

D. Cooper, H. Hara, D. Ayares, 2012, Xenotransplantation.

&agr;1,3-Galactosyltransferase Gene-Knockout Miniature Swine Produce Natural Cytotoxic Anti-Gal Antibodies

D. Sachs, R. Hawley, D. Cooper, 2004, Transplantation.

Rapid loss of intraportally transplanted islets: an overview of pathophysiology and preventive strategies

R. Bottino, D. Cooper, N. Campanile, 2007, Xenotransplantation.

Encapsulated and ‘ free ’ pig islet xenotransplantation : recent experience and clinical progress *

R. Bottino, D. Cooper, 2019 .

In vitro exposure of pig neonatal isletlike cell clusters to human blood

R. Bottino, M. Wijkstrom, M. Trucco, 2015, Xenotransplantation.

Limitations of the pig‐to‐non‐human primate islet transplantation model

R. Bottino, M. Wijkstrom, D. Cooper, 2013, Xenotransplantation.

Potential benefits and risks of clinical xenotransplantation

D. Cooper, D. Ayares, 2012 .

Overcoming the barriers to xenotransplantation: prospects for the future

D. Cooper, B. Ekser, 2010, Expert review of clinical immunology.

Porcine hematopoietic cell xenotransplantation in nonhuman primates is complicated by thrombotic microangiopathy

D. Sachs, S. Robson, L. Bühler, 2001, Bone Marrow Transplantation.

Persistence of Indirect but Not Direct T Cell Xenoresponses in Baboon Recipients of Pig Cell and Organ Transplants

D. Sachs, B. Illigens, D. Cooper, 2016, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Early Clinical Experience of Hormonal Therapy in the Brain-Dead Potential Organ Donor

D. Cooper, B. Ekser, D. Novitzky, 2013 .

Production and characterization of transgenic pigs expressing porcine CTLA4‐Ig

M. Mendicino, D. Cooper, D. Ayares, 2009, Xenotransplantation.

Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys

T. Starzl, Yifan Dai, A. Jevnikar, 2005, Nature Medicine.

Is interleukin‐6 receptor blockade (tocilizumab) beneficial or detrimental to pig‐to‐baboon organ xenotransplantation?

D. Cooper, H. Hara, D. Ayares, 2019, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Frankenswine, or bringing home the bacon

D. Cooper, 2008, Organogenesis.

1,3-Galactosyltransferase Gene-Knockout Pigs for Xenotransplantation: Where Do We Go From Here?

R. Pierson, H. Ohdan, D. Cooper, 2007 .

Primitive hematopoietic cell populations reside in the spleen: Studies in the pig, baboon, and human.

K. Parmar, D. Cooper, F. Dor, 2006, Experimental hematology.

Immunological Unresponsiveness in Chimeric Miniature Swine following MHC-Mismatched Spleen Transplantation

K. Kuwaki, D. Cooper, S. Houser, 2005, Transplantation.

Modulation of platelet aggregation in baboons: implications for mixed chimerism in xenotransplantation. II. The effects of cyclophosphamide on pig peripheral blood progenitor cell-induced aggregation.

S. Robson, D. Cooper, J. Appel, 2001, Transplantation.

Investigation of potential carbohydrate antigen targets for human and baboon antibodies

N. Bovin, D. Cooper, M. Ezzelarab, 2010, Xenotransplantation.

Islet Xenotransplantation: Are We Really Ready for Clinical Trials?

D. Cooper, P. Rood, P. Rood, 2006, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Porcine IL‐6, IL‐1β, and TNF‐α regulate the expression of pro‐inflammatory‐related genes and tissue factor in human umbilical vein endothelial cells

Z. Cai, Zesong Li, Jia Xu, 2018, Xenotransplantation.

In vitro and in vivo investigation of a novel monoclonal antibody to plasma cells (W5 mAb)

H. Bazin, D. Latinne, D. Cooper, 2004, Xenotransplantation.

Pig heart and lung xenotransplantation: Present status.

D. Cooper, R. Chaban, R. N. Iii, 2022, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

How the COVID‐19 pandemic may impact public support for clinical xenotransplantation in the United States?

R. Bottino, D. Cooper, M. F. Knoll, 2020, Xenotransplantation.

Immunobiological barriers to xenotransplantation.

D. Cooper, B. Ekser, A. Tector, 2015, International journal of surgery.

Evidence for GTKO/β4GalNT2KO Pigs as the Preferred Organ-source for Old World Nonhuman Primates as a Preclinical Model of Xenotransplantation

D. Cooper, H. Hara, D. Ayares, 2020, Transplantation direct.

Clinical Pig Kidney Xenotransplantation: How Close Are We?

D. Eckhoff, D. Cooper, R. Mannon, 2019, Journal of the American Society of Nephrology : JASN.

The Potential Role of Genetically-Modified Pig Mesenchymal Stromal Cells in Xenotransplantation

D. Cooper, M. Ezzelarab, D. Ayares, 2014, Stem Cell Reviews and Reports.

Adipose-derived mesenchymal stromal cells from genetically modified pigs: immunogenicity and immune modulatory properties.

D. Cooper, M. Ezzelarab, H. Hara, 2012, Cytotherapy.

Is There a Correlation Between Anti-Pig Antibody Levels in Humans and Geographic Location During Childhood?

D. Cooper, H. Hara, D. Ayares, 2013, Transplantation.

Xenotransplantation-The Future of Corneal Transplantation?

D. Cooper, H. Hara, 2011, Cornea.

The immunology of corneal xenotransplantation: a review of the literature

D. Cooper, H. Hara, 2010, Xenotransplantation.

Late onset of development of natural anti‐nonGal antibodies in infant humans and baboons: implications for xenotransplantation in infants

H. Tai, L. Bailey, J. Ijzermans, 2007, Transplant international : official journal of the European Society for Organ Transplantation.

(2) α1,3‐galactosyltransferase gene‐knockout was an essential step towards successful pig organ transplantation in primates

D. Cooper, D. Cooper, 2007 .

Antibodies directed to pig non‐Gal antigens in naïve and sensitized baboons

D. Cooper, M. Ezzelarab, H. Hara, 2006, Xenotransplantation.

Elicited Antibodies in Baboons Exposed to Tissues from α1,3-Galactosyltransferase Gene-Knockout Pigs

D. Sachs, D. Cooper, H. Schuurman, 2006, Transplantation.

Reducing Gal expression on the pig organ – a retrospective review

D. Cooper, M. Ezzelarab, D. Cooper, 2005, Xenotransplantation.

The above letter was sent to Rouhani et al.: Drs Dor, Rouhani, and Cooper offered the following reply

D. Cooper, F. Rouhani, F. Dor, 2005 .

Xenogeneic thymokidney and thymic tissue transplantation in a pig-to-baboon model: I. evidence for pig-specific T-cell unresponsiveness1

R. Colvin, D. Sachs, M. Sykes, 2003, Transplantation.

An investigation of the specificity of induced anti‐pig antibodies in baboons

D. Cooper, L. Buhler, A. Zhu, 2003, Xenotransplantation.

A reliable, rapid and inexpensive two-color fluorescence assay to monitor serum cytotoxicity in xenotransplantation.

R. Oriol, D. Cooper, E. Koren, 1999, Journal of immunological methods.

Anti-GaL IgG antibodies in sera of newborn humans and baboons and its significance in pig xenotransplantation.

R. Michler, D. Cooper, S. Itescu, 1997, Transplantation.

Ratites (ostrich, emu) as potential heart donors for humans: Immunologic, anatomic, and physiologic considerations

R. Oriol, S. Kosanke, D. Cooper, 1996 .

Ratites (ostrich, emu) as potential heart donors for humans: immunologic considerations.

R. Oriol, D. Cooper, Y. Ye, 1996, Transplantation proceedings.

Major oligosaccharide epitopes found in tissues of 23 animal species, potential donors for organ xenotransplantation.

R. Oriol, D. Cooper, J. Candelier, 1996, Transplantation proceedings.

The reducing end of αGal oligosaccharides contributes to their efficiency in blocking natural antibodies of human and baboon sera

R. Oriol, D. Cooper, D. Joziasse, 1996, Transplant international : official journal of the European Society for Organ Transplantation.

Newborn baboon serum anti-alpha galactosyl antibody levels and cytotoxicity to cultured pig kidney (PK15) cells.

R. Michler, D. Cooper, H. Xu, 1995, Transplantation.

PROTECTION OF PIG KIDNEY (PK15) CELLS FROM THE CYTOTOXIC EFFECT OF ANTI‐PIG ANTIBODIES BY α‐GALACTOSYL OLIGOSACCHARIDES1

R. Oriol, D. Cooper, Y. Ye, 1994, Transplantation.

SPECIFIC INTRAVENOUS CARBOHYDRATE THERAPY A NEW CONCEPT IN INHIBITING ANTIBODY‐MEDIATED REJECTION—EXPERIENCE WITH ABO‐INCOMPATIBLE CARDIAC ALLOGRAFTING IN THE BABOON

R. Oriol, S. Kosanke, D. Cooper, 1993, Transplantation.

Depletion of natural antibodies in non-human primates--a step towards successful discordant xenografting in humans.

D. Cooper, 1992, Clinical transplantation.

Heart Xenotransplantation: Historical Background, Experimental Progress, and Clinical Prospects.

D. Cooper, J. Bhama, P. Bajona, 2016, The Annals of thoracic surgery.

What is the clinical relevance of deviant serum calcium and phosphate levels after pig‐to‐primate kidney xenotransplantation?

D. Cooper, E. Judd, Aaron C K Lucander, 2022, Xenotransplantation.

Expert Opinion Special Feature: Patient Selection for Initial Clinical Trials of Pig Organ Transplantation.

R. Pierson, J. Markmann, T. Kawai, 2022, Transplantation.

The 2021 IXA Keith Reemtsma Lecture: Moving xenotransplantation to the clinic

D. Cooper, 2021, Xenotransplantation.

Old World Monkeys are less than ideal transplantation models for testing pig organs lacking three carbohydrate antigens (Triple-Knockout)

D. Eckhoff, D. Cooper, H. Hara, 2020, Scientific Reports.

The complex functioning of the complement system in xenotransplantation

D. Cooper, H. Hara, Hongmin Zhou, 2019, Xenotransplantation.

Carbohydrate antigen expression and anti‐pig antibodies in New World capuchin monkeys: Relevance to studies of xenotransplantation

D. Cooper, H. Hara, D. Ayares, 2019, Xenotransplantation.

Development of a consensus protocol to quantify primate anti‐non‐Gal xenoreactive antibodies using pig aortic endothelial cells

R. Pierson, S. Robson, D. Cooper, 2014, Xenotransplantation.

The Role of SLAs in Xenotransplantation.

D. Cooper, H. Hara, J. Ladowski, 2020, Transplantation.

How strong is the T cell response in the pig‐to‐primate model?

D. Cooper, L. Buhler, 2005, Xenotransplantation.

COAGULATION AND THROMBOTIC DISORDERS ASSOCIATED WITH PIG ORGAN AND HEMATOPOIETIC CELL TRANSPLANTATION IN NONHUMAN PRIMATES

D. Sachs, T. Kawai, S. Robson, 2000, Transplantation.

Porcine kidney and heart transplantation in baboons undergoing a tolerance induction regimen and antibody adsorption.

R. Colvin, D. Sachs, A. Cosimi, 1999, Transplantation.

Chapter 16 – Xenotransplantation

D. Cooper, R. Wagner, 2012 .

Thrombotic microangiopathy and graft arteriopathy in pig hearts following transplantation into baboons

K. Kuwaki, D. Cooper, S. Houser, 2004, Xenotransplantation.

A Brief History of Clinical Cross-Species Organ Xenotransplantation

D. Cooper, 2020 .

The Role of Costimulation Blockade in Solid Organ and Islet Xenotransplantation

D. Cooper, B. Ekser, K. Samy, 2017, Journal of immunology research.

Using α1,3-galactosyltransferase gene-knockout pig organs in nonhuman primates

D. Cooper, D. J. van der Windt, 2007 .

Transplant Tolerance: Current Insights and Strategies for Long-Term Survival of Xenografts

Z. Cai, Yifan Dai, D. Cooper, 2018, Archivum Immunologiae et Therapiae Experimentalis.

Induction of mixed hematopoietic chimerism in the pig-to-baboon model.

D. Sachs, L. Bühler, S. Gojo, 2000, Transplantation proceedings.

Acute Humoral Xenograft Rejection: Destruction of the Microvascular Capillary Endothelium in Pig-to-Nonhuman Primate Renal Grafts

T. Sablinski, R. Colvin, D. Sachs, 2000, Laboratory Investigation.

Peripheral blood progenitor cell mobilization and leukapheresis in pigs.

D. Sachs, S. Gojo, D. Cooper, 1999, Laboratory animal science.

CHANGE FROM AEROBIC TO ANAEROBIC METABOLISM AFTER BRAIN DEATH, AND REVERSAL FOLLOWING TRIIODOTHYRONINE THERAPY

D. Cooper, S. Isaacs, Tiomitri Novitzky, 1988, Transplantation.

XENOGENEIC THYMUS TRANSPLANTATION IN A PIG-TO-

R. Colvin, J. Wain, D. Sachs, 2003 .

ABO‐incompatible allotransplantation as a basis for clinical xenotransplantation

D. Cooper, G. Stussi, L. West, 2006, Xenotransplantation.

Incidence and cytotoxicity of antibodies in cynomolgus monkeys directed to nonGal antigens, and their relevance for experimental models

Xiaocheng Zhu, D. Cooper, M. Ezzelarab, 2006, Transplant international : official journal of the European Society for Organ Transplantation.

A novel approach to "neutralization" of preformed antibodies: cardiac allotransplantation across the ABO blood group barrier as a paradigm of discordant transplantation.

S. Kosanke, D. Cooper, Y. Ye, 1992, Transplantation proceedings.

Role of P‐selectin and P‐selectin glycoprotein ligand‐1 interaction in the induction of tissue factor expression on human platelets after incubation with porcine aortic endothelial cells

D. Cooper, M. Ezzelarab, D. Ayares, 2014, Xenotransplantation.

Tumor Prostaglandins and Estrogen Receptors: Prediction of Survival in Patients with Early Breast Cancer

A. Wilson, M. Baum, D. Cooper, 1991 .

Thomas E. Starzl, MD, PhD, 1926–2017

D. Cooper, A. Joseph Tector, 2017, Xenotransplantation.

The case for xenotransplantation

D. Cooper, 2015, Clinical transplantation.

“You cannot stay in the laboratory forever”*: Taking pig kidney xenotransplantation from the laboratory to the clinic

D. Cooper, H. Hara, 2021, EBioMedicine.

Aspects of histocompatibility testing in xenotransplantation.

J. Houp, D. Cooper, H. Hara, 2021, Transplant immunology.

Pig kidney xenotransplantation: Progress toward clinical trials

D. Eckhoff, D. Cooper, H. Hara, 2020, Clinical transplantation.

Introduction: The Present Status of Xenotransplantation Research.

D. Cooper, 2020, Methods in molecular biology.

Perspectives on the Optimal Genetically Engineered Pig in 2018 for Initial Clinical Trials of Kidney or Heart Xenotransplantation.

D. Cooper, M. Ezzelarab, H. Hara, 2018, Transplantation.

The Case for Cardiac Xenotransplantation in Neonates: Is Now the Time to Reconsider Xenotransplantation for Hypoplastic Left Heart Syndrome?

D. Cooper, H. Hara, W. Carlo, 2018, Pediatric Cardiology.

Bringing Home The Bacon: Update on The State of Kidney Xenotransplantation

D. Cooper, H. Hara, J. Li, 2018, Blood Purification.

Low anti‐pig antibody levels are key to the success of solid organ xenotransplantation: But is this sufficient?

D. Cooper, M. Ezzelarab, H. Hara, 2017, Xenotransplantation.

Anti-Neu5Gc and anti-non-Neu5Gc antibodies in healthy humans

D. Cooper, M. Ezzelarab, H. Hara, 2017, PloS one.

Initial in vitro studies on tissues and cells from GTKO/CD46/NeuGcKO pigs

R. Bottino, D. Cooper, M. Ezzelarab, 2016, Xenotransplantation.

David K. C. Cooper, MD, PhD: Professor of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, PA.

D. Cooper, 2015, Transplantation.

Early graft failure of GalTKO pig organs in baboons is reduced by expression of a human complement pathway‐regulatory protein

R. Pierson, D. Cooper, M. Ezzelarab, 2015, Xenotransplantation.

Initial in vitro investigation of the human immune response to corneal cells from genetically engineered pigs.

Y. Mizuguchi, K. Isse, D. Cooper, 2011, Investigative ophthalmology & visual science.

An in vitro model of pig liver xenotransplantation—pig complement is associated with reduced lysis of wild‐type and genetically modified pig cells

H. Tai, D. Cooper, M. Ezzelarab, 2010, Xenotransplantation.

Outwitting evolution *

D. Cooper, D. Cooper, 2010, Xenotransplantation.

In vitro investigation of pig cells for resistance to human antibody‐mediated rejection

H. Tai, D. Cooper, M. Ezzelarab, 2008, Transplant international : official journal of the European Society for Organ Transplantation.

Cardiovascular , Pulmonary and Renal Pathology Thrombotic Microangiopathy Associated with Humoral Rejection of Cardiac Xenografts from 1 , 3-Galactosyltransferase Gene-Knockout Pigs in Baboons

R. Colvin, D. Sachs, K. Kuwaki, 2010 .

Investigation of red blood cells from α1,3‐galactosyltransferase‐knockout pigs for human blood transfusion

D. Cooper, F. Rouhani, F. Dor, 2004, Transfusion.

Non-specific removal of antibodies in patients with idiopathic dilated cardiomyopathy: implications for xenotransplantation.

R. Hetzer, G. Wallukat, Johannes Müller, 2004, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Reduction of anti‐Galα1,3Gal antibodies by infusion of types 2 and 6 gal trisaccharides conjugated to poly‐l‐lysine

K. Kuwaki, D. Cooper, H. Schuurman, 2004 .

Correlation of Biochemical and Hematological Changes with Graft Failure Following Pig Heart and Kidney Transplantation in Baboons

N. Mueller, D. Sachs, S. Robson, 2003, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Review Article Outwitting Evolution - Progress Towards Clinical Xenotransplantation

D. Cooper, 2003 .

Suppressing Natural Antibody Production

D. Sachs, D. Cooper, M. Awwad, 2001 .

Plasma perfusion by apheresis through a gal immunoaffinity column successfully depletes anti-Gal antibody: experience with 275 aphereses in baboons.

D. Sachs, S. Gojo, D. Cooper, 2000, Transplantation proceedings.

Anti-Galalpha1-3Gal antibody levels in organ transplant recipients receiving immunosuppressive therapy.

S. Saidman, A. Bartholomew, A. Cosimi, 2000, Transplantation.

Xenogeneic and allogeneic skin grafting after retrovirus-mediated SLA class II DR gene transfer in baboons.

D. Sachs, S. Gojo, D. Cooper, 2000, Transplantation proceedings.

Neutralization of the Cytotoxic Effect of Anti-αGal Antibodies with Monoclonal Anti-idiotypic Antibodies

D. Cooper, E. Koren, F. Neethling, 1997 .

Cobra venom factor stimulates anti-alpha-galactose antibody production in baboons. Implications for pig-to-human xenotransplantation.

D. Cooper, Y. Ye, T. Kobayashi, 1996, Transplantation.

Screening of baboons as potential liver donors for humans

D. Cooper, T. Kobayashi, M. Niekrasz, 1995, Transplantation proceedings.

Monomorphic and polymorphic carbohydrate antigens on pig tissues: implications for organ xenotransplantation in the pig‐to‐human model

R. Oriol, D. Cooper, Y. Ye, 1994, Transplant international : official journal of the European Society for Organ Transplantation.

A brief history of clinical xenotransplantation.

D. Cooper, B. Ekser, A. Tector, 2015, International journal of surgery.

Thyroid hormone: relevance to xenotransplantation

A. Thomson, D. Cooper, M. Ezzelarab, 2016, Xenotransplantation.

Human T cells upregulate CD69 after coculture with xenogeneic genetically-modified pig mesenchymal stromal cells.

D. Cooper, M. Ezzelarab, D. Ayares, 2013, Cellular immunology.

Do mesenchymal stem cells function across species barriers? Relevance for xenotransplantation

D. Cooper, M. Ezzelarab, Jiang Li, 2012, Xenotransplantation.

Babesia as a complication of immunosuppression following pig‐to‐baboon heart transplantation

D. Cooper, M. Ezzelarab, R. Wagner, 2007, Xenotransplantation.

Christiaan Barnard and his contributions to heart transplantation.

D. Cooper, 2001, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

The Management of Chronic Rejection: Retransplantation

R. Lanza, D. Cooper, 1984 .

Potential of aspirin to inhibit thrombotic microangiopathy in alpha1,3-galactosyltransferase gene-knockout pig hearts after transplantation in baboons.

D. Sachs, K. Kuwaki, S. Robson, 2005, Transplantation proceedings.

Reduction of Consumptive Coagulopathy Using Porcine Cytomegalovirus-Free Cardiac Porcine Grafts in Pig-to-Primate Xenotransplantation

N. Mueller, D. Sachs, K. Kuwaki, 2004, Transplantation.

Porcine cytomegalovirus and coagulopathy in pig-to-primate xenotransplantation1

N. Mueller, D. Sachs, S. Robson, 2003, Transplantation.

ABO-incompatible organ and bone marrow transplantation: current status

L. Bühler, D. Cooper, A. Wu, 2003, Transplant international : official journal of the European Society for Organ Transplantation.

Characterization of baboon class I major histocompatibility molecules. Implications for baboon-to-human xenotransplantation.

R. Kennedy, W. Hildebrand, D. Cooper, 1996, Transplantation.

Sequence alignment analysis of proteins involved in platelet-endothelial cell interaction identifies molecular incompatibilities between Homo sapiens and Sus scrofa

D. Cooper, Lisha Mou, C. Pengfei, 2017 .

Thrombocytopenia after pig‐to‐baboon liver xenotransplantation: where do platelets go?

D. Cooper, B. Gridelli, M. Ezzelarab, 2011, Xenotransplantation.

Expression of Tissue Factor and Initiation of Clotting by Human Platelets and Monocytes After Incubation With Porcine Endothelial Cells

D. Cooper, J. McVey, A. Dorling, 2008, Transplantation.

Disseminated intravascular coagulation in association with the delayed rejection of pig-to-baboon renal xenografts.

R. Colvin, F. Bach, D. Sachs, 1998, Transplantation.

Clinical survey of heart transplantation between ABO blood group-incompatible recipients and donors.

D. Cooper, 1990, The Journal of heart transplantation.

Posttransplant lymphoproliferative disease after allogeneic transplantation of the spleen in miniature swine.

N. Mueller, K. Kuwaki, D. Cooper, 2004, Transplantation.

Potential Antigens Involved in Delayed Xenograft Rejection in a Ggta1/Cmah Dko Pig-to-Monkey Model

Z. Cai, Yifan Dai, Jia Xu, 2017, Scientific Reports.

A potential role of TLR2 in xenograft rejection of porcine iliac endothelial cells: An in vitro study

Z. Cai, Zongpei Song, D. Cooper, 2019, Xenotransplantation.

Angiopoietin‐1 and angiopoietin‐2 protect porcine iliac endothelial cells from human antibody‐mediated complement‐dependent cytotoxicity through phosphatidylinositide 3‐kinase/AKT pathway activation

Z. Cai, Zesong Li, Jia Xu, 2017, Xenotransplantation.

Histopathology of pig kidney grafts with/without expression of the carbohydrate Neu5Gc in immunosuppressed baboons

D. Eckhoff, D. Cooper, M. Ezzelarab, 2021, Xenotransplantation.

Genetically engineered pigs

R. Oriol, D. Cooper, D. K. C Cooper, 1993, The Lancet.

Kidney Xenotransplantation in Nonhuman Primates

D. Eckhoff, D. Cooper, H. Hara, 2020 .

Buccal mucosal cell immunohistochemistry: a simple method of determining the ABH phenotype of baboons, monkeys, and pigs

S. Specht, D. Cooper, M. Ezzelarab, 2006, Xenotransplantation.

Primates as models for xenotransplantation

K. Kuwaki, D. Cooper, F. Dor, 2003 .

Xenotransplantation--how far have we come?

D. Cooper, C. Knosalla, B. Gollackner, 2002, Transplant immunology.

The forgotten French: The ‘heroic’ era of kidney transplantation

D. Cooper, 2017, Journal of medical biography.

Jewish, Christian and Muslim theological perspectives about xenotransplantation

K. Fitzgerald, D. Cooper, A. Padela, 2018, Xenotransplantation.

Genetically-engineered pig-to-human organ transplantation: a new beginning.

K. Dou, D. Cooper, Xuan Zhang, 2022, Science Bulletin.

Genetically engineered pig kidney transplantation in a brain‐dead human subject

D. Cooper, 2021, Xenotransplantation.

Scientific and psychosocial ethical considerations for initial clinical trials of kidney xenotransplantation

Luz A. Padilla, D. Cooper, L. Padilla, 2021, Xenotransplantation.

Factors influencing attitudes toward xenotransplantation clinical trials: A report of focus group studies

Luz A. Padilla, D. Cooper, L. Padilla, 2021, Xenotransplantation.

Heart surgery and transplantation: innovations impacting on concepts of life and death

D. Cooper, 2020, Medical Humanities.

Attitudes to Clinical Pig Kidney Xenotransplantation among Medical Providers and Patients.

Luz A. Padilla, D. Cooper, Vineeta Kumar, 2020, Kidney360.

Public Perceptions Toward the Clinical Trials of Organ Xenotransplantation

Luz A. Padilla, D. Cooper, Alan J Lipps, 2020 .

Clinical Xenotransplantation: Pathways and Progress in the Transplantation of Organs and Tissues Between Species

D. Cooper, G. Byrne, 2020 .

Psychosocial challenges of xenotransplantation: the need for a multidisciplinary, religious, and cultural dialogue

Kyeonghee Jang, D. Cooper, B. Nour, 2016, Xenotransplantation.

Porcine bioprosthetic heart valves: The next generation.

A. Menkis, R. Manji, D. Cooper, 2012, American heart journal.

Recommendations to the IRB review process in preparation of xenotransplantation clinical trials

Luz A. Padilla, D. Cooper, D. Cleveland, 2020, Xenotransplantation.

Paediatric xenotransplantation clinical trials and the right to withdraw

Luz A. Padilla, D. Cooper, D. Cleveland, 2019, Journal of Medical Ethics.

A Brief History of Cross-Species Organ Transplantation

D. Cooper, 2012, Proceedings.

Xenotransplantation--state of the art.

D. Cooper, 1996, Frontiers in bioscience : a journal and virtual library.

Skin xenotransplantation: Historical review and clinical potential.

D. Cooper, H. Hara, T. King, 2018, Burns : journal of the International Society for Burn Injuries.

Global Consultation on Regulatory Requirements for Xenotransplantation in Clinical Trials

D. Cooper, D. Cooper, 2009, Xenotransplantation.

Attitudes toward xenotransplantation: A survey of parents and pediatric cardiac providers

Luz A. Padilla, D. Cooper, W. Carlo, 2020, Pediatric transplantation.

Meta‐analysis of public perception toward xenotransplantation

Luz A. Padilla, D. Cooper, Alan J Lipps, 2020, Xenotransplantation.

Pig Liver Xenotransplantation: A Review of Progress Toward the Clinic

K. Dou, D. Cooper, Kai-shan Tao, 2016, Transplantation.

Will the pig solve the transplantation backlog?

D. Sachs, D. Cooper, B. Gollackner, 2002, Annual review of medicine.

D. Eckhoff, D. Cooper, Vineeta Kumar, 2021, Transplantation.

The problem of the “4th xenoantigen” after pig organ transplantation in non‐human primates may be overcome by expression of human “protective” proteins

D. Cooper, H. Hara, D. Ayares, 2020, Xenotransplantation.

Is sensitization to pig antigens detrimental to subsequent allotransplantation?

M. Breimer, D. Cooper, H. Hara, 2018, Xenotransplantation.

What will be the cost of a genetically‐engineered pig organ for clinical xenotransplantation?

D. Cooper, 2020, Xenotransplantation.

Episodes of hypovolemia/dehydration in baboons with pig kidney transplants: A new syndrome of clinical importance?

D. Cooper, Takayuki Yamamoto, H. Iwase, 2018, Xenotransplantation.

Financial aspects of organ procurement from deceased donors in the USA—Relevance to xenotransplantation

D. Cooper, Ryan J Saari, 2017, Xenotransplantation.

The immune system in infants: Relevance to xenotransplantation

D. Cooper, H. Hara, W. Carlo, 2020, Pediatric transplantation.

Clinical trials of pediatric cardiac xenotransplantation

D. Cooper, D. Cleveland, L. Padilla, 2020, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Selection of Patients for Initial Clinical Trials of Solid Organ Xenotransplantation.

R. Pierson, M. Wijkstrom, D. Cooper, 2017, Transplantation.

The ethics debate in relation to xenotransplantation.

D. Cooper, C. Smetanka, 2005, Revue scientifique et technique.

Current Topics of Relevance to the Xenotransplantation of Free Pig Islets

D. Cooper, Lisha Mou, Ying Lu, 2022, Frontiers in Immunology.

Serum Antibody Binding and Cytotoxicity to Pig Cells in Chinese Subjects: Relevance to Clinical Renal Xenotransplantation

D. Cooper, Gang Chen, Tao Li, 2022, Frontiers in Immunology.

Initial reflections on the world's first clinical genetically engineered pig heart transplant.

D. Cooper, 2022, Xenotransplantation.

Invited commentary

D. Cooper, 2022 .

Evidence suggesting that deletion of expression of N‐glycolylneuraminic acid (Neu5Gc) in the organ‐source pig is associated with increased antibody‐mediated rejection of kidney transplants in baboons

D. Eckhoff, D. Cooper, M. Ezzelarab, 2021, Xenotransplantation.

Renal xenotransplantation: experimental progress and clinical prospects.

M. Wijkstrom, D. Cooper, M. Ezzelarab, 2017, Kidney international.

Progress in Clinical Encapsulated Islet Xenotransplantation.

E. Wolf, P. Gianello, D. Cooper, 2016, Transplantation.

First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes—Executive summary

B. Hering, D. Cooper, G. Rayat, 2016, Xenotransplantation.

Xenotransplantation of solid organs in the pig-to-primate model.

D. Cooper, B. Gridelli, P. Rigotti, 2009, Transplant immunology.

Development of retrocorneal membrane following pig‐to‐monkey penetrating keratoplasty

D. Cooper, H. Hara, D. Ayares, 2017, Xenotransplantation.

Decellularization methods for developing porcine corneal xenografts and future perspectives

Lester J. Smith, D. Cooper, H. Hara, 2019, Xenotransplantation.

A comparison of three methods of decellularization of pig corneas to reduce immunogenicity.

D. Cooper, H. Hara, Whayoung Lee, 2014, International journal of ophthalmology.

Comparison of porcine corneal decellularization methods and importance of preserving corneal limbus through decellularization

Lester J. Smith, D. Cooper, H. Hara, 2020, bioRxiv.

Initial study of α1,3‐galactosyltransferase gene‐knockout/CD46 pig full‐thickness corneal xenografts in rhesus monkeys

Yifan Dai, D. Cooper, H. Hara, 2017, Xenotransplantation.

Characterization of Porcine Corneal Endothelium for Xenotransplantation

D. Cooper, H. Hara, D. Ayares, 2014, Seminars in ophthalmology.

Will donor‐derived neoplasia be problematic after clinical pig organ or cell xenotransplantation?

E. Klein, D. Cooper, H. Iwase, 2018, Xenotransplantation.

Immunosuppressive and metabolic agents that influence allo‐ and xenograft survival by in vivo expansion of T regulatory cells

D. Cooper, Lisha Mou, H. Hara, 2020, Xenotransplantation.

Potential pathological role of pro‐inflammatory cytokines (IL‐6, TNF‐α, and IL‐17) in xenotransplantation

Z. Cai, D. Cooper, Lisha Mou, 2019, Xenotransplantation.

Human IL‐6, IL‐17, IL‐1β, and TNF‐α differently regulate the expression of pro‐inflammatory related genes, tissue factor, and swine leukocyte antigen class I in porcine aortic endothelial cells

Z. Cai, Zesong Li, Jia Xu, 2017, Xenotransplantation.

Expression of NeuGc on Pig Corneas and Its Potential Significance in Pig Corneal Xenotransplantation

D. Cooper, H. Hara, D. Ayares, 2016, Cornea.

A milestone in xenotransplantation research

D. Cooper, D. Cooper, 2014, Xenotransplantation.

Clinical xenotransplantion—how close are we?

D. Cooper, David KC Cooper, 2003, The Lancet.

The Pig as a Source of Cardiac Xenografts

D. Cooper, L. Buhler, J. Appel, 2001, Journal of cardiac surgery.

Pig‐to‐Monkey Islet Xenotransplantation Using Multi‐Transgenic Pigs

R. Bottino, M. Wijkstrom, M. Trucco, 2014, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Activation of Cytomegalovirus in Pig-to-Primate Organ Xenotransplantation

David K. C. Cooper, Amitinder Kaur, N. Mueller, 2002, Journal of Virology.

Comparison of hematologic, biochemical, and coagulation parameters in α1,3‐galactosyltransferase gene‐knockout pigs, wild‐type pigs, and four primate species

D. Cooper, B. Gridelli, M. Ezzelarab, 2012, Xenotransplantation.

Bridging to Allotransplantation—Is Pig Liver Xenotransplantation the Best Option?

D. Cooper, B. Ekser, P. Vagefi, 2021, Transplantation.

Insulin secretion and glucose metabolism in alpha 1,3‐galactosyltransferase knock‐out pigs compared to wild‐type pigs

R. Bottino, D. Cooper, D. Ayares, 2010, Xenotransplantation.

Long‐Term Controlled Normoglycemia in Diabetic Non‐Human Primates After Transplantation with hCD46 Transgenic Porcine Islets

R. Bottino, B. Loveland, M. Trucco, 2009, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Extended coagulation profiles of healthy baboons and of baboons rejecting GT‐KO pig heart grafts

D. Cooper, M. Ezzelarab, M. Yazer, 2006, Xenotransplantation.

Virological implications of the use of primates in xenotransplantation.

B. Reichart, M. Essex, D. Cooper, 1987, Transplantation proceedings.

Circulating miRNA or circulating DNA—Potential biomarkers for organ transplant rejection

Yifan Dai, D. Cooper, Lisha Mou, 2018, Xenotransplantation.

Circulating Organ-Specific MicroRNAs Serve as Biomarkers in Organ-Specific Diseases: Implications for Organ Allo- and Xeno-Transplantation

Z. Cai, Yifan Dai, D. Cooper, 2016, International journal of molecular sciences.

The potential role of 3D-bioprinting in xenotransplantation.

Ping Li, Lester J. Smith, Wenjun Zhang, 2019, Current opinion in organ transplantation.

Facilitating Physiologic Self-Regeneration: A Step Beyond Islet Cell Replacement

R. Bottino, M. Trucco, D. Cooper, 2005, Pharmaceutical Research.

Cardiac allotransplantation across the ABO-blood group barrier by the neutralization of preformed antibodies: the baboon as a model for the human.

S. Kosanke, D. Cooper, Y. Ye, 1994, Laboratory animal science.

Evidence for the important role of inflammation in xenotransplantation

C. Esmon, D. Cooper, H. Hara, 2019, Journal of Inflammation.

The Potential of the Combination of CRISPR/Cas9 and Pluripotent Stem Cells to Provide Human Organs from Chimaeric Pigs

Z. Cai, Yifan Dai, D. Cooper, 2015, International journal of molecular sciences.

Cardiac xenotransplantation: from concept to clinic

R. Pierson, D. Cooper, R. Tönjes, 2022, Cardiovascular research.

The safety of xenotransplantation.

D. Cooper, 1998, Transplantation proceedings.

Initial in vivo experience of pig artery patch transplantation in baboons using mutant MHC (CIITA-DN) pigs.

M. Wijkstrom, D. Cooper, M. Ezzelarab, 2015, Transplant immunology.

Xenotransplantation: The Challenge to Current Psychosocial Attitudes

D. Cooper, J. Appel, I. Alwayn, 2000 .

Xenotransplantation: the challenge to current psychosocial attitudes.

D. Cooper, J. Appel, I. Alwayn, 2000, Progress in transplantation.

Xenograft transplantation.

D. Cooper, 1989, Transplantation.

Relative effects of GAL+ and GALlow/− porcine hematopoietic cells on primate platelet aggregation and endothelial cell activation: implications for the induction of mixed hematopoietic chimerism in the pig‐to‐primate model

S. Robson, D. Cooper, C. Knosalla, 2004, Xenotransplantation.

In vitro and in vivo investigation of anticomplement agents FUT-175 and K76COOH, in the prevention of hyperacute rejection following discordant xenotransplantation in a nonhuman primate model.

D. Cooper, W. Hancock, Y. Ye, 1996, Transplantation proceedings.

ABO‐incompatible organ and bone marrow transplantation: current status

L. Bühler, D. Cooper, A. Wu, 2003 .

Histopathology of Liver Xenotransplantation in the Nonhuman Primate

S. Kosanke, D. Cooper, L. Mieles, 1997 .

Technique of Endoscopic Biopsy of Islet Allografts Transplanted into the Gastric Submucosal Space in Pigs

K. Haruma, J. Hata, R. Bottino, 2013, Cell transplantation.

Endoscopic Gastric Submucosal Transplantation of Islets (ENDO‐STI): Technique and Initial Results in Diabetic Pigs

M. Trucco, R. Bottino, M. Trucco, 2009, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Streptozotocin-associated lymphopenia in cynomolgus monkeys

R. Bottino, M. Wijkstrom, M. Trucco, 2014, Islets.

Prolongation of Xenograft Survival by Cobra Venom Factor

D. Cooper, T. Kobayashi, E. Kemp, 1997 .

The spleen as a site for hematopoiesis.

D. Cooper, F. Dor, J. Down, 2010, Transplantation.

Accommodation — The Role of Natural Antibody and Complement in Discordant Xenograft Rejection

J. Platt, F. Bach, D. Cooper, 1991 .

Activation of porcine cytomegalovirus, but not porcine lymphotropic herpesvirus, in pig-to-baboon xenotransplantation.

N. Mueller, D. Sachs, D. Cooper, 2004, The Journal of infectious diseases.

Reduced Efficacy of Ganciclovir Against Porcine and Baboon Cytomegalovirus in Pig‐to‐Baboon Xenotransplantation

N. Mueller, D. Sachs, D. Cooper, 2003, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Circulating pig‐specific DNA as a novel biomarker for monitoring xenograft rejection

Z. Cai, Yifan Dai, Zongpei Song, 2019, Xenotransplantation.

Can spleen transplantation induce tolerance? A review of the literature

D. Cooper, F. Dor, B. Gollackner, 2003, Transplant international : official journal of the European Society for Organ Transplantation.

Cytotoxic effects of human preformed anti-Gal IgG and complement on cultured pig cells.

D. Cooper, Y. Ye, N. Zuhdi, 1994, Transplantation proceedings.

Genetic engineering of porcine endothelial cell lines for evaluation of human-to-pig xenoreactive immune responses

Lester J. Smith, W. Goggins, Jianyun Liu, 2021, Scientific Reports.

Attempted Depletion of Passenger Leukocytes by Irradiation in Pigs

H. Tai, D. Cooper, M. Ezzelarab, 2011, Journal of transplantation.

Induced regulatory T cells: mechanisms of conversion and suppressive potential.

A. Thomson, G. Raimondi, D. Cooper, 2012, Human immunology.

Hematopoietic chimerism following allotransplantation of the spleen, splenocytes or kidney in pigs.

H. Tai, A. Nakao, D. Cooper, 2014, Transplant immunology.

Cyclophosphamide dosage in pigs.

D. Cooper, R. Wagner, G. Echeverri, 2009, Annals of transplantation.

Alloantibody and xenoantibody cross-reactivity in transplantation.

S. Saidman, D. Cooper, Y. Tseng, 2004, Transplantation.

Inhibition of baboon platelet aggregation in vitro and in vivo by the garlic derivative, ajoene

S. Robson, D. Cooper, E. Romano, 2003, Xenotransplantation.

Experience with Clinical Heart Xenotransplantation

D. Cooper, Y. Ye, 1991 .

Spleen transplantation in miniature swine: surgical technique and results in major histocompatibility complex-matched donor and recipient pairs*

D. Sachs, T. Kawai, D. Cooper, 2003, Transplantation.

Anti-CD154 monoclonal antibody and thromboembolism revisted.

D. Cooper, C. Knosalla, B. Gollackner, 2002, Transplantation.

Anti-CD154 monoclonal antibody and thromboembolism.

S. Robson, D. Cooper, L. Buhler, 2001, Transplantation.

Data on B cell phenotypes in baboons with pig artery patch grafts receiving conventional immunosuppressive therapy

D. Eckhoff, E. Klein, D. Cooper, 2018, Data in brief.

In vitro testing of an anti-CD40 monoclonal antibody, clone 2C10, in primates and pigs.

D. Cooper, H. Hara, D. Ayares, 2015, Transplant immunology.

Therapeutic issues in the treatment of vascularized xenotransplants using gal-knockout donors in nonhuman primates

D. Cooper, B. Ekser, M. Veroux, 2011, Current opinion in organ transplantation.

The “Baby Fae” baboon heart transplant—Potential cause of rejection

D. Cooper, H. Hara, D. Cleveland, 2019, Xenotransplantation.

An approach to induction of tolerance to pig cardiac xenografts in neonates

D. Cooper, H. Hara, D. Cleveland, 2018, Xenotransplantation.

Depletion of anti-Gal(alpha)1-3Gal antibody in baboons by specific alpha-Gal immunoaffinity columns.

D. Sachs, A. Cosimi, D. Cooper, 1998, Xenotransplantation.

Myroides Infection in a Baboon After Prolonged Pig Kidney Graft Survival

E. Klein, M. Wijkstrom, A. Humar, 2015, Transplantation direct.

A review of pig liver xenotransplantation: Current problems and recent progress

K. Dou, D. Cooper, K. Tao, 2019, Xenotransplantation.

Physiologic changes following brain death.

D. Cooper, M. Basker, 1999, Transplantation proceedings.

Histopathology of spleen allograft rejection in miniature swine

K. Kuwaki, D. Cooper, S. Houser, 2005, International journal of experimental pathology.

What Therapeutic Regimen Will Be Optimal for Initial Clinical Trials of Pig Organ Transplantation?

D. Eckhoff, D. Cooper, M. Ezzelarab, 2021, Transplantation.

The Long and Winding Road to Clinical Xenotransplantation: A Personal Journey

D. Cooper, 2022, European Surgical Research.

Xenotransplantation--will tolerance be essential?

D. Cooper, 2006, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Production of α1,3-galactosyltransferase and cytidine monophosphate-N-acetylneuraminic acid hydroxylase gene double-deficient pigs by CRISPR/Cas9 and handmade cloning

Z. Cai, Zesong Li, Xi Xiang, 2016, The Journal of reproduction and development.

Stable expression of the human thrombomodulin transgene in pig endothelial cells is associated with a reduction in the inflammatory response.

D. Cooper, H. Hara, D. Ayares, 2021, Cytokine.

TNF-α promotes human antibody-mediated complement-dependent cytotoxicity of porcine endothelial cells through downregulating P38-mediated Occludin expression

Z. Cai, Jia Xu, D. Cooper, 2019, Cell Communication and Signaling.

Therapeutic regulation of systemic inflammation in xenograft recipients

M. Wijkstrom, D. Cooper, M. Ezzelarab, 2017, Xenotransplantation.

Gene Expression of Porcine Lymphotrophic Herpesvirus-1 in Miniature Swine with Posttransplant Lymphoproliferative Disorder

D. Sachs, D. Cooper, R. Wilkinson, 2007, Transplantation.

Immunological selection and monitoring of patients undergoing pig kidney transplantation

D. Cooper, H. Hara, J. Foote, 2021, Xenotransplantation.

Early weaning of piglets fails to exclude porcine lymphotropic herpesvirus

N. Mueller, D. Sachs, K. Kuwaki, 2005, Xenotransplantation.

The pig as a potential organ donor for man. A study of potentially transferable disease from donor pig to recipient man.

J. C. Fox, S. Kosanke, D. Cooper, 1994, Transplantation.

Xenotransplantation research and the 'International Journal of Surgery'.

D. Cooper, B. Ekser, 2018, International journal of surgery.

Depletion of natural anti-pig antibodies by the continuous infusion of oligosaccharides in a pig-to-baboon model.

D. Sachs, L. Bühler, D. Cooper, 2002, Transplantation proceedings.

Miniature swine and hDAF pig kidney transplantation in baboons treated with a nonmyeloablative regimen and CD154 blockade.

D. Sachs, L. Bühler, H. Kitamura, 2001, Transplantation proceedings.

Effects of xenogeneic thymic transplantation in baboons.

J. Wain, D. Sachs, D. Neville, 2001, Transplantation proceedings.

Cardiac xenotransplantation technology provides materials for improved bioprosthetic heart valves.

A. Menkis, R. Manji, D. Cooper, 2011, The Journal of thoracic and cardiovascular surgery.

Pig xenogeneic antigen modification with green coffee bean alpha-galactosidase.

R. Cummings, D. Cooper, J. Wen, 1999, Xenotransplantation.

Response to commentaries on: α1,3-galactosyltransferase gene-knockout pigs for xenotransplantation : Where do we go from here?

D. Cooper, 2007 .

How important is the anti-Gal antibody response following the implantation of a porcine bioprosthesis?

D. Cooper, 2009, The Journal of heart valve disease.

Preformed antibodies to alpha1,3-galactosyltransferase gene-knockout (GT-KO) pig cells in humans, baboons, and monkeys: implications for xenotransplantation.

D. Cooper, M. Ezzelarab, H. Hara, 2005, Transplantation proceedings.

Experimental Pig Heart Xenotransplantation-Recent Progress and Remaining Problems.

D. Cooper, 2019, The Annals of thoracic surgery.

The potential role of xenotransplantation in treating endstage cardiac disease: a summary of the report of the Xenotransplantation Advisory Committee of the International Society for Heart and Lung Transplantation

A. Keogh, D. Cooper, 2001, Current opinion in cardiology.

Pig-to-nonhuman primate organ xenotransplantation

D. Sachs, D. Cooper, M. Ezzelarab, 2005 .

Presidential address: 6th Congress of the International Xenotransplantation Association.

D. Cooper, 2003, Xenotransplantation.

Xenotransplantation: the road ahead

D. Cooper, 2006 .

Reduction of anti-Galalpha1,3Gal antibodies by infusion of types 2 and 6 gal trisaccharides conjugated to poly-L-lysine.

K. Kuwaki, D. Cooper, H. Schuurman, 2004, Xenotransplantation.

Islet xenotransplantation from genetically engineered pigs

R. Bottino, M. Wijkstrom, M. Trucco, 2013, Current opinion in organ transplantation.

E. Wolf, D. Cooper, D. Ayares, 2016, Xenotransplantation.

Potential Antigens Involved in Delayed Xenograft Rejection in a Ggta1/Cmah Dko Pig-to-Monkey Model

Z. Cai, Yifan Dai, Jia Xu, 2017, Scientific Reports.

The future of cardiac xenotransplantation

R. Pierson, D. Cooper, 2022, Nature Reviews Cardiology.

Letter to the Editor

S. Robson, D. Cooper, S. Daniel, 2004 .

Monitoring of porcine and baboon cytomegalovirus infection in xenotransplantation

N. Mueller, D. Cooper, M. Ezzelarab, 2009, Xenotransplantation.

Letter to Authors

M. Sykes, D. Cooper, 2006 .

Toward clinical islet xenotransplantation – are revisions to the IXA guidelines warranted?

R. Bottino, M. Wijkstrom, M. Trucco, 2013, Xenotransplantation.

The Potential Role of Genetically-Modified Pig Mesenchymal Stromal Cells in Xenotransplantation

D. Cooper, M. Ezzelarab, D. Ayares, 2013, Stem Cell Reviews and Reports.

Role of complement regulatory protein expression and CD154 blockade in Gal-independent xenograft rejection

R. Pierson, D. Cooper, M. Ezzelarab, 2010 .

Cardiac Xenotransplantation in Nonhuman Primates

D. Cooper, 2020 .

The potential of genetically-engineered pigs in providing an alternative source of organs and cells for transplantation

Yifan Dai, R. Bottino, M. Trucco, 2013, Journal of biomedical research.

Genetically-Engineered Pig-to-Baboon Liver Xenotransplantation: Histopathology of Xenografts and Native Organs

David Ayares, Burcin Ekser, Jing He, 2012, PloS one.

The human T‐cell proliferative response to triple‐knockout pig cells in mixed lymphocyte reaction

D. Cooper, H. Hara, D. Ayares, 2020, Xenotransplantation.

The final obstacle to successful pre‐clinical xenotransplantation?

D. Eckhoff, D. Cooper, H. Hara, 2020, Xenotransplantation.

Downregulation of Gabarapl1 significantly attenuates antibody binding to porcine aortic endothelial cells

Z. Cai, Yifan Dai, Xiliang Wang, 2019, Xenotransplantation.

Transplantation of hepatocytes from genetically engineered pigs into baboons

J. Gerlach, M. Wijkstrom, D. Cooper, 2017, Xenotransplantation.

Clinical trials of pig heart transplantation.

D. Cooper, 2020, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Pathophysiology of Brain Death and Effects of Hormonal Therapy in Large Animal Models

D. Cooper, D. Novitzky, Wicomb Wn, 2013 .

GLUCOSE METABOLISM IN GENETICALLY ENGINEERED PIGS Casu

R. Bottino, M. Wijkstrom, M. Trucco, 2013 .

Does central nervous system toxicity occur in transplant patients with hypocholesterolemia receiving cyclosporine?

D. Cooper, N. Zuhdi, D. Novitzky, 1989, The Journal of heart transplantation.

In vitro model for hyperacute rejection of xenogeneic cells.

R. Oriol, D. Cooper, Y. Ye, 1994, Transplantation proceedings.

The case for the therapeutic use of mechanistic/mammalian target of rapamycin (mTOR) inhibitors in xenotransplantation

D. Cooper, H. Hara, Akihiro Maenaka, 2023, Xenotransplantation.

ANTI-PIG ANTIBODY IN INFANTS: CAN A GENETICALLY-ENGINEERED PIG HEART BRIDGE TO ALLOTRANSPLANTATION?

Luz A. Padilla, D. Cooper, H. Hara, 2020, The Annals of thoracic surgery.

Human CTLA4-Ig therapy can give false-positive anti-pig antibody results in primates after xenotransplantation.

D. Cooper, H. Hara, D. Ayares, 2019, Transplant immunology.

Glycans derived from porcine stomach mucin are effective inhibitors of natural anti-alpha-galactosyl antibodies in vitro and after intravenous infusion in baboons.

R. Cummings, D. Cooper, Y. Ye, 1996, Transplantation.

Guy Alexandre - An appreciation of his innovative contributions to organ transplantation.

D. Cooper, 2020, Transplant immunology.

Potential alternative approaches to xenotransplantation.

Z. Cai, Yifan Dai, D. Cooper, 2015, International journal of surgery.

Porcine red blood cells as a source of blood transfusion in humans

D. Cooper, 2003, Xenotransplantation.

A nonmyeloablative regimen with CD40L blockade leads to humoral and cellular hyporesponsiveness to pig hematopoietic cells in baboons.

D. Sachs, M. Sykes, L. Bühler, 2000, Transplantation proceedings.

Increased Procurement of Thoracic Donor Organs After Thyroid Hormone Therapy.

D. Cooper, D. Novitzky, Zhibao Mi, 2015, Seminars in thoracic and cardiovascular surgery.

The optimal hormonal replacement modality selection for multiple organ procurement from brain-dead organ donors

D. Cooper, D. Novitzky, Zhibao Mi, 2014, Clinical epidemiology.

Immunoadsorption of natural antibodies from human serum by affinity chromatography using specific carbohydrates protects pig cells from cytotoxic destruction.

R. Oriol, D. Cooper, Y. Ye, 1994, Transplantation proceedings.

Heterogeneity of preformed human antipig xenogeneic antibodies.

D. Cooper, Y. Ye, N. Zuhdi, 1992, Transplantation proceedings.

Serum amyloid a as an indicator of impending xenograft failure: Experimental studies.

D. Cooper, H. Hara, Takayuki Yamamoto, 2018, International journal of surgery.

Experimental Xenotransplantation in Nonhuman Primates Using Distantly Related Donor Species

D. Cooper, Y. Ye, 1991 .

Potential target molecules on pig kidneys recognized by naïve and elicited baboon antibodies.

S. Robson, D. Cooper, S. Daniel, 2004, Xenotransplantation.

Xenotransplantation: A historical–ethical account of viewpoints

D. Cooper, Daniel J. Hurst, D. Rodger, 2023, Xenotransplantation.

Evidence that sensitization to triple‐knockout pig cells will not be detrimental to subsequent allotransplantation

D. Cooper, H. Hara, D. Ayares, 2021, Xenotransplantation.

Old World Monkeys are less than ideal transplantation models for testing pig organs lacking three carbohydrate antigens (Triple-Knockout)

D. Eckhoff, D. Cooper, H. Hara, 2020, Scientific Reports.

Recent progress in the pig‐to‐nonhuman primate kidney transplantation model: Report of a symposium

D. Cooper, 2022, Xenotransplantation.

Informed Consent for Potential Recipients of Pig Kidney Xenotransplantation in the United States.

Luz A. Padilla, D. Cooper, D. Cleveland, 2022, Transplantation.

The pig as organ donor for man.

N Zuhdi, D. Cooper, Y. Ye, 1992, Transplantation proceedings.

Effect of intravenous immunoglobulin (IVIg) on primate complement-dependent cytotoxicity of genetically engineered pig cells: relevance to clinical xenotransplantation

D. Cooper, H. Hara, D. Ayares, 2020, Scientific Reports.

Auxiliary liver allografting and xenografting in the nonhuman primate.

S. Kosanke, D. Cooper, Y. Ye, 1995, Transplantation.

Failure of intrathymic inoculation of donor-specific splenocytes to prolong cardiac or renal allograft survival in dogs.

S. Kosanke, D. Cooper, T. Kobayashi, 1995, Transplant immunology.

Injection of porcine anti-idiotypic antibodies to primate anti-Gal antibodies leads to active inhibition of serum cytotoxicity in a baboon.

D. Sachs, L. Bühler, D. Cooper, 2000, Transplantation proceedings.

Collagenous Colitis‐like Condition in Immunosuppressed Infant Baboons

L. Rigatti, J. Ijzermans, E. Klein, 2012, Inflammatory bowel diseases.

Activation of human endothelial cells by mobilized porcine leukocytes in vitro: Implications for mixed chimerism in xenotransplantation1

S. Robson, D. Cooper, M. Awwad, 2002, Transplantation.

Preventing the Induced Anti-Pig Antibody Response

D. Sachs, D. Cooper, L. Buhler, 2001 .

Intravenous administration of alpha-galactosyl carbohydrates reduces in vivo baboon serum cytotoxicity to pig kidney cells and transplanted pig hearts.

G. Koren, R. Oriol, S. Kosanke, 1994, Transplantation proceedings.

Serum amyloid A as a marker of inflammation in xenotransplantation

D. Cooper, M. Ezzelarab, H. Hara, 2018 .

Corrigendum to “The Role of Costimulation Blockade in Solid Organ and Islet Xenotransplantation”

D. Cooper, B. Ekser, K. Samy, 2018, Journal of immunology research.

IN VITRO INVESTIGATION OF HUMAN CELLULAR AND HUMORAL RESPONSES TO CELLS FROM GENETICALLY- MODIFIED PIGS: 679

B. Loveland, D. Cooper, M. Ezzelarab, 2008 .

Asts-Ast Report Of Fda Meeting On Regulatory Expectations For Xenotransplantation Products.

A. Kirk, J. Markmann, P. Reese, 2023, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Multi‐transgenic pigs for xenoislet transplantation

R. Bottino, M. Wijkstrom, M. Trucco, 2013 .

TNF-α promotes human antibody-mediated complement-dependent cytotoxicity of porcine endothelial cells through downregulating P38-mediated Occludin expression

Z. Cai, Jia Xu, D. Cooper, 2019, Cell Communication and Signaling.

Session 1: Recent Scientific Advances in Xeno

R. Pierson, B. Hering, D. Sachs, 2017 .

Characterization of the acute clinical illness associated with human immunodeficiency virus infection.

Rodney J. Lovett, D. Cooper, D. Grant, 1988, Archives of internal medicine.

A clinical survey of cardiac transplantation between ABO blood group-incompatible recipients and donors.

D. Cooper, 1990, Transplantation proceedings.

Natural anti‐pig antibodies in infant baboons

D. Cooper, H. Hara, D. Ayares, 2021, Xenotransplantation.

Evidence for the important role of inflammation in xenotransplantation

C. Esmon, D. Cooper, H. Hara, 2019, Journal of Inflammation.

Anti-Gal alpha 1-3Gal IgM and IgG antibody levels in sera of humans and old world non-human primates.

D. Cooper, M. Awwad, R. Mañez, 2002, Xenotransplantation.

Specific intravenous carbohydrate therapy: a new approach to the inhibition of antibody-mediated rejection following ABO-incompatible allografting and discordant xenografting.

R. Oriol, D. Cooper, Y. Ye, 1993, Transplantation proceedings.

Are pigs transgenic for human complement regulatory proteins necessary for xenotransplantation?

B. Loveland, D. Cooper, M. Sandrin, 2000, Transplantation.

Histopathology of hyperacute rejection of the heart: experimental and clinical observations in allografts and xenografts.

H. Reichenspurner, B. Reichart, A. Rose, 1991, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Xenotransplantation-The Future of Corneal Transplantation?

D. Cooper, H. Hara, 2011, Cornea.

Regulatory Dendritic Cell Infusion Prolongs Kidney Allograft Survival in Nonhuman Primates

A. Demetris, A. Thomson, A. Zahorchak, 2013, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

The Choice of Anatomical Site for Islet Transplantation

J. Ijzermans, D. Cooper, G. Echeverri, 2008, Cell transplantation.

Regulation of Clinical Xenotransplantation-Time for a Reappraisal.

R. Pierson, C. Ahn, B. Hering, 2017, Transplantation.

Progress in pig‐to‐non‐human primate transplantation models (1998–2013): a comprehensive review of the literature

D. Cooper, M. Ezzelarab, H. Hara, 2014, Xenotransplantation.

Initial in vitro studies on tissues and cells from GTKO/CD46/NeuGcKO pigs

R. Bottino, D. Cooper, M. Ezzelarab, 2016, Xenotransplantation.

Reduction of Early Graft Loss After Intraportal Porcine Islet Transplantation in Monkeys

R. Bottino, M. Trucco, D. Cooper, 2007, Transplantation.

Renal xenotransplantation: experimental progress and clinical prospects.

M. Wijkstrom, D. Cooper, M. Ezzelarab, 2017, Kidney international.