Yuguang Zhao

发表

Novel microRNAs encoded by herpesvirus of turkeys (HVT): Evidence of miRNA evolution by duplication

M. Watson, Yongxiu Yao, V. Nair, 2009 .

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

P. Sopp, D. Stuart, P. Klenerman, 2020, Nature Immunology.

Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike

R. Owens, D. Stuart, G. Screaton, 2020, Cell Host & Microbe.

Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike

R. Owens, D. Stuart, G. Screaton, 2020, SSRN Electronic Journal.

Antiepileptic Drug Carbamazepine Binds to a Novel Pocket on the Wnt Receptor Frizzled-8

E. Jones, Yuguang Zhao, Jingshan Ren, 2020, Journal of medicinal chemistry.

Production of cell surface and secreted glycoproteins in mammalian cells.

Weixian Lu, E. Jones, A. R. Aricescu, 2015, Methods in molecular biology.

Structural basis of fibrillar collagen trimerization and related genetic disorders

E. Jones, K. Harlos, J. Bourhis, 2012, Nature Structural &Molecular Biology.

Automation of large scale transient protein expression in mammalian cells

D. Stuart, Weixian Lu, C. Siebold, 2011, Journal of structural biology.

Interaction of Marek's disease virus oncoprotein Meq with heat-shock protein 70 in lymphoid tumour cells.

V. Nair, Yuguang Zhao, Lorraine P. Smith, 2009, The Journal of general virology.

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients

P. Sopp, D. Stuart, P. Klenerman, 2020, bioRxiv.

Structural characterisation of a nanobody derived from a naïve library that neutralises SARS-CoV-2

J. Naismith, P. Rijal, Yuguang Zhao, 2020 .

Structure of the Dual-Mode Wnt Regulator Kremen1 and Insight into Ternary Complex Formation with LRP6 and Dickkopf

E. Jones, Yuguang Zhao, V. Jackson, 2016, Structure.

Structure of glycosylated NPC1 luminal domain C reveals insights into NPC2 and Ebola virus interactions

D. Stuart, K. Harlos, Yuguang Zhao, 2016, FEBS letters.

Determination and comparison of specific activity of the HIF‐prolyl hydroxylases

P. Ratcliffe, C. Pugh, D. Mole, 2004, FEBS letters.

Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit

F. Svensson, P. Fish, P. Whiting, 2022, Journal of medicinal chemistry.

Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10

D. Stuart, Z. Rao, E. Jones, 2020, Nature Communications.

Notum deacylates octanoylated ghrelin

E. Jones, A. Snijders, Steven A. Howell, 2021, Molecular metabolism.

The SARS-CoV-2 Spike harbours a lipid binding pocket which modulates stability of the prefusion trimer

D. Stuart, T. Walter, J. Radecke, 2020, bioRxiv.

ProcessingEpitope Precursor Recognition and Analogue Provides Insight on Antigenic Aminopeptidase with Bound Substrate Crystal Structure of Insulin-Regulated

K. Harlos, Yuguang Zhao, D. Georgiadis, 2015 .

A sensitive and rapid assay for homologous recombination in mosquito cells: impact of vector topology and implications for gene targeting

P. Eggleston, Yuguang Zhao, 2001, BMC Genetics.

Functional evaluation of the role of reticuloendotheliosis virus long terminal repeat (LTR) integrated into the genome of a field strain of Marek's disease virus.

V. Nair, Yuguang Zhao, L. Petherbridge, 2010, Virology.

Improving baculovirus recombination.

I. Jones, Yuguang Zhao, David A. G. Chapman, 2003, Nucleic acids research.

Cachd1 is a novel Frizzled- and LRP6-interacting protein required for neurons to acquire left-right asymmetric character

Stephen W. Wilson, Thomas A. Hawkins, Elena Dreosti, 2022, bioRxiv.

5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit.

F. Svensson, P. Fish, P. Whiting, 2020, Journal of medicinal chemistry.

Dynamics of the secreted frizzled related protein Sizzled and potential implications for binding to bone morphogenetic protein-1 (BMP-1)

K. Harlos, J. Bourhis, Yuguang Zhao, 2022, Scientific Reports.

Structures of Ebola Virus Glycoprotein Complexes with Tricyclic Antidepressant and Antipsychotic Drugs.

D. Stuart, A. Townsend, Yuguang Zhao, 2018, Journal of medicinal chemistry.

Structural Analysis and Development of Notum Fragment Screening Hits

P. Fish, E. Jones, K. Harlos, 2022, ACS chemical neuroscience.

Small-molecule inhibitors of carboxylesterase Notum

P. Fish, E. Jones, Yuguang Zhao, 2021, Future medicinal chemistry.

Structure of the human NK cell NKR-P1:LLT1 receptor:ligand complex reveals clustering in the immune synapse

J. Hašek, J. Stránský, T. Skálová, 2022, Nature Communications.

Comparative sequence analysis of a highly oncogenic but horizontal spread-defective clone of Marek’s disease virus

V. Nair, S. Baigent, S. Spatz, 2007, Virus Genes.

The Antigenic Anatomy of SARS-CoV-2 Receptor Binding Domain

D. Stuart, P. Klenerman, J. Knight, 2020, SSRN Electronic Journal.

Stable transformation of an Anopheles gambiae cell line mediated by the Hermes mobile genetic element

P. Eggleston, Yuguang Zhao, 1998 .

Self-excision of the BAC sequences from the recombinant Marek's disease virus genome increases replication and pathogenicity

V. Nair, S. Baigent, Yuguang Zhao, 2008, Virology Journal.

Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera

D. Stuart, P. Klenerman, J. Knight, 2021, Cell.

Reduced Neutralization of SARS-CoV-2 B.1.1.7 Variant from Naturally Acquired and Vaccine Induced Antibody Immunity

D. Stuart, P. Klenerman, J. Knight, 2021, Social Science Research Network.

Switching of Receptor Binding Poses between Closely Related Enteroviruses

D. Stuart, L. Qin, Kuan-Ying A. Huang, 2022, Viruses.

Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity.

E. Saridakis, K. Harlos, Yuguang Zhao, 2017, Journal of medicinal chemistry.

Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity.

F. Svensson, P. Fish, E. Jones, 2021, Journal of medicinal chemistry.

Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity.

F. Svensson, P. Fish, E. Jones, 2023, European journal of medicinal chemistry.

Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

R. Owens, D. Stuart, D. Clare, 2020, Nature Structural & Molecular Biology.

Comparative full-length sequence analysis of oncogenic and vaccine (Rispens) strains of Marek's disease virus.

V. Nair, S. Spatz, Yuguang Zhao, 2007, The Journal of general virology.

Marek's Disease Virus Type 2 (MDV-2)-Encoded MicroRNAs Show No Sequence Conservation with Those Encoded by MDV-1

M. Zavolan, A. Sewer, Yongxiu Yao, 2007, Journal of Virology.

Targeting Marek's disease virus by RNA interference delivered from a herpesvirus vaccine.

V. Nair, Yuguang Zhao, Lorraine P. Smith, 2009, Vaccine.

Cloning of Gallid herpesvirus 3 (Marek's disease virus serotype-2) genome as infectious bacterial artificial chromosomes for analysis of viral gene functions.

V. Nair, S. Baigent, Yuguang Zhao, 2009, Journal of virological methods.

A BAC clone of MDV strain GX0101 with REV-LTR integration retained its pathogenicity

V. Nair, Yuguang Zhao, Z. Cui, 2009 .

Herpesvirus of turkey reconstituted from bacterial artificial chromosome clones induces protection against Marek's disease.

V. Nair, S. Baigent, Yuguang Zhao, 2006, The Journal of general virology.

Critical Role of the Virus-Encoded MicroRNA-155 Ortholog in the Induction of Marek's Disease Lymphomas

Venugopal Nair, Yuguang Zhao, Yongxiu Yao, 2011, PLoS pathogens.

MicroRNA Profile of Marek's Disease Virus-Transformed T-Cell Line MSB-1: Predominance of Virus-Encoded MicroRNAs

M. Watson, Yongxiu Yao, V. Nair, 2008, Journal of Virology.

MicroRNA profile of Marek ’ s disease virus-transformed T-cell line MSB-1 : 1 Predominance of virus-encoded microRNAs 2 3 4

M. Watson, Yongxiu Yao, V. Nair, 2008 .

Novel MicroRNAs (miRNAs) Encoded by Herpesvirus of Turkeys: Evidence of miRNA Evolution by Duplication

M. Watson, Yongxiu Yao, V. Nair, 2009, Journal of Virology.

The crystal structure of human dopamine β-hydroxylase at 2.9 Å resolution

K. Harlos, T. Walter, Yuguang Zhao, 2016, Science Advances.

Crystal structure of the human NKR-P1 bound to its lymphocyte ligand LLT1 reveals receptor clustering in the immune synapse

J. Hašek, J. Stránský, T. Skálová, 2021, bioRxiv.

Caffeine inhibits Notum activity by binding at the catalytic pocket

Weixian Lu, E. Jones, Yuguang Zhao, 2020, Communications Biology.

Unexpected mode of engagement between enterovirus 71 and its receptor SCARB2

D. Stuart, D. Rowlands, Z. Rao, 2018, Nature Microbiology.

Differential expression of microRNAs in Marek's disease virus-transformed T-lymphoma cell lines.

M. Watson, N. Saunders, Yongxiu Yao, 2009, The Journal of general virology.

A Functional MicroRNA-155 Ortholog Encoded by the Oncogenic Marek's Disease Virus

Xiaowei Wang, Yongxiu Yao, V. Nair, 2008, Journal of Virology.

MicroRNAs 221 and 222 target p27Kip1 in Marek's disease virus-transformed tumour cell line MSB-1.

Yongxiu Yao, V. Nair, Yuguang Zhao, 2009, The Journal of general virology.

Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike

David I Stuart, Raymond J Owens, Tomas Malinauskas, 2020, bioRxiv.

Gene targeting in mosquito cells: a demonstration of 'knockout' technology in extrachromosomal gene arrays

P. Eggleston, Yuguang Zhao, 2001, BMC Genetics.

Structure of the Wnt signaling enhancer LYPD6 and its interactions with the Wnt coreceptor LRP6

Weixian Lu, E. Jones, K. Harlos, 2018, FEBS letters.

Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera

D. Stuart, P. Klenerman, J. Knight, 2021, Cell.

Mutagenesis of the repeat regions of herpesviruses cloned as bacterial artificial chromosomes.

V. Nair, Yuguang Zhao, 2010, Methods in molecular biology.

Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen.

P. Fish, E. Jones, D. Steadman, 2019 .

Unexpected mode of engagement between enterovirus 71 and its receptor SCARB2

D. Stuart, D. Rowlands, Z. Rao, 2018, Nature Microbiology.

Stereotyped antibody responses target posttranslationally modified gluten in celiac disease.

Gur Yaari, Yuguang Zhao, Moriah Gidoni, 2017, JCI insight.

Short-term efficacy and safety of prednisone in herpes zoster and the effects on IL-6 and IL-10

Yuguang Zhao, B. Du, Liangliang Sun, 2019, Experimental and therapeutic medicine.

Picornavirus uncoating intermediate captured in atomic detail

D. Stuart, Mark A. Williams, D. Rowlands, 2013, Nature Communications.

Impact of the B.1.1.7 variant on neutralizing monoclonal antibodies recognizing diverse epitopes on SARS-CoV-2 Spike

M. Malim, M. Shankar-Hari, A. Hayday, 2021, bioRxiv.

Target Identification and Mode of Action of Four Chemically Divergent Drugs against Ebolavirus Infection

D. Stuart, Yuguang Zhao, E. Fry, 2017, Journal of medicinal chemistry.

Toremifene interacts with and destabilizes the Ebola virus glycoprotein

D. Stuart, K. Harlos, S. Padilla-Parra, 2016, Nature.

The antigenic anatomy of SARS-CoV-2 receptor binding domain

D. Stuart, P. Klenerman, J. Knight, 2021, Cell.

Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

R. Owens, D. Stuart, D. Clare, 2020, Nature Structural & Molecular Biology.

Structures and therapeutic potential of anti-RBD human monoclonal antibodies against SARS-CoV-2

D. Stuart, Che Ma, M. Carroll, 2022, Theranostics.

Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient

R. Owens, D. Stuart, G. Screaton, 2020, Nature Structural & Molecular Biology.

Challenges in Searching for Zika Therapeutics

Yuguang Zhao, Yuguang Zhao, 2016 .

Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

R. Owens, D. Stuart, D. Clare, 2020, Nature Structural & Molecular Biology.

X-Ray Crystal Structure of the Full Length Human Chitotriosidase (CHIT1) Reveals Features of Its Chitin Binding Domain

Firas Fadel, A. Mitschler, A. Podjarny, 2016, PloS one.

The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variants

D. Stuart, M. Diamond, P. Goulder, 2021, Cell Host & Microbe.

Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum

S. Madhi, D. Stuart, P. Klenerman, 2021, Cell.

Antibody evasion by the P.1 strain of SARS-CoV-2

D. Stuart, P. Klenerman, J. Knight, 2021, Cell.

Antibody evasion by the Brazilian P.1 strain of SARS-CoV-2

D. Stuart, P. Klenerman, J. Knight, 2021, bioRxiv.

Structure-Based in Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library

D. Stuart, S. Padilla-Parra, C. Schofield, 2019, Journal of medicinal chemistry.

Crystal structure of signal regulatory protein gamma (SIRPγ) in complex with an antibody Fab fragment

R. Owens, D. Stuart, A. Barclay, 2013, BMC Structural Biology.

Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant

M. Malim, M. Shankar-Hari, A. Hayday, 2021, Immunity.

Structural characterization of melatonin as an inhibitor of the Wnt deacylase Notum

Weixian Lu, E. Jones, Yuguang Zhao, 2019, Journal of pineal research.

New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM.

K. Harlos, Firas Fadel, R. Cachau, 2015, Acta crystallographica. Section D, Biological crystallography.

Molecular Architecture of a Complex between an Adhesion Protein from the Malaria Parasite and Intracellular Adhesion Molecule 1

A. Craig, S. Larsen, M. Higgins, 2013, The Journal of Biological Chemistry.

Lysosome sorting of β-glucocerebrosidase by LIMP-2 is targeted by the mannose 6-phosphate receptor

D. Stuart, S. Padilla-Parra, Yuguang Zhao, 2014, Nature Communications.

Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

R. Owens, D. Stuart, D. Clare, 2020, Nature Structural & Molecular Biology.

Atomic-resolution monitoring of protein maturation in live human cells by NMR

I. Bertini, L. Banci, Yuguang Zhao, 2013, Nature chemical biology.

Structural Insights into Notum Covalent Inhibition

F. Svensson, P. Fish, Weixian Lu, 2021, Journal of medicinal chemistry.

Screening of a custom-designed acid fragment library identifies 1-phenylpyrroles and 1-phenylpyrrolidines as inhibitors of Notum carboxylesterase activity.

F. Svensson, P. Fish, E. Jones, 2020, Journal of medicinal chemistry.

Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors

F. Svensson, P. Fish, E. Jones, 2019, Bioorganic & medicinal chemistry letters.

Poly(A) Binding Protein 1 Enhances Cap-Independent Translation Initiation of Neurovirulence Factor from Avian Herpesvirus

V. Nair, Yuguang Zhao, Lorraine P. Smith, 2014, PloS one.

Structure of the SARS-CoV-2 spike S1 protein in complex with CR3022 Fab

R. Owens, D. Stuart, Yuguang Zhao, 2020 .

Structural Insights into the Inhibition of Wnt Signaling by Cancer Antigen 5T4/Wnt-Activated Inhibitory Factor 1

K. Harlos, Yuguang Zhao, T. Malinauskas, 2014, Structure.

STRUCTURE OF THE WNT DEACYLASE NOTUM IN COMPLEX WITH A BENZOTRIAZOLE FRAGMENT

P. Fish, D. Steadman, M. Bictash, 2019 .

Crystal Structure of Insulin-Regulated Aminopeptidase with Bound Substrate Analogue Provides Insight on Antigenic Epitope Precursor Recognition and Processing

E. Saridakis, K. Harlos, Yuguang Zhao, 2015, The Journal of Immunology.

New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM.

K. Harlos, Firas Fadel, R. Cachau, 2015, Acta crystallographica. Section D, Biological crystallography.

Stereotyped antibody responses target posttranslationally modified gluten in celiac disease.

K. Lundin, L. Sollid, Yuguang Zhao, 2017, JCI insight.

Structural insights into Frizzled3 through nanobody modulators

E. Pardon, Weixian Lu, Yuguang Zhao, 2024, Nature communications.