T. Brown

发表

Complete androgen insensitivity syndrome: long-term medical, surgical, and psychosexual outcome.

J. Money, A. Wisniewski, C. Migeon, 2000, The Journal of clinical endocrinology and metabolism.

Androgen receptor levels and 5 alpha-reductase activities in preputial skin and chordee tissue of boys with isolated hypospadias.

J. Gearhart, G. Berkovitz, T. Brown, 1988, The Journal of urology.

Endocrine evaluation of adults with mild hypospadias.

P. Donohoue, P. Walsh, J. Gearhart, 1990, The Journal of urology.

Androgens in Prostate Cancer and Benign Prostatic Hyperplasia

T. Brown, 2002 .

In vitro testicular toxicity models: opportunities for advancement via biomedical engineering techniques.

A. Piersma, T. Hartung, Hanry Yu, 2013, ALTEX.

Lobe-specific apoptotic cell death in rat prostate after androgen ablation by castration.

J. Tilly, K. I. Tilly, B. Zirkin, 1995, Endocrinology.

Endocrine and Paracrine Regulation of Mammalian Spermatogenesis

B. Zirkin, T. Brown, J. Jarow, 2011 .

Superoxide dismutase in the prostate lobes of aging brown Norway rats

T. Brown, Angela S. Pechenino, 2006, The Prostate.

Differential age‐associated regulation of clusterin expression in prostate lobes of brown norway rats

M. D. Anway, T. Brown, J. Omwancha, 2009, The Prostate.

Sequence of the intron/exon junctions of the coding region of the human androgen receptor gene and identification of a point mutation in a family with complete androgen insensitivity

F. S. French, D. Lubahn, H. Higgs, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Sequence of the intron/exon junctions of the coding region of the human androgen receptor gene and identification of a point mutation in a family with complete androgen insensitivity

F. S. French, D. Lubahn, H. Higgs, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Deletion of the steroid-binding domain of the human androgen receptor gene in one family with complete androgen insensitivity syndrome: evidence for further genetic heterogeneity in this syndrome.

F. S. French, D. Lubahn, E. Wilson, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Cell proliferation and expression of cell cycle regulatory proteins that control the G1/S transition are age dependent and lobe specific in the Brown Norway rat model of prostatic hyperplasia.

T. Brown, Jinchun Yan, 2008, Endocrinology.

Cultured human skin fibroblasts: a model for the study of androgen action

C. Migeon, T. Brown, 1981, Molecular and Cellular Biochemistry.

Androgen receptors in boys with isolated bilateral cryptorchidism.

J. Gearhart, G. Berkovitz, T. Brown, 1988, American journal of diseases of children.

Studies of up-regulation of androgen receptors in genital skin fibroblasts

C. Migeon, G. Berkovitz, T. Brown, 1988, Molecular and Cellular Endocrinology.

Simultaneous quantification of steroids in rat intratesticular fluid by HPLC-isotope dilution tandem mass spectrometry.

B. Zirkin, L. Luo, T. Brown, 2012, Journal of andrology.

Low-dose human chorionic gonadotropin maintains intratesticular testosterone in normal men with testosterone-induced gonadotropin suppression.

K. Herbst, B. Zirkin, T. Brown, 2005, The Journal of clinical endocrinology and metabolism.

Suppression Testosterone in Normal Men with Testosterone-Induced Gonadotropin Low-Dose Human Chorionic Gonadotropin Maintains Intratesticular

K. Herbst, B. Zirkin, T. Brown, 2005 .

Bioactivity of androgens within the testes and serum of normal men.

B. Zirkin, T. Brown, J. Jarow, 2005, Journal of andrology.

Intratesticular testosterone concentrations comparable with serum levels are not sufficient to maintain normal sperm production in men receiving a hormonal contraceptive regimen.

K. Herbst, B. Zirkin, T. Brown, 2004, Journal of andrology.

Binding of methyltrienolone to androgen receptors in human skin fibroblasts is enhanced by insulin.

C. Migeon, T. Brown, Y. T. Chang, 1992, Journal of andrology.

A naturally occurring mutation in the human androgen receptor of a subject with complete androgen insensitivity confers binding and transactivation by estradiol

T. Brown, T. W. Bonagura, M. Deng, 2007, Molecular and Cellular Endocrinology.

Androgen Insensitivity Syndromes:Paradox of Phenotypic Feminization with Male Genotype and Normal Testicular Androgen Secretion

C. Migeon, T. Brown, 1987 .

9 Androgen receptors

C. Migeon, G. Berkovitz, T. Brown, 1983 .

Ambiguous genitalia with perineoscrotal hypospadias in 46,XY individuals: long-term medical, surgical, and psychosexual outcome.

J. Money, K. M. Ngai, A. Wisniewski, 2002, Pediatrics.

Intratesticular Androgen Levels, Androgen Receptor Localization, and Androgen Receptor Expression in Adult Rat Sertoli Cells1

B. Zirkin, M. D. Anway, T. Brown, 2004, Biology of reproduction.

Human androgen insensitivity due to point mutations encoding amino acid substitutions in the androgen receptor steroid‐binding domain

C. Migeon, T. Brown, B. Mendonca, 1995, Human mutation.

Complete deletion of the androgen receptor gene: definition of the null phenotype of the androgen insensitivity syndrome and determination of carrier status.

H. Willard, F. S. French, D. Lubahn, 1992, The Journal of clinical endocrinology and metabolism.

Nonsteroidal selective androgen receptors modulators (SARMs): designer androgens with flexible structures provide clinical promise.

T. Brown, 2004, Endocrinology.

Human complete androgen insensitivity with normal dihydrotestosterone receptor binding capacity in cultured genital skin fibroblasts: evidence for a qualitative abnormality of the receptor.

C. Migeon, T. Brown, M. Maes, 1982, The Journal of clinical endocrinology and metabolism.

Androgen insensitivity with mental retardation: a contiguous gene syndrome?

M. Savage, I. Hughes, T. Brown, 1997, Journal of medical genetics.

Age- and lobe-specific responses of the brown Norway rat prostate to androgen.

B. Zirkin, T. Brown, P. Banerjee, 1994, Biology of reproduction.

Castration-induced apoptotic cell death in the Brown Norway rat prostate decreases as a function of age.

T. Brown, P. Banerjee, S. Banerjee, 2000, Endocrinology.

Androgen receptors in normal and abnormal male sexual differentiation.

C. Migeon, T. Brown, 1986, Advances in experimental medicine and biology.

Lobe-specific telomerase activity in the intact adult brown Norway rat prostate and its regional distribution within the prostatic ducts.

B. Zirkin, T. Brown, P. Banerjee, 1998, Endocrinology.

Familial gynecomastia with increased extraglandular aromatization of plasma carbon19-steroids.

C. Migeon, G. Berkovitz, T. Brown, 1985, The Journal of clinical investigation.

Characterization of alternative amino acid substitutions at arginine 830 of the androgen receptor that cause complete androgen insensitivity in three families.

T. Brown, M. Kaufman, L. Pinsky, 1995, Human molecular genetics.

Aging and caloric restriction: Effects on Leydig cell steroidogenesis

B. Zirkin, L. Luo, T. Brown, 2005, Experimental Gerontology.

Androgen receptor dependent and independent activities of testosterone on hepatic microsomal drug metabolism.

T. Brown, C. Bardin, F. E. Greene, 1976, Endocrinology.

Regional Expression of Transforming Growth Factor-α in Rat Ventral Prostate during Postnatal Development, after Androgen Ablation, and after Androgen Replacement.

B. Zirkin, T. Brown, P. Banerjee, 1998, Endocrinology.

A clinical syndrome of mild androgen insensitivity.

C. Migeon, T. Brown, E. Schoen, 1984, The Journal of clinical endocrinology and metabolism.

Human androgen insensitivity mutation does not alter oligonucleotide recognition by the androgen receptor-dht complex

C. Migeon, T. Brown, S. Rothwell, 1983, Molecular and Cellular Endocrinology.

Comparison of methyltrienolone and dihydrotestosterone binding and metabolism in human genital skin fibroblasts.

C. Migeon, T. Brown, S. Rothwell, 1981, Journal of steroid biochemistry.

Inhibition of androgen binding in human foreskin fibroblasts by antiandrogens

C. Sultan, C. Migeon, T. Brown, 1981, Steroids.

The ontogeny of the androgen receptor in human foreskin.

P. Walsh, T. Brown, L. Nyberg, 1981, The Journal of clinical endocrinology and metabolism.

Androgen binding in nuclear matrix of human genital skin fibroblasts from patients with androgen insensitivity syndrome.

C. Migeon, T. Brown, 1986, The Journal of clinical endocrinology and metabolism.

Studies of the locus for androgen receptor: localization on the human X chromosome and evidence for homology with the Tfm locus in the mouse.

B. Migeon, J. Axelman, C. Migeon, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Increased androgen receptor expression correlates with development of age-dependent, lobe-specific spontaneous hyperplasia of the brown Norway rat prostate.

T. Brown, P. Banerjee, S. Banerjee, 2001, Endocrinology.

Influence of cell culture conditions on aromatase activity in human genital skin fibroblasts

C. Migeon, G. Berkovitz, T. Brown, 1989, In Vitro Cellular & Developmental Biology.

Down-regulation of the glucocorticoid receptor by dexamethasone in cultured human skin fibroblasts: implications for the regulation of aromatase activity.

C. Migeon, G. Berkovitz, T. Brown, 1988, The Journal of clinical endocrinology and metabolism.

Time-dependent biphasic response of aromatase to dexamethasone in cultured human skin fibroblasts.

C. Migeon, G. Berkovitz, T. Brown, 1986, The Journal of clinical endocrinology and metabolism.

Inhibition of 5 alpha-reductase activity and alteration of nuclear testosterone. Dihydrotestosterone ratio in human genital skin fibroblasts.

C. Migeon, G. Berkovitz, T. Brown, 1984, Journal of andrology.

The Nuclear Uptake of 6α-[3H]Methylprogesterone and Its 20α -Hydroxy Metabolite: The Requirement for Multiple Receptors*

T. Brown, C. Bardin, L. Bullock, 1981 .

The biological actions and metabolism of 6 alpha-methylprogesterone: a progestin that mimics and modifies the effects of testosterone.

T. Brown, C. Bardin, L. Bullock, 1981, Endocrinology.

In vitro and in vivo binding of progestins to the androgen receptor of mouse kidney: correlation with biological activities.

T. Brown, C. Bardin, L. Bullock, 1979, Endocrinology.

In vivo metabolism and binding of 6 alpha-methylprogesterone; a progestin with anti-androgenic and synandrogenic activities.

T. Brown, C. Bardin, L. Bullock, 1979, Advances in experimental medicine and biology.

Conference summary on prostate growth and aging, 13–15 September 2000 *

T. Brown, Chung Lee, 2001, The Prostate.

The Mechanism of Androgen and Progestin Action on Mouse Kidney

T. Brown, C. Bardin, L. Bullock, 1980 .

Sibship with 17-ketosteroid reductase (17-KSR) deficiency and hypothyroidism. Lack of linkage of histocompatibility leucocyte antigen and 17-KSR loci.

C. Migeon, T. Brown, R. Lanes, 1983, The Journal of clinical endocrinology and metabolism.

Gonadal function in men with the Martin-Bell (fragile-X) syndrome.

N. Carpenter, C. Migeon, G. Berkovitz, 1986, American journal of medical genetics.

46,XY intersex individuals: phenotypic and etiologic classification, knowledge of condition, and satisfaction with knowledge in adulthood.

J. Money, A. Wisniewski, C. Migeon, 2002, Pediatrics.

Androgen action in prostate function and disease.

B. Zirkin, T. Brown, P. Banerjee, 2018, American journal of clinical and experimental urology.

2 Androgen Action

T. Brown, 2003 .

Androgen receptor gene mutations in human prostate cancer.

W. Isaacs, J. Epstein, D. Hardy, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of energy metabolism pathways by estrogens and estrogenic chemicals and potential implications in obesity associated with increased exposure to endocrine disruptors.

J. Russo, Jin-Qiang Chen, T. Brown, 2009, Biochimica et biophysica acta.

Aromatase activity in cultured human genital skin fibroblasts.

C. Migeon, G. Berkovitz, T. Brown, 1984, The Journal of clinical endocrinology and metabolism.

Functional characterization of naturally occurring mutant androgen receptors from subjects with complete androgen insensitivity.

F. S. French, D. Lubahn, E. Wilson, 1990, Molecular endocrinology.

Testosterone lowers aromatase activity in cultured human genital skin fibroblasts

C. Migeon, G. Berkovitz, T. Brown, 1990, Molecular and Cellular Endocrinology.

Liquid chromatographic separation of enantiomers of adrenergic agonists.

T. Brown, J. Gal, 1986, Journal of pharmacological methods.

Gene expression changes are age‐dependent and lobe‐specific in the brown Norway rat model of prostatic hyperplasia

M. D. Anway, T. Brown, J. Chaudhary, 2009, The Prostate.

Are there specific genetic defects affecting the male reproductive tract? What are the underlying mechanisms? Turner’s and Klinefelter’s syndromes, genetic loci, GnRH/LH/FSH, steroid biosynthesis and androgen insensitivity

T. Brown, 2010 .

Abnormal gonadal differentiation in two subjects with ambiguous genitalia, Mullerian structures, and normally developed testes: Evidence for a defect in gonadal ridge development

J. Pelletier, E. Perlman, C. Migeon, 1996, Human Genetics.

Bcl-2 protein expression correlates with cell survival and androgen independence in rat prostatic lobes.

T. Brown, P. Banerjee, Subhadra Banerjee, 2002, Endocrinology.

Age-dependent and lobe-specific spontaneous hyperplasia in the brown Norway rat prostate.

B. Zirkin, T. Brown, J. Strandberg, 1998, Biology of reproduction.

Targeting the human androgen receptor gene with platinated triplex-forming oligonucleotides.

T. Brown, P. Miller, M. Graham, 2015, Biochemistry.

Identification and Characterization of a Novel Androgen Response Element Composed of a Direct Repeat*

T. Brown, J. Corden, Zhifeng Zhou, 1997, The Journal of Biological Chemistry.

Androgen receptors.

C. Migeon, G. Berkovitz, T. Brown, 1983, Clinics in endocrinology and metabolism.

Progestins can mimic, inhibit and potentiate the actions of androgens.

O. Jänne, T. Brown, C. Bardin, 1983, Pharmacology & therapeutics.

Serum estrogen, but not testosterone, levels differ between black and white men in a nationally representative sample of Americans.

N. Rifai, E. Platz, J. Yager, 2006, The Journal of clinical endocrinology and metabolism.

Mechanisms of hormone carcinogenesis: evolution of views, role of mitochondria.

J. Yager, Jin-Qiang Chen, T. Brown, 2008, Advances in experimental medicine and biology.

Molecular basis of androgen insensitivity

F. S. French, D. Lubahn, W. Yarbrough, 1990 .

Complete Androgen Insensitivity Syndrome: Long-Term Medical, Surgical, and Psychosexual Outcome

J. Money, A. Wisniewski, C. Migeon, 2001 .

Telomerase activity in normal adult Brown Norway rat seminal vesicle: regional distribution and age-dependent changes.

B. Zirkin, T. Brown, P. Banerjee, 1998, Endocrinology.

Nuclear factor-kappaB activates transcription of the androgen receptor gene in Sertoli cells isolated from testes of adult rats.

T. Brown, B. Chatterjee, A. Roy, 2004, Endocrinology.

Effect of glutathione depletion on Leydig cell steroidogenesis in young and old brown Norway rats.

B. Zirkin, T. Brown, Haolin Chen, 2008, Endocrinology.

Selective androgen receptor modulators: in pursuit of tissue-selective androgens.

T. Brown, J. Omwancha, 2006, Current opinion in investigational drugs.

The Regulation of the β-Glucuronidase Gene by Androgens and Progestins

T. Brown, C. Bardin, N. Mills, 1978 .

Castration-Induced Apoptotic Cell Death in the Brown Norway Rat Prostate Decreases as a Function of Age1.

T. Brown, P. Banerjee, Subhadra Banerjee, 2000, Endocrinology.

Genetic Determination of Androgen Responsiveness

T. Brown, 2000 .

Androgen Metabolism and Action

T. Brown, 1999 .

Human androgen insensitivity syndrome.

T. Brown, 1995, Journal of andrology.

The influence of 4-hydroxy-4-androstene-3,17-dione on androgen metabolism and action in cultured human foreskin fibroblasts.

C. Migeon, G. Berkovitz, T. Brown, 1987, Journal of steroid biochemistry.

Aromatase activity in human skin fibroblasts grown in cell culture

G. Berkovitz, T. Brown, M. Fujimoto, 1987, Steroids.

Molecular modeling and in vitro investigations of the human androgen receptor DNA-binding domain: application for the study of two mutations

L. Chiche, S. Lumbroso, J. Lobaccaro, 1996, Molecular and Cellular Endocrinology.

Provocative aspects of androgen genetics

T. Brown, 1996, The Prostate. Supplement.

Molecular genetics of human androgen insensitivity

C. Migeon, T. Brown, Y. Chang, 2005, European Journal of Pediatrics.

Molecular Biology of Human Androgen Insensitivity Syndrome

C. Migeon, T. Brown, Y. Chang, 1994 .

Male Pseudohermaphroditism: Defects in Androgen-Dependent Target Tissues

T. Brown, 1987 .

The additive effects of progestins on testosterone-stimulated hepatic ethylmorphine metabolism and cytochrome P-450 content

T. Brown, C. Bardin, F. E. Greene, 1977, Steroids.

Androgen receptor in cultured human testicular fibroblasts.

C. Migeon, G. Berkovitz, T. Brown, 1985, The Journal of clinical endocrinology and metabolism.

A clinician looks at androgen resistance

V. Toscano, T. Brown, A. Boldrini, 1996, Steroids.

Mechanism of Testosterone Deficiency in the Transgenic Sickle Cell Mouse

B. Zirkin, T. Brown, Haolin Chen, 2015, PloS one.

Sequence variation in the androgen receptor gene is not a common determinant of male sexual orientation.

J. Nathans, D. Hamer, V. King, 1993, American journal of human genetics.

Endocrine-disrupting chemicals and public health protection: a statement of principles from The Endocrine Society.

T J Woodruff, A C Gore, R Thomas Zoeller, 2012, Endocrinology.

Increased androgen receptor expression correlates with development of age-dependent, lobe-specific spontaneous hyperplasia of the brown Norway rat prostate.

T. Brown, P. Banerjee, S Banerjee, 2001, Endocrinology.

Endocrine-disrupting chemicals and public health protection: a statement of principles from The Endocrine Society.

R. Zoeller, T. Woodruff, N. Skakkebæk, 2012, Endocrinology.

In vitro testicular toxicity models: opportunities for advancement via biomedical engineering techniques.

A. Piersma, T. Hartung, Hanry Yu, 2013, ALTEX.

Androgen receptor dysfunction in human androgen insensitivity

T. Brown, 1995, Trends in Endocrinology & Metabolism.

Effects of 10-(2-propynyl)-estr-4-ene-3,17-dione (MDL 18,962)--a mechanism-based irreversible inhibitor of aromatase--in cultured human foreskin fibroblasts.

C. Migeon, G. Berkovitz, T. Brown, 1987, Journal of steroid biochemistry.