S. Charnock

发表

The structure of the feruloyl esterase module of xylanase 10B from Clostridium thermocellum provides insights into substrate recognition.

G J Davies, G. Davies, C. Fontes, 2001, Structure.

Pectate lyase 10A from Pseudomonas cellulosa is a modular enzyme containing a family 2a carbohydrate-binding module.

G. Davies, S. Charnock, G. Black, 2001, The Biochemical journal.

The Enzymatic Synthesis of Glycosidic Bonds

B. Henrissat, G. Davies, S. Charnock, 2001 .

Fluorogenic kinetic assay for high-throughput discovery of stereoselective ketoreductases relevant to pharmaceutical synthesis.

W. Fessner, S. Charnock, G. Black, 2017, Bioorganic & medicinal chemistry.

Three-dimensional structures of UDP-sugar glycosyltransferases illuminate the biosynthesis of plant polysaccharides.

B. Henrissat, G. Davies, S. Charnock, 2001, Plant physiology.

Structure of the nucleotide-diphospho-sugar transferase, SpsA from Bacillus subtilis, in native and nucleotide-complexed forms.

G. Davies, S. Charnock, 1999, Biochemistry.

A multi-enzyme strategy for the production of a highly valuable lactonized statin side-chain precursor

S. Charnock, Đ. Vasić-Rački, Z. Blažević, 2020 .

2‐Deoxyribose‐5‐phosphate aldolase from Thermotoga maritima in the synthesis of a statin side‐chain precursor: characterization, modeling and optimization

W. Fessner, S. Charnock, Đ. Vasić-Rački, 2019, Journal of Chemical Technology & Biotechnology.

Three-Dimensional Structures of UDP-Sugar Glycosyltransferases Illuminate the Biosynthesis of Plant Polysaccharides 1

B. Henrissat, G. Davies, S. Charnock, 2001 .

Model-based optimization of the enzymatic aldol addition of propanal to formaldehyde: A first step towards enzymatic synthesis of 3-hydroxybutyric acid

S. Charnock, M. Sudar, Đ. Vasić-Rački, 2019, Chemical Engineering Research and Design.

Substrate Specificity in Glycoside Hydrolase Family 10

S. Andrews, H. Gilbert, J. Lakey, 2000, The Journal of Biological Chemistry.

Characterization of Escherichia coli OtsA, a trehalose-6-phosphate synthase from glycosyltransferase family 20.

G. Davies, R. Gibson, S. Charnock, 2002, Acta crystallographica. Section D, Biological crystallography.

The Topology of the Substrate Binding Clefts of Glycosyl Hydrolase Family 10 Xylanases Are Not Conserved*

H. Gilbert, G. Hazlewood, M. Beylot, 1998, The Journal of Biological Chemistry.

Key Residues in Subsite F Play a Critical Role in the Activity of Pseudomonas fluorescens Subspecies cellulosa Xylanase A Against Xylooligosaccharides but Not Against Highly Polymeric Substrates such as Xylan*

R. Pickersgill, H. Gilbert, J. Lakey, 1997, The Journal of Biological Chemistry.

Cloning, purification and characterization of the 6-phospho-3-hexulose isomerase YckF from Bacillus subtilis.

G. Davies, S. Charnock, J. Colby, 2001, Acta crystallographica. Section D, Biological crystallography.

Profiling Substrate Promiscuity of Wild-Type Sugar Kinases for Multi-fluorinated Monosaccharides.

F. Parmeggiani, G. Davies, S. Charnock, 2020, Cell chemical biology.

Rapid Screening of Diverse Biotransformations for Enzyme Evolution

F. Parmeggiani, P. Barran, S. Charnock, 2020, JACS Au.

Biochemical characterisation of an α1,4 galactosyltransferase from Neisseria weaveri for the synthesis of α1,4-linked galactosides.

F. Parmeggiani, S. Charnock, S. Flitsch, 2020, Organic & biomolecular chemistry.

Characterization of a novel pectate lyase, Pel10A, from Pseudomonas cellulosa.

J. Turkenburg, G. Davies, S. Charnock, 2001, Acta crystallographica. Section D, Biological crystallography.

2-Deoxyribose-5-phosphate aldolase from Thermotoga maritima in the synthesis of a statin-side chain precursor: characterization, modelling and optimization: DERATm in the synthesis of a statin-side chain precursor

Fessner, S. Charnock, Đ. Vasić-Rački, 2019 .

Cascade Synthesis of l-Homoserine Catalyzed by Lyophilized Whole Cells Containing Transaminase and Aldolase Activities: The Mathematical Modeling Approach

S. Charnock, M. Sudar, P. Clapés, 2021, Industrial & Engineering Chemistry Research.

Screening and characterization of a diverse panel of metagenomic imine reductases for biocatalytic reductive amination

Peiyuan Yao, S. Charnock, N. Turner, 2020, Nature Chemistry.

Clostridium thermocellum Xyn10B carbohydrate-binding module 22-2: the role of conserved amino acids in ligand binding.

P. Simpson, D. Bolam, H. Gilbert, 2001, Biochemistry.

Influence of the aglycone region of the substrate binding cleft of Pseudomonas xylanase 10A on catalysis.

S. Andrews, H. Gilbert, S. Charnock, 2001, Biochemistry.

Structural and Biochemical Analysis of Cellvibrio japonicus Xylanase 10C

H. Gilbert, G. Davies, S. Charnock, 2004, Journal of Biological Chemistry.

Les enzymes : applications industrielles et analytiques

S. Charnock, Barry Mac Cleary, 2005 .

Cytochromes P450 (P450s): A review of the class system with a focus on prokaryotic P450s.

S. Charnock, G. Black, D. Cook, 2020, Advances in protein chemistry and structural biology.

Photo-biocatalytic One-Pot Cascades for the Enantioselective Synthesis of 1,3-Mercaptoalkanol Volatile Sulfur Compounds.

S. Charnock, Jesmine Lim, D. Castagnolo, 2018, Angewandte Chemie.

Enantioselective Synthesis of α‐Thiocarboxylic Acids by Nitrilase Biocatalysed Dynamic Kinetic Resolution of α‐Thionitriles

S. Charnock, Silvia Anselmi, D. Castagnolo, 2020, Chemistry.

Three-dimensional structures of the Mn and Mg dTDP complexes of the family GT-2 glycosyltransferase SpsA: a comparison with related NDP-sugar glycosyltransferases.

G J Davies, G. Davies, N. Tarbouriech, 2001, Journal of molecular biology.

Discovery of a multi-functional biocatalyst for asymmetric conjugate reduction-reductive amination

Roger M. Howard, F. Parmeggiani, S. Charnock, 2021 .

Multifunctional xylooligosaccharide/cephalosporin C deacetylase revealed by the hexameric structure of the Bacillus subtilis enzyme at 1.9A resolution.

H. Gilbert, D. Scott, J. Turkenburg, 2003, Journal of molecular biology.

Functional Analysis of Enzyme Families Using Residue-Residue Coevolution Similarity Networks

Anil Wipat, Christian Atallah, David James Skelton, 2019, bioRxiv.

Cellvibrio japonicus α-L-arabinanase 43A has a novel five-blade β-propeller fold

D. Nurizzo, E. Dodson, H. Gilbert, 2002, Nature Structural Biology.

A community based programme to improve access to dental services for drug users

S. Charnock, M. Williams, V. Brookes, 2004, British Dental Journal.

Engineering a Cytidine Aminotransferase for Biocatalytic Production of the Covid-19 Antiviral Molnupiravir

A. Green, S. Charnock, N. Turner, 2021 .

The X6 "thermostabilizing" domains of xylanases are carbohydrate-binding modules: structure and biochemistry of the Clostridium thermocellum X6b domain.

G J Davies, D. Bolam, H. Gilbert, 2000, Biochemistry.

Structure of a Family 15 Carbohydrate-binding Module in Complex with Xylopentaose

D. Bolam, H. Gilbert, G. Davies, 2001, The Journal of Biological Chemistry.

Cascade enzymatic synthesis of l-homoserine – mathematical modelling as a tool for process optimisation and design

Martina Sudar, Đurđa Vasić-Rački, Pere Clapés, 2020 .

Combining Aldolases and Transaminases for the Synthesis of 2‑Amino-4-hydroxybutanoic Acid

W. Fessner, P. D. D. María, J. Joglar, 2017 .

Crystal structures of a family 8 polysaccharide lyase reveal open and highly occluded substrate‐binding cleft conformations

J. Turkenburg, S. Charnock, E. Taylor, 2011, Proteins.

Functional analysis of a group A streptococcal glycoside hydrolase Spy1600 from family 84 reveals it is a beta-N-acetylglucosaminidase and not a hyaluronidase.

G. Davies, Matthew S Macauley, D. Vocadlo, 2006, The Biochemical journal.

Structure of a group A streptococcal phage-encoded virulence factor reveals a catalytically active triple-stranded beta-helix.

E. Dodson, J. Turkenburg, G. Davies, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Measurement of carbohydrates in grain, feed and food

S. Charnock, B. McCleary, R. Lloyd, 2006 .

nanoDSF as screening tool for enzyme libraries and biotechnology development

W. Fessner, A. Magnusson, S. Charnock, 2018, The FEBS journal.

Cytochromes P450: History, Classes, Catalytic Mechanism, and Industrial Application.

S. Charnock, G. Black, D. Cook, 2016, Advances in protein chemistry and structural biology.

Process Requirements of Galactose Oxidase Catalyzed Oxidation of Alcohols

John M. Woodley, Nicholas J. Turner, Simon J. Charnock, 2015 .

Substrate Specificity in Glycoside Hydrolase Family 10

Z. Dauter, Z. Derewenda, G. Davies, 2000, The Journal of Biological Chemistry.

An innovative route for the production of atorvastatin side-chain precursor by DERA-catalysed double aldol addition

S. Charnock, Đ. Vasić-Rački, Z. Blažević, 2020 .

Group A streptococcus cell‐associated pathogenic proteins as revealed by growth in hyaluronic acid‐enriched media

Meng Zhang, I. Humphery-Smith, S. Charnock, 2007, Proteomics.

The gene encoding the ribulose monophosphate pathway enzyme, 3-hexulose-6-phosphate synthase, from Aminomonas aminovorus C2A1 is adjacent to coding sequences that exhibit similarity to histidine biosynthesis enzymes.

S. Charnock, J. Colby, E. Taylor, 2004, Antonie van Leeuwenhoek.

Cellvibrio japonicus alpha-L-arabinanase 43A has a novel five-blade beta-propeller fold.

D. Nurizzo, E. Dodson, H. Gilbert, 2002, Nature structural biology.

Zymophore identification enables the discovery of novel phenylalanine ammonia lyase enzymes

Mark S. Dunstan, Nicholas J. Turner, David Leys, 2017, Scientific Reports.

Convergent evolution sheds light on the anti-β-elimination mechanism common to family 1 and 10 polysaccharide lyases

J. Turkenburg, G. Davies, S. Charnock, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Molecular biology: the way forward for Megazyme

S. Charnock, R. Lloyd, B. McCleary, 2005 .

Enantioselective Aldol Addition of Acetaldehyde to Aromatic Aldehydes Catalyzed by Proline-Based Carboligases

T. Saravanan, S. Charnock, G. Poelarends, 2020, ACS catalysis.

Insights into trehalose synthesis provided by the structure of the retaining glucosyltransferase OtsA.

Ruth Lloyd, J. Turkenburg, G. Davies, 2002, Chemistry & biology.

Regioselective Radical Alkylation of Arenes Using Evolved Photoenzymes.

G. Scholes, S. Charnock, Daniel G. Oblinsky, 2023, Journal of the American Chemical Society.

Evidence that galactanase A from Pseudomonas fluorescens subspecies cellulosa is a retaining family 53 glycosyl hydrolase in which E161 and E270 are the catalytic residues.

B. Henrissat, H. Gilbert, J. Lakey, 1997, Biochemistry.

Synthesis of pharmaceutically relevant 2-aminotetralin and 3-aminochroman derivatives via enzymatic reductive amination.

S. Charnock, N. Turner, J. Marshall, 2021, Angewandte Chemie.

Promiscuity in ligand-binding: The three-dimensional structure of a Piromyces carbohydrate-binding module, CBM29-2, in complex with cello- and mannohexaose

Didier Nurizzo, D. Nurizzo, D. Bolam, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Enantioselective Synthesis of Pharmaceutically Active γ-Aminobutyric Acids Using a Tailor-Made Artificial Michaelase in One-Pot Cascade Reactions

T. Saravanan, A. Thunnissen, T. Pijning, 2019, ACS catalysis.