C. Koehler

发表

Importing Mitochondrial Proteins: Machineries and Mechanisms

T. Lithgow, N. Pfanner, A. Chacińska, 2009, Cell.

Metabolic regulation in pluripotent stem cells during reprogramming and self-renewal.

G. Daley, M. Teitell, C. Koehler, 2012, Cell stem cell.

UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells

Laurent Vergnes, Michael A Teitell, M. Teitell, 2011, The EMBO journal.

A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development.

Jayoung Choi, Yuan Dong, Yibin Wang, 2007, Genes & development.

Assembly of the three small Tim proteins precedes docking to the mitochondrial carrier translocase

N. Pfanner, P. Rehling, B. Guiard, 2008, EMBO reports.

Mitochondrial Transfer by Photothermal Nanoblade Restores Metabolite Profile in Mammalian Cells.

Ting-Hsiang Wu, Alexander N Patananan, Michael A Teitell, 2016, Cell metabolism.

Protein Translocation Across Membranes

David K. Hwang, C. Koehler, 2006 .

Gazing at Translocation in the Mitochondrion

C. Koehler, S. Walsh, Susan Walsh, 2008, Cell.

A mitochondrial rhomboid protease.

A. M. van der Bliek, C. Koehler, 2003, Developmental cell.

Cardiolipin defi nes the interactome of the major ADP / ATP carrier protein of the mitochondrial inner membrane

J. Loo, C. Koehler, P. Boontheung, 2008 .

Dynamin-2 controls phagophore maturation

C. Koehler, S. Itskanov, Alejandro Martorell Riera, 2019 .

Dynamin-2 facilitates Atg9 recycling from nascent autophagosomes

A. M. van der Bliek, C. Koehler, S. Itskanov, 2018, bioRxiv.

Redox pathways of the mitochondrion.

C. Koehler, Kristen N Beverly, Edward P Leverich, 2006, Antioxidants & redox signaling.

Repurposing Approach Identifies Auranofin with Broad Spectrum Antifungal Activity That Targets Mia40-Erv1 Pathway

T. Hazbun, P. Pascuzzi, M. Seleem, 2017, Front. Cell. Infect. Microbiol..

Mammalian Polynucleotide Phosphorylase Is an Intermembrane Space RNase That Maintains Mitochondrial Homeostasis

H. McBride, M. Teitell, S. Wasiak, 2006, Molecular and Cellular Biology.

The Tim8-Tim13 complex has multiple substrate binding sites and binds cooperatively to Tim23.

M. Sawaya, C. Koehler, Kristen N Beverly, 2008, Journal of molecular biology.

Trichomonas vaginalis Hmp35, a Putative Pore-forming Hydrogenosomal Membrane Protein, Can Form a Complex in Yeast Mitochondria*

C. Koehler, Patricia J. Johnson, S. Dyall, 2003, Journal of Biological Chemistry.

The Role of Tim9p in the Assembly of the TIM22 Import Complexes

C. Koehler, S. Curran, D. Wong, 2003, Traffic.

The Essential Function of the Small Tim Proteins in the TIM22 Import Pathway Does Not Depend on Formation of the Soluble 70-Kilodalton Complex

W. Oppliger, C. Koehler, S. Curran, 2001, Molecular and Cellular Biology.

Tim18p, a New Subunit of the TIM22 Complex That Mediates Insertion of Imported Proteins into the Yeast Mitochondrial Inner Membrane

W. Oppliger, M. Murphy, T. Junne, 2000, Molecular and Cellular Biology.

Tim 18 p , a New Subunit of the TIM 22 Complex That Mediates Insertion of Imported Proteins into the Yeast Mitochondrial Inner Membrane

W. Oppliger, M. Murphy, T. Junne, 2000 .

Protein translocation pathways of the mitochondrion

C. Koehler, 2000, FEBS letters.

Different import pathways through the mitochondrial intermembrane space for inner membrane proteins

C. Koehler, G. Schatz, D. Leuenberger, 1999, The EMBO journal.

How membrane proteins travel across the mitochondrial intermembrane space.

C. Koehler, G. Schatz, S. Merchant, 1999, Trends in biochemical sciences.

Import of mitochondrial carriers mediated by essential proteins of the intermembrane space.

C. Koehler, R. Schweyen, K. Tokatlidis, 1998, Science.

Interaction of mitochondrial targeting signals with acidic receptor domains along the protein import pathway: evidence for the ‘acid chain’ hypothesis

K. Mihara, C. Koehler, S. Rospert, 1998, The EMBO journal.

Tim9p, an essential partner subunit of Tim10p for the import of mitochondrial carrier proteins

S. Merchant, W. Oppliger, T. Junne, 1998, The EMBO journal.

Meiosis I Arrest Abnormalities Lead to Severe Oligozoospermia in Meiosis 1 Arresting Protein (M1ap)-Deficient Mice1

P. Donahoe, Naifang Lu, J. McCarrey, 2013, Biology of reproduction.

Human polynucleotide phosphorylase: location matters.

M. Teitell, C. Koehler, Hsiao-Wen Chen, 2007, Trends in cell biology.

PNPase knockout results in mtDNA loss and an altered metabolic gene expression program

B. Gregory, M. Teitell, T. Teslaa, 2018, PloS one.

Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition

B. Carragher, C. Potter, A. Noble, 2020, Nature Communications.

Stendomycin selectively inhibits TIM23-dependent mitochondrial protein import.

J. Bastien, Christoph Potting, D. Hoepfner, 2017, Nature chemical biology.

A small molecule probe elucidates the role of mitochondrial translocase TIMM44 in PINK1/Parkin regulated mitophagy

A. M. van der Bliek, C. Koehler, E. Torres, 2022, bioRxiv.

Functional characterization of a mitochondrial Ser/Thr protein phosphatase in cell death regulation.

J. Weiss, Yibin Wang, Haipeng Sun, 2009, Methods in enzymology.

Macrocytic anemia and mitochondriopathy resulting from a defect in sideroflexin 4.

V. Mootha, B. Paw, S. Dimauro, 2013, American journal of human genetics.

A role for cytochrome c and cytochrome c peroxidase in electron shuttling from Erv1

C. Koehler, Deepa V. Dabir, Sung-Kun Kim, 2007, The EMBO journal.

The complexity of cardiolipin in health and disease.

C. Koehler, S. Claypool, 2012, Trends in biochemical sciences.

The Taz1p Transacylase Is Imported and Sorted into the Outer Mitochondrial Membrane via a Membrane Anchor Domain

C. Koehler, S. Claypool, Jenny D Herndon, 2013, Eukaryotic Cell.

Mitochondrial import of the long and short isoforms of human uncoupling protein 3

M. Murphy, C. Koehler, A. Renold, 2000, FEBS letters.

The Role of Hot13p and Redox Chemistry in the Mitochondrial TIM22 Import Pathway*

David K. Hwang, C. Koehler, S. Curran, 2004, Journal of Biological Chemistry.

Redox regulation of protein folding in the mitochondrial intermembrane space.

H. Tienson, C. Koehler, 2009, Biochimica et biophysica acta.

Role of Twin Cys-Xaa9-Cys Motif Cysteines in Mitochondrial Import of the Cytochrome c Oxidase Biogenesis Factor Cmc1*

H. Tienson, C. Koehler, A. Barrientos, 2012, The Journal of Biological Chemistry.

The small Tim proteins and the twin Cx3C motif.

C. Koehler, 2004, Trends in biochemical sciences.

ER–mitochondria contacts: Actin dynamics at the ER control mitochondrial fission via calcium release

C. Koehler, Janos Steffen, 2018, The Journal of cell biology.

The effect of mitochondrial DNA on milk production and health of dairy cattle

C. Koehler, M. Schutz, D. Beitz, 1994 .

New tools for the identification of developmentally regulated enhancer regions in embryonic and adult zebrafish.

Mitchell P. Levesque, C. Koehler, M. Harris, 2013, Zebrafish.

Replacement of bovine mitochondrial DNA by a sequence variant within one generation.

A. Myers, C. Koehler, D. Beitz, 1991, Genetics.

Pharmacologic rescue of an enzyme-trafficking defect in primary hyperoxaluria 1

C. Koehler, C. Danpure, Non Miyata, 2014, Proceedings of the National Academy of Sciences.

Characteristics of mammary mitochondria in lines of mice genetically divergent for milk production.

M. Rothschild, C. Koehler, D. Beitz, 1989, Journal of dairy science.

Cardiolipin defines the interactome of the major ADP/ATP carrier protein of the mitochondrial inner membrane

J. Loo, C. Koehler, P. Boontheung, 2008, The Journal of cell biology.

PNPASE Regulates RNA Import into Mitochondria

M. Teitell, R. Lightowlers, H. Morse, 2010, Cell.

Mass spectrometric identification of proteins released from mitochondria undergoing permeability transition

G. Kroemer, S. Patterson, E. Daugas, 2000, Cell Death and Differentiation.

A mutation in PNPT1, encoding mitochondrial-RNA-import protein PNPase, causes hereditary hearing loss.

M. Teitell, R. Goodyear, G. Richardson, 2012, American journal of human genetics.

Measuring energy metabolism in cultured cells, including human pluripotent stem cells and differentiated cells

M. Teitell, C. Malone, C. Koehler, 2012, Nature Protocols.

UCP 2 regulates energy metabolism and differentiation potential of human pluripotent stem cells

M. Teitell, I. Kurland, W. Lee, 2011 .

P53 Regulates Rapid Apoptosis in Human Pluripotent Stem Cells.

M. Teitell, T. Teslaa, C. Koehler, 2016, Journal of molecular biology.

Patterns that define the four domains conserved in known and novel isoforms of the protein import receptor Tom20.

R. Waller, T. Lithgow, P. Keeling, 2005, Journal of molecular biology.

New developments in mitochondrial assembly.

C. Koehler, 2004, Annual review of cell and developmental biology.

PNPASE and RNA trafficking into mitochondria.

M. Teitell, E. Shimada, C. Koehler, 2012, Biochimica et biophysica acta.

Correcting human mitochondrial mutations with targeted RNA import

M. Teitell, E. Shimada, C. Koehler, 2012, Proceedings of the National Academy of Sciences.

A New Function in Translocation for the Mitochondrial i-AAA Protease Yme1: Import of Polynucleotide Phosphorylase into the Intermembrane Space

M. Teitell, C. Koehler, Robert N Rainey, 2006, Molecular and Cellular Biology.

In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer

H. Christofk, M. Fishbein, D. Shackelford, 2019, Nature.

Loss of function of SLC25A46 causes lethal congenital pontocerebellar hypoplasia.

P. Lockhart, S. Nelson, K. Zerres, 2016, Brain : a journal of neurology.

MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria

R. Houtkooper, S. Roy, G. Hajnóczky, 2010, Nature Cell Biology.

Elm1p, a protein kinase that regulates cell morphology in Saccharomyces cerevisiae

C. Koehler, 1995 .

Molecular analysis of cytoplasmic genetic variation in Holstein cows.

A. Myers, C. Koehler, M. Schutz, 1989, Journal of animal science.

Recovery of mitochondrial DNA from blood leukocytes using detergent lysis

A. Myers, C. Koehler, D. Beitz, 1992, Biochemical Genetics.

The calcium-binding aspartate/glutamate carriers, citrin and aralar1, are new substrates for the DDP1/TIMM8a-TIMM13 complex.

L. Tranebjaerg, C. Koehler, R. Varga, 2004, Human molecular genetics.

Aim32 is a dual-localized 2Fe-2S mitochondrial protein that functions in redox quality control

C. Koehler, Deepa V. Dabir, Y. Jami-Alahmadi, 2021, The Journal of biological chemistry.

Presence of a Member of the Mitochondrial Carrier Family in Hydrogenosomes: Conservation of Membrane-Targeting Pathways between Hydrogenosomes and Mitochondria

C. Turck, P. Bradley, C. Koehler, 2000, Molecular and Cellular Biology.

Regulation of dimorphism in Saccharomyces cerevisiae: involvement of the novel protein kinase homolog Elm1p and protein phosphatase 2A

S. G. Coats, A. Myers, C. Koehler, 1993, Molecular and cellular biology.

Correction for The Cardiolipin Transacylase, Tafazzin, Associates with Two Distinct Respiratory Components Providing Insight into Barth Syndrome

J. Loo, J. McCaffery, C. Koehler, 2008, Molecular biology of the cell.

Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS)

E. L. Guenther, Albert C. Pan, D. Eisenberg, 2017, Proceedings of the National Academy of Sciences.

FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity

B. Paw, L. Zon, H. Lodish, 2018, The Journal of Biological Chemistry.

TMEM14C is required for erythroid mitochondrial heme metabolism.

Jerry Kaplan, Harvey F Lodish, Daniel E Bauer, 2014, The Journal of clinical investigation.

The role of the Tim8p–Tim13p complex in a conserved import pathway for mitochondrial polytopic inner membrane proteins

C. Koehler, S. Curran, D. Leuenberger, 2002, The Journal of cell biology.

Tim54p connects inner membrane assembly and proteolytic pathways in the mitochondrion

David K. Hwang, H. Tienson, C. Koehler, 2007, The Journal of cell biology.

Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria.

E. Schon, T. Bird, A. de Groof, 2009, The American journal of pathology.

Defining functional classes of Barth syndrome mutation in humans.

Angela C. M. Luyf, E. Gottlieb, F. Vaz, 2016, Human molecular genetics.

Osm1 facilitates the transfer of electrons from Erv1 to fumarate in the redox-regulated import pathway in the mitochondrial intermembrane space

C. Koehler, Deepa V. Dabir, Sonya E. Neal, 2017, Molecular biology of the cell.

Reconstitution of the mia40-erv1 oxidative folding pathway for the small tim proteins.

H. Tienson, J. Loo, C. Koehler, 2009, Molecular biology of the cell.

Defective Mitochondrial Protein Translocation Precludes Normal Caenorhabditis elegans Development*

C. Koehler, S. Curran, P. L. Larsen, 2004, Journal of Biological Chemistry.

A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B).

T. Hughes, Q. Morris, D. Ray, 2018, ACS chemical biology.

Serine‐threonine protein kinase activity of Elm1p, a regulator of morphologic differentiation in Saccharomyces cerevisiae

A. Myers, C. Koehler, 1997, FEBS letters.

The TCL1 oncoprotein binds the RNase PH domains of the PNPase exoribonuclease without affecting its RNA degrading activity.

Stuart A. Sievers, M. Teitell, S. French, 2007, Cancer letters.

A small molecule inhibitor of redox-regulated protein translocation into mitochondria.

M. Teitell, R. Damoiseaux, C. Koehler, 2013, Developmental cell.

Defining the Role of Oxygen Tension in Human Neural Progenitor Fate

M. Teitell, C. Malone, W. Lowry, 2014, Stem cell reports.

The Tim9p–Tim10p complex binds to the transmembrane domains of the ADP/ATP carrier

W. Oppliger, C. Koehler, S. Curran, 2002, The EMBO journal.

Tim8-Tim13 complex

M. Sawaya, C. Koehler, Kristen N Beverly, 2008 .

Adaptation of a Genetic Screen Reveals an Inhibitor for Mitochondrial Protein Import Component Tim44*

R. Damoiseaux, C. Koehler, Zhiye Tang, 2017, The Journal of Biological Chemistry.

The great escape: Mgr2 of the mitochondrial TIM23 translocon is a gatekeeper Tasked with releasing membrane proteins.

C. Koehler, Janos Steffen, 2014, Molecules and Cells.

The mitochondrial import gene tomm22 is specifically required for hepatocyte survival and provides a liver regeneration model

D. Stainier, Silvia Curado, C. Koehler, 2010, Disease Models & Mechanisms.

Spatial mapping of mitochondrial networks and bioenergetics in lung cancer

Kellen L. Olszewski, Stefano Soatto, Mark Ellisman, 2023, Nature.

Mitochondrial Calcium Uniporter Deficiency in Zebrafish Causes Cardiomyopathy With Arrhythmia

C. Koehler, Yali Zhao, Jau-Nian Chen, 2020, Frontiers in Physiology.

Mitochondrial mislocalization and altered assembly of a cluster of Barth syndrome mutant tafazzins

J. McCaffery, C. Koehler, S. Claypool, 2006, The Journal of cell biology.

Human deafness dystonia syndrome is a mitochondrial disease.

S. Merchant, T. Junne, C. Koehler, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Human deafness dystonia syndrome is caused by a defect in assembly of the DDP1/TIMM8a-TIMM13 complex.

L. Tranebjaerg, C. Koehler, S. Curran, 2002, Human molecular genetics.

Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocation

Robert Damoiseaux, Scott S. Walker, R. Damoiseaux, 2010, Proceedings of the National Academy of Sciences.

Barth syndrome mutations that cause tafazzin complex lability

Xianlin Han, C. Koehler, S. Claypool, 2011, The Journal of cell biology.

Rapid degradation of mutant SLC25A46 by the ubiquitin-proteasome system results in MFN1/2-mediated hyperfusion of mitochondria

A. Vashisht, J. Wohlschlegel, J. Wan, 2017, Molecular biology of the cell.

Mitochondrial Function and Biogenesis

M. Bauer, C. Koehler, 2004, Topics in Current Genetics.

Hereditary Spastic Paraplegia: Respiratory Choke or Unactivated Substrate?

C. Koehler, S. Claypool, 2005, Cell.

Contiguous X-chromosome Deletion Syndrome Encompassing the BTK, TIMM8A, TAF7L, and DRP2 Genes

H. Ochs, K. Sullivan, A. Šedivá, 2007, Journal of Clinical Immunology.

Mia40 Protein Serves as an Electron Sink in the Mia40-Erv1 Import Pathway*

H. Tienson, C. Koehler, A. Barrientos, 2015, The Journal of Biological Chemistry.

14 – The Function of TIM22 in the Insertion of Inner Membrane Proteins in Mitochondria

C. Koehler, Robert N Rainey, Y. Oktay, 2007 .

Mitochondrial biogenesis. Protein import into and across the inner membrane

C. Koehler, S. Curran, 2004 .

In Vitro Analysis of Yeast Mitochondrial Protein Import

R. Stuart, C. Koehler, 2007, Current Protocols in Cell Biology.