Taisaku Tanaka

发表

ASB17061, a novel chymase inhibitor, prevented the development of angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice.

Y. Tomimori, A. Manno, Taisaku Tanaka, 2019, European journal of pharmacology.

Human chymase stimulates Ca2+ signaling in human polymorphonuclear cells.

Y. Tomimori, Taisaku Tanaka, Tsuyoshi Muto, 2003, Immunology letters.

Structure-based design, synthesis, and binding mode analysis of novel and potent chymase inhibitors.

Taisaku Tanaka, Junko Futamura-Takahashi, Tsuyoshi Muto, 2018, Bioorganic & medicinal chemistry letters.

Discovery of novel series of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones as human chymase inhibitors using structure-based drug design.

Taisaku Tanaka, Tsuyoshi Muto, H. Sugawara, 2013, Bioorganic & medicinal chemistry.

Pharmacokinetic/pharmacodynamic analyses of chymase inhibitor SUN13834 in NC/Nga mice and prediction of effective dosage for atopic dermatitis patients.

Y. Tomimori, Taisaku Tanaka, Tsuyoshi Muto, 2011, International Immunopharmacology.

Discovery and dimeric approach of novel Natriuretic Peptide Receptor A (NPR-A) agonists.

M. Sugiyama, M. Furuya, Y. Okamura, 2017, Bioorganic & medicinal chemistry.

Involvement of mast cell chymase in bleomycin-induced pulmonary fibrosis in mice.

Y. Tomimori, Taisaku Tanaka, Tsuyoshi Muto, 2003, European journal of pharmacology.

Identification of 6-substituted 4-arylsulfonyl-1,4-diazepane-2,5-diones as a novel scaffold for human chymase inhibitors.

T. Nakatsuka, Y. Tomimori, Taisaku Tanaka, 2007, Bioorganic & medicinal chemistry letters.

Mouse mast cell protease-1 cleaves angiotensin I to form angiotensin II.

Y. Tomimori, Taisaku Tanaka, Tsuyoshi Muto, 2003, Biochemical and biophysical research communications.

Discovery and in vivo effects of novel human natriuretic peptide receptor A (NPR-A) agonists with improved activity for rat NPR-A.

M. Furuya, Y. Okamura, Taisaku Tanaka, 2017, Bioorganic & medicinal chemistry.

Formal total synthesis of altohyrtin C (spongistatin 2). Part 2: Construction of fully elaborated ABCD and EF fragments

Taisaku Tanaka, M. Nakata, N. Kanoh, 2003 .

Synthetic studies on altohyrtins (spongistatins): synthesis of the C29–C44 (EF) portion

Taisaku Tanaka, M. Nakata, N. Kanoh, 2001 .

Discovery and SAR of a novel series of Natriuretic Peptide Receptor-A (NPR-A) agonists.

M. Furuya, Y. Okamura, Taisaku Tanaka, 2017, Bioorganic & medicinal chemistry letters.

Targeting PTPRZ inhibits stem cell-like properties and tumorigenicity in glioblastoma cells

M. Noda, Taisaku Tanaka, Masahito Matsumoto, 2017, Scientific Reports.

Oral chymase inhibitor SUN13834 ameliorates skin inflammation as well as pruritus in mouse model for atopic dermatitis.

T. Nakatsuka, Y. Tomimori, Taisaku Tanaka, 2008, European journal of pharmacology.

Oral administration of chymase inhibitor improves dermatitis in NC/Nga mice.

T. Nakatsuka, Y. Tomimori, Taisaku Tanaka, 2007, The Journal of investigative dermatology.

Development of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones as orally active human chymase inhibitors.

T. Nakatsuka, Y. Tomimori, Taisaku Tanaka, 2007, Bioorganic & medicinal chemistry letters.