B. De Geest

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Successful treatment of established heart failure in mice with recombinant HDL (Milano)

R. Amin, H. Kempen, J. Aboumsallem, 2018, British journal of pharmacology.

Adenoviral gene transfer of ABIN‐1 protects mice from TNF/galactosamine‐induced acute liver failure and lethality

C. Libert, A. Wullaert, R. Beyaert, 2005, Hepatology.

Role of Oxidative Stress in Heart Failure: Insights from Gene Transfer Studies

Mudit Mishra, B. De Geest, 2021, Biomedicines.

Administration of apo A-I (Milano) nanoparticles reverses pathological remodelling, cardiac dysfunction, and heart failure in a murine model of HFpEF associated with hypertension

H. Kempen, Mudit Mishra, I. Muthuramu, 2020, Scientific Reports.

HDLassociated PAF‐AH reduces endothelial adhesiveness in apoE−/− mice

D. Stengel, D. Collen, P. V. Van Veldhoven, 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Humoral immune response in mice against a circulating antigen induced by adenoviral transfer is strictly dependent on expression in antigen-presenting cells.

D. Collen, B. De Geest, S. Van Linthout, 2003, Blood.

Elimination of innate immune responses and liver inflammation by PEGylation of adenoviral vectors and methylprednisolone.

D. Collen, B. De Geest, J. Snoeys, 2005, Human gene therapy.

Human Apolipoprotein A-I Gene Transfer Reduces the Development of Experimental Diabetic Cardiomyopathy

M. Shakibaei, S. Felix, C. Tschöpe, 2008, Circulation.

Effects of adenovirus-mediated human apo A-I gene transfer on neointima formation after endothelial denudation in apo E-deficient mice.

D. Collen, B. Geest, B. De Geest, 1997, Circulation.

Hepatocyte-specific Dyrk1a gene transfer rescues plasma apolipoprotein A-I levels and aortic Akt/GSK3 pathways in hyperhomocysteinemic mice.

A. Tlili, J. Delabar, N. Janel, 2013, Biochimica et biophysica acta.

Regression and stabilization of advanced murine atherosclerotic lesions: a comparison of LDL lowering and HDL raising gene transfer strategies

B. De Geest, F. Jacobs, S. Gordts, 2011, Journal of Molecular Medicine.

A critical reassessment of murine and rabbit models of atherosclerosis: focus on lesion progression and remodelling

B. De Geest, Neha Singh, F. Jacobs, 2012, Acta cardiologica.

New perspectives on biological HDL-targeted therapies

R. Amin, I. Muthuramu, B. De Geest, 2017, Expert opinion on biological therapy.

The relative atherogenicity of VLDL and LDL is dependent on the topographic site[S]

J. Martens, B. De Geest, F. Jacobs, 2009, Journal of Lipid Research.

Mesangial matrix expansion in a novel mouse model of diabetic kidney disease associated with the metabolic syndrome

M. Stegall, E. Lerut, M. Naesens, 2020 .

Increased Remnant Lipoproteins in Apo E Deficient Mice Induce Coronary Atherosclerosis following Transverse Aortic Constriction and Aggravate the Development of Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure

Mudit Mishra, I. Muthuramu, B. De Geest, 2022, Biomedicines.

Impaired cholesterol efflux capacity and vasculoprotective function of high-density lipoprotein in heart transplant recipients.

D. Rader, B. De Geest, Neha Singh, 2014, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Impact of HDL on adipose tissue metabolism and adiponectin expression.

C. Tschöpe, U. Kintscher, B. De Geest, 2010, Atherosclerosis.

The diameter of liver sinusoidal fenestrae is not a major determinant of lipoprotein levels and atherosclerosis in cholesterol-fed rabbits.

B. De Geest, F. Jacobs, Yingmei Feng, 2011, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

Effect of overexpression of human apo A-I in C57BL/6 and C57BL/6 apo E-deficient mice on 2 lipoprotein-associated enzymes, platelet-activating factor acetylhydrolase and paraoxonase. Comparison of adenovirus-mediated human apo A-I gene transfer and human apo A-I transgenesis.

D. Stengel, D. Collen, B. De Geest, 2000, Arteriosclerosis, thrombosis, and vascular biology.

Sustained expression of human apolipoprotein A-I after adenoviral gene transfer in C57BL/6 mice: role of apolipoprotein A-I promoter, apolipoprotein A-I introns, and human apolipoprotein E enhancer.

D. Collen, B. De Geest, P. Holvoet, 2000, Human gene therapy.

The Liver as a Target Organ for Gene Therapy: State of the Art, Challenges, and Future Perspectives

I. Muthuramu, B. De Geest, F. Jacobs, 2012, Pharmaceuticals.

Human ApoA-I Transfer Attenuates Transplant Arteriosclerosis via Enhanced Incorporation of Bone marrow–derived Endothelial Progenitor Cells

B. De Geest, F. Jacobs, J. Snoeys, 2007, Arteriosclerosis, thrombosis, and vascular biology.

Effect of promoters and enhancers on expression, transgene DNA persistence, and hepatotoxicity after adenoviral gene transfer of human apolipoprotein A-I.

D. Collen, B. De Geest, S. Van Linthout, 2002, Human gene therapy.

Hepatocyte-Specific SR-BI Gene Transfer Corrects Cardiac Dysfunction in Scarb1-Deficient Mice and Improves Pressure Overload-Induced Cardiomyopathy

R. Amin, J. Aboumsallem, Mudit Mishra, 2018, Arteriosclerosis, thrombosis, and vascular biology.

Critical role of scavenger receptor-BI-expressing bone marrow-derived endothelial progenitor cells in the attenuation of allograft vasculopathy after human apo A-I transfer.

B. De Geest, F. Jacobs, M. Tjwa, 2009, Blood.

The Arg123-Tyr166 central domain of human ApoAI is critical for lecithin:cholesterol acyltransferase-induced hyperalphalipoproteinemia and HDL remodeling in transgenic mice.

D. Collen, B. De Geest, P. Holvoet, 2000, Arteriosclerosis, thrombosis, and vascular biology.

Reconstituted HDL (Milano) Treatment Efficaciously Reverses Heart Failure with Preserved Ejection Fraction in Mice

H. Kempen, J. Aboumsallem, Mudit Mishra, 2018, International journal of molecular sciences.

Vascular-Protective Effects of High-Density Lipoprotein Include the Downregulation of the Angiotensin II Type 1 Receptor

C. Tschöpe, B. De Geest, H. Schultheiss, 2009, Hypertension.

The role of liver sinusoidal cells in hepatocyte-directed gene transfer.

E. Wisse, B. De Geest, F. Jacobs, 2010, The American journal of pathology.

Early effect of a single intravenous injection of ethanol on hepatic sinusoidal endothelial fenestrae in rabbits

E. Wisse, B. De Geest, F. Jacobs, 2009, Comparative hepatology.

Lipid emulsions potently increase transgene expression in hepatocytes after adenoviral transfer.

D. Collen, T. V. van Berkel, B. De Geest, 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

An efficient and safe herpes simplex virus type 1 amplicon vector for transcriptionally targeted therapy of human hepatocellular carcinomas.

H. Huynh, K. S. Lim, P. Lam, 2007, Molecular therapy : the journal of the American Society of Gene Therapy.

Antibodies against oxidized LDL for non-invasive diagnosis of atherosclerotic vascular disease.

D. Collen, B. De Geest, 2001, European heart journal.

Down-regulation of endothelial TLR4 signalling after apo A-I gene transfer contributes to improved survival in an experimental model of lipopolysaccharide-induced inflammation

C. Tschöpe, B. De Geest, H. Schultheiss, 2010, Journal of Molecular Medicine.

Plasminogen activation by staphylokinase enhances local spreading of S. aureus in skin infections

P. Verhamme, M. Hoylaerts, R. Lijnen, 2014, BMC Microbiology.

Topical HDL administration reduces vein graft atherosclerosis in apo E deficient mice.

Y. Ni, Qingbo Xu, F. Chen, 2011, Atherosclerosis.

Impact of High-Density Lipoproteins on Sepsis

Mudit Mishra, B. De Geest, 2022, International journal of molecular sciences.

The origin of intimal smooth muscle cells: are we on a steady road back to the past?

B. De Geest, 2009, Cardiovascular research.

Therapeutic potential of HDL in cardioprotection and tissue repair.

B. De Geest, Neha Singh, S. Van Linthout, 2015, Handbook of experimental pharmacology.

Prevents Injury-induced Neointima Formation and Reduces Spontaneous Atherosclerosis in Acetylhydrolase − Adenovirus-mediated Gene Transfer of Human Platelet-activating Factor Adenovirus-mediated Gene Transfer of Human Platelet-activating Factor–acetylhydrolase Prevents Injury-induced Neointima Forma

D. Stengel, D. Collen, P. V. Van Veldhoven, 2022 .

Coconut Oil Aggravates Pressure Overload-Induced Cardiomyopathy without Inducing Obesity, Systemic Insulin Resistance, or Cardiac Steatosis

R. Amin, P. V. Van Veldhoven, Mudit Mishra, 2017, International journal of molecular sciences.

Construction of an oncolytic herpes simplex virus that precisely targets hepatocellular carcinoma cells.

Xiaoliu Zhang, A. Rivera, B. De Geest, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

Selective HDL-Raising Human Apo A-I Gene Therapy Counteracts Cardiac Hypertrophy, Reduces Myocardial Fibrosis, and Improves Cardiac Function in Mice with Chronic Pressure Overload

R. Amin, J. Aboumsallem, Mudit Mishra, 2017, International journal of molecular sciences.

Fixation methods for electron microscopy of human and other liver.

F. Braet, E. Wisse, H. Duimel, 2010, World journal of gastroenterology.

Hepatocyte-specific ABCA1 transfer increases HDL cholesterol but impairs HDL function and accelerates atherosclerosis.

B. De Geest, M. Hoekstra, F. Jacobs, 2010, Cardiovascular research.

Endothelium-enriched microRNAs as diagnostic biomarkers for cardiac allograft vasculopathy.

S. Fieuws, B. De Geest, Neha Singh, 2015, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Apolipoprotein A-I gene transfer exerts immunomodulatory effects and reduces vascular inflammation and fibrosis in ob/ob mice

B. Pieske, C. Tschöpe, I. Muthuramu, 2016, Journal of Inflammation.

High-Density Lipoprotein-Targeted Therapies for Heart Failure

Mudit Mishra, B. De Geest, 2020, Biomedicines.

Effective Treatment of Diabetic Cardiomyopathy and Heart Failure with Reconstituted HDL (Milano) in Mice

H. Kempen, J. Aboumsallem, Mudit Mishra, 2019, International journal of molecular sciences.

The Role of Sodium-Glucose Cotransporter-2 Inhibitors in Heart Failure Management: The Continuing Challenge of Clinical Outcome Endpoints in Heart Failure Trials

Mudit Mishra, B. De Geest, Luxi Ji, 2023, Pharmaceutics.

Beneficial effects of selective HDL-raising gene transfer on survival, cardiac remodelling and cardiac function after myocardial infarction in mice

B. Geest, I. Muthuramu, B. De Geest, 2013, Gene Therapy.

Lipid Lowering and HDL Raising Gene Transfer Increase Endothelial Progenitor Cells, Enhance Myocardial Vascularity, and Improve Diastolic Function

I. Muthuramu, B. De Geest, Neha Singh, 2012, PloS one.

Circulating apoptotic endothelial cells and apoptotic endothelial microparticles independently predict the presence of cardiac allograft vasculopathy.

S. Fieuws, B. De Geest, W. Droogné, 2012, Journal of the American College of Cardiology.

Gene therapy to improve high-density lipoprotein metabolism and function.

B. De Geest, F. Jacobs, S. Gordts, 2010, Current pharmaceutical design.

Cholesterol-Lowering Gene Therapy Prevents Heart Failure with Preserved Ejection Fraction in Obese Type 2 Diabetic Mice

J. Aboumsallem, Mudit Mishra, I. Muthuramu, 2019, International journal of molecular sciences.

Cholesterol-Lowering Gene Therapy Counteracts the Development of Non-ischemic Cardiomyopathy in Mice.

R. Amin, T. Dresselaers, U. Himmelreich, 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

Selective Homocysteine Lowering Gene Transfer Improves Infarct Healing, Attenuates Remodelling, and Enhances Diastolic Function after Myocardial Infarction in Mice

I. Muthuramu, B. De Geest, Neha Singh, 2013, PloS one.

Gene therapy for familial hypercholesterolemia.

B. De Geest, F. Jacobs, S. Gordts, 2011, Current pharmaceutical design.

Plasminogen activation by staphylokinase enhances local spreading of S. aureus in skin infections

P. Verhamme, M. Hoylaerts, R. Lijnen, 2014, BMC Microbiology.

Enhanced Antitumor Efficacy of a Vascular Disrupting Agent Combined with an Antiangiogenic in a Rat Liver Tumor Model Evaluated by Multiparametric MRI

Y. Ni, G. Marchal, F. Chen, 2012, PloS one.

Corrective effects of hepatotoxicity by hepatic Dyrk1a gene delivery in mice with intermediate hyperhomocysteinemia

J. Delabar, N. Janel, J. Paul, 2015, Molecular genetics and metabolism reports.

Adenoviral low density lipoprotein receptor attenuates progression of atherosclerosis and decreases tissue cholesterol levels in a murine model of familial hypercholesterolemia.

B. De Geest, F. Jacobs, J. Snoeys, 2008, Atherosclerosis.

Low-density lipoprotein receptor gene transfer in hypercholesterolemic mice improves cardiac function after myocardial infarction

B. Geest, B. De Geest, F. Jacobs, 2011, Gene Therapy.

Permanent ligation of the left anterior descending coronary artery in mice: a model of post-myocardial infarction remodelling and heart failure.

I. Muthuramu, B. De Geest, F. Jacobs, 2014, Journal of visualized experiments : JoVE.

Overexpression of tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) in mice does not affect adipogenesis or adipose tissue development

I. Scroyen, H. Lijnen, B. De Geest, 2006, Thrombosis and Haemostasis.

Apolipoprotein A-I gene transfer exerts immunomodulatory effects and reduces vascular inflammation and fibrosis in ob/ob mice

R. Amin, B. Pieske, C. Tschöpe, 2016, Journal of Inflammation.

Administration of apo A-I (Milano) nanoparticles reverses pathological remodelling, cardiac dysfunction, and heart failure in a murine model of HFpEF associated with hypertension

H. Kempen, Mudit Mishra, I. Muthuramu, 2020, Scientific Reports.

Markers of endothelial injury and platelet microparticles are distinct in patients with stable native coronary artery disease and with cardiac allograft vasculopathy.

B. De Geest, Neha Singh, J. Van Cleemput, 2015, International journal of cardiology.

The impact of air pollution and weather on cardiovascular events: The importance of time scale and historical air quality improvement.

Mudit Mishra, B. De Geest, 2020, European journal of preventive cardiology.

Species differences in hepatocyte-directed gene transfer: implications for clinical translation.

B. De Geest, F. Jacobs, J. Snoeys, 2009, Current gene therapy.

Adenovirus-Mediated Gene Transfer of Human Platelet-Activating Factor–Acetylhydrolase Prevents Injury-Induced Neointima Formation and Reduces Spontaneous Atherosclerosis in Apolipoprotein E–Deficient Mice

D. Stengel, D. Collen, P. V. Van Veldhoven, 2001, Circulation.

The origin of intimal smooth muscle cells: are we on a steady road back to the past?

B. De Geest, 2009, Cardiovascular research.

Role of the Arg123–Tyr166 Paired Helix of Apolipoprotein A-I in Lecithin:Cholesterol Acyltransferase Activation*

D. Collen, Y. Engelborghs, B. De Geest, 1997, The Journal of Biological Chemistry.

Racial/ethnic differences in hypertension prevalence: Public health impact versus clinical importance of baseline data of the HELIUS study

J. Aboumsallem, Mudit Mishra, B. De Geest, 2018, European journal of preventive cardiology.

Pleiotropic effects of HDL: towards new therapeutic areas for HDL-targeted interventions.

I. Muthuramu, B. De Geest, S. Gordts, 2013, Current molecular medicine.

New Perspectives on Cholesterol and Lipoprotein Metabolism

Mudit Mishra, B. De Geest, 2023, International journal of molecular sciences.

Role of high-density lipoproteins in cardioprotection and in reverse remodeling: therapeutic implications.

Mudit Mishra, B. De Geest, 2021, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Doxorubicin-induced cardiomyopathy: TERT gets to the heart of the matter.

Mudit Mishra, B. De Geest, 2021, Molecular therapy : the journal of the American Society of Gene Therapy.