Victoria M Mcleod

发表

Pharmacokinetics and tumor disposition of PEGylated, methotrexate conjugated poly-l-lysine dendrimers.

L. Kaminskas, B. Kelly, Victoria M Mcleod, 2009, Molecular pharmaceutics.

Molecular weight (hydrodynamic volume) dictates the systemic pharmacokinetics and tumour disposition of PolyPEG star polymers.

J. Quinn, Jinming Hu, T. P. Davis, 2015, Nanomedicine : nanotechnology, biology, and medicine.

A comparison of changes to doxorubicin pharmacokinetics, antitumor activity, and toxicity mediated by PEGylated dendrimer and PEGylated liposome drug delivery systems.

Ben J Boyd, Christopher J H Porter, Lisa M Kaminskas, 2012, Nanomedicine : nanotechnology, biology, and medicine.

Association of chemotherapeutic drugs with dendrimer nanocarriers: an assessment of the merits of covalent conjugation compared to noncovalent encapsulation.

L. Kaminskas, Victoria M Mcleod, B. Boyd, 2012, Molecular pharmaceutics.

Pulmonary administration of a doxorubicin-conjugated dendrimer enhances drug exposure to lung metastases and improves cancer therapy.

D. Owen, L. Kaminskas, B. Kelly, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Differences in colloidal structure of PEGylated nanomaterials dictate the likelihood of accelerated blood clearance.

L. Kaminskas, Victoria M Mcleod, B. Boyd, 2011, Journal of pharmaceutical sciences.

PEGylation of polylysine dendrimers improves absorption and lymphatic targeting following SC administration in rats.

L. Kaminskas, B. Kelly, Victoria M Mcleod, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Dendrimers for biomedical applications

L. Kaminskas, Victoria M Mcleod, B. Boyd, 2014 .

Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumor-burdened lymph nodes after intravenous and subcutaneous administration in rats.

D. Owen, D. Ascher, T. Velkov, 2015, Molecular pharmaceutics.

Lymphatic transport and lymph node targeting of methotrexate-conjugated PEGylated dendrimers are enhanced by reducing the length of the drug linker or masking interactions with the injection site.

D. Owen, L. Kaminskas, B. Kelly, 2017, Nanomedicine : nanotechnology, biology, and medicine.

Effect of increased surface hydrophobicity via drug conjugation on the clearance of inhaled PEGylated polylysine dendrimers

D. Owen, C. Pouton, L. Kaminskas, 2017, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

The Pharmacokinetics and Biodistribution of a 64 kDa PolyPEG Star Polymer After Subcutaneous and Pulmonary Administration to Rats.

J. Quinn, Jinming Hu, T. P. Davis, 2016, Journal of pharmaceutical sciences.

Optimal PEGylation can improve the exposure of interferon in the lungs following pulmonary administration.

L. Kaminskas, Victoria M Mcleod, C. Porter, 2015, Journal of pharmaceutical sciences.

Dysregulation of steroid hormone receptors in motor neurons and glia associates with disease progression in ALS mice.

W. Boon, T. Rupasinghe, C. L. Lau, 2020, Endocrinology.

Reducing Dendrimer Generation and PEG Chain Length Increases Drug Release and Promotes Anticancer Activity of PEGylated Polylysine Dendrimers Conjugated with Doxorubicin via a Cathepsin-Cleavable Peptide Linker.

D. Owen, L. Kaminskas, B. Kelly, 2018, Molecular pharmaceutics.

Capping methotrexate α-carboxyl groups enhances systemic exposure and retains the cytotoxicity of drug conjugated PEGylated polylysine dendrimers.

D. Owen, L. Kaminskas, B. Kelly, 2011, Molecular Pharmaceutics.

An Evaluation of Optimal PEGylation Strategies for Maximizing the Lymphatic Exposure and Antiviral Activity of Interferon after Subcutaneous Administration.

L. Kaminskas, Victoria M Mcleod, C. Porter, 2017, Biomacromolecules.

Distribution of therapeutic proteins into thoracic lymph after intravenous administration is protein size‐dependent and primarily occurs within the liver and mesentery

A. Johnston, Laura I. Selby, C. Nowell, 2018, Journal of controlled release : official journal of the Controlled Release Society.

The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer

N. Gray, K. Harvey, J. Westermarck, 2021, Cell.

A Comparison of the Pharmacokinetics and Pulmonary Lymphatic Exposure of a Generation 4 PEGylated Dendrimer Following Intravenous and Aerosol Administration to Rats and Sheep

Victoria M Mcleod, C. Porter, P. Enkhbaatar, 2015, Pharmaceutical Research.

Dissociation of disease onset, progression and sex differences from androgen receptor levels in a mouse model of amyotrophic lateral sclerosis

D. Tomas, W. Boon, Victoria M Mcleod, 2021, Scientific Reports.

Androgen receptor antagonism accelerates disease onset in the SOD1G93A mouse model of amyotrophic lateral sclerosis

U. Roessner, W. Boon, T. Rupasinghe, 2019, British journal of pharmacology.

PEGylation of interferon α2 improves lymphatic exposure after subcutaneous and intravenous administration and improves antitumour efficacy against lymphatic breast cancer metastases.

Christopher J H Porter, Lisa M Kaminskas, David B Ascher, 2013, Journal of controlled release : official journal of the Controlled Release Society.

PEGylation does not significantly change the initial intravenous or subcutaneous pharmacokinetics or lymphatic exposure of trastuzumab in rats but increases plasma clearance after subcutaneous administration.

D. Ascher, Victoria M Mcleod, C. Porter, 2015, Molecular pharmaceutics.

Characterisation and tumour targeting of PEGylated polylysine dendrimers bearing doxorubicin via a pH labile linker.

D. Owen, B. Kelly, Victoria M Mcleod, 2011, Journal of controlled release : official journal of the Controlled Release Society.

Doxorubicin-conjugated PEGylated dendrimers show similar tumoricidal activity but lower systemic toxicity when compared to PEGylated liposome and solution formulations in mouse and rat tumor models.

Ben J. Boyd, Christopher J. H. Porter, Carleen Cullinane, 2012, Molecular pharmaceutics.

Mapping Motor Neuron Vulnerability in the Neuraxis of Male SOD1G93A Mice Reveals Widespread Loss of Androgen Receptor Occurring Early in Spinal Motor Neurons

W. Boon, C. L. Lau, Victoria M Mcleod, 2022, Frontiers in Endocrinology.

Pulmonary administration of a doxorubicin-conjugated dendrimer enhances drug exposure to lung metastases and improves cancer therapy.

D. Owen, B. Kelly, Victoria M Mcleod, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Doxorubicin Conjugation and Drug Linker Chemistry Alter the Intravenous and Pulmonary Pharmacokinetics of a PEGylated Generation 4 Polylysine Dendrimer in Rats.

D. Owen, B. Kelly, Victoria M Mcleod, 2018, Journal of pharmaceutical sciences.

Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumor-burdened lymph nodes after intravenous and subcutaneous administration in rats.

D. Owen, D. Ascher, T. Velkov, 2015, Molecular pharmaceutics.