A. Pinkerton

J. Millán, E. Sergienko, W. C. O'Neill, 2015, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling

N. LaRusso, T. Chung, E. Sergienko, 2017, Hepatology.

TGR 5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases via cAMP / G α s signaling Short title : TGR 5 in hepatic cystogenesis

N. LaRusso, T. Chung, E. Sergienko, 2017 .

Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelial cells accelerates coronary artery disease in a mouse model of familial hypercholesterolemia

J. Millán, K. Margulies, A. Gerdes, 2017, PloS one.

Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor.

T. Chung, M. Hedrick, E. Sergienko, 2012, Bioorganic & medicinal chemistry letters.

Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes.

T. Chung, Brock T Brown, M. Hedrick, 2014, Bioorganic & medicinal chemistry letters.

Diaryl substituted pyrazoles as potent CCR2 receptor antagonists.

M. Struthers, J. Demartino, A. Pinkerton, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and physicochemical characterization of novel phenotypic probes targeting the nuclear factor-kappa B signaling pathway

John Calvin Reed, G. Roth, R. G. Correa, 2013, Beilstein journal of organic chemistry.

Aberrant lipid metabolism in anaplastic thyroid carcinoma reveals stearoyl CoA desaturase 1 as a novel therapeutic target.

J. Copland, R. Smallridge, L. Marlow, 2015, The Journal of clinical endocrinology and metabolism.

Table 4, Probe and Analog Submissions to MLSMR (BioFocus DPI) for Gli-Sufu Antagonist ML340

Santhi Ganji, Ian Pass, Robert Ardecky, 2014 .

Systemic inhibition of tissue-nonspecific alkaline phosphatase alters the brain-immune axis in experimental sepsis

W. Geldenhuys, J. Millán, S. Benkovic, 2019, Scientific Reports.

Scheme 1, Synthesis of ML261, conditions

Jiwen Zou, Santhi Ganji, Ian Pass, 2013 .

Small-molecule antagonists of Gli function

Tram A. Ngo, Jennifer K. T. Casabar, T. Chung, 2014 .

Synthesis and SAR of thiophene containing kinesin spindle protein (KSP) inhibitors.

T. Z. Hoffman, A. Shiau, D. Severance, 2007, Bioorganic & medicinal chemistry letters.

Functional Antagonists of EBI-2

M. Jackson, T. Chung, Brock T Brown, 2015 .

Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenströms macroglobulinemia

M. Heckman, A. Pinkerton, T. Caulfield, 2014, Blood Cancer Journal.

Pharmacological TNAP inhibition efficiently inhibits arterial media calcification in a warfarin rat model but deserves careful consideration of potential physiological bone formation/mineralization impairment.

J. Millán, A. Pinkerton, E. Neven, 2020, Bone.

Optimization of a Urea-containing Series of Nicotinamide Phosphoribosyltransferase (NAMPT) Activators.

M. Jackson, E. Sergienko, S. Gardell, 2021, Bioorganic & medicinal chemistry letters.

Discovery of 1-[2-(1-methyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-3-(pyridin-4-ylmethyl)urea as a potent NAMPT (nicotinamide phosphoribosyltransferase) activator with attenuated CYP inhibition.

E. Sergienko, M. Yokoyama, S. Gardell, 2021, Bioorganic & medicinal chemistry letters.

Figure 10, SAR strategy for Scaffold I

Jiwen Zou, Santhi Ganji, Ian Pass, 2014 .

SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex.

K. Brown, M. Bosenberg, Z. Ronai, 2015, Cancer research.

Abstract 4459: Accelerated drug discovery platform yields synthesis of novel stearoyl-CoA desaturase 1 inhibitors that demonstrate anti-tumor efficacy in several models of aggressive cancer

Amy L. Lane, D. Radisky, J. Copland, 2015 .

Identification and Characterization of Novel Human Glucose-6-Phosphate Dehydrogenase Inhibitors

S. Rahlfs, K. Becker, M. Hedrick, 2013, Journal of biomolecular screening.

Ectopic calcification in pseudoxanthoma elasticum responds to inhibition of tissue-nonspecific alkaline phosphatase

E. Chew, H. Dietz, W. Gahl, 2017, Science Translational Medicine.

Bull. Soc. Chim. Fr.

Anthony B. Pinkerton, Michael Wörle, Reinhard Nesper, 1957 .

Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 3: Identification and biological activity of indanone containing mGlu2 receptor potentiators.

A. Pinkerton, J. James, U. Campbell, 2005, Bioorganic & medicinal chemistry letters.

6-Benzylamino 4-oxo-1,4-dihydro-1,8-naphthyridines and 4-oxo-1,4-dihydroquinolines as HIV integrase inhibitors.

Huanming Chen, A. Pinkerton, Samedy Ouk, 2011, Bioorganic & medicinal chemistry letters.

A Ruthenium-Catalyzed Three-Component Coupling to Form E-Vinyl Chlorides

B. Trost, A. Pinkerton, 1999 .

Non-metathesis ruthenium-catalyzed C-C bond formation.

B. Trost, A. Pinkerton, F. Toste, 2001, Chemical reviews.

Discovery of a Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase inhibitor (R,Z)-N-((1-ethylpyrrolidin-2-yl)methyl)-2-(2-fluorobenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (ML276) that reduces parasite growth in vitro.

Stefan Vasile, Eigo Suyama, Michael Vicchiarelli, 2012, Journal of medicinal chemistry.

Stereocontrolled total synthesis of (+)-streptazolin by a palladium-catalyzed reductive diyne cyclization.

B. Trost, A. Pinkerton, Cheol K. Chung, 2004, Angewandte Chemie.

A Ru-Catalyzed Four-Component Coupling

B. Trost, A. Pinkerton, 2000 .

Synthesis of 1,1-disubstituted alkenes via a Ru-catalyzed addition.

B. Trost, A. Pinkerton, F. Toste, 2001, Journal of the American Chemical Society.

Ruthenium-catalyzed two-component addition to form 1,3-dienes: optimization, scope, applications, and mechanism.

B. Trost, A. Pinkerton, M. Seidel, 2001, Journal of the American Chemical Society.

Stereocontrolled total synthesis of (+)-streptazolin by a palladium-catalyzed reductive diyne cyclization.

B. Trost, A. Pinkerton, Cheol K. Chung, 2004, Angewandte Chemie.

Preparation of TADDOL Derivatives for New Applications

D. Seebach, V. Gramlich, A. Pinkerton, 1999 .

SORPTION BEHAVIOR OF PERTECHNETATE ON REILLEX(tm)-HPQ ANION EXCHANGE RESIN FROM NITRIC ACID SOLUTION

A. Pinkerton, J. R. Ball, K. R. Ashley, 1994 .

Syntheses of nido-9,11-X2-7,8-C2B9H10 − anions (X=Cl, Br or I) and the synthesis and structural characterization of N(C2H5)4[commo-3,3′-Co(4,7-Br2-3,1,2-CoC2B9H9)2]

A. Pinkerton, P. K. Hurlburt, J. Huffman, 2000 .

EXTRACTION OF CESIUM AND STRONTIUM INTO HYDROCARBON SOLVENTS USING TETRA-C-ALKYL COBALT DICARBOLLIDE

A. Pinkerton, P. K. Hurlburt, Rebecca L. Miller, 1995 .

Evidence That the DNA Endonuclease ARTEMIS also Has Intrinsic 5′-Exonuclease Activity*

K. Schwarz, M. Lieber, M. Hedrick, 2014, The Journal of Biological Chemistry.

Sorption Behavior of Uranium onto Reillex™-HPQ Anion Exchange Resin from Nitric and Hydrochloric Acid Solutions

A. Pinkerton, J. Adams, J. R. Ball, 1995 .

Inhibition of Tissue-Nonspecific Alkaline Phosphatase Attenuates Ectopic Mineralization in the Abcc6-/- Mouse Model of PXE but Not in the Enpp1 Mutant Mouse Models of GACI.

J. Sundberg, J. Uitto, J. Millán, 2019, The Journal of investigative dermatology.

Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor.

M. Jackson, J. Millán, E. Sergienko, 2018, Bioorganic & medicinal chemistry letters.

ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse.

R. Rodriguiz, W. Wetsel, M. Caron, 2016, ACS chemical biology.

Discovery of ML314, a Brain Penetrant Non-Peptidic β-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor.

M. Caron, T. Chung, M. Hedrick, 2013, ACS medicinal chemistry letters.

A Ruthenium-Catalyzed Pyrrolidine and Piperidine Synthesis

B. Trost, A. Pinkerton, Doris Kremzow, 2000 .

Arylmethylamino steroids as antiparasitic agents

S. Rahlfs, K. Becker, E. Davioud‐Charvet, 2017, Nature Communications.

HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter.

H. Freeze, J. Cashman, A. Richardson, 2012, Chemistry & biology.

A three-component coupling approach to cyclopentanoids.

B. Trost, A. Pinkerton, B M Trost, 2001, The Journal of organic chemistry.

Formation of vinyl halides via a ruthenium-catalyzed three-component coupling.

B. Trost, A. Pinkerton, 2002, Journal of the American Chemical Society.

Small Molecules Targeting the Mitochondrial Permeability Transition

M. Jackson, T. Chung, D. Bourdette, 2015 .

Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11.

Seth M. Cohen, T. Chung, R. Deshaies, 2017, Nature chemical biology.

Benzodiazepinone Derivatives Protect against Endoplasmic Reticulum Stress-Mediated Cell Death in Human Neuronal Cell Lines

D. Sheffler, John Calvin Reed, N. Cosford, 2014, ACS chemical neuroscience.

Accelerated Aging and Clearance of Host Anti-inflammatory Enzymes by Discrete Pathogens Fuels Sepsis.

V. Nizet, J. Marth, J. Millán, 2018, Cell host & microbe.

Induction of β‐cell replication by a synthetic HNF4α antagonist

E. Keinan, F. Levine, A. Pinkerton, 2013, Stem cells.

Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2.

L. Bristow, A. Pinkerton, J. Vernier, 2003, Molecular pharmacology.

Targeting tumor phenotypic plasticity and metabolic remodeling in adaptive cross-drug tolerance

P. Majumder, Shiladitya Sengupta, A. Goldman, 2019, Science Signaling.

Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response

Jennifer E. Golden, T. Chung, R. Kaufman, 2014, ACS medicinal chemistry letters.

A screen for inducers of bHLH activity identifies pitavastatin as a regulator of p21, Rb phosphorylation and E2F target gene expression in pancreatic cancer

K. Scully, A. Lowy, A. Pinkerton, 2017, Oncotarget.

Group II mGlu Receptor Activation Suppresses Norepinephrine Release in the Ventral Hippocampus and Locomotor Responses to Acute Ketamine Challenge

D. Lorrain, L. Bristow, A. Pinkerton, 2003, Neuropsychopharmacology.

Targeting eIF4F translation initiation complex with SBI-756 sensitises B lymphoma cells to venetoclax

M. Jackson, D. Fruman, Z. Ronai, 2020, British Journal of Cancer.

Cardioprotective inhibitors of reperfusion injury

T. Chung, Derek A. Stonich, R. Kitsis, 2013 .

Repurposing antimalarial aminoquinolines and related compounds for treatment of retinal neovascularization

M. Boulton, S. Vasile, M. Grant, 2018, PloS one.

Functional Agonists of the Apelin (APJ) Receptor

T. Chung, M. Hedrick, E. Sergienko, 2013 .

High-Throughput Screening for Small-Molecule Inhibitors of Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase 6-Phosphogluconolactonase

S. Rahlfs, K. Becker, M. Hedrick, 2012, Journal of biomolecular screening.

PPARδ repression in Huntington’s disease and its essential role in CNS translate into a potent agonist therapy

Gene W. Yeo, C. Ross, E. Masliah, 2016 .

The Compound SBI-0090799 Inhibits Zika Virus Infection by Blocking De Novo Formation of the Membranous Replication Compartment

S. Chanda, R. Bartenschlager, L. Riva, 2021, Journal of virology.

PPARδ repression in Huntington’s disease and its essential role in CNS translate into a potent agonist therapy

Gene W. Yeo, C. Ross, E. Masliah, 2015, Nature Medicine.

Diabetes reversal by inhibition of the low molecular weight tyrosine phosphatase

R. Liddington, N. Bottini, T. Mustelin, 2017, Nature chemical biology.

Chronic Kidney Disease-Induced Arterial Media Calcification in Rats Prevented by Tissue Non-Specific Alkaline Phosphatase Substrate Supplementation Rather Than Inhibition of the Enzyme

J. Millán, A. Pinkerton, E. Neven, 2021, Pharmaceutics.

Inhibitors of tissue-nonspecific alkaline phosphatase (TNAP): from hits to leads.

N. Cosford, P. Teriete, A. Pinkerton, 2013, Methods in molecular biology.

Neurotensin receptor allosterism revealed in complex with a biased allosteric modulator

Reid H. J. Olsen, Samuel T. Slocum, Ryan T. Strachan, 2022, bioRxiv.

An Optimized Dihydrodibenzothiazepine Lead Compound (SBI-0797750) as a Potent and Selective Inhibitor of Plasmodium falciparum and P. vivax Glucose 6-Phosphate Dehydrogenase 6-Phosphogluconolactonase

S. Rahlfs, T. Chung, M. Hedrick, 2022, Antimicrobial agents and chemotherapy.

Glucose 6-phosphate dehydrogenase 6-phosphogluconolactonase: characterization of the Plasmodium vivax enzyme and inhibitor studies

S. Rahlfs, K. Becker, L. Bode, 2019, Malaria Journal.

Discovery of b-Arrestin Biased, Orally Bioavailable and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators.

M. Jackson, M. Caron, T. Chung, 2019, Journal of medicinal chemistry.

A new strategy for cyclopentenone synthesis.

B. Trost, A. Pinkerton, 2000, Organic letters.

Neurotensin receptor 1-biased ligand attenuates neurotensin-mediated excitation of ventral tegmental area dopamine neurons and dopamine release in the nucleus accumbens

M. Caron, T. Hnasko, Vivien Zell, 2023, Neuropharmacology.

Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 2: 4-thiopyridyl acetophenones as non-tetrazole containing mGlu2 receptor potentiators.

A. Pinkerton, J. James, J. Vernier, 2004, Bioorganic & medicinal chemistry letters.

Phenyl-tetrazolyl acetophenones: discovery of positive allosteric potentiatiors for the metabotropic glutamate 2 receptor.

D. Lorrain, L. Bristow, A. Pinkerton, 2004, Journal of medicinal chemistry.

Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase.

M. Jackson, Z. J. Holmes, N. Bottini, 2021, Journal of medicinal chemistry.

A RUTHENIUM-CATALYZED TWO-COMPONENT ADDITION TO FORM 1,3-DIENES

B. Trost, A. Pinkerton, 1999 .

Enhanced geometrical control in a Ru-catalyzed three component coupling

B. Trost, A. Pinkerton, 2000 .

A Ruthenium-Catalyzed Three-Component Coupling to Form E-Vinyl Chlorides.

B. Trost, A. Pinkerton, 1999 .

Probing the CXCR6/CXCL16 Axis: Targeting Prevention of Prostate Cancer Metastasis

R. Taichman, T. Chung, M. Hedrick, 2014 .

Discovery of small molecule antagonists of chemokine receptor CXCR6 that arrest tumor growth in SK-HEP-1 mouse xenografts as a model of hepatocellular carcinoma.

A. Pinkerton, D. Divlianska, E. Sugarman, 2019, Bioorganic & medicinal chemistry letters.

Glucose 6-phosphate dehydrogenase 6-phosphogluconolactonase: characterization of the Plasmodium vivax enzyme and inhibitor studies

S. Rahlfs, K. Becker, L. Bode, 2019, Malaria Journal.

Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5α Promotes Cancer Invasion and Tumor Growth

M. Abelman, S. McWeeney, E. Sergienko, 2021, Cancer Research.

A synthesis of trisubstituted alkenes by a Ru-catalyzed addition.

B. Trost, A. Pinkerton, Hong C Shen, 2002, Chemistry.

A Synthesis of Trisubstituted Alkenes by a Ru‐Catalyzed Addition.

B. Trost, A. Pinkerton, Hong C Shen, 2002 .

Synthesis of 1,1-disubstituted alkenes via a Ru-catalyzed addition.

B. Trost, A. Pinkerton, F. Toste, 2001, Journal of the American Chemical Society.

Author Correction: Arylmethylamino steroids as antiparasitic agents

S. Rahlfs, K. Becker, E. Davioud‐Charvet, 2019, Nature Communications.

Mechanisms of release of nucleotides and integration of their action as P2X- and P2Y-receptor activating molecules.

T Kendall Harden, Richard C Boucher, T. K. Harden, 2003, Molecular pharmacology.

Identification and characterization of small molecule inhibitors of the ubiquitin ligases Siah1/2 in melanoma and prostate cancer cells.

R. Liddington, M. Jackson, M. Gleave, 2019, Cancer letters.

Selective UBC 13 Inhibitors

Tram A. Ngo, J. Reed, T. Chung, 2014 .

Discovery of ML358, a Selective Small Molecule Inhibitor of the SKN-1 Pathway Involved in Drug Detoxification and Resistance in Nematodes.

C. Leung, K. Choe, A. Pinkerton, 2015, ACS chemical biology.

Allosteric Potentiators of the Metabotropic Glutamate Receptor 2 (mGlu2). Part 3. Identification and Biological Activity of Indanone Containing mGlu2 Receptor Potentiators.

A. Pinkerton, 2005 .

6-Benzylamino 4-oxo-1,4-dihydro-1,8-naphthyridines and 4-oxo-1,4-dihydroquinolines as HIV integrase inhibitors.

Huanming Chen, A. Pinkerton, Samedy Ouk, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5.

T. Rao, A. Shiau, L. Staszewski, 2010, Bioorganic & medicinal chemistry letters.