S. Ananthan

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Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes

Tudor I. Oprea, Jennifer E. Golden, Joshua A. Bittker, 2015, Cell.

Development and Validation of a High-Throughput Screen for Inhibitors of SARS CoV and Its Application in Screening of a 100,000-Compound Library

E Lucile White, Subramaniam Ananthan, C. Jonsson, 2007, SLAS Discovery.

(S)-N-(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2-carboxamide as a small molecule inhibitor probe for the study of respiratory syncytial virus infection.

Jennifer E. Golden, Nichole A. Tower, C. Jonsson, 2012, Journal of medicinal chemistry.

in Screening of a 100,000-Compound Library Development and Validation of a High-Throughput Screen for Inhibitors of SARS CoV and Its Application

B. Jonsson, E. White, W. Severson, 2013 .

Recent Advances in Structure-Based Virtual Screening of G-Protein Coupled Receptors

Subramaniam Ananthan, Wei Zhang, S. Ananthan, 2009, The AAPS Journal.

Design, Synthesis, and Structure–Activity Relationship Studies of a Series of [4-(4-Carboxamidobutyl)]-1-arylpiperazines: Insights into Structural Features Contributing to Dopamine D3 versus D2 Receptor Subtype Selectivity

M. Reith, I. Padmalayam, L. Zhai, 2014, Journal of medicinal chemistry.

Novel substituted pyrimidines as HCV replication (replicase) inhibitors.

X. Tong, R. Reynolds, B. Feld, 2012, Bioorganic & Medicinal Chemistry Letters.

Pyridofuran substituted pyrimidine derivatives as HCV replication (replicase) inhibitors.

X. Tong, M. Maccoss, R. Reynolds, 2012, Bioorganic & medicinal chemistry letters.

5-Benzothiazole substituted pyrimidine derivatives as HCV replication (replicase) inhibitors.

X. Tong, M. Maccoss, R. Reynolds, 2012, Bioorganic & medicinal chemistry letters.

Identification of novel small molecule activators of nuclear factor‐κb with neuroprotective action via high‐throughput screening

K. Wennerberg, E. White, S. Ananthan, 2011, Journal of neuroscience research.

A cell based high-throughput screening approach for the discovery of new inhibitors of respiratory syncytial virus

Jennifer E. Golden, C. Jonsson, D. Chung, 2013, Virology Journal.

Synthesis, opioid receptor binding, and functional activity of 5'-substituted 17-cyclopropylmethylpyrido[2',3':6,7]morphinans.

N. Khare, R. Rothman, C. Dersch, 2003, Bioorganic & medicinal chemistry letters.

Novel ligands for the opioid receptors: synthesis and structure-activity relationships among 5'-aryl and 5'-heteroaryl 17-cyclopropylmethyl-4,5 alpha-epoxypyrido[2',3':6,7]morphinans.

N. Khare, R. Rothman, C. Dersch, 2003, Bioorganic & medicinal chemistry.

Opioid Peptide Receptor Studies. 8. One of the Mouse Brain δNCX Binding Sites is Similar to the Cloned Mouse Opioid δ Receptor: Further Evidence for Heterogeneity of δ Opioid Receptors

K. Rice, R. Rothman, Heng Xu, 1998, Peptides.

Allosteric modulatory effects of SRI-20041 and SRI-30827 on cocaine and HIV-1 Tat protein binding to human dopamine transporter

C. Zhan, S. Ananthan, Yaxia Yuan, 2017, Scientific Reports.

Synthesis and structure-activity relationships of 3,5-disubstituted 4,5-dihydro-6H-imidazo[1,5-a][1,4]benzodiazepin-6-ones at diazepam-sensitive and diazepam-insensitive benzodiazepine receptors.

P. Skolnick, S. Ananthan, S. Ealick, 1993, Journal of medicinal chemistry.

Unique Functional and Structural Properties of the LRRK2 Protein ATP-binding Pocket*

L. DeLucas, A. West, E. White, 2014, The Journal of Biological Chemistry.

Studies of the Biogenic Amine Transporters. 13. Identification of “Agonist” and “Antagonist” Allosteric Modulators of Amphetamine-Induced Dopamine Release

R. Rothman, C. Dersch, S. Ananthan, 2009, Journal of Pharmacology and Experimental Therapeutics.

Studies of the Biogenic Amine Transporters. 12. Identification of Novel Partial Inhibitors of Amphetamine-Induced Dopamine Release

R. Rothman, C. Dersch, S. Ananthan, 2008, Journal of Pharmacology and Experimental Therapeutics.

Discovery of novel frizzled-7 inhibitors by targeting the receptor’s transmembrane domain

Wei Zhang, Yonghe Li, Wenyan Lu, 2017, Oncotarget.

A Novel Mu-Delta Opioid Agonist Demonstrates Enhanced Efficacy with Reduced Tolerance and Dependence in Mouse Neuropathic Pain Models.

J. Streicher, S. Ananthan, W. Lei, 2020, The journal of pain : official journal of the American Pain Society.

14-Alkoxy- and 14-acyloxypyridomorphinans: μ agonist/δ antagonist opioid analgesics with diminished tolerance and dependence side effects.

R. Rothman, C. Dersch, Heng Xu, 2012, Journal of medicinal chemistry.

SRI-32743, a novel allosteric modulator, attenuates HIV-1 Tat protein-induced inhibition of the dopamine transporter and alleviates the potentiation of cocaine reward in HIV-1 Tat transgenic mice

C. Zhan, S. Ananthan, T. Cirino, 2022, Neuropharmacology.

SoRI 9409, a non-peptide opioid μ receptor agonist/δ receptor antagonist, fails to stimulate [35S]-GTP-γ-S binding at cloned opioid receptors

K. Rice, R. Rothman, Heng Xu, 2001, Brain Research Bulletin.

Reaction of benzaldehyde with other carbonyl compounds over thoria and mixed oxides of thoria: Development of an effective catalyst and a process for the conversion of benzaldehyde to phenyl alkyl ketones

S. Ananthan, N. Venkatasubramanian, C. N. Pillai, 1984 .

The effects of the novel DA D3 receptor antagonist SR 21502 on cocaine reward, cocaine seeking and cocaine-induced locomotor activity in rats

S. Ananthan, R. Ranaldi, E. Galaj, 2014, Psychopharmacology.

Identification of a novel partial inhibitor of dopamine transporter among 4-substituted 2-phenylquinazolines.

R. Rothman, C. Dersch, S. Ananthan, 2002, Bioorganic & medicinal chemistry letters.

Studies of the biogenic amine transporters. VIII: Identification of a novel partial inhibitor of dopamine uptake and dopamine transporter binding

F. Carroll, R. Rothman, C. Dersch, 2002, Synapse.

Hu antigen R (HuR) multimerization contributes to glioma disease progression

N. Filippova, S. Bae, L. Nabors, 2017, The Journal of Biological Chemistry.

High-Throughput Screening Identifies a Bisphenol Inhibitor of SV40 Large T Antigen ATPase Activity

Brooks E. Maki, Jennifer E. Golden, Nichole A. Tower, 2012, Journal of biomolecular screening.

Opioid peptide receptor studies. 1. Identification of a novel δ-opioid receptor binding site in rat brain membranes

K. Rice, R. Rothman, Heng Xu, 1995, Peptides.

Reaction of nitriles under acidic conditions. Part I. A general method of synthesis of condensed pyrimidines

S. Ananthan, M. B. Devani, C. Shishoo, 1980 .

Reaction of nitriles under acidic conditions: a novel, direct formation of condensed 4-chloropyrimidines

S. Ananthan, M. B. Devani, C. Shishoo, 1984 .

Reaction of nitriles under acidic conditions. Part III. A facile synthesis of thienopyrimidin-4(3H)-ones

S. Ananthan, M. B. Devani, C. Shishoo, 1984 .

A facile synthesis of 3-amino-5-substitutedaminoisothiazole-4-carboxylic acid derivatives

S. Ananthan, M. B. Devani, C. Shishoo, 1988 .

Studies in the synthesis and interconversion of isomeric triazolothienopyrimidines

S. Ananthan, M. B. Devani, C. Shishoo, 1981 .

Targeting Chikungunya Virus Replication by Benzoannulene Inhibitors.

Nichole A. Tower, M. Heise, B. Tekwani, 2021, Journal of medicinal chemistry.

Reaction of nitriles under acidic conditions. Part VI. Synthesis of condensed 4-chloro- and 4-aminopyrimidines from ortho-aminonitriles

S. Ananthan, M. B. Devani, C. Shishoo, 1990 .

Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans.

S K Saini, K. Rice, R. Rothman, 1999, Journal of medicinal chemistry.

Antituberculous Activity of Norfloxacin Mannich Bases with Isatin Derivatives

P. Yogeeswari, D. Sriram, S. Ananthan, 2001, Chemotherapy.

High throughput screening of a library based on kinase inhibitor scaffolds against Mycobacterium tuberculosis H37Rv.

Lynn Rasmussen, E Lucile White, Wei Zhang, 2012, Tuberculosis.

Antituberculosis activity of the molecular libraries screening center network library.

Lynn Rasmussen, E Lucile White, Wei Zhang, 2009, Tuberculosis.

Discovery of Novel Benzoquinazolinones and Thiazoloimidazoles, Inhibitors of Influenza H5N1 and H1N1 Viruses, from a Cell-Based High-Throughput Screen

D. Smee, C. Jonsson, D. Noah, 2011, Journal of biomolecular screening.

Synthesis of Pyrimidines and Condensed Pyrimidines Through Reactions of Nitriles with o-Aminocarbonyl Substrates under Acidic Conditions

S. Ananthan, C. Shishoo, K. Jain, 2009 .

Reaction of Nitriles Under Acidic Conditions. Part 4. Synthesis of Condensed 4-Chloro- and 4-Aminopyrimidines from ortho-Aminonitriles.

S. Ananthan, M. B. Devani, C. Shishoo, 1990 .

Studies on the synthesis and interconversion of isomeric triazolothienopyrimidines. Part III. Cyclization reactions of 2‐amino‐3‐(1H‐1,2,4‐triazol‐3‐yl)thiophenes

S. Ananthan, M. B. Devani, C. Shishoo, 1987 .

Studies on the synthesis of 2-(2-arylvinyl)thieno[2,3-d]pyrimidines and 5-(2-arylvinyl)triazolothieno[3,2-e]pyrimidines

S. Ananthan, M. B. Devani, C. Shishoo, 1985 .

High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv.

Lynn Rasmussen, E Lucile White, Subramaniam Ananthan, 2009, Tuberculosis.

High Throughput Screening for Inhibitors of Mycobacterium tuberculosis H 37 Rv

R. Reynolds, E. White, S. Ananthan, 2012 .

Crystal structure of 3-methyl-2,6-bis(4-methyl-1,3-thiazol-5-yl)piperidin-4-one

S. Ananthan, A. Manimaran, K. Sethusankar, 2014, Acta crystallographica. Section E, Structure reports online.

Heterocyclization of functionalized ketene acetals: Synthesis of pyrimidines via vinylamidine intermediates

S. Ananthan, M. B. Devani, C. Shishoo, 1984 .

Mono and bis(bioreductive) alkylating agents: synthesis and antitumor activities in a B16 melanoma model.

D. Witiak, S. Ananthan, V. Verhoef, 1989, Journal of medicinal chemistry.

Identification of Quinolinones as Antivirals against Venezuelan Equine Encephalitis Virus

M. Heise, R. Bostwick, Nathaniel J. Moorman, 2021, Antimicrobial agents and chemotherapy.

High-Throughput Screening of a 100,000-Compound Library for Inhibitors of Influenza A Virus (H3N2)

M. McDowell, C. Jonsson, D. Chung, 2008, Journal of biomolecular screening.

The delta opioid receptor antagonist, SoRI‐9409, decreases yohimbine stress‐induced reinstatement of ethanol‐seeking

S. Ananthan, S. Bartlett, C. Nielsen, 2012, Addiction biology.

Novel dopamine receptor 3 antagonists inhibit the growth of primary and temozolomide resistant glioblastoma cells

Emily R. Gordon, S. Cooper, M. Napierala, 2021, PloS one.

Synthesis of indenes from phenylpropanones using alumina catalyst

N. Pant, S. Ananthan, K. Narayanan, 1986 .

Novel non-peptidic opioid compounds with immunopotentiating effects.

S. Ananthan, R. Weber, M. Riley, 1998, Advances in experimental medicine and biology.

Identification of quinazoline compounds as novel potent inhibitors of Wnt/β-catenin signaling in colorectal cancer cells

Yonghe Li, Wenyan Lu, S. Ananthan, 2016, Oncotarget.

Interactions between Cocaine and the Putative Allosteric Dopamine Transporter Ligand SRI-31142

Amy R. Johnson, S. Ananthan, M. Banks, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Novel allosteric modulator SRI-32743 reverses HIV-1 Tat-induced increase in dopamine release in the caudate putamen of inducible Tat transgenic mice.

S. Ananthan, M. Ferris, C. Augelli-Szafran, 2022, The Journal of pharmacology and experimental therapeutics.

The role of human dopamine transporter in NeuroAIDS☆

C. Zhan, S. Ananthan, Jun Zhu, 2017, Pharmacology & therapeutics.

Recombinant human immunodeficiency virus‐1 transactivator of transcription1–86 allosterically modulates dopamine transporter activity

S. Ananthan, C. Mactutus, R. Booze, 2011, Synapse.

Identification of Opioid Ligands Possessing Mixed μ Agonist/δ Antagonist Activity among Pyridomorphinans Derived from Naloxone, Oxymorphone, and Hydropmorphone

N. Khare, R. Rothman, C. Dersch, 2004 .

Potentiation of rat lymphocyte proliferation by novel non-peptidic synthetic opioids.

K. Rice, R. Tamez-Guerra, C. Rodríguez-Padilla, 2005, International immunopharmacology.

Lifting the Mask: Identification of New Small Molecule Inhibitors of Uropathogenic Escherichia coli Group 2 Capsule Biogenesis

Brooks E. Maki, Nichole A. Tower, Carlos C. Goller, 2014, PloS one.

Synthesis and Structure-Activity Relationships of 5'-Aryl-14-alkoxypyridomorphinans: Identification of a Mu Opioid Receptor Agonist/Delta Opioid Receptor Antagonist Ligand with Systemic Antinociceptive Activity and Diminished Opioid Side Effects.

K. Houseknecht, J. Streicher, S. Ananthan, 2020, Journal of medicinal chemistry.

Opioid ligands with mixed μ/δ opioid receptor interactions: An emerging approach to novel analgesics

S. Ananthan, 2006, The AAPS Journal.

Synthesis of 5H-Triazolo[1,5-d]- and 5H- Tetrazolo- [1,5-d]thieno[3,2-f]-1,4-diazepin-6(7H)-ones

S. Ananthan, M. B. Devani, C. Shishoo, 1988 .

Synthesis of 5H-Triazolo(1,5-d)- and 5H-Tetrazolo(1,5-d)thieno(3,2-f)-1,4-diazepin-6(7H)-ones.

S. Ananthan, M. B. Devani, C. Shishoo, 1988 .

A Novel Delta Opioid Receptor Antagonist, SoRI-9409, Produces a Selective and Long-Lasting Decrease in Ethanol Consumption in Heavy-Drinking Rats

S. Ananthan, S. Bartlett, C. Nielsen, 2008, Biological Psychiatry.

Discovery of a novel inhibitor of kinesin-like protein KIFC1.

Wei Zhang, R. Bostwick, Yonghe Li, 2016, The Biochemical journal.

Structure-based design of inhibitors of purine nucleoside phosphorylase. 3. 9-Arylmethyl derivatives of 9-deazaguanine substituted on the methylene group.

S E Ealick, W C Guida, W. Guida, 1993, Journal of medicinal chemistry.

Targeting the HuR Oncogenic Role with a New Class of Cytoplasmic Dimerization Inhibitors

N. Filippova, D. Crossman, L. Nabors, 2021, Cancer Research.

In vivo pharmacological characterization of SoRI 9409, a nonpeptidic opioid mu-agonist/delta-antagonist that produces limited antinociceptive tolerance and attenuates morphine physical dependence.

J. L. Wells, S. Ananthan, E J Bilsky, 2001, The Journal of pharmacology and experimental therapeutics.

Opioid ligands with mixed mu/delta opioid receptor interactions: an emerging approach to novel analgesics.

S. Ananthan, 2006, The AAPS journal.

SoRI 9409, a non-peptide opioid mu receptor agonist/delta receptor antagonist, fails to stimulate [35S]-GTP-gamma-S binding at cloned opioid receptors.

K. Rice, R. Rothman, S. Ananthan, 2001, Brain research bulletin.

The selective dopamine D3 receptor antagonist, SR 21502, reduces cue-induced reinstatement of heroin seeking and heroin conditioned place preference in rats.

S. Ananthan, R. Ranaldi, E. Galaj, 2015, Drug and alcohol dependence.

Pramipexole at a Low Dose Induces Beneficial Effect in the Harmaline‐induced Model of Essential Tremor in Rats

S. Ananthan, U. Głowacka, K. Ossowska, 2016, CNS neuroscience & therapeutics.

Synthesis, opioid receptor binding, and bioassay of naltrindole analogues substituted in the indolic benzene moiety.

K. Rice, R. Rothman, S. Ananthan, 1998, Journal of medicinal chemistry.

A High‐Throughput Screen for Chemical Inhibitors of Exocytic Transport in Yeast

G. Piazza, N. M. Nebane, E. White, 2010, Chembiochem : a European journal of chemical biology.

Synthesis and SAR of geminal substitutions at the C5' carbosugar position of pyrimidine-derived HCV inhibitors.

X. Tong, M. Maccoss, N. Bansal, 2012, Bioorganic & medicinal chemistry letters.

Synthesis and SAR of pyridothiazole substituted pyrimidine derived HCV replication inhibitors.

X. Tong, M. Maccoss, N. Bansal, 2012, Bioorganic & medicinal chemistry letters.

3-Isopropyl-1-{2-[(1-methyl-1H-tetrazol-5-yl)sulfanyl]acetyl}-2,6-diphenylpiperidin-4-one hemihydrate

M. N. Ponnuswamy, S. Ananthan, P. Sugumar, 2013, Acta Crystallographica Section E.

3,5-Dimethyl-1-{2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetyl}-2,6-diphenylpiperidin-4-one

M. N. Ponnuswamy, S. Ananthan, P. Sugumar, 2013, Acta crystallographica. Section E, Structure reports online.

Synthetic and computer-assisted analysis of the structural requirements for selective, high-affinity ligand binding to diazepam-insensitive benzodiazepine receptors.

P. Skolnick, K. Koehler, S. Ananthan, 1993, Journal of medicinal chemistry.

N′-[(E)-2-Chlorobenzylidene]-2-[(1,3,4-thiadiazol-2-yl)sulfanyl]acetohydrazide

S. Ananthan, P. Ramesh, D. Saravanan, 2011, Acta crystallographica. Section E, Structure reports online.

The dopamine D3 receptor antagonist, SR 21502, facilitates extinction of cocaine conditioned place preference.

S. Ananthan, R. Ranaldi, E. Galaj, 2016, Drug and alcohol dependence.

A Cell Based HTS Approach for the Discovery of New Inhibitors of RSV

Jennifer E. Golden, Nichole A. Tower, C. Jonsson, 2013 .

Identification of a Series of Quinazolinediones as Potent, Selective, Post-Entry Inhibitors of Human Respiratory Syncytial Virus ( h RSV) via a Cell-Based High Throughput Screen and Chemical Optimization

Jennifer E. Golden, Nichole A. Tower, Carrie W. Evans, 2013 .

The novel dopamine D3 receptor antagonist, SR 21502, reduces cocaine conditioned place preference in rats

S. Ananthan, R. Ranaldi, P. Hachimine, 2014, Neuroscience Letters.

The dopamine D3 receptor antagonist, SR 21502, facilitates extinction of cocaine conditioned place preference.

S. Ananthan, E. Galaj, R. Nisanov, 2016, Drug and alcohol dependence.

Synthesis, opioid receptor binding, and functional activity of 5'-substituted 17-cyclopropylmethylpyrido[2',3':6,7]morphinans.

N. Khare, R. Rothman, C. Dersch, 2003, Bioorganic & medicinal chemistry letters.

POTENTIAL OF NATURAL BIO-POLYMERS IN STABILIZATION OF SOIL

S. Ananthan, M. Padmapriya, K. Rakesh, 2019 .

Structure‐based approach to pharmacophore identification, in silico screening, and three‐dimensional quantitative structure–activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function

A. Anderson, N. Schormann, D. Chattopadhyay, 2008, Proteins.

HTS-Driven Discovery of New Chemotypes with West Nile Virus Inhibitory Activity

Qianjun Li, C. Jonsson, D. Chung, 2010, Molecules.

Programs to facilitate tuberculosis drug discovery: the tuberculosis antimicrobial acquisition and coordinating facility.

R. Reynolds, S. Ananthan, Marie-Aude Guié, 2007, Infectious disorders drug targets.

Studies of the Biogenic Amine Transporters. 13. Identification of “Agonist” and “Antagonist” Allosteric Modulators of Amphetamine-Induced Dopamine Release

R. Rothman, C. Dersch, S. Ananthan, 2009, Journal of Pharmacology and Experimental Therapeutics.