D. Guo

发表

Emerging coronaviruses: Genome structure, replication, and pathogenesis

Qianyun Liu, Yu Chen, Qianyun Liu, 2020, Journal of medical virology.

Molecular mechanisms of coronavirus RNA capping and methylation

Yu Chen, D. Guo, 2016, Virologica Sinica.

Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase

T. Ahola, P. Tien, Ji’an Pan, 2009, Proceedings of the National Academy of Sciences.

Yeast-based assays for the high-throughput screening of inhibitors of coronavirus RNA cap guanine-N7-methyltransferase

Yu Chen, D. Guo, Ying Sun, 2014, Antiviral Research.

Genome-Wide Analysis of Protein-Protein Interactions and Involvement of Viral Proteins in SARS-CoV Replication

Xiaolu Lu, Marta L. DeDiego, L. Enjuanes, 2008, PloS one.

Oxidative stress transforms 3CLpro into an insoluble and more active form to promote SARS-CoV-2 replication

Ting Yu, D. Guo, B. Zhao, 2021, Redox Biology.

The potent human immunodeficiency virus type 1 (HIV-1) entry inhibitor HR212 blocks formation of the envelope glycoprotein gp41 six-helix bundle.

P. Tien, Shuwen Wu, D. Guo, 2013, AIDS research and human retroviruses.

The Nucleocapsid Protein of Coronaviruses Acts as a Viral Suppressor of RNA Silencing in Mammalian Cells

Xiaoping Zhou, Hong Wang, P. Tien, 2015, Journal of Virology.

Genome-wide analysis of protein–protein interactions and involvement of viral proteins in SARS-CoV-2 replication

Jingquan Tan, D. Guo, Xiaoxue Peng, 2021, Cell & bioscience.

Hepatitis C Virus Sensitizes Host Cells to TRAIL-Induced Apoptosis by Up-Regulating DR4 and DR5 via a MEK1-Dependent Pathway

D. Guo, Hui-yi Yan, Qingzhen Liu, 2012, PloS one.

World Society for Virology first international conference: Tackling global virus epidemics

Zhènglì Shí, L. Kramer, M. Söderlund-Venermo, 2021, Virology.

Efficient Inhibition of Avian and Seasonal Influenza A Viruses by a Virus-Specific Dicer-Substrate Small Interfering RNA Swarm in Human Monocyte-Derived Macrophages and Dendritic Cells

D. Bamford, P. Österlund, I. Julkunen, 2018, Journal of Virology.

The DEAD-Box RNA Helicase DDX3 Interacts with NF-κB Subunit p65 and Suppresses p65-Mediated Transcription

Yu Chen, D. Guo, N. Xiang, 2016, PloS one.

The DEAD‐box RNA helicase DDX1 interacts with RelA and enhances nuclear factor kappaB‐mediated transcription

Y. Mu, Ji’an Pan, D. Guo, 2009, Journal of cellular biochemistry.

HCV NS3/4A protein activates HIV-1 transcription from its long terminal repeat.

D. Guo, M. Ishaq, Jiajie Hu, 2008, Virus research.

HCV NS 3 / 4 A protein activates HIV-1 transcription from its long terminal repeat fe Scie patie atitis n HIV riptio A fail enha o the

D. Guo, M. Ishaq, Jiajie Hu, 2008 .

Engineering a Reliable and Convenient SARS-CoV-2 Replicon System for Analysis of Viral RNA Synthesis and Screening of Antiviral Inhibitors

J. Liu, F. Yu, T. Pan, 2021, mBio.

Immune regulator ABIN1 suppresses HIV-1 transcription by negatively regulating the ubiquitination of Tat

Liu Cao, Yu Chen, D. Guo, 2017, Retrovirology.

Hantavirus nucleocapsid protein interacts with the Fas-mediated apoptosis enhancer Daxx.

T. Mäkelä, V. Koistinen, A. Vaheri, 2002, The Journal of general virology.

Identification of Novel Subgenomic RNAs and Noncanonical Transcription Initiation Signals of Severe Acute Respiratory Syndrome Coronavirus

P. Tien, Ying Zhu, J. Xu, 2005, Journal of Virology.

The Hsp70 inhibitor 2-phenylethynesulfonamide inhibits replication and carcinogenicity of Epstein–Barr virus by inhibiting the molecular chaperone function of Hsp70

Huan Wang, Weisi Guo, Yaqian Zhang, 2018, Cell Death & Disease.

The N‐terminal ubiquitin‐associated domain of Cezanne is crucial for its function to suppress NF‐κB pathway

Liu Cao, Yu Chen, D. Guo, 2018, Journal of cellular biochemistry.

Identification of AaCASPS7, an effector caspase in Aedes albopictus.

H. Liu, D. Guo, Jialu Qiao, 2016, Gene.

Reverse genetics systems for SARS‐CoV‐2

D. Guo, Xiaoxue Peng, Ji-An Pan, 2022, Journal of medical virology.

Modulating the tumor microenvironment via oncolytic virus and PI3K inhibition synergistically restores immune checkpoint therapy response in PTEN-deficient glioblastoma

D. Guo, Fan Xing, Junyu Wu, 2021, Signal Transduction and Targeted Therapy.

Hepatitis B virus-triggered PTEN/β-catenin/c-Myc signaling enhances PD-L1 expression to promote immune evasion.

Li Tang, Y. Yue, D. Guo, 2019, American journal of physiology. Gastrointestinal and liver physiology.

A novel phosphorylation site in SARS-CoV-2 nucleocapsid regulates its RNA-binding capacity and phase separation in host cells

D. Guo, Fan Xing, Junyu Wu, 2022, Journal of molecular cell biology.

Evidence of Infection of Human Embryonic Stem Cells by SARS-CoV-2

D. Guo, Liu Cao, Fan Xing, 2022, Frontiers in Cellular and Infection Microbiology.

N7-Methylation of the Coronavirus RNA Cap Is Required for Maximal Virulence by Preventing Innate Immune Recognition

S. Perlman, A. Gorbalenya, V. Thiel, 2022, mBio.

A Novel Strategy for Analyzing RNA-Protein Interactions by Surface Plasmon Resonance Biosensor

D. Guo, Yaling Yang, Quan Wang, 2008, Molecular biotechnology.

Innate Immune Responses in Human Monocyte-Derived Dendritic Cells Are Highly Dependent on the Size and the 5′ Phosphorylation of RNA Molecules

D. Bamford, P. Österlund, I. Julkunen, 2011, The Journal of Immunology.

Highly Dependent on the Size and the 5 Monocyte-Derived Dendritic Cells Are Innate Immune Responses in Human JulkunenPoranen

D. Bamford, P. Österlund, L. P. Sarin, 2011 .

Inhibition of Hepatitis B Virus Gene Expression and Replication by Hepatocyte Nuclear Factor 6

Yu Chen, D. Guo, Guojun Yu, 2015, Journal of Virology.

Hepatitis B virus‐regulated growth of liver cancer cells occurs through the microRNA‐340‐5p‐activating transcription factor 7‐heat shock protein A member 1B axis

Jun Luo, Mingxiong Guo, Xiaolu Li, 2019, Cancer science.

Co-infecting pathogens can contribute to inflammatory responses and severe symptoms in COVID-19

M. Shi, E. Holmes, N. Zhong, 2020, Journal of thoracic disease.

A Specific Cytotoxic T-lymphocyte Epitope Presentation System for Antitumor Immunity

D. Guo, Hexiao Shen, ChangZhen Liu, 2022 .

Severe acute respiratory syndrome coronavirus protein 6 mediates ubiquitin-dependent proteosomal degradation of N-Myc (and STAT) interactor

Yu Chen, D. Guo, Weijia Cheng, 2015, Virologica Sinica.

Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle East respiratory syndrome coronavirus

Yu Chen, D. Guo, Yi Wang, 2015, Virus Research.

The adenosine analog prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variants

M. Shi, Jincun Zhao, Feng Cong, 2022, Science Translational Medicine.

VHL negatively regulates SARS coronavirus replication by modulating nsp16 ubiquitination and stability

Yu Chen, D. Guo, Shuliang Chen, 2015, Biochemical and Biophysical Research Communications.

Structure-Function Analysis of Severe Acute Respiratory Syndrome Coronavirus RNA Cap Guanine-N7-Methyltransferase

Ying Sun, T. Ahola, S. Qiu, 2013, Journal of Virology.

Biochemical characterization of exoribonuclease encoded by SARS coronavirus.

Ping Chen, Xiaojiang S. Chen, D. Guo, 2007, Journal of biochemistry and molecular biology.

Bivalent Copper Ions Promote Fibrillar Aggregation of KCTD1 and Induce Cytotoxicity

D. Guo, Zhi-li Ma, Feifei Song, 2016, Scientific Reports.

Current status of severe fever with thrombocytopenia syndrome in China

F. Zhan, D. Guo, Qin Wang, 2017, Virologica Sinica.

Identification and Characterization of Severe Acute Respiratory Syndrome Coronavirus Subgenomic RNAs

P. Tien, Ying Zhu, J. Xu, 2006, Advances in experimental medicine and biology.

Molecular diagnosis of central nervous system opportunistic infections and mortality in HIV-infected adults in Central China

Y. Xiong, D. Guo, W. Hou, 2017, AIDS Research and Therapy.

Translational control of the subgenomic RNAs of severe acute respiratory syndrome coronavirus

D. Guo, Snawar Hussain, Yaling Yang, 2009, Virus Genes.

PTEN-L promotes type I interferon responses and antiviral immunity

Hongyun Wang, Yu Chen, D. Guo, 2017, Cellular & Molecular Immunology.

ORF8 protein of SARS‐CoV‐2 reduces male fertility in mice

Kui-biao Li, D. Guo, Tingting Yu, 2022, Journal of medical virology.

HIV-1 inhibition in cells with CXCR4 mutant genome created by CRISPR-Cas9 and piggyBac recombinant technologies

D. Guo, W. Hou, Li Wu, 2018, Scientific Reports.

The functions of tumor suppressor PTEN in innate and adaptive immunity

D. Guo, Lang Chen, 2017, Cellular &Molecular Immunology.

Phosphorylation of Ser82 on IRF3 Acts as Negative-feedback Regulation of IRF3-dependent Innate Immunity.

D. Guo, Xue Liu, Q. Cheng, 2022, The international journal of biochemistry & cell biology.

P200 family protein IFI204 negatively regulates type I interferon responses by targeting IRF7 in nucleus

Liu Cao, Yu Chen, Qianyun Liu, 2019, PLoS pathogens.

SARS-CoV nucleocapsid protein antagonizes IFN-β response by targeting initial step of IFN-β induction pathway, and its C-terminal region is critical for the antagonism

Ji’an Pan, D. Guo, Jiali Tao, 2010, Virus Genes.

Old Weapon for New Enemy: Drug Repurposing for Treatment of Newly Emerging Viral Diseases

D. Guo, 2020, Virologica Sinica.

Characterization of the guanine-N7 methyltransferase activity of coronavirus nsp14 on nucleotide GTP

Ying Sun, Yu Chen, D. Guo, 2013, Virus Research.

Hepatitis B e Antigen Inhibits NF-κB Activity by Interrupting K63-Linked Ubiquitination of NEMO

Yu Chen, D. Guo, Liang Guo, 2018, Journal of Virology.

An unconventional role of an ASB family protein in NF-κB activation and inflammatory response during microbial infection and colitis

Yingfang Liu, Yu Chen, D. Guo, 2021, Proceedings of the National Academy of Sciences.

Global analysis of HBV-mediated host proteome and ubiquitylome change in HepG2.2.15 human hepatoblastoma cell line

D. Guo, Xiaojun Peng, Long Lu, 2021, Cell & bioscience.

Phosphorylation of RNA Molecules ¢ Highly Dependent on the Size and the 5 Monocyte-Derived Dendritic Cells Are Innate Immune Responses in Human

D. Bamford, P. Österlund, L. P. Sarin, 2011 .

Activity of IFN Regulatory Factor 3 Controls Nuclear Import and DNA-Binding Bipartite Nuclear Localization Signal

D. Guo, K. Meng, Ting Fang, 2015 .

Short peptides derived from the interaction domain of SARS coronavirus nonstructural protein nsp10 can suppress the 2′-O-methyltransferase activity of nsp10/nsp16 complex

Ying Sun, Yu Chen, D. Guo, 2012, Virus Research.

Immunization with plasmid DNA encoding influenza A virus nucleoprotein fused to a tissue plasminogen activator signal sequence elicits strong immune responses and protection against H5N1 challenge in mice.

Z. Pan, Pan Tao, D. Guo, 2008, Journal of virological methods.

Identification and Structure-Activity Relationships of Diarylhydrazides as Novel Potent and Selective Human Enterovirus Inhibitors.

P. Tien, Hai-Bing Zhou, C. Dong, 2016, Journal of medicinal chemistry.

AMIGO2 modulates T cell functions and its deficiency in mice ameliorates experimental autoimmune encephalomyelitis

R. Lahesmaa, Mohd Moin Khan, J. Kuja-Panula, 2017, Brain, Behavior, and Immunity.

A soluble DR5‐Fc chimeric protein attenuates inflammatory responses induced by coronavirus MHV‐A59 and SARS‐CoV‐2

D. Guo, Zengyi Ma, Lihong Liu, 2022, Journal of medical virology.

Meterials and Methods Mhv Preparation Rnp Purification and Sds-page Gel Analysis

Y. Xiang, M. Gui, Yu Chen, 2022 .

Expression, purification, and secondary structure characterization of recombinant KCTD1

P. Tien, Gengfu Xiao, D. Guo, 2012, Biochemistry (Moscow).

NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury

Huanhuan Liang, Yingfang Liu, D. Guo, 2017, Nature Communications.

Bone marrow-derived mesenchymal stem cells suppress NK cell recruitment and activation in PolyI:C-induced liver injury.

D. Guo, Changyong Li, Jinming Shi, 2015, Biochemical and biophysical research communications.

Bone Marrow-Derived Mesenchymal Stem Cells Attenuate Immune-Mediated Liver Injury and Compromise Virus Control During Acute Hepatitis B Virus Infection in Mice.

D. Guo, Changyong Li, Dan Liu, 2017, Stem cells and development.

Upregulation of miR-520c-3p via hepatitis B virus drives hepatocellular migration and invasion by the PTEN/AKT/NF-κB axis

junwei sun, Mingxiong Guo, Yunbo Shi, 2022, Molecular therapy. Nucleic acids.

Coronavirus nsp10/nsp16 Methyltransferase Can Be Targeted by nsp10-Derived Peptide In Vitro and In Vivo To Reduce Replication and Pathogenesis

Ying Sun, T. Ahola, Yu Chen, 2015, Journal of Virology.

Bovine PrPC directly interacts with alphaB-crystalline.

P. Tien, Gengfu Xiao, Mingxiong Guo, 2005, FEBS letters.

Circulation of human metapneumovirus among children with influenza‐like illness in Wuhan, China

Q. Hu, D. Zhou, Bin Yu, 2016, Journal of medical virology.

Synthetic toll-like receptor 7 agonist as a conjugated adjuvant enhances the Th 1 type immunogenicity of influenza virus vaccine

Xinping Huang, D. Guo, B. Liu, 2009 .

Comparison of model‐specific histopathology in mouse models of COVID‐19

D. Guo, Jing-diao Chen, B. Ke, 2022, Journal of medical virology.

PML Body Component Sp100A Is a Cytosolic Responder to IFN and Activator of Antiviral ISGs

D. Guo, Yilei Ma, Jingjing Li, 2022, mBio.

Transmission Patterns of Seasonal Influenza in China between 2010 and 2018

Dayan Wang, Y. Shu, Lei Yang, 2022, Viruses.

Identification and characterization of a ribose 2 O methyltransferase encoded by ′ the ronivirus branch of

Chen, Yu, B. Neuman, 2017 .

Identification and Characterization of a Ribose 2′-O-Methyltransferase Encoded by the Ronivirus Branch of Nidovirales

B. Neuman, T. Ahola, Yu Chen, 2016, Journal of Virology.

Identification and Characterization of a Ribose 2 ′-O-Methyltransferase Encoded 1 by the Ronivirus Branch of Nidovirales 2

Chen, Ying Sun, Yu, 2016 .

Gelsolin deposits in renal tissues of the patients with lupus nephritis

B. Liu, D. Guo, D. Sun, 2016 .

Gene Silencing Efficiency and INF-β Induction Effects of Splicing miRNA 155-Based Artificial miRNA with Pre-miRNA Stem-Loop Structures

D. Guo, T. Hu, Ying Sun, 2012, Biochemical Genetics.

Virome characterization of game animals in China reveals a spectrum of emerging pathogens

M. Suchard, P. Lemey, M. Shi, 2022, Cell.

Characterization of a novel Cullin5 binding domain in HIV-1 Vif.

Y. Xiong, D. Guo, Wenyan Zhang, 2007, Journal of molecular biology.

CCR5 editing by Staphylococcus aureus Cas9 in human primary CD4+ T cells and hematopoietic stem/progenitor cells promotes HIV-1 resistance and CD4+ T cell enrichment in humanized mice

D. Guo, W. Hou, Dongcheng Wu, 2019, Retrovirology.

The adenosine analogue prodrug ATV006 is orally bioavailable and has potent preclinical efficacy against SARS-CoV-2 and its variants

Jincun Zhao, Feng Cong, D. Guo, 2021, bioRxiv.

Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models

Jincun Zhao, Liu Cao, Feng Cong, 2021, Journal of medicinal chemistry.

Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models

Jincun Zhao, Liu Cao, Feng Cong, 2020, bioRxiv.

Metatranscriptomic Analysis Reveals the Virome and Viral Genomic Evolution of Medically Important Mites

M. Shi, D. Guo, Zhigang Liu, 2020, Journal of Virology.

Molecular and pathological characterization of two H5N1 avian influenza viruses isolated from wild ducks

D. Guo, H. Cai, Qingzhen Liu, 2008, Virus Genes.

Molecular diagnosis of central nervous system opportunistic infections and mortality in HIV-infected adults in Central China

Y. Xiong, D. Guo, W. Hou, 2017, AIDS research and therapy.

Virus-like particle vaccine comprised of the HA, NA, and M1 proteins of an avian isolated H5N1 influenza virus induces protective immunity against homologous and heterologous strains in mice.

Z. Pan, Pan Tao, D. Guo, 2009, Viral immunology.

Inhibition of HIV-1 Transcription and Replication by a Newly Identified Cyclin T1 Splice Variant*

Xiaoyun Wu, Johnny J. He, D. Guo, 2013, The Journal of Biological Chemistry.

A Convenient and Biosafe Replicon with Accessory Genes of SARS-CoV-2 and Its Potential Application in Antiviral Drug Discovery

M. Shi, Liu Cao, D. Guo, 2021, Virologica Sinica.

Dopamine signaling regulates the projection patterns in the mouse chiasm

Xinping Huang, D. Guo, S. Chan, 2015, Brain Research.

The RNA Capping Enzyme Domain in Protein A is Essential for Flock House Virus Replication

T. Ahola, Yu Chen, D. Guo, 2018, Viruses.

Chimeric classical swine fever (CSF)-Japanese encephalitis (JE) viral replicon as a non-transmissible vaccine candidate against CSF and JE infections.

Robert W. Li, Z. Pan, Ling Li, 2012, Virus research.

Identification of small interfering RNAs which inhibit the replication of several Enterovirus 71 strains in China.

Fan Yang, D. Guo, Lina Zhao, 2009, Journal of virological methods.

Antiviral Activity of Interferon Alpha-Inducible Protein 27 Against Hepatitis B Virus Gene Expression and Replication

Yu Chen, D. Guo, M. Shereen, 2021, Frontiers in Microbiology.

Specific Expression of Interferon-γ Induced by Synergistic Activation Mediator-Derived Systems Activates Innate Immunity and Inhibits Tumorigenesis.

D. Guo, W. Hou, Zhan-Qiu Yang, 2017, Journal of microbiology and biotechnology.

Inhibition of hepatitis B virus by the CRISPR/Cas9 system via targeting the conserved regions of the viral genome.

Yu Chen, D. Guo, Shuliang Chen, 2015, The Journal of general virology.

Hepatitis B Virus Polymerase Suppresses NF-κB Signaling by Inhibiting the Activity of IKKs via Interaction with Hsp90β

D. Guo, Andong Wu, Y. Wang, 2014, PloS one.

Human immunodeficiency virus coinfection with hepatitis B virus leads to a decrease in extracellular and intracellular hepatitis B antigen.

W. Pan, Shuwen Wu, D. Guo, 2015, AIDS research and human retroviruses.

Mechanisms and Effects on HBV Replication of the Interaction between HBV Core Protein and Cellular Filamin B

Rongrong Hua, D. Guo, Yishuang Sun, 2018, Virologica Sinica.

Hepatitis B Virus Induces Autophagy to Promote its Replication by the Axis of miR‐192‐3p‐XIAP Through NF kappa B Signaling

Mingxiong Guo, Yunbo Shi, D. Guo, 2019, Hepatology.

Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq

M. Shi, Yuedong Yang, Huicui Meng, 2021, Signal Transduction and Targeted Therapy.

Knockdown of Cellular RNA Helicase DDX3 by Short Hairpin RNAs Suppresses HIV-1 Viral Replication Without Inducing Apoptosis

D. Guo, Qingzhen Liu, M. Ishaq, 2008, Molecular biotechnology.

USP10 regulates B cell response to SARS-CoV-2 or HIV-1 nanoparticle vaccines through deubiquitinating AID

J. Liu, Xin He, T. Pan, 2022, Signal Transduction and Targeted Therapy.

Comparative Studies of Various Artificial microRNA Expression Vectors for RNAi in Mammalian Cells

Ping Chen, D. Guo, T. Hu, 2010, Molecular biotechnology.

Construction of an Artificial MicroRNA Expression Vector for Simultaneous Inhibition of Multiple Genes in Mammalian Cells

Ping Chen, D. Guo, T. Hu, 2009, International journal of molecular sciences.

A systems biology perspective on rational design of peptide vaccine against virus infections.

Jiajia Chen, Bairong Shen, Ying Wang, 2012, Current topics in medicinal chemistry.

Endogenous reverse transcriptase and RNase H-mediated antiviral mechanism in embryonic stem cells

Junjiu Huang, Liu Cao, D. Guo, 2021, Cell Research.

CRISPR-Cas Targeting of Host Genes as an Antiviral Strategy

D. Guo, Shuliang Chen, Xiao Yu, 2018, Viruses.

Regulation of the Alternative Splicing and Function of Cyclin T1 by the Serine‐Arginine‐Rich Protein ASF/SF2

D. Guo, Guozhen Gao, Panpan Hou, 2017, Journal of cellular biochemistry.

Application of CRISPR/Cas9-Based Gene Editing in HIV-1/AIDS Therapy

D. Guo, Shuliang Chen, Qiao Xiao, 2019, Front. Cell. Infect. Microbiol..

A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220.

Hong Wang, Zhixiang Zuo, Cedric E. Dos Santos, 2017, Cancer research.

Expression, purification, and secondary structure characterization of recombinant KCTD1

P. Tien, Gengfu Xiao, D. Guo, 2012, Biochemistry (Moscow).

Current status of severe fever with thrombocytopenia syndrome in China

F. Zhan, D. Guo, Qin Wang, 2017, Virologica Sinica.

A Novel Approach to Block HIV-1 Coreceptor CXCR4 in Non-toxic Manner

D. Guo, Ji-An Pan, Jieqiong Zhou, 2014, Molecular Biotechnology.

Lentiviral vector-derived shRNAs confer enhanced suppression of Semliki forest virus replication in BHK-21 cells compared to shRNAs expressed from plasmids

T. Ahola, Ji’an Pan, Yu Chen, 2009, Biotechnology Letters.

Generation of a stable mammalian cell line for simultaneous expression of multiple genes by using 2A peptide-based lentiviral vector

Ping Chen, D. Guo, T. Hu, 2009, Biotechnology Letters.

Pathogens and epidemiologic feature of severe fever with thrombocytopenia syndrome in Hubei province, China

F. Zhan, D. Guo, Jing Cheng, 2017, Virus Research.

The tumor suppressor PTEN has a critical role in antiviral innate immunity

Yuxin Yin, E. Jokitalo, H. Shu, 2015, Nature Immunology.

Biochemical and Structural Insights into the Mechanisms of SARS Coronavirus RNA Ribose 2′-O-Methylation by nsp16/nsp10 Protein Complex

Ying Sun, T. Ahola, P. Tien, 2011, PLoS pathogens.

NSUN2-mediated m5C methylation of IRF3 mRNA negatively regulates type I interferon responses

Hongyun Wang, Hao Tang, Yu Chen, 2021, bioRxiv.

Non-Structural Protein 5 of Zika Virus Interacts with p53 in Human Neural Progenitor Cells and Induces p53-Mediated Apoptosis

D. Guo, Miao He, Junyu Wu, 2021, Virologica Sinica.

Isolation of Virus from a SARS Patient and Genome-wide Analysis of Genetic Mutations Related to Pathogenesis and Epidemiology from 47 SARS-CoV Isolates

P. Tien, Gengfu Xiao, Mo Liu, 2005, Virus Genes.

Genome editing of the HIV co-receptors CCR5 and CXCR4 by CRISPR-Cas9 protects CD4+ T cells from HIV-1 infection

D. Guo, W. Hou, Li Wu, 2017, Cell & Bioscience.

Hepatitis B e antigen and its precursors promote the progress of hepatocellular carcinoma by interacting with NUMB and decreasing p53 activity

Lei Cui, D. Guo, Dan Liu, 2016, Hepatology.

Specific inhibition of HIV‐1 replication by short hairpin RNAs targeting human cyclin T1 without inducing apoptosis

P. Tien, Y. Xiong, Yu Peng, 2005, FEBS letters.

Hepatitis B virus promotes cancer cell migration by downregulating miR-340-5p expression to induce STAT3 overexpression

D. Guo, C. Fan, Lang Chen, 2017, Cell & Bioscience.

NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury

Huanhuan Liang, Yingfang Liu, D. Guo, 2017, Nature Communications.

SARS-CoV-2's origin should be investigated worldwide for pandemic prevention

Weizhong Yang, Guizhen Wu, L. Ren, 2021, The Lancet.

A distinct name is needed for the new coronavirus

Wenjie Tan, Shibo Jiang, Jingdong Song, 2020, The Lancet.

Single mutation at the amino acid position 627 of PB2 that leads to increased virulence of an H5N1 avian influenza virus during adaptation in mice can be compensated by multiple mutations at other sites of PB2.

D. Guo, T. Hu, Qingzhen Liu, 2009, Virus research.

Isolation and characterization of spontaneously immortalized B‐lymphocyte lines from HIV‐infected patients with and without non‐Hodgkin's Lymphoma

Han Liu, Li Liu, F. Zhou, 2019, Cancer medicine.

M2 pyruvate kinase enhances HIV-1 transcription from its long terminal repeat

D. Guo, T. Hu, M. Ishaq, 2010, Frontiers in Biology.

The Ubiquitin E3 Ligase Parkin Inhibits Innate Antiviral Immunity Through K48-Linked Polyubiquitination of RIG-I and MDA5

D. Guo, M. He, Yuanyuan Cao, 2020, Frontiers in Immunology.

CCDC50 suppresses NLRP3 inflammasome activity by mediating autophagic degradation of NLRP3

D. Guo, Zibo Li, Miao He, 2022, EMBO reports.

A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection

Yingfang Liu, Jun Li, Ji’an Pan, 2020, Cell Research.

The sumoylation of zinc‐fingers and homeoboxes 1 (ZHX1) by ubc9 regulates its stability and transcriptional repression activity

D. Guo, Lixin Ma, Shuliang Chen, 2013, Journal of Cellular Biochemistry.

Immune regulator ABIN1 suppresses HIV-1 transcription by negatively regulating the ubiquitination of Tat

Liu Cao, Yu Chen, D. Guo, 2017, Retrovirology.

Genome modification of CXCR4 by Staphylococcus aureus Cas9 renders cells resistance to HIV-1 infection

D. Guo, Wenzhe Ho, W. Hou, 2017, Retrovirology.

Ubiquitin ligase Fbw7 restricts the replication of hepatitis C virus by targeting NS5B for ubiquitination and degradation.

Yu Chen, D. Guo, N. Xiang, 2016, Biochemical and biophysical research communications.

HIV-1 inhibition in cells with CXCR4 mutant genome created by CRISPR-Cas9 and piggyBac recombinant technologies

D. Guo, W. Hou, Li Wu, 2018, Scientific Reports.

Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors.

D. Guo, Liu Yang, C. Fan, 2021, Journal of agricultural and food chemistry.

Bipartite Nuclear Localization Signal Controls Nuclear Import and DNA-Binding Activity of IFN Regulatory Factor 3

K. Meng, D. Guo, Mingzhu Zhu, 2015, The Journal of Immunology.

Bovine PrPC directly interacts with αB‐crystalline

Rui Gong, Ao Shen, P. Tien, 2005 .

Protein-protein interactions: the yeast two-hybrid system.

J. Valkonen, D. Guo, M. Rajamäki, 2008, Methods in molecular biology.

Functional Characterization of Syncytin-A, a Newly Murine Endogenous Virus Envelope Protein

Shuli Kang, P. Tien, Gengfu Xiao, 2007, Journal of Biological Chemistry.

Autophagy receptor CCDC50 tunes the STING-mediated interferon response in viral infections and autoimmune diseases

D. Guo, J. Gu, Zibo Li, 2021, Cellular & Molecular Immunology.

Inhibition of hepatitis B virus replication by activation of the cGAS-STING pathway.

Y. Wang, P. Tien, D. Guo, 2016, The Journal of general virology.

The epidemiology and etiology of influenza‐like illness in Chinese children from 2008 to 2010

Q. Hu, D. Zhou, Bin Yu, 2012, Journal of medical virology.

A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection

Yingfang Liu, Ji’an Pan, D. Guo, 2020, Cell Research.

The Functional and Antiviral Activity of Interferon Alpha-Inducible IFI6 Against Hepatitis B Virus Replication and Gene Expression

Yu Chen, D. Guo, M. Shereen, 2021, Frontiers in Immunology.

Suppression of HIV-1 Integration by Targeting HIV-1 Integrase for Degradation with A Chimeric Ubiquitin Ligase

D. Guo, W. Hou, Lang Chen, 2020, Virologica Sinica.

Genome editing of CXCR4 by CRISPR/cas9 confers cells resistant to HIV-1 infection

Yu Chen, D. Guo, Wenzhe Ho, 2015, Scientific Reports.

Emerging coronaviruses: Genome structure, replication, and pathogenesis

Qianyun Liu, Yu Chen, Qianyun Liu, 2020, Journal of medical virology.

Electron microscopy studies of the coronavirus ribonucleoprotein complex

Y. Xiang, M. Gui, Yu Chen, 2017, Protein & Cell.

Safety and Considerations of the COVID-19 Vaccine Massive Deployment

D. Guo, Yongxiang Yi, Junwei Li, 2021, Virologica Sinica.

RNA Cap Guanine-N7-Methyltransferase Acute Respiratory Syndrome Coronavirus Structure-Function Analysis of Severe

T. Ahola, S. Qiu, Yingliang Wu, 2014 .

Suppression of USP8 sensitizes cells to ferroptosis via SQSTM1/p62-mediated ferritinophagy

D. Guo, Zengyi Ma, Chuanxin Huang, 2022, Protein & cell.

Aptamer beacons for visualization of endogenous protein HIV-1 reverse transcriptase in living cells.

Qinxue Hu, Zhi-ping Zhang, Xian-En Zhang, 2011, Biosensors & bioelectronics.

ABIN1 inhibits HDAC1 ubiquitination and protects it from both proteasome‐ and lysozyme‐dependent degradation

Xueqing Li, D. Guo, Dongcheng Wu, 2018, Journal of cellular biochemistry.

Coronavirus: epidemiology, genome replication and the interactions with their hosts

P. Rottier, D. Guo, Z. Shí, 2016, Virologica Sinica.

Hepatitis B virus promotes cancer cell migration by downregulating miR-340-5p expression to induce STAT3 overexpression

D. Guo, C. Fan, Lang Chen, 2017, Cell & Bioscience.

SARS-CoV-2 ORF3a sensitizes cells to ferroptosis via Keap1-NRF2 axis

D. Guo, Xue Liu, C. Ke, 2023, Redox biology.

Combining thioridazine and loratadine for the treatment of gastrointestinal tumor

B. Liu, Xinping Huang, D. Guo, 2017, Oncology letters.

PACT inhibits the replication of SARS‐CoV‐2 through the blockage of GSK‐3β‐N‐nsp3 cascade

Jia-Yu Pan, D. Guo, Xiaoxue Peng, 2023, Journal of medical virology.

SARS-CoV-2 ORF3a sensitizes cells to ferroptosis via Keap1-NRF2 axis

D. Guo, Xue Liu, C. Ke, 2023, Redox Biology.

The Impact of Accumulated Mutations in SARS-CoV-2 Variants on the qPCR Detection Efficiency

D. Guo, Tiefeng Xu, Yanxi Ji, 2022, Frontiers in Cellular and Infection Microbiology.

A comprehensive evolutionary and epidemiological characterization of insertion and deletion mutations in SARS-CoV-2 genomes

M. Shi, D. Guo, Liu Cao, 2021, Virus evolution.

Genome editing of the HIV co-receptors CCR5 and CXCR4 by CRISPR-Cas9 protects CD4+ T cells from HIV-1 infection

D. Guo, W. Hou, Li Wu, 2017, Cell & Bioscience.

Distinct and relatively mild clinical characteristics of SARS-CoV-2 BA.5 infections against BA.2

D. Guo, Yang Yang, Yuchen Gu, 2023, Signal transduction and targeted therapy.

Genome scale screening identification of SaCas9/gRNAs for targeting HIV-1 provirus and suppression of HIV-1 infection.

Z. Ke, D. Guo, Shuliang Chen, 2018, Virus research.

Live attenuated coronavirus vaccines deficient in N7-Methyltransferase activity induce both humoral and cellular immune responses in mice

Yu Chen, Qianyun Liu, D. Guo, 2021, Emerging microbes & infections.

The Hsp70 inhibitor 2-phenylethynesulfonamide inhibits replication and carcinogenicity of Epstein–Barr virus by inhibiting the molecular chaperone function of Hsp70

Huan Wang, Yaqian Zhang, W. Guo, 2018, Cell Death & Disease.

The RNA polymerase of cytoplasmically replicating Zika virus binds with chromatin DNA in nuclei and regulates host gene transcription

D. Guo, Niu Wang, Fan Xing, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Amino acid derivatives of the (-) enantiomer of gossypol are effective fusion inhibitors of human immunodeficiency virus type 1.

Shuwen Wu, P. Tien, Jian Yang, 2012, Antiviral research.

CDK4/6 inhibition enhances oncolytic virus efficacy by potentiating tumor-selective cell killing and T cell activation in refractory glioblastoma.

D. Guo, Kai Li, Fan Xing, 2022, Cancer research.

Individual bat virome analysis reveals co-infection and spillover among bats and virus zoonotic potential

M. Shi, E. Holmes, D. Guo, 2023, Nature communications.

DDB1 is a cellular substrate of NS3/4A protease and required for hepatitis C virus replication.

Xi Chen, Lin Guo, H. Shu, 2013, Virology.

DDB 1 is a cellular substrate of NS 3 / 4 A protease and required for hepatitis C virus replication

Xi Chen, Lin Guo, H. Shu, 2012 .

Individual bat viromes reveal the co-infection, spillover and emergence risk of potential zoonotic viruses

M. Shi, E. Holmes, Bo Li, 2022, bioRxiv.

CCR5 editing by Staphylococcus aureus Cas9 in human primary CD4+ T cells and hematopoietic stem/progenitor cells promotes HIV-1 resistance and CD4+ T cell enrichment in humanized mice

D. Guo, W. Hou, Dongcheng Wu, 2019, Retrovirology.

Artificial intelligence redefines RNA virus discovery

M. Shi, E. Holmes, Jun-hua Tian, 2023, bioRxiv.

Isoform‐specific interaction of pyruvate kinase with hepatitis C virus NS5B

D. Guo, You Zhou, Qingzhen Liu, 2008, FEBS letters.

The functions of tumor suppressor PTEN in innate and adaptive immunity

D. Guo, Lang Chen, 2017, Cellular &Molecular Immunology.

HBV X Protein Induces Degradation of UBXN7, a Novel Negative Regulator of NF-κB Signaling, to Promote HBV Replication

junwei sun, Mingxiong Guo, D. Guo, 2022, Cellular and molecular gastroenterology and hepatology.

The regulation of NLRP3 inflammasome activation by CCDC50-mediated autophagy

D. Guo, Zibo Li, Panpan Hou, 2022, Autophagy.

Hepatitis B Virus Induces Autophagy to Promote its Replication by the Axis of miR-1923 p-XIAP via NF-κB Signaling

Mingxiong Guo, Yunbo Shi, D. Guo, 2018 .

The tumor suppressor PTEN has a critical role in antiviral innate immunity

Yuxin Yin, E. Jokitalo, H. Shu, 2015, Nature Immunology.

Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase

T. Ahola, P. Tien, Ji’an Pan, 2009, Proceedings of the National Academy of Sciences.

NSUN2-mediated m5C methylation of IRF3 mRNA negatively regulates type I interferon responses during various viral infections

Xiaoping Zhou, Hongyun Wang, Hao Tang, 2023, Emerging microbes & infections.

Comparative Studies of Various Artificial microRNA Expression Vectors for RNAi in Mammalian Cells

Ping Chen, D. Guo, T. Hu, 2010, Molecular biotechnology.

A specific cytotoxic T‐lymphocyte epitope presentation system for antitumor immunity

D. Guo, Hexiao Shen, ChangZhen Liu, 2009, International journal of cancer.

Synthesis of deuterated S-217622 (Ensitrelvir) with antiviral activity against coronaviruses including SARS-CoV-2

Ming Yan, Feng Cong, D. Guo, 2023, Antiviral Research.

A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220.

Hong Wang, Zhixiang Zuo, Cedric E. Dos Santos, 2017, Cancer research.

Repurposing Old Drugs as Novel Inhibitors of Human MIF from Structural and Functional Analysis.

D. Guo, Liu Yang, C. Fan, 2021, Bioorganic & medicinal chemistry letters.

Using artificial intelligence to document the hidden RNA virosphere

E. Holmes, Jun-hua Tian, D. Guo, 2024, bioRxiv.