Xiaotao Lu

发表

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

Xiaotao Lu, Alexandra Schäfer, Ralph S. Baric, 2020, Science Translational Medicine.

Tomlinson-Harashima Precoding Algorithms for Physical-Layer Security in Wireless Networks

R. D. Lamare, Xiaotao Lu, Keke Zu, 2016 .

Non-Linear Precoding Techniques for Physical-Layer Security in Wireless Networks

Xiaotao Lu, 2015 .

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

Xiaotao Lu, Ralph S. Baric, Amy C. Sims, 2018, mBio.

Identification and Characterization of Severe Acute Respiratory Syndrome Coronavirus Replicase Proteins

K. Subbarao, J. McAuliffe, Xiaotao Lu, 2004, Journal of Virology.

The coronavirus proofreading exoribonuclease mediates extensive viral recombination

A. Pruijssers, Maria L. Agostini, Laura J. Stevens, 2020, bioRxiv.

Genetic Analysis of Murine Hepatitis Virus nsp4 in Virus Replication

Xiaotao Lu, M. Denison, Jennifer S Sparks, 2007, Journal of Virology.

Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice

R. Baric, T. Sheahan, A. Pruijssers, 2020, Cell Reports.

Proofreading-deficient coronaviruses adapt over long-term passage for increased fidelity and fitness without reversion of exoribonuclease-inactivating mutations

Kevin W Graepel, Xiaotao Lu, M. Denison, 2017, bioRxiv.

Proofreading-Deficient Coronaviruses Adapt for Increased Fitness over Long-Term Passage without Reversion of Exoribonuclease-Inactivating Mutations

Kevin W Graepel, Xiaotao Lu, M. Denison, 2017, mBio.

Small-Molecule Antiviral β-d-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

R. Baric, A. Kolykhalov, T. Sheahan, 2019, Journal of Virology.

Coronavirus Replicase-Reporter Fusions Provide Quantitative Analysis of Replication and Replication Complex Formation

Rachel L. Graham, Xiaotao Lu, M. Denison, 2014, Journal of Virology.

Chimeric Exchange of Coronavirus nsp5 Proteases (3CLpro) Identifies Common and Divergent Regulatory Determinants of Protease Activity

A. Mesecar, Xiaotao Lu, M. Denison, 2013, Journal of Virology.

Mutations in the SARS-CoV-2 RNA dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms

R. Baric, T. Sheahan, A. Pruijssers, 2022, Science Translational Medicine.

Murine Hepatitis Virus nsp14 Exoribonuclease Activity Is Required for Resistance to Innate Immunity

Kevin W Graepel, Yize Li, S. Weiss, 2017, Journal of Virology.

Mouse hepatitis virus nsp14 exoribonuclease activity is required for resistance to innate immunity

Kevin W Graepel, Yize Li, S. Weiss, 2017, bioRxiv.

Effects of Mutagenesis of Murine Hepatitis Virus NSP1 and NSP14 on Replication in Culture

Xiaotao Lu, M. Denison, L. D. Eckerle, 2006, Advances in experimental medicine and biology.

Cleavage between Replicase Proteins p28 and p65 of Mouse Hepatitis Virus Is Not Required for Virus Replication

R. Baric, B. Yount, Rachel L. Graham, 2004, Journal of Virology.

Intracellular andin Vitro-Translated 27-kDa Proteins Contain the 3C-like Proteinase Activity of the Coronavirus MHV-A59

Xiaotao Lu, M. Denison, Yiqin Lu, 1996, Virology.

Murine hepatitis virus nsp4 N258T mutants are not temperature-sensitive

Xiaotao Lu, M. Denison, S. Baker, 2012, Virology.

Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice

Xiaotao Lu, Alexandra Schäfer, Ralph S. Baric, 2020, bioRxiv.

High Fidelity of Murine Hepatitis Virus Replication Is Decreased in nsp14 Exoribonuclease Mutants

Xiaotao Lu, M. Denison, L. D. Eckerle, 2007, Journal of Virology.

Infidelity of SARS-CoV Nsp14-Exonuclease Mutant Virus Replication Is Revealed by Complete Genome Sequencing

Timothy B. Stockwell, Xiaotao Lu, Kelvin Li, 2010, PLoS pathogens.

Temperature-Sensitive Mutants and Revertants in the Coronavirus Nonstructural Protein 5 Protease (3CLpro) Define Residues Involved in Long-Distance Communication and Regulation of Protease Activity

Xiaotao Lu, M. Denison, Christopher C. Stobart, 2012, Journal of Virology.

Durability of mRNA-1273 vaccine–induced antibodies against SARS-CoV-2 variants

J. Mascola, R. Baric, E. Boritz, 2021, Science.

Identification of a critical horseshoe-shaped region in the nsp5 (Mpro, 3CLpro) protease interdomain loop (IDL) of coronavirus mouse hepatitis virus (MHV)

Xiaotao Lu, M. Denison, E. Hasik, 2020, bioRxiv.

Coronavirus Protein Processing and RNA Synthesis Is Inhibited by the Cysteine Proteinase Inhibitor E64d

R. A. Spence, X. Lu, Xiaotao Lu, 1995, Virology.

A Novel Mutation in Murine Hepatitis Virus nsp5, the Viral 3C-Like Proteinase, Causes Temperature-Sensitive Defects in Viral Growth and Protein Processing

R. Baric, Eric Donaldson, Xiaotao Lu, 2008, Journal of Virology.

Fitness Barriers Limit Reversion of a Proofreading-Deficient Coronavirus

Kevin W Graepel, Maria L. Agostini, Xiaotao Lu, 2019, Journal of Virology.

A mutation in the coronavirus nsp13-helicase impairs enzymatic activity and confers partial remdesivir resistance

S. Darst, E. Campbell, A. Pruijssers, 2023, mBio.

Distinct genetic determinants and mechanisms of SARS-CoV-2 resistance to remdesivir

R. Baric, T. Sheahan, A. Pruijssers, 2022, bioRxiv.

Identification and characterization of a serine-like proteinase of the murine coronavirus MHV-A59

Xiaotao Lu, M. Denison, Y. Lu, 1995, Journal of virology.

Infidelity of SARS-CoV Nsp14-Exonuclease Mutant Virus Replication Is Revealed by Complete Genome Sequencing

Timothy B. Stockwell, R. Baric, Kelvin Li, 2010, PLoS pathogens.