J. Simon

发表

Tailored magnetic nanoparticles for optimizing magnetic fluid hyperthermia.

Kannan M Krishnan, K. Krishnan, R. M. Ferguson, 2012, Journal of biomedical materials research. Part A.

Enhancing cancer therapeutics using size-optimized magnetic fluid hyperthermia.

K. Krishnan, R. M. Ferguson, A. Khandhar, 2012, Journal of applied physics.

Drug screening for hearing loss: using the zebrafish lateral line to screen for drugs that prevent and cause hearing loss.

D. Raible, E. Rubel, J. Simon, 2010, Drug discovery today.

Upregulation of RhoB via c-Jun N-terminal kinase signaling induces apoptosis of the human gastric carcinoma NUGC-3 cells treated with NSC12618.

Kyoung-Jae Won, Y. Oh, M. Won, 2011, Carcinogenesis.

NSC126188, a piperazine alkyl derivative, induces apoptosis via upregulation of RhoB in HeLa cells

M. Won, Bo-Kyung Kim, K. Chung, 2011, Investigational New Drugs.

A Proteomic Investigation of Ligand-dependent HSP90 Complexes Reveals CHORDC1 as a Novel ADP-dependent HSP90-interacting Protein*

J. Simon, J. Gano, Jacob J. Gano, 2009, Molecular & Cellular Proteomics.

Functional Mechanotransduction Is Required for Cisplatin-Induced Hair Cell Death in the Zebrafish Lateral Line

D. Raible, E. Rubel, D. Hailey, 2013, The Journal of Neuroscience.

Composition and Antimicrobial Activity of Anemopsis californica leaf oil.

M. O’Connell, R. Estell, J. Simon, 2005, Journal of agricultural and food chemistry.

An in vivo Biomarker to Characterize Ototoxic Compounds and Novel Protective Therapeutics

D. Raible, E. Rubel, J. Simon, 2022, bioRxiv.

Cerulenin-mediated apoptosis is involved in adenine metabolic pathway.

Seung-Hee Lee, H. Yoo, M. Won, 2006, Biochemical and biophysical research communications.

A small-molecule inhibitor of Tcf/β-catenin signaling down-regulates PPARγ and PPARδ activities

J. Simon, S. Handeli, 2008, Molecular Cancer Therapeutics.

ORC-13661 protects sensory hair cells from aminoglycoside and cisplatin ototoxicity

Esra D. Camci, Nerissa K. Kirkwood, D. Raible, 2019, JCI insight.

Identification of FDA-Approved Drugs and Bioactives that Protect Hair Cells in the Zebrafish (Danio rerio) Lateral Line and Mouse (Mus musculus) Utricle

D. Raible, E. Rubel, J. Simon, 2009, Journal of the Association for Research in Otolaryngology.

A potent peptide-steroid conjugate accumulates in cartilage and reverses arthritis without evidence of systemic corticosteroid exposure

Emily J. Girard, J. Olson, A. Strand, 2020, Science Translational Medicine.

Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies

J. Simon, S. Chowdhury, A. Bedalov, 2020, Molecules.

Development of Pyrazolone and Isoxazol-5-one Cambinol Analogues as Sirtuin Inhibitors

A. Schuler, J. Simon, M. Scian, 2014, Journal of medicinal chemistry.

Inhibitors of Sir2: evaluation of splitomicin analogues.

J. Simon, J. Posakony, M. Hirao, 2004, Journal of medicinal chemistry.

Sirtuin modulators.

J. Simon, A. Bedalov, Vid Leko, 2012, Nature reviews. Drug discovery.

Grb2 SH3 binding to peptides from Sos: evaluation of a general model for SH3-ligand interactions.

S. Schreiber, J. Simon, 1995, Chemistry & biology.

Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions.

S. Schreiber, Hongtao Yu, J. Chen, 1995, Science.

Functional Discovery via a Compendium of Expression Profiles

Yudong D. He, T. Hughes, C. J. Roberts, 2000, Cell.

A small-molecule inhibitor of Tcf / B-catenin signaling down-regulates PPAR ; and PPAR D activities

J. Simon, S. Handeli, 2008 .

The predicted β12–β13 loop is important for inhibition of PP2Acα by the antitumor drug fostriecin

J. Simon, D. Evans, D. R. Evans, 2001 .

The ribonucleoside AICAr induces differentiation of myeloid leukemia by activating the ATR/Chk1 via pyrimidine depletion

J. Simon, Vilma Dembitz, D. Visnjic, 2019, The Journal of Biological Chemistry.

Hair Cell Toxicity in Anti-cancer Drugs: Evaluating an Anti-cancer Drug Library for Independent and Synergistic Toxic Effects on Hair Cells Using the Zebrafish Lateral Line

Y. Hirose, J. Simon, Henry C. Ou, 2011, Journal of the Association for Research in Otolaryngology.

Targeted inhibition of cell-surface serine protease Hepsin blocks prostate cancer bone metastasis

V. Vasioukhin, F. Béliveau, R. Leduc, 2014, Oncotarget.

Activities toward Prostate Carcinoma baicalensis with Antiandrogenic and Growth-Inhibitory Characterization of Chemical Constituents in Scutellaria

P. Nelson, J. Simon, M. Bonham, 2005 .

Neuroscience. NAD to the rescue.

J. Simon, A. Bedalov, 2004, Science.

Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes.

R. DePinho, A. Schuler, R. Kollipara, 2006, Cancer research.

Thymidine incorporation is highly predictive of colony formation and can be used for high-throughput screening.

J. Lamb, J. Simon, S. Goehle, 2001, BioTechniques.

Non-specific chemical inhibition of the Fanconi anemia pathway sensitizes cancer cells to cisplatin

A. D’Andrea, T. Taniguchi, J. Simon, 2012, Molecular Cancer.

Correction: Telomere Length as a Quantitative Trait: Genome-Wide Survey and Genetic Mapping of Telomere Length-Control Genes in Yeast

L. Kruglyak, D. Ruderfer, J. Akey, 2006, PLoS genetics.

Identification of small molecules inducing apoptosis by cell-based assay using fission yeast deletion mutants

Seung-Hee Lee, K. Hoe, Dong-Uk Kim, 2008, Investigational New Drugs.

Screening for chemicals that affect hair cell death and survival in the zebrafish lateral line

D. Raible, E. Rubel, J. Simon, 2012, Hearing Research.

Chemotypic variation of essential oils in the medicinal plant, Anemopsis californica.

M. O’Connell, J. Simon, F. O. Holguin, 2008, Phytochemistry.

Differential toxicities of anticancer agents among DNA repair and checkpoint mutants of Saccharomyces cerevisiae.

L. Hartwell, C. J. Roberts, S. Friend, 2000, Cancer research.

Identification of Genetic and Chemical Modulators of Zebrafish Mechanosensory Hair Cell Death

D. Raible, E. Rubel, J. Simon, 2008, PLoS genetics.

Cell-based assays for identification of novel double-strand break-inducing agents.

P. Szankasi, J. Lamb, M. Cronk, 2002, Journal of the National Cancer Institute.

Hst3 Is Regulated by Mec1-dependent Proteolysis and Controls the S Phase Checkpoint and Sister Chromatid Cohesion by Deacetylating Histone H3 at Lysine 56*

E. Foss, S. Thaminy, J. Simon, 2007, Journal of Biological Chemistry.

Yeast as a model system for anticancer drug discovery

J. Simon, A. Bedalov, 2004, Nature Reviews Cancer.

Identification of Selective Inhibitors of NAD+-dependent Deacetylases Using Phenotypic Screens in Yeast*

Manfred Jung, M. Jung, J. Simon, 2003, Journal of Biological Chemistry.

Identification of a small molecule inhibitor of Sir2p

D. Gottschling, J. Simon, A. Bedalov, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3

Kam Y. J. Zhang, David M. Hockenbery, J. Zimmerberg, 2001, Nature Cell Biology.

Fate plasticity and reprogramming in genetically distinct populations of Danio leucophores

Jennifer C. Lee, J. Lippincott-Schwartz, D. Raible, 2019, Proceedings of the National Academy of Sciences.

NAD‐Dependent Deacetylases as Therapeutic Targets

Hongzhe Li, J. Simon, A. Bedalov, 2009 .

Screen of FDA-approved drug library reveals compounds that protect hair cells from aminoglycosides and cisplatin

Edwin W. Rubel, D. Raible, E. Rubel, 2012, Hearing Research.

Use of Yeast as a Model System for Identifying and Studying Anticancer Drugs

Jun O. Liu, J. Simon, 2007 .

Yeast as a model system for anticancer drug discovery

J. Simon, 2001, Expert opinion on therapeutic targets.

Using Isoform-Specific Inhibitors to Target Lipid Kinases

J. Simon, 2006, Cell.

The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis.

P. Nelson, C. Craik, L. True, 2014, Cancer discovery.

Title : The Androgen-Regulated Protease TMPRSS 2 Activates a Proteolytic Cascade Involving Components of the Tumor Microenvironment and Promotes Prostate Cancer Metastasis

P. Nelson, C. Craik, L. True, 2014 .

NAD to the Rescue

J. Simon, A. Bedalov, 2004, Science.

NAD+-Dependent Deacetylase Hst1p Controls Biosynthesis and Cellular NAD+ Levels in Saccharomyces cerevisiae

J. Simon, Antonio Bedalov, Julian A. Simon, 2003, Molecular and Cellular Biology.

Inhibition of vaccinia virus replication by nitazoxanide.

D. Hockenbery, A. Geballe, J. Simon, 2018, Virology.

Telomere Length as a Quantitative Trait: Genome-Wide Survey and Genetic Mapping of Telomere Length-Control Genes in Yeast

Leonid Kruglyak, Joshua M Akey, L. Kruglyak, 2006, PLoS genetics.

Characterization of Chemical Constituents in Scutellaria baicalensis with Antiandrogenic and Growth-Inhibitory Activities toward Prostate Carcinoma

P. Nelson, J. Simon, M. Bonham, 2005, Clinical Cancer Research.

Chloroquine kills hair cells in zebrafish lateral line and murine cochlear cultures: Implications for ototoxicity

Esra D. Camci, D. Raible, E. Rubel, 2020, Hearing Research.

Phenotypic Optimization of Urea-Thiophene Carboxamides To Yield Potent, Well Tolerated, and Orally Active Protective Agents against Aminoglycoside-Induced Hearing Loss.

D. Raible, E. Rubel, R. J. Herr, 2018, Journal of medicinal chemistry.

Identification and characterization of small-molecule inhibitors of hepsin

J. Chevillet, V. Vasioukhin, J. Simon, 2008, Molecular Cancer Therapeutics.

THE FHCRC/NCI YEAST ANTICANCER DRUG SCREEN

S. Holbeck, J. Simon, 2007 .

Chemical screening for hair cell loss and protection in the zebrafish lateral line.

D. Raible, E. Rubel, J. Simon, 2010, Zebrafish.

RETRACTED: The retinoic acid receptor/CaMKII interaction: Pharmacologic inhibition of CaMKII enhances the differentiation of myeloid leukemia cells

A. Schuler, S. Collins, J. Simon, 2007 .

Retraction notice to "The retinoic acid receptor/CaMKII interaction: pharmacologic inhibition of CaMKII enhances the differentiation of myeloid leukemia cells" [Blood Cells Mol. Dis. 39 (2007) 307-315].

A. Schuler, S. Collins, J. Simon, 2009, Blood Cells, Molecules & Diseases.

Disruption of protein-membrane binding and identification of small-molecule inhibitors of coagulation factor VIII.

B. Stoddard, Shari M. Kaiser, J. Simon, 2004, Chemistry & biology.

Fish in a Dish: Drug Discovery for Hearing Habilitation.

D. Raible, E. Rubel, J. Simon, 2013, Drug discovery today. Disease models.

Enterocyte-Specific Inactivation of SIRT1 Reduces Tumor Load in the APC+/min Mouse Model

J. Simon, A. Bedalov, U. Lao, 2013, PloS one.

Sirtuin modulators.

J. Simon, A. Bedalov, Vid Leko, 2011, Handbook of experimental pharmacology.

Identification of Small Molecule Inhibitors of Cisplatin-Induced Hair Cell Death: Results of a 10,000 Compound Screen in the Zebrafish Lateral Line

D. Raible, E. Rubel, J. Simon, 2015, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

Quinoline Ring Derivatives Protect Against Aminoglycoside-Induced Hair Cell Death in the Zebrafish Lateral Line

D. Raible, E. Rubel, J. Simon, 2012, Journal of the Association for Research in Otolaryngology.

Long-term tracking demonstrates effectiveness of a partnership-led training program to advance the careers of biomedical researchers from underrepresented groups

B. Thompson, J. Simon, S. Holte, 2019, PloS one.

KN-62 analogues as potent differentiating agents of HL-60 cells.

A. Schuler, S. Collins, J. Simon, 2007, Leukemia research.

Screening for chemicals that affect hair cell death and survival in the zebrafish lateral line

D. Raible, E. Rubel, J. Simon, 2012, Hearing Research.

Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes.

R. DePinho, A. Schuler, R. Kollipara, 2006, Cancer research.

Upregulation of RhoB via c-Jun N-terminal kinase signaling induces apoptosis of the human gastric carcinoma NUGC-3 cells treated with NSC12618.

Kyoung-Jae Won, Y. Oh, M. Won, 2011, Carcinogenesis.

Biology, Chemistry, and Pharmacology of Sirtuins.

J. Simon, S. Chowdhury, A. Bedalov, 2016, Methods in enzymology.

Fate plasticity and reprogramming in genetically distinct populations of Danio leucophores

Jennifer C. Lee, J. Lippincott-Schwartz, D. Raible, 2019, Proceedings of the National Academy of Sciences.

Chemotypic variation of essential oils in the medicinal plant, Anemopsis californica.

M. O’Connell, J. Simon, S. Micheletto, 2008, Phytochemistry.