Zihai Li

M. Dhodapkar, N. Puig, M. Samur, 2020, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis.

Y. Hannun, G. Chiosis, B. Ogretmen, 2015, Journal of hepatology.

Targeting inflammasome/IL-1 pathways for cancer immunotherapy

Zihai Li, Bei Liu, B. Guo, 2016, Scientific Reports.

Regulation of dendritic cell function improves survival in experimental sepsis through immune chaperone

Pengfei Li, Zihai Li, Bei Liu, 2019, Innate immunity.

Endoplasmic Reticulum Stress in Multiple Myeloma: From Molecular Mechanisms to Therapeutic Opportunities

Zihai Li, Bei Liu, 2015 .

Erratum: Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone

B. Hao, Matthew M. Staron, Zihai Li, 2012, Nature Communications.

Erratum: Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone

B. Hao, Matthew M. Staron, Zihai Li, 2012, Nature Communications.

chaperoning integrin and TLR but not immunoglobulin Endoplasmic reticulum HSP90b1 (gp96, grp94) optimizes B cell function via

Zihai Li, Bei Liu, 2008 .

Concomitant Medication Effects on Immune Checkpoint Inhibitor Efficacy and Toxicity

Zihai Li, M. Gatti-Mays, J. Strauss, 2022, Frontiers in Oncology.

Development of molecular and pharmacological switches for chimeric antigen receptor T cells

Zihai Li, B. Riesenberg, No-Joon Song, 2019, Experimental Hematology & Oncology.

Sex differences in bladder cancer: emerging data and call to action

D. Theodorescu, Zihai Li, Xue Li, 2022, Nature Reviews Urology.

Combination of Imatinib Mesylate with Autologous Leukocyte-Derived Heat Shock Protein and Chronic Myelogenous Leukemia

P. Srivastava, C. Runowicz, U. Hegde, 2005, Clinical Cancer Research.

Determining the Role of TLR Agonists in T Cell-Based Cancer Therapy

S. Mehrotra, K. Majchrzak, Zihai Li, 2021 .

Harnessing the IL-7/IL-7Rα axis to improve tumor immunotherapy

S. Mehrotra, J. Wrangle, Zihai Li, 2016, Oncoimmunology.

blunts oral squamous cancer development and dampens the functional expansion of myeloid-derived suppressor cells

Hong-gang Yu, Yongliang Zhang, Zihai Li, 2016 .

CD24 blunts oral squamous cancer development and dampens the functional expansion of myeloid-derived suppressor cells

Hong-gang Yu, Yongliang Zhang, Zihai Li, 2016, Oncoimmunology.

Cell surface expression of heat shock protein gp96 enhances cross-presentation of cellular antigens and the generation of tumor-specific T cell memory.

Zihai Li, Hong Zheng, J. Dai, 2003, Cancer immunity.

Heat shock factor 1‐independent activation of dendritic cells by heat shock: implication for the uncoupling of heat‐mediated immunoregulation from the heat shock response

I. Benjamin, S. Basu, Zihai Li, 2003, European journal of immunology.

Overcoming immune tolerance to cancer by heat shock protein vaccines.

Zihai Li, Bei Liu, Anna M DeFilippo, 2002, Molecular cancer therapeutics.

Neutrophil‐to‐lymphocyte ratio and overall survival in all sites of head and neck squamous cell carcinoma

A. Alberg, T. Day, J. Wrangle, 2016, Head & neck.

Translational landscape of glioblastoma immunotherapy for physicians: guiding clinical practice with basic scientific evidence

C. Bolyard, Zihai Li, Bill X. Wu, 2022, Journal of Hematology & Oncology.

glycoprotein Ib-IX-V complex Heat-shock protein gp96/grp94 is an essential chaperone for the platelet

Aleksandra Stojanovic, Xiaoping Du, Matthew M. Staron, 2012 .

Heat-shock protein gp96/grp94 is an essential chaperone for the platelet glycoprotein Ib-IX-V complex.

Aleksandra Stojanovic, Xiaoping Du, Matthew M. Staron, 2011, Blood.

Pancreatic cancer cells render tumor-associated macrophages metabolically reprogrammed by a GARP and DNA methylation-mediated mechanism

Mengwen Zhang, Zihai Li, Anqi Li, 2021, Signal Transduction and Targeted Therapy.

Maturation and Antitumor Immunity Protein gp96 Induces Dendritic Cell Cell Surface Targeting of Heat Shock

Zihai Li, Hong Zheng, D. Stoilova, 2010 .

Molecular Chaperones and Cell Signalling: Molecular Chaperones as Inducers of Tumour Immunity

Zihai Li, P. Banerjee, 2005 .

An integrated view of the roles and mechanisms of heat shock protein gp96-peptide complex in eliciting immune response.

Zihai Li, Hong Zheng, J. Dai, 2002, Frontiers in bioscience : a journal and virtual library.

Myeloid Endoplasmic Reticulum Resident Chaperone GP96 Facilitates Inflammation and Steatosis in Alcohol‐Associated Liver Disease

R. Bataller, G. Chiosis, P. Mandrekar, 2021, Hepatology communications.

Exploring the Functional Complementation between Grp94 and Hsp90

Zihai Li, D. Gewirth, F. Hong, 2016, PloS one.

Role of heat shock protein in chaperoning tumor antigens and modulating anti-tumor immunity

Zihai Li, 2003 .

HSPPC-96: a personalised cancer vaccine

Zihai Li, M. Caudill, 2001, Expert opinion on biological therapy.

Heat shock-induced dendritic cell maturation is coupled by transient aggregation of ubiquitinated proteins independently of heat shock factor 1 or inducible heat shock protein 70.

Zihai Li, J. Dai, Anna M DeFillipo, 2004, Molecular immunology.

ProteinsTranscription Factor for Heat Shock Molecule Is Regulated by a Major Cell-Associated Antigens to MHC Class I Cutting Edge : Cross-Presentation

Zihai Li, Hong Zheng, 2004 .

Cutting Edge: Cross-Presentation of Cell-Associated Antigens to MHC Class I Molecule Is Regulated by a Major Transcription Factor for Heat Shock Proteins1

Zihai Li, Hong Zheng, 2004, The Journal of Immunology.

Activation of NK cells by extracellular heat shock protein 70 through induction of NKG2D ligands on dendritic cells.

Zihai Li, Y. Qiao, Bei Liu, 2008, Cancer immunity.

Unfolded protein response in cancer: the Physician's perspective

Kezhong Zhang, Zihai Li, Xuemei Li, 2011, Journal of hematology & oncology.

Differential Immune Signatures in the Tumor Microenvironment are Associated with Colorectal Cancer Racial Disparities: A Cohort Study of Biorepository Data

Dongjun Chung, V. Findlay, Zihai Li, 2020 .

Heat shock proteins transfer peptides during antigen processing and CTL priming

P. Srivastava, Zihai Li, H. Udono, 2004, Immunogenetics.

TLR4 Up-Regulation at Protein or Gene Level Is Pathogenic for Lupus-Like Autoimmune Disease1

R. Medzhitov, M. Freudenberg, Zihai Li, 2006, The Journal of Immunology.

Drosophila canopy b is a cochaperone of glycoprotein 93

Zihai Li, Crystal Morales, Crystal G Morales, 2017, The Journal of Biological Chemistry.

Essential role of the molecular chaperone gp96 in regulating melanogenesis

K. Helke, V. Hearing, Yongliang Zhang, 2014, Pigment cell & melanoma research.

Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-β

D. Carbone, Yiping Yang, Zihai Li, 2020, Science Translational Medicine.

PRMT5 is required for lymphomagenesis triggered by multiple oncogenic drivers.

S. Natsugoe, A. Rustgi, H. Nakagawa, 2015, Cancer discovery.

Autoimmune Disease Level Is Pathogenic for Lupus-Like TLR 4 Up-Regulation at Protein or Gene Freudenberg

R. Medzhitov, M. Freudenberg, Zihai Li, 2006 .

ER Stress-induced Inflammasome Activation Contributes to Hepatic Inflammation and Steatosis

Kezhong Zhang, Zihai Li, B. Guo, 2016, Journal of clinical & cellular immunology.

This information is current as Macrophages by Lipopolysaccharide Proinflammatory Mediators in Murine Selective and Low-Grade Induction of Molecular Mechanisms Responsible for the

Liwu Li, Zihai Li, D. Capelluto, 2012 .

Murine but Not Human Basophil Undergoes Cell-Specific Proteolysis of a Major Endoplasmic Reticulum Chaperone

Matthew M. Staron, Zihai Li, Bei Liu, 2012, PloS one.

Endoplasmic reticulum heat shock protein gp96/grp94 is a pro‐oncogenic chaperone, not a tumor suppressor

Zihai Li, S. Rachidi, Shaoli Sun, 2015, Hepatology.

Modulation of Endoplasmic Reticulum Stress Controls CD4+ T-cell Activation and Antitumor Function

J. Thaxton, Yongliang Zhang, Zihai Li, 2017, Cancer Immunology Research.

The Emerging Roles of Endoplasmic Reticulum Stress in Balancing Immunity and Tolerance in Health and Diseases: Mechanisms and Opportunities

Zihai Li, Anqi Li, B. Riesenberg, 2020, Frontiers in Immunology.

IL-2Rα mediates temporal regulation of IL-2 signaling and enhances immunotherapy

A. Goldrath, S. Mehrotra, E. Garrett-Mayer, 2015, Science Translational Medicine.

Induction of Foxp3 and activation of Tregs by HSP gp96 for treatment of autoimmune diseases

Yuxiu Xu, Zihai Li, Changfei Li, 2021, iScience.

Humoral immune responses to Streptococcus pneumoniae in the setting of HIV-1 infection.

J. Kilby, Zihai Li, Wei Jiang, 2015, Vaccine.

Gut homeostasis and regulatory T cell induction depend on molecular chaperone gp96 in CD11c+ cells

Zihai Li, B. Reizis, C. Westwater, 2017, Scientific Reports.

Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo

P. Ohashi, A. Elford, Zihai Li, 2003, Nature Medicine.

COVID-19 mRNA booster vaccines elicit strong protection against SARS-CoV-2 Omicron variant in patients with cancer

P. Shields, Zihai Li, No-Joon Song, 2021, Cancer Cell.

Role of chaperones and FcgammaR in immunogenic death.

M. Dhodapkar, Zihai Li, K. Dhodapkar, 2008, Current opinion in immunology.

Sex as a predictor of response to cancer immunotherapy.

Dongjun Chung, Zihai Li, H. Kwon, 2018, The Lancet. Oncology.

Myeloid-Derived Suppressor Cells: New Insights into the Pathogenesis and Therapy of MDS

Zihai Li, H. Papadaki, A. Stiff, 2022, Journal of clinical medicine.

Low-dose IFN-γ induces tumor cell stemness in tumor microenvironment of non-small cell lung cancer

J. Xia, Bin Zhang, Zihai Li, 2019, bioRxiv.

Structural and Functional Analysis of GRP94 in the Closed State Reveals an Essential Role for the Pre-N Domain and a Potential Client-Binding Site.

Zihai Li, D. Gewirth, F. Hong, 2017, Cell reports.

Immune checkpoint inhibitor-related thrombocytopenia: incidence, risk factors and effect on survival

G. Otterson, Songzhu Zhao, Lai Wei, 2021, Cancer Immunology, Immunotherapy.

MHC Class I Assembly Function and Intracellular Transport Routes for Hepatitis B Virus Antigen Cross-presentation by Heat Shock Protein gp96

Yuxiu Xu, Zihai Li, Changfei Li, 2022, Infectious Diseases & Immunity.

Preoperative platelet counts and postoperative outcomes in cancer surgery: a multicenter, retrospective cohort study

C. Balch, Zihai Li, Hong Li, 2019, Platelets.

CNPY2 is a Key Initiator of the PERK-CHOP Pathway of the Unfolded Protein Response

J. Diehl, Zihai Li, C. Davies, 2017, Nature Structural &Molecular Biology.

Regulatory T Cells Potentiates Suppressive Function of Expression of Heat Shock Protein gp96 TLR4 Hyperresponsiveness via Cell Surface

Zihai Li, S. Ngoi, A. Vella, 2007 .

Deletion of CD24 Impairs Development of Heat Shock Protein gp96–Driven Autoimmune Disease through Expansion of Myeloid-Derived Suppressor Cells

J. Thaxton, Zihai Li, Yang Liu, 2014, The Journal of Immunology.

Perturbation of NK cell peripheral homeostasis accelerates prostate carcinoma metastasis.

C. Higano, S. Plymate, Gang Liu, 2013, The Journal of clinical investigation.

Platelet count correlates with stage and predicts survival in melanoma

Zihai Li, Maneet Kaur, S. Rachidi, 2019, Platelets.

CD8 T Cells for Robust Effector Function Synergistically Stimulate Primary Specific 4-1BB and OX40 Dual Costimulation

Zihai Li, R. Mittler, Seung‐Joo Lee, 2004 .

Nonblocking Monoclonal Antibody Targeting Soluble MIC Revamps Endogenous Innate and Adaptive Antitumor Responses and Eliminates Primary and Metastatic Tumors

Zihai Li, Guangfu Li, K. Staveley-O’Carroll, 2015, Clinical Cancer Research.

Cutting Edge: Targeting Thrombocytes to Rewire Anticancer Immunity in the Tumor Microenvironment and Potentiate Efficacy of PD-1 Blockade

Zihai Li, B. Riesenberg, C. Timmers, 2019, The Journal of Immunology.

α7 Helix Region of αI Domain Is Crucial for Integrin Binding to Endoplasmic Reticulum Chaperone gp96

G. Chiosis, Zihai Li, D. Gewirth, 2013, The Journal of Biological Chemistry.

Reticulum Chaperone gp 96 : A for Integrin Binding to Endoplasmic I Domain Is Crucial α 7 Helix Region of α Protein Structure and Folding :

G. Chiosis, Zihai Li, D. Gewirth, 2013 .

Canopy Homolog 2 contributes to liver oncogenesis by promoting unfolded protein response–dependent destabilization of tumor protein P53

W. Gu, Yizhou Dong, Zihai Li, 2022 .

Extracellular gp96 is a crucial mediator for driving immune hyperactivation and liver damage

Zihai Li, Jingmin Zhao, Changfei Li, 2020, Scientific Reports.

Oocyte–Targeted Deletion Reveals That Hsp90b1 Is Needed for the Completion of First Mitosis in Mouse Zygotes

Zihai Li, E. Christians, C. Audouard, 2011, PloS one.

Innate Immune Responses to Highly Pathogenic Coronaviruses and Other Significant Respiratory Viral Infections

Zihai Li, D. Hayes, N. Funderburg, 2020, Frontiers in Immunology.

Molecular Mechanisms Responsible for the Selective and Low-Grade Induction of Proinflammatory Mediators in Murine Macrophages by Lipopolysaccharide

Liwu Li, Zihai Li, D. Capelluto, 2012, The Journal of Immunology.

COVID-19 vaccines for patients with cancer: benefits likely outweigh risks

Zihai Li, Tian Zhang, Joyce K. Hwang, 2021, Journal of Hematology & Oncology.

The Role of Platelets in Tumor Growth, Metastasis, and Immune Evasion

Zihai Li, Anqi Li, B. Riesenberg, 2019, Platelets.

Hedgehog-induced PD-L1 on tumor-associated macrophages is critical for suppression of tumor-infiltrating CD8+ T cell function

R. Baiocchi, Xiaopei Huang, Yiping Yang, 2021, JCI insight.

Combination strategies to maximize the benefits of cancer immunotherapy

Zihai Li, Lei Zheng, Delong Liu, 2021, Journal of Hematology & Oncology.

Fact or fiction - identifying the elusive multiple myeloma stem cell

Zihai Li, Bei Liu, Yubin Kang, 2013, Journal of Hematology & Oncology.

Interaction of Toll-Like Receptors with the Molecular Chaperone Gp96 Is Essential for Its Activation of Cytotoxic T Lymphocyte Response

Junwei Hou, Zihai Li, Lipeng Qiu, 2016, PloS one.

Heat-shock proteins in infection-mediated inflammation-induced tumorigenesis

Zihai Li, Zihai Li, Mark G Goldstein, 2009, Journal of hematology & oncology.

The Regulation of the Unfolded Protein Response and Its Roles in Tumorigenesis and Cancer Therapy

Zihai Li, F. Hong, Jordan Morreall, 2019, Cancer Drug Discovery and Development.

Inflammasome activation plays an important role in the development of spontaneous colitis

Zihai Li, B. Guo, Shaoli Sun, 2016 .

Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice.

C. Fernández-Hernando, Dianqing Wu, Jonathan D. Smith, 2008, The Journal of clinical investigation.

GARP Dampens Cancer Immunity by Sustaining Function and Accumulation of Regulatory T Cells in the Colon.

Yongliang Zhang, Zihai Li, H. Kwon, 2019, Cancer research.

Definition of a multiple myeloma progenitor population in mice driven by enforced expression of XBP1s.

Zihai Li, C. Wallace, Bei Liu, 2019, JCI insight.

DeepMAPS: Single-cell biological network inference using heterogeneous graph transformer

Juexin Wang, Qin Ma, Zihai Li, 2021 .

Biological network inference from single-cell multi-omics data using heterogeneous graph transformer

Lingtao Su, Juexin Wang, Zihai Li, 2021, bioRxiv.

Ovarian cancer immunotherapy: opportunities, progresses and challenges

C. Runowicz, R. Stevens, H. Swede, 2010, Journal of Hematology & Oncology.

Endoplasmic reticulum stress in hepatic steatosis and inflammatory bowel diseases

Zihai Li, B. Guo, Beichu Guo, 2014, Front. Genet..

Differential immune signatures in the tumor microenvironment are associated with colon cancer racial disparities

Dongjun Chung, V. Findlay, Zihai Li, 2021, Cancer medicine.

Molecular Profiling of Multiple Human Cancers Defines an Inflammatory Cancer-Associated Molecular Pattern and Uncovers KPNA2 as a Uniform Poor Prognostic Cancer Marker

W. J. Zheng, Zihai Li, Tingting Qin, 2013, PloS one.

Vaccination with Human Pluripotent Stem Cells Generates a Broad Spectrum of Immunological and Clinical Responses Against Colon Cancer

R. Xu, Zihai Li, Hui Zeng, 2009, Stem cells.

TLR4 Hyperresponsiveness via Cell Surface Expression of Heat Shock Protein gp96 Potentiates Suppressive Function of Regulatory T Cells1

Zihai Li, S. Ngoi, A. Vella, 2007, The Journal of Immunology.

Type 2 dendritic cells mediate control of cytotoxic T cell resistant tumors

Zihai Li, S. Ngoi, C. Koivisto, 2021, JCI insight.

Define and visualize pathological architectures of human tissues from spatially resolved transcriptomics using deep learning

Dongjun Chung, J. Otero, Juexin Wang, 2021, bioRxiv.

Essential roles of grp94 in gut homeostasis via chaperoning canonical Wnt pathway

Dianqing Wu, Matthew M. Staron, Zihai Li, 2013, Proceedings of the National Academy of Sciences.

Immune therapy of chronic myelogenous leukemia.

D. Scheinberg, M. Baccarani, M. Horowitz, 2005, Leukemia research.

Immunoregulatory functions and the therapeutic implications of GARP-TGF-β in inflammation and cancer

Zihai Li, Anqi Li, Xue Li, 2018, Journal of Hematology & Oncology.

Recent updates in cancer immunotherapy: a comprehensive review and perspective of the 2018 China Cancer Immunotherapy Workshop in Beijing

Zihai Li, M. Rubinstein, Delong Liu, 2018, Journal of Hematology & Oncology.

B lymphocytes confer immune tolerance via cell surface GARP-TGF-β complex.

M. Shlomchik, G. Gilkeson, Zihai Li, 2018, JCI insight.

Androgen conspires with the CD8+ T cell exhaustion program and contributes to sex bias in cancer

Lei Zhou, Dongjun Chung, L. Fong, 2022, Science Immunology.

Deletion of muscle GRP94 impairs both muscle and body growth by inhibiting local IGF production

Soohyung Park, Catherine A Makarewich, Zihai Li, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Targeting Metabolic Pathways of Myeloid Cells Improves Cancer Immunotherapy

C. Bolyard, Zihai Li, G. Xin, 2021, Frontiers in Cell and Developmental Biology.

GP96 is a GARP chaperone and controls regulatory T cell functions.

J. Thaxton, Yongliang Zhang, Zihai Li, 2015, The Journal of clinical investigation.

Is CD47 an innate immune checkpoint for tumor evasion?

Zihai Li, Hyunwoo Kwon, yang-xin fu, 2017, Journal of Hematology & Oncology.

TLRs and Integrins Bond-Independent Chaperone Function for HSP 90 b 1 , HSPC 4 ) and Retains Disulfide ( grp 94 , Mammalian Heat Shock Protein gp 96 Glycoprotein 93 Is an Ortholog of Drosophila

B. Hao, Zihai Li, Yi Yang, 2009 .

TLRs and Integrins Bond-Independent Chaperone Function for HSP 90 b 1 , HSPC 4 ) and Retains Disulfide ( grp 94 , Mammalian Heat Shock Protein gp 96 Glycoprotein 93 Is an Ortholog of Drosophila

B. Hao, Zihai Li, Yi Yang, 2009 .

Ortholog of Mammalian Heat Shock Glycoprotein 93 Is anDrosophila

B. Hao, Zihai Li, Yi Yang, 2009 .

Publish, not perish: Introducing Experimental Hematology & Oncology

C. Hsueh, Zihai Li, Delong Liu, 2012, Experimental Hematology & Oncology.

1-1-2017 PD-1 , PD-L 1 ( B 7-H 1 ) and Tumor-site Immune Modulation Therapy : the Historical Perspective

R. Yuan, Zihai Li, Delong Liu, 2019 .

Molecular Chaperone gp96 Is a Novel Therapeutic Target of Multiple Myeloma

R. DePinho, G. Chiosis, Zihai Li, 2013, Clinical Cancer Research.

Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages.

P. Srivastava, L. Lefrançois, Zihai Li, 2007, Immunity.

Sex Differences in Monocyte Activation in Systemic Lupus Erythematosus (SLE)

G. Gilkeson, Zihai Li, Wei Jiang, 2014, PloS one.

Aberrant high expression of immunoglobulin G in epithelial stem / progenitor-like cells contributes to tumor initiation and metastasis

W. Liu, Wei Liu, Zihai Li, 2015 .

Endoplasmic reticulum HSP90b1 (gp96, grp94) optimizes B-cell function via chaperoning integrin and TLR but not immunoglobulin.

Zihai Li, Bei Liu, 2008, Blood.

Correction: Molecular Profiling of Multiple Human Cancers Defines an Inflammatory Cancer-Associated Molecular Pattern and Uncovers KPNA2 as a Uniform Poor Prognostic Cancer Marker

W. J. Zheng, Zihai Li, Tingting Qin, 2014, PLoS ONE.

Regulatory T cells and Toll-like receptors: what is the missing link?

Zihai Li, J. Dai, Bei Liu, 2009, International immunopharmacology.

Roles of heat-shock proteins in antigen presentation and cross-presentation.

P. Srivastava, Zihai Li, A. Ménoret, 2002, Current opinion in immunology.

Vaccination with poly(IC:LC) and peptide-pulsed autologous dendritic cells in patients with pancreatic cancer

M. Thomas, M. Nishimura, S. Mehrotra, 2017, Journal of Hematology & Oncology.

Next-generation immuno-oncology agents: current momentum shifts in cancer immunotherapy

Zihai Li, Delong Liu, C. Pan, 2020, Journal of Hematology & Oncology.

PD-1, PD-L1 (B7-H1) and Tumor-Site Immune Modulation Therapy: The Historical Perspective

R. Yuan, Zihai Li, Delong Liu, 2017, Journal of Hematology & Oncology.

RNA binding protein PCBP1 is an intracellular immune checkpoint for shaping T cell responses in cancer immunity

Dongjun Chung, P. Howe, Zihai Li, 2020, Science Advances.

IL-2 and Beyond in Cancer Immunotherapy.

S. Mehrotra, J. Wrangle, Zihai Li, 2018, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

On the genesis and prognosis of variant translocations in chronic myeloid leukemia.

Zihai Li, P. Benn, M. Fang, 2007, Cancer genetics and cytogenetics.

Potent intestinal Th17 priming through peripheral lipopolysaccharide‐based immunization

M. Oft, Zihai Li, S. Ngoi, 2010, Journal of leukocyte biology.

Fueling Cancer Immunotherapy With Common Gamma Chain Cytokines

E. Bartee, Zihai Li, C. Paulos, 2019, Front. Immunol..

Nitric oxide production is regulated by fever‐range thermal stimulation of murine macrophages

E. Repasky, Zihai Li, M. Pritchard, 2005, Journal of leukocyte biology.

Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-&bgr; signaling

D. Rockey, P. Howe, Yongliang Zhang, 2017, The Journal of clinical investigation.

Heat Shock Protein–Peptide Complexes, Reconstituted In Vitro, Elicit Peptide-specific Cytotoxic T Lymphocyte Response and Tumor Immunity

Pramod K. Srivastava, Rajiv Y. Chandawarkar, Zihai Li, 1997, The Journal of experimental medicine.

Transforming growth factor–β1 in regulatory T cell biology

M. Rosenblum, C. Bolyard, Zihai Li, 2022, Science Immunology.

Antibody-mediated neutralization of soluble MIC significantly enhances CTLA4 blockade therapy

Zihai Li, Guangfu Li, K. Staveley-O’Carroll, 2017, Science Advances.

Chaperone gp96-independent Inhibition of Endotoxin Response by Chaperone-based Peptide Inhibitors*

Zihai Li, Bei Liu, F. Hong, 2012, The Journal of Biological Chemistry.

Th17 Cells in Cancer: The Ultimate Identity Crisis

S. Mehrotra, Zihai Li, Richard A. Himes, 2014, Front. Immunol..

The forgotten tale of immunoglobulin allotypes in cancer risk and treatment

Zihai Li, J. Pandey, 2013, Experimental Hematology & Oncology.

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

Charles J. Vaske, Rohan N. Borkar, Brian D. Kelly, 2016, Journal of Immunotherapy for Cancer.

Flow cytometry cannot assess surface binding of perforin to target cells

F. Appelbaum, T. Gooley, Zihai Li, 2022 .

Microbial TLR Agonists and Humoral Immunopathogenesis in HIV Disease

Zhenxian Zhou, J. Kilby, Zihai Li, 2013, Epidemiology.

RESEPT: tissue architecture inference and visualization from spatially resolved transcriptomics

Dong Xu, Dongjun Chung, Juexin Wang, 2021, bioRxiv.

Cancer Therapy : Preclinical Molecular Chaperone gp 96 Is a Novel Therapeutic Target of Multiple Myeloma

R. DePinho, G. Chiosis, Zihai Li, 2013 .

To affinity and beyond: Harnessing the T Cell receptor for cancer immunotherapy

J. Thaxton, Zihai Li, 2014, Human vaccines & immunotherapeutics.

The clinical features, treatment, and prognosis of primary mediastinal malignant melanoma

Zihai Li, Bai-jiang Zhang, Yongming Zhang, 2017, Medicine.

An Endoplasmic Reticulum Protein Implicated in Chaperoning Peptides to Major Histocompatibility of Class I Is an Aminopeptidase*

P. Srivastava, M. L. Niswonger, Zihai Li, 2001, The Journal of Biological Chemistry.

Roles of heat shock protein gp96 in the ER quality control: redundant or unique function?

Zihai Li, Yi Yang, 2005, Molecules and cells.

Autologous Tumor-Derived Heat Shock Protein Vaccine as a New Paradigm for Individualized Cancer Therapeutics

Zihai Li, J. Dai, 2006 .

Cancer immunotherapy: are we there yet?

Lieping Chen, Zihai Li, M. Rubinstein, 2013, Experimental Hematology & Oncology.

Cell surface expression of an endoplasmic reticulum resident heat shock protein gp96 triggers MyD88-dependent systemic autoimmune diseases

Zihai Li, Hong Zheng, D. Stoilova, 2003, Proceedings of the National Academy of Sciences of the United States of America.

IL6 Fuels Durable Memory for Th17 Cell–Mediated Responses to Tumors

G. Lesinski, K. Armeson, Zihai Li, 2020, Cancer Research.

The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1

G. Chiosis, Zihai Li, S. Usmani, 2010, Journal of hematology & oncology.

The anti-myeloma activity of a novel purine scaffold HSP 90 inhibitor PUH 71 is via inhibition of both HSP 90 A and HSP 90 B 1

G. Chiosis, Zihai Li, S. Usmani, 2010 .

Murine Th17 cells utilize IL-2 receptor gamma chain cytokines but are resistant to cytokine withdrawal-induced apoptosis

E. Garrett-Mayer, J. Wrangle, Zihai Li, 2017, Cancer Immunology, Immunotherapy.

b-catenin and PI 3 K d inhibition expands precursor Th 17 cells with heightened stemness and antitumor activity

J. Wrangle, K. Majchrzak, Zihai Li, 2018 .

β-catenin and PI3Kδ inhibition expands precursor Th17 cells with heightened stemness and antitumor activity.

J. Wrangle, K. Majchrzak, Zihai Li, 2017, JCI insight.

Centrobin-mediated Regulation of the Centrosomal Protein 4.1-associated Protein (CPAP) Level Limits Centriole Length during Elongation Stage*

Zihai Li, R. Gudi, C. Vasu, 2015, The Journal of Biological Chemistry.

Systemic translocation of Staphylococcus drives autoantibody production in HIV disease

A. Alekseyenko, Min Li, Quanzhen Li, 2019, Microbiome.

Immune chaperone gp96 drives the contributions of macrophages to inflammatory colon tumorigenesis.

Yongliang Zhang, Zihai Li, X. Ouyang, 2014, Cancer research.

Lower circulating platelet counts and antiplatelet therapy independently predict better outcomes in patients with head and neck squamous cell carcinoma

A. Alberg, T. Day, Zihai Li, 2014, Journal of Hematology & Oncology.

In vivo and in situ programming of tumor immunity by combining oncolytics and PD-1 immune checkpoint blockade

E. Bartee, Zihai Li, 2017, Experimental Hematology & Oncology.

IL-27 Induces CCL5 Production by T Lymphocytes, Which Contributes to Antitumor Activity

X. Pan, Yizhou Dong, Zihai Li, 2022, The Journal of Immunology.

CNPY2 Contributes to Liver Oncogenesis by Promoting UPR-dependent destabilization of p53.

W. Gu, Yizhou Dong, Zihai Li, 2022, Hepatology.

Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone

B. Hao, Matthew M. Staron, Zihai Li, 2010, Nature communications.

Roles, Mechanisms, and Opportunities of Heat Shock Protein gp96/grp94 in Infections and Inflammation-Associated Malignancies

Zihai Li, S. Meng, 2018 .

GRP94 Is an Essential Regulator of Pancreatic &bgr;-Cell Development, Mass, and Function in Male Mice

Hongju Wu, Zihai Li, Jingjing Wang, 2018, Endocrinology.

Moesin, an Ezrin/Radixin/Moesin Family Member, Regulates Hepatic Fibrosis

D. Rockey, S. Karvar, Zihai Li, 2019, Hepatology.

17 AAG for HSP90 inhibition in cancer--from bench to bedside.

Zihai Li, Zihai Li, S. Usmani, 2009, Current molecular medicine.

The Molecular Chaperone gp96/GRP94 Interacts with Toll-like Receptors and Integrins via Its C-terminal Hydrophobic Domain*

Zihai Li, D. Gewirth, Bei Liu, 2012, The Journal of Biological Chemistry.

Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94.

Maulik R. Patel, Pallav D. Patel, Weilin Sun, 2015, Journal of medicinal chemistry.

GRP94/gp96 in Cancer: Biology, Structure, Immunology, and Drug Development.

Yongliang Zhang, Zihai Li, Bill X. Wu, 2016, Advances in cancer research.

Characterization of the Grp94/OS-9 chaperone-lectin complex.

M. Cosgrove, Zihai Li, D. Gewirth, 2014, Journal of molecular biology.

Systemic translocation of Staphylococcus drives autoantibody production in HIV disease

A. Alekseyenko, Min Li, Quanzhen Li, 2019, Microbiome.

Essential roles of IL‐12 and dendritic cells but not IL‐23 and macrophages in lupus‐like diseases initiated by cell surface HSP gp96

Zihai Li, J. Dai, D. Cua, 2007, European journal of immunology.

Gut homeostasis and regulatory T cell induction depend on molecular chaperone gp96 in CD11c+ cells

Zihai Li, B. Reizis, C. Westwater, 2017, Scientific Reports.

Autocrine transforming growth factor β1 in regulatory T cell biology-gone but not missed.

Zihai Li, Bill X. Wu, Ephraim A. Ansa-Addo, 2021, Immunity.

gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis.

Matthew M. Staron, H. Aguila, Zihai Li, 2010, Blood.

Sex Differences in Using Systemic Inflammatory Markers to Prognosticate Patients with Head and Neck Squamous Cell Carcinoma

Dongjun Chung, Zihai Li, H. Kwon, 2018, Cancer Epidemiology, Biomarkers & Prevention.

A Bayesian Multivariate Mixture Model for Spatial Transcriptomics Data

Brian Neelon, Dongjun Chung, Won Chang, 2021, bioRxiv.

TREATMENT WITH SOLUBLE CD24 ATTENUATES COVID-19-ASSOCIATED SYSTEMIC IMMUNOPATHOLOGY

Dongjun Chung, C. Bolyard, Qin Ma, 2021, Journal of Hematology & Oncology.

Glycoprotein A repetitions predominant (GARP) positively regulates transforming growth factor (TGF) β3 and is essential for mouse palatogenesis

S. Kaneko, Zihai Li, Anqi Li, 2017, The Journal of Biological Chemistry.

Mapping the Interactome of a Major Mammalian Endoplasmic Reticulum Heat Shock Protein 90

Hongyu Zhao, O. Ohara, H. Hirano, 2017, PloS one.

Sex differences in bladder cancer: emerging data and call to action

D. Theodorescu, Zihai Li, Xue Li, 2022, Nature Reviews Urology.

Ovarian cancer immunotherapy: opportunities, progresses and challenges

C. Runowicz, R. Stevens, H. Swede, 2010, Journal of Hematology & Oncology.

An autologous tumor-derived heat shock protein vaccine for high risk ovarian cancer

P. Srivastava, C. Runowicz, Zihai Li, 2005 .

Unfolded protein response in cancer: the Physician's perspective

Kezhong Zhang, Zihai Li, Xuemei Li, 2011, Journal of hematology & oncology.

Ovarian cancer immunotherapy: opportunities, progresses and challenges

C. Runowicz, R. Stevens, H. Swede, 2010, Journal of hematology & oncology.

IRIS-FGM: an integrative single-cell RNA-Seq interpretation system for functional gene module analysis.

Changlin Wan, Dongjun Chung, Chi Zhang, 2021, Bioinformatics.

Molecular Mechanisms Responsible for the Selective and Low-Grade Induction of Proinflammatory Mediators in Murine Macrophages by Lipopolysaccharide

Liwu Li, Zihai Li, D. Capelluto, 2012, Journal of Immunology.

Converting Tumoral PD-L1 into a 4-1BB Agonist for Safer and More Effective Cancer Immunotherapy.

Zihai Li, M. Rubinstein, Joseph H. Azar, 2022, Cancer Discovery.

Molecular Chaperones and Cell Signalling: Molecular Chaperones as Inducers of Tumour Immunity

Zihai Li, P. Banerjee, 2005 .

Dexamethasone, paclitaxel, etoposide, cyclophosphamide (d-TEC) and G-CSF for stem cell mobilisation in multiple myeloma

J. Clive, Zihai Li, R. Bona, 2001, Bone Marrow Transplantation.

gp96-Independent Inhibition of Endotoxin Response By Chaperone-Based Peptide Inhibitors CHAPERONE-BASED INHIBITORS AGAINST LPS

M. Noman, Zihai Li, Bei Liu, 2012 .

Inflammasome activation plays an important role in the development of spontaneous colitis

Zihai Li, Shaoli Sun, Jinyu Zhang, 2014, Mucosal Immunology.

B lymphocytes confer immune tolerance via cell surface GARP-TGF-β complex.

M. Shlomchik, G. Gilkeson, Zihai Li, 2018, JCI insight.

Recent updates in cancer immunotherapy: a comprehensive review and perspective of the 2018 China Cancer Immunotherapy Workshop in Beijing

Zihai Li, M. Rubinstein, Delong Liu, 2018, Journal of Hematology & Oncology.

gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis.

Matthew M. Staron, H. Aguila, Zihai Li, 2010, Blood.

Structural and Functional Analysis of GRP94 in the Closed State Reveals an Essential Role for the Pre-N Domain and a Potential Client-Binding Site.

Zihai Li, D. Gewirth, F. Hong, 2017, Cell reports.

Heat-shock protein gp96/grp94 is an essential chaperone for the platelet glycoprotein Ib-IX-V complex.

Aleksandra Stojanovic, Xiaoping Du, Matthew M. Staron, 2011, Blood.

Molecular Mechanisms Responsible for the Selective and Low-Grade Induction of Proinflammatory Mediators in Murine Macrophages by Lipopolysaccharide

Liwu Li, Zihai Li, D. Capelluto, 2012, The Journal of Immunology.

Glycoprotein A repetitions predominant (GARP) positively regulates transforming growth factor (TGF) β3 and is essential for mouse palatogenesis

S. Kaneko, Zihai Li, Anqi Li, 2017, The Journal of Biological Chemistry.

Microbial TLR Agonists and Humoral Immunopathogenesis in HIV Disease

Zhenxian Zhou, J. Kilby, Zihai Li, 2013, Epidemiology.

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two

Charles J. Vaske, Joe Y. Chang, Scott R. Presnell, 2016, Journal for ImmunoTherapy of Cancer.

Plasmacytoid Dendritic Cells Mediate Synergistic Effects of HIV and Lipopolysaccharide on CD27+ IgD– Memory B Cell Apoptosis

M. Lederman, N. Greenspan, Yong Gao, 2014, Journal of Virology.

GARP Dampens Cancer Immunity by Sustaining Function and Accumulation of Regulatory T Cells in the Colon.

Yongliang Zhang, Zihai Li, H. Kwon, 2019, Cancer research.

TREATMENT WITH SOLUBLE CD24 ATTENUATES COVID-19-ASSOCIATED SYSTEMIC IMMUNOPATHOLOGY

Dongjun Chung, Mohammad Yusuf, C. Bolyard, 2021, medRxiv.

Heat‐Shock Proteins

P. Srivastava, Zihai Li, 2003, Current protocols in immunology.

Molecular Pathogenesis of Genetic and Inherited Diseases Aminoacyl-tRNA Synthetase-Interacting Multifunctional Protein 1/p43 Controls Endoplasmic Reticulum Retention of Heat Shock Protein gp96 Its Pathological Implications in Lupus-Like Autoimmune Diseases

Sunghoon Kim, Jin Young Kim, Bum-Joon Park, 2007 .

Characterization of the Grp94/OS-9 chaperone-lectin complex.

M. Cosgrove, Zihai Li, D. Gewirth, 2014, Journal of molecular biology.

Drosophila Glycoprotein 93 Is an Ortholog of Mammalian Heat Shock Protein gp96 (grp94, HSP90b1, HSPC4) and Retains Disulfide Bond-Independent Chaperone Function for TLRs and Integrins1

B. Hao, Zihai Li, Yi Yang, 2009, The Journal of Immunology.

Priming of T cells by heat shock protein-peptide complexes as the basis of tumor vaccines.

Zihai Li, Z. Li, Zihai Li, 1997, Seminars in immunology.

Cell therapy must be regulated as medicine

Zihai Li, Delong Liu, 2016, Experimental Hematology & Oncology.

Impaired neutralizing antibody response to COVID-19 mRNA vaccines in cancer patients

P. Shields, E. Oltz, Zihai Li, 2021, Cell & bioscience.