E. Loechler

发表

The precautionary principle: protecting public health, the environment and the future of our children

Philip J. Landrigan, Andrew Stirling, David Kriebel, 2004 .

The precautionary principle in environmental science.

R. Levins, M. Stoto, T. Schettler, 2001, Environmental health perspectives.

The precautionary principle in environmental science.

R. Levins, M. Stoto, T. Schettler, 2001, Environmental Health Perspectives.

DNA Polymerase II (polB) Is Involved in a New DNA Repair Pathway for DNA Interstrand Cross-Links inEscherichia coli

M. Berardini, E. Loechler, P. Foster, 1999, Journal of bacteriology.

Identification of the 9-aminoacridine/DNA complex responsible for photodynamic inactivation of P22.

J. King, E. Loechler, 1986, Biochemistry.

Construction of a human shuttle vector containing a single nitrogen mustard interstrand, DNA-DNA cross-link at a unique plasmid location.

D. Grueneberg, J. Ojwang, M. Benasutti, 1991, Cancer research.

Synthesis of a duplex oligonucleotide containing a nitrogen mustard interstrand DNA-DNA cross-link.

D. Grueneberg, J. Ojwang, E. Loechler, 1989, Cancer research.

The major, N2-dG adduct of (+)-anti-B[a]PDE shows a dramatically different mutagenic specificity (predominantly, G --> A) in a 5'-CGT-3' sequence context.

N. Geacintov, E. Loechler, T. Liu, 1997, Biochemistry.

Extrachromosomal probes for mutagenesis by carcinogens: studies on the mutagenic activity of O6-methylguanine built into a unique site in a viral genome.

J. Essigmann, E. Loechler, K. Fowler, 1985, Environmental health perspectives.

Covalent electrophilic catalysis of the breakdown of hyponitrite to nitrous oxide by aldehydes, ketones, and carbon dioxide

E. Loechler, T. Hollocher, A. M. Schneider, 1987 .

The role of adduct site-specific mutagenesis in understanding how carcinogen-DNA adducts cause mutations: perspective, prospects and problems.

E. Loechler, 1996, Carcinogenesis.

AP sites are not significantly involved in mutagenesis by the (+)-anti diol epoxide of benzo[a]pyrene: the complexity of its mutagenic specificity is likely to arise from adduct conformational polymorphism.

E. Loechler, E. Drouin, 1993, Biochemistry.

Molecular modeling benzo[a]pyrene N2-dG adducts in the two overlapping active sites of the Y-family DNA polymerase Dpo4.

E. Loechler, S. Chandani, 2007, Journal of molecular graphics & modelling.

Mirror image stereoisomers of the major benzo[a]pyrene N2-dG adduct are bypassed by different lesion-bypass DNA polymerases in E. coli.

Jun Yin, A. Nagalingam, E. Loechler, 2006, DNA repair.

A role for DNA polymerase V in G --> T mutations from the major benzo[a]pyrene N2-dG adduct when studied in a 5'-TGT sequence in E. coli.

Jun Yin, E. Loechler, K. Seo, 2004, DNA repair.

Construction and characterization of extrachromosomal probes for mutagenesis by carcinogens: site-specific incorporation of O6-methylguanine into viral and plasmid genomes.

J. Essigmann, E. Loechler, K. Fowler, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Environmental Carcinogens and Mutagens

E. Loechler, 2003 .

Toward an understanding of the role of DNA adduct conformation in defining mutagenic mechanism based on studies of the major adduct (formed at N(2)-dG) of the potent environmental carcinogen, benzo[a]pyrene.

R. Kozack, E. Loechler, S. Jelinsky, 2000, Mutation research.

Sequence specific mutagenesis of the major (+)-anti-benzo[a]pyrene diol epoxide-DNA adduct at a mutational hot spot in vitro and in Escherichia coli cells.

N. Geacintov, E. Loechler, A. Basu, 1997, Chemical research in toxicology.

Evidence for a recombination-independent pathway for the repair of DNA interstrand cross-links based on a site-specific study with nitrogen mustard.

M. Berardini, E. Loechler, W. Mackay, 1997, Biochemistry.

Mechanism of the reaction of dithiols with flavins

E. Loechler, T. Hollocher, 1975 .

A hypothesis for what conformation of the major adduct of (+)-anti-B[a]PDE (N2-dG) causes G-->T versus G-->A mutations based upon a correlation between mutagenesis and molecular modeling results.

R. Kozack, E. Loechler, R. Shukla, 1999, Carcinogenesis.

Are base substitution and frameshift mutagenesis pathways interrelated? An analysis based upon studies of the frequencies and specificities of mutations induced by the (+)-anti diol epoxide of benzo[a]pyrene.

E. Loechler, H. Rodriguez, Henry Rodriguez, 1995, Mutation research.

Amino acid architecture that influences dNTP insertion efficiency in Y-family DNA polymerase V of E. coli.

Jun Yin, P. Donthamsetti, E. Loechler, 2009, Journal of molecular biology.

The major, N2-Gua adduct of the (+)-anti-benzo[a]pyrene diol epoxide is capable of inducing G-->A and G-->C, in addition to G-->T, mutations.

N. Geacintov, E. Loechler, S. Jelinsky, 1995, Biochemistry.

Homology modeling of four Y-family, lesion-bypass DNA polymerases: the case that E. coli Pol IV and human Pol kappa are orthologs, and E. coli Pol V and human Pol eta are orthologs.

E. Loechler, S. Chandani, C. H. Lee, 2006, Journal of molecular graphics & modelling.

Environmental and Occupational Causes of Cancer: New Evidence 2005-2007

R. Clapp, M. Jacobs, E. Loechler, 2008, Reviews on environmental health.

Adduct‐induced base‐shifts: A mechanism by which the adducts of bulky carcinogens might induce mutations

E. Loechler, 1989, Biopolymers.

The major, N2-dG adduct of (+)-anti-B[a]PDE induces G-->A mutations in a 5'-AGA-3' sequence context.

N. Geacintov, E. Loechler, R. Shukla, 1999, Carcinogenesis.

Mutagenesis by the (+)-anti-diol epoxide of benzo[a]pyrene: what controls mutagenic specificity?

E. Loechler, H. Rodriguez, 1993, Biochemistry.

Genetic effects of oxidative DNA damages: comparative mutagenesis of the imidazole ring-opened formamidopyrimidines (Fapy lesions) and 8-oxo-purines in simian kidney cells

M. Kalam, E. Loechler, A. Basu, 2006, Nucleic acids research.

Genetic effects of oxidative DNA damages: comparative mutagenesis of the imidazole ring-opened formamidopyrimidines (Fapy lesions) and 8-oxo-purines in simian kidney cells

M. Kalam, E. Loechler, A. Basu, 2006, Nucleic Acids Research.

Rotation about the C6-O6 bond in O6-methylguanine: the syn and anti conformers can be of similar energies in duplex DNA as estimated by molecular modeling techniques.

E. Loechler, 1991, Carcinogenesis.

In vivo mutagenesis by O6-methylguanine built into a unique site in a viral genome.

J. Essigmann, E. Loechler, C. Green, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Factors that influence the mutagenic patterns of DNA adducts from chemical carcinogens.

E. Loechler, S. Jelinsky, K. Seo, 2000, Mutation research.

A violation of the Swain-Scott principle, and not SN1 versus SN2 reaction mechanisms, explains why carcinogenic alkylating agents can form different proportions of adducts at oxygen versus nitrogen in DNA.

E. Loechler, 1994, Chemical research in toxicology.

Molecular modeling studies of O2-alkylthymines and O4-alkylthymines in DNA: structures that may be pertinent to the incorporation of the corresponding dAlkTTP into DNA by DNA polymerases in vitro.

E. Loechler, 1990, Mutation research.

Mutagenesis studies with four stereoisomeric N2-dG benzo[a]pyrene adducts in the identical 5'-CGC sequence used in NMR studies: G->T mutations dominate in each case.

A. Nagalingam, Matthew R. Tiffany, E. Loechler, 2005, Mutagenesis.

Mutagenesis studies of the major benzo[a]pyrene N2-dG adduct in a 5'-TG versus a 5'-UG sequence: removal of the methyl group causes a modest decrease in the [G->T/G->A] mutational ratio.

A. Nagalingam, E. Loechler, K. Seo, 2005, Mutagenesis.

Molecular modeling of the major benzo[a]pyrene N2-dG adduct in cases where mutagenesis results are known in double stranded DNA.

E. Loechler, C. H. Lee, 2003, Mutation research.

Molecular modeling of the major adduct of (+)-anti-B[a]PDE (N2-dG) in the eight conformations and the five DNA sequences most relevant to base substitution mutagenesis.

R. Kozack, E. Loechler, 1999, Carcinogenesis.

How stereochemistry affects mutagenesis by N2-deoxyguanosine adducts of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene: configuration of the adduct bond is more important than those of the hydroxyl groups.

N. Geacintov, E. Loechler, S. Jelinsky, 1997, Biochemistry.

Targeted A --> T and G --> T mutations induced by site-specific deoxyadenosine and deoxyguanosine adducts, respectively, from the (+)-anti-diol epoxide of dibenz[a,j]anthracene in M13mp7L2.

J. DiGiovanni, E. Loechler, R. Harvey, 1996, Biochemistry.

How are potent bulky carcinogens able to induce such a diverse array of mutations?

E. Loechler, 1995, Molecular carcinogenesis.

The major, N2-Gua adduct of the (+)-anti-benzo[a]pyrene diol epoxide can be unstable in double-stranded DNA.

E. Loechler, E. Drouin, J. Lech, 1995, Biochemistry.

Construction of Escherichia coli vectors containing deoxyadenosine and deoxyguanosine adducts from (+)-anti-dibenz[a,j]anthracene diol epoxide at a defined site.

J. DiGiovanni, E. Loechler, R. Harvey, 1993, Chemical research in toxicology.

Mutational specificity of the (+)-anti-diol epoxide of benzo[a]pyrene in a supF gene of an Escherichia coli plasmid: DNA sequence context influences hotspots, mutagenic specificity and the extent of SOS enhancement of mutagenesis.

E. Loechler, H. Rodriguez, Henry Rodriguez, 1993, Carcinogenesis.

8 – Mechanisms by Which Aflatoxins and Other Bulky Carcinogens Induce Mutations

D. Eaton, J. Groopman, E. Loechler, 1993 .

Mutagenic specificity of the (+)anti‐diol epoxide of dibenz[a,j]anthracene in the supF gene of an Escherichia coli plasmid

J. DiGiovanni, E. Loechler, R. Harvey, 1993, Molecular carcinogenesis.

An Escherichia coli plasmid-based, mutational system in which supF mutants are selectable: insertion elements dominate the spontaneous spectra.

E. Loechler, H. Rodriguez, E. T. Snow, 1992, Mutation research.

Mutagenesis by (+)-anti-B[a]P-N2-Gua, the major adduct of activated benzo[a]pyrene, when studied in an Escherichia coli plasmid using site-directed methods.

M. Benasutti, E. Loechler, W. Mackay, 1992, Carcinogenesis.

Construction of an Escherichia coli vector containing the major DNA adduct of activated benzo[a]pyrene at a defined site.

M. Benasutti, E. Loechler, Z. Ezzedine, 1988, Chemical research in toxicology.

Molecular modeling in mutagenesis and carcinogenesis.

E. Loechler, 1991, Methods in enzymology.

Y-Family DNA Polymerases Have Three Structural Elements That Promote Accurate dCTP Insertion And Minimize dATP/dGTP/dTTP Misinsertion Opposite a N2-dG Adduct of Benzo[a]pyrene

Gabriel Sholder, Peter Tonzi, E. Loechler, 2019, bioRxiv.

DNA polymerase IV mediates efficient and quick recovery of replication forks stalled at N2-dG adducts

H. Maki, T. Katayama, R. Fuchs, 2014, Nucleic acids research.

Mapping the binding site of aflatoxin B1 in DNA: systematic analysis of the reactivity of aflatoxin B1 with guanines in different DNA sequences.

M. Whitlow, M. Benasutti, E. Loechler, 1988, Biochemistry.

Cellular Responses to Chemical Carcinogens

E. Loechler, B. Henry, K. Seo, 2002 .

Mapping the binding site of aflatoxin B1 in DNA: molecular modeling of the binding sites for the N(7)-guanine adduct of aflatoxin B1 in different DNA sequences.

M. Whitlow, M. Teeter, E. Loechler, 1988, Journal of biomolecular structure & dynamics.

Reduction of flavins by thiols. 1. Reaction mechanism from the kinetics of the attack and breakdown steps

E. Loechler, T. Hollocher, 1980 .

Reduction of flavins by thiols. 3. The case for concerted N,S-acetal formation in attack and an early transition state in breakdown

E. Loechler, T. Hollocher, 1980 .

The Use of Salmonella Bacteriophage P22 to Study the Multiple Mechanisms of Acridine-Induced Damage

J. King, E. Loechler, H. Strauss, 1983 .

A method to accurately quantitate intensities of (32)P-DNA bands when multiple bands appear in a single lane of a gel is used to study dNTP insertion opposite a benzo[a]pyrene-dG adduct by Sulfolobus DNA polymerases Dpo4 and Dbh.

Gabriel Sholder, E. Loechler, 2015, DNA repair.

Structural model of the Y-Family DNA polymerase V/RecA mutasome.

E. Loechler, S. Chandani, 2013, Journal of molecular graphics & modelling.

Translesion Synthesis and Mutagenic Pathways in Escherichia coli Cells

E. Loechler, S. Chandani, 2010 .

Architecture of Y-Family DNA Polymerases Relevant to Translesion DNA Synthesis as Revealed in Structural and Molecular Modeling Studies

E. Loechler, Christopher Jacobs, S. Chandani, 2010, Journal of nucleic acids.

Y-Family DNA polymerases may use two different dNTP shapes for insertion: a hypothesis and its implications.

E. Loechler, S. Chandani, 2009, Journal of molecular graphics & modelling.

How Y-Family DNA polymerase IV is more accurate than Dpo4 at dCTP insertion opposite an N2-dG adduct of benzo[a]pyrene.

Amanda L. Creech, Gabriel Sholder, E. Loechler, 2015, DNA repair.

Genetic effects of thymine glycol: site-specific mutagenesis and molecular modeling studies.

J. Essigmann, E. Loechler, A. Basu, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Molecular modeling of the conformational complexity of (+)-anti-B[a]PDE-adducted DNA using simulated annealing.

R. Kozack, E. Loechler, 1997, Carcinogenesis.

Letter: Mechanism of the reaction of dithiols with flavins.

E. Loechler, T. Hollocher, 1975, Journal of the American Chemical Society.

Mutagenesis and repair of O6-substituted guanines.

J. Essigmann, E. Loechler, C. Green, 1986, IARC scientific publications.

Molecular modeling of four stereoisomers of the major B[a]PDE adduct (at N(2)-dG) in five cases where the structure is known from NMR studies: molecular modeling is consistent with NMR results.

E. Loechler, S. Chandani, C. H. Lee, 2002, Chemical research in toxicology.

Evidence from in vitro replication that O6-methylguanine can adopt multiple conformations.

E. Loechler, M. Dosanjh, B. Singer, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Free-energy perturbation methods to study structure and energetics of DNA adducts: results for the major N2-dG adduct of benzo[a]pyrene in two conformations and different sequence contexts.

E. Loechler, S. Chandani, C. H. Lee, 2005, Chemical Research in Toxicology.

Covalent Electrophilic Catalysis of the Breakdown of Hyponitrite to Nitrous Oxide by Aldehydes, Ketones, and Carbon Dioxide.

E. Loechler, T. Hollocher, A. M. Schneider, 1987 .

DNA guanine-guanine crosslinking sequence specificity of isophosphoramide mustard, the alkylating metabolite of the clinical antitumor agent ifosfamide

M. Berardini, E. Loechler, R. Struck, 2000, Cancer Chemotherapy and Pharmacology.

The role of carcinogen DNA adduct structure in the induction of mutations.

J. Essigmann, M. Benasutti, E. Loechler, 1990, Progress in clinical and biological research.

Mutagenic specificity of alkylated and oxidized DNA bases as determined by site-specific mutagenesis.

J. Essigmann, E. Loechler, A. Basu, 1989, Annali dell'Istituto superiore di sanita.

SCIENCE FOR THE PEOPLE

E. Loechler, J. Beckwith, J. King, 1972, Nature.

Structural model of the Y-Family DNA polymerase V/RecA mutasome.

E. Loechler, S. Chandani, 2013, Journal of molecular graphics & modelling.

Gabriel Sholder, E. Loechler, 2015, DNA repair.