G. Fang

发表

Spindle Checkpoint Protein Dynamics at Kinetochores in Living Cells

E. Salmon, S. Stewart, B. Howell, 2004, Current Biology.

The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition

James K. Chen, G. Fang, D. Kang, 2002, The Journal of cell biology.

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

I. Mellman, Daniel J. Anderson, M. J. C. Ludlam, 2012, Proceedings of the National Academy of Sciences.

Cdk1 phosphorylation of BubR1 controls spindle checkpoint arrest and Plk1-mediated formation of the 3F3/2 epitope

G. Fang, O. K. Wong, 2007, The Journal of cell biology.

Anillin Is a Substrate of Anaphase-promoting Complex/Cyclosome (APC/C) That Controls Spatial Contractility of Myosin during Late Cytokinesis*[boxs]

G. Fang, Wei-meng Zhao, Guowei Fang, 2005, Journal of Biological Chemistry.

Control of mitotic transitions by the anaphase-promoting complex.

M. Kirschner, Hongtao Yu, G. Fang, 1999, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1.

M. Kirschner, Hongtao Yu, G. Fang, 1998, Molecular cell.

AMPKα2 activation by an energy-independent signal ensures chromosomal stability during mitosis

X. Yao, J. Zang, Yuanyuan Huang, 2021, iScience.

Anaphase-Promoting Complex/Cyclosome Controls the Stability of TPX2 during Mitotic Exit

S. Stewart, G. Fang, Scott Stewart, 2005, Molecular and Cellular Biology.

Cyclin B and E2F-1 expression in prostate carcinoma cells treated with the novel retinoid CD437 are regulated by the ubiquitin-mediated pathway.

M. Kirschner, A. Rishi, M. Dawson, 2002, Cancer research.

Oxytricha telomere-binding protein: DNA-dependent dimerization of the alpha and beta subunits.

T. Cech, G. Fang, Thomas R. Cech, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Oxytricha telomere-binding protein: separable DNA-binding and dimerization domains of the alpha-subunit.

T. Cech, G. Fang, J. Gray, 1993, Genes & development.

Characterization of a G-quartet formation reaction promoted by the beta-subunit of the Oxytricha telomere-binding protein.

T. Cech, G. Fang, Thomas R. Cech, 1993, Biochemistry.

DDA3 associates with MCAK and controls chromosome congression.

Chang-Young Jang, G. Fang, 2011, Biochemical and biophysical research communications.

DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement

J. Yates, Chang-Young Jang, G. Fang, 2008, The Journal of cell biology.

Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies.

L. Lam, Xin Lu, S. Rosenberg, 2017, Cancer research.

Sirt1 Regulates Microtubule Dynamics Through Negative Regulation of Plk1 in Mitosis

Chang-Young Jang, Kwang-Hoon Chun, Xiang Zhang, 2015, Journal of cellular biochemistry.

DDA3 associates with microtubule plus ends and orchestrates microtubule dynamics and directional cell migration

X. Yao, Peng Xia, G. Fang, 2013, Scientific Reports.

Phospho-regulation of DDA3 function in mitosis.

J. Yates, Chang-Young Jang, G. Fang, 2010, Biochemical and biophysical research communications.

FAM29A, a target of Plk1 regulation, controls the partitioning of NEDD1 between the mitotic spindle and the centrosomes

G. Fang, Hui Zhu, Kayleen Fang, 2009, Journal of Cell Science.

The N-terminal domain of DDA3 regulates the spindle-association of the microtubule depolymerase Kif2a and controls the mitotic function of DDA3

Chang-Young Jang, G. Fang, 2009, Cell cycle.

Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a

J. Yates, Chang-Young Jang, G. Fang, 2009, Journal of Cell Science.

Telomerase RNA localized in the replication band and spherical subnuclear organelles in hypotrichous ciliates

T. Cech, G. Fang, Thomas R. Cech, 1995, The Journal of cell biology.

Methylation of PLK1 by SET7/9 ensures accurate kinetochore–microtubule dynamics

Tarsha L Ward, X. Yao, M. Ye, 2019, Journal of molecular cell biology.

Plk1- and (cid:2) -TrCP – dependent degradation of Bora controls mitotic progression

J. Yates, Chang-Young Jang, G. Fang, 2008 .

Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor.

Chaohong Sun, L. Hasvold, Chang H. Park, 2017, Journal of Medicinal Chemistry.

Nuf2 and Hec1 Are Required for Retention of the Checkpoint Proteins Mad1 and Mad2 to Kinetochores

E. Salmon, J. DeLuca, B. Howell, 2003, Current Biology.

Mechanism, function and regulation of microtubule-dependent microtubule amplification in mitosis

G. Fang, Hui Zhu, Kayleen Fang, 2009, Molecules and cells.

Targeting protein-protein interaction by small molecules.

Weiru Wang, G. Fang, Weiru Wang, 2014, Annual review of pharmacology and toxicology.

The β subunit of Oxytricha telomere-binding protein promotes G-quartet formation by telomeric DNA

T. Cech, G. Fang, 1993, Cell.

Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20

M. Kirschner, G. Wagner, Yingxi Lin, 2000, Nature Structural Biology.

Structure of the Mad 2 spindle assembly checkpoint protein and its interaction with Cdc 20

M. Kirschner, G. Wagner, Yingxi Lin, 2000 .

Bora and the Kinase Aurora A Cooperatively Activate the Kinase Plk1 and Control Mitotic Entry

J. Yates, Chang-Young Jang, G. Fang, 2008, Science.

Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry.

V. Dixit, Jinfeng Liu, Xiaodong Huang, 2011, Molecular cell.

Chfr is required for tumor suppression and Aurora A regulation

H. Saya, Junjie Chen, Xiaochun Yu, 2005, Nature Genetics.

Oxytricha telomere-bindin p.rotei.n: . separable DNA-binding anommerlzauon domains of the -subunit

T. Cech, G. Fang, J. Gray, 1993 .

Cep55, a microtubule-bundling protein, associates with centralspindlin to control the midbody integrity and cell abscission during cytokinesis.

G. Fang, Wei-meng Zhao, A. Seki, 2006, Molecular biology of the cell.

Breast cancer-specific gene 1 interacts with the mitotic checkpoint kinase BubR1

Jingwen Liu, Anu Gupta, G. Fang, 2003, Oncogene.

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation.

M. Kirschner, Hongtao Yu, G. Fang, 1998, Genes & development.

Abstract 2734: Veliparib (ABT-888) potentiates the cytotoxic activity of DNA alkylating agents by trapping PARP onto damaged chromatin

P. Ellis, Eric F. Johnson, G. Fang, 2014 .

Destruction box-dependent degradation of aurora B is mediated by the anaphase-promoting complex/cyclosome and Cdh1.

S. Stewart, G. Fang, Scott Stewart, 2005, Cancer research.

Inducing precocious anaphase in cultured mammalian cells.

E. Salmon, G. Fang, J. Canman, 2002, Cell motility and the cytoskeleton.

Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation

Maikun Teng, Liwen Niu, Xuebiao Yao, 2015, Nature chemical biology.

Ras inhibition via direct Ras binding--is there a path forward?

Weiru Wang, G. Fang, J. Rudolph, 2012, Bioorganic & medicinal chemistry letters.

RCS1, a substrate of APC/C, controls the metaphase to anaphase transition

J. Yates, G. Fang, Wei-meng Zhao, 2008, Proceedings of the National Academy of Sciences.

Determining the position of the cell division plane

Timothy J. Mitchison, Julie C. Canman, Tarun M. Kapoor, 2003, Nature.

Aurora A regulates the activity of HURP by controlling the accessibility of its microtubule-binding domain.

Chang-Young Jang, G. Fang, J. Wong, 2008, Molecular biology of the cell.

MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis.

G. Fang, Wei-meng Zhao, Guowei Fang, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Visualization of Mad2 Dynamics at Kinetochores, along Spindle Fibers, and at Spindle Poles in Living Cells

A. Murray, E. Salmon, B. Howell, 2000, The Journal of cell biology.

Plk1- and β-TrCP–dependent degradation of Bora controls mitotic progression

J. Yates, Chang-Young Jang, G. Fang, 2008, The Journal of cell biology.

Cdk 1 phosphorylation of BubR 1 controls spindle checkpoint arrest and Plk 1-mediated formation of the 3 F 3 / 2 epitope

G. Fang, O. K. Wong, 2007 .

Plx1 is the 3F3/2 kinase responsible for targeting spindle checkpoint proteins to kinetochores

G. Fang, O. K. Wong, 2005, The Journal of cell biology.

Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex.

G. Fang, Guowei Fang, 2002, Molecular biology of the cell.

Molecular cloning of telomere-binding protein genes from Stylonychia mytilis.

T. Cech, G. Fang, Thomas R. Cech, 1991, Nucleic acids research.

SKAP associates with kinetochores and promotes the metaphase-to-anaphase transition

G. Fang, A. Seki, Lin Fang, 2009, Cell cycle.

Loading of the 3F3/2 antigen onto kinetochores is dependent on the ordered assembly of the spindle checkpoint proteins.

G. Fang, O. K. Wong, 2006, Molecular biology of the cell.

Centromere cohesion: regulating the guardian

G. Fang, Lin Fang, 2007, Cell Research.

HURP controls spindle dynamics to promote proper interkinetochore tension and efficient kinetochore capture

G. Fang, J. Wong, 2006, The Journal of cell biology.

Mitotic kinases regulate MT-polymerizing/MT-bundling activity of DDA3.

J. Yates, Chang-Young Jang, G. Fang, 2011, Biochemical and biophysical research communications.

PLK1 Phosphorylates Mitotic Centromere-associated Kinesin and Promotes Its Depolymerase Activity*

Xia Ding, Yuejia Huang, X. Yao, 2010, The Journal of Biological Chemistry.

CKAP2 Is a Spindle-associated Protein Degraded by APC/C-Cdh1 during Mitotic Exit*

G. Fang, A. Seki, 2007, Journal of Biological Chemistry.

Anaphase onset does not require the microtubule-dependent depletion of kinetochore and centromere-binding proteins

A. Straight, E. Salmon, K. B. Shannon, 2002, Journal of Cell Science.

Mitotic Regulator SKAP Forms a Link between Kinetochore Core Complex KMN and Dynamic Spindle Microtubules*

Xia Ding, Yuejia Huang, X. Yao, 2012, The Journal of Biological Chemistry.

CENP-E Kinesin Interacts with SKAP Protein to Orchestrate Accurate Chromosome Segregation in Mitosis*

H. Zou, Xia Ding, Jian Du, 2011, The Journal of Biological Chemistry.

FAM29A promotes microtubule amplification via recruitment of the NEDD1–γ-tubulin complex to the mitotic spindle

J. Yates, Chang-Young Jang, G. Fang, 2008, The Journal of cell biology.

Microtubule amplification in the assembly of mitotic spindle and the maturation of kinetochore fibers

G. Fang, Hui Zhu, Kayleen Fang, 2009, Communicative & integrative biology.

Oxytricha telomere-binding protein: DNA-dependent dimerization

T. Cech, G. Fang, 2005 .

Visualization and orchestration of the dynamic molecular society in cells

X. Yao, G. Fang, 2009, Cell Research.

4 Telomere Proteins

T. Cech, G. Fang, 1995 .

MAD2B is an inhibitor of the anaphase-promoting complex.

G. Fang, G. Fang, J. Chen, 2001, Genes & development.

Bora and the Kinase Aurora A Cooperatively Activate the Kinase Plk1 and Control Mitotic Entry

J. Yates, Chang-Young Jang, G. Fang, 2008, Science.

Aurora A regulates the activity of HURP by controlling the accessibility of its microtubule-binding domain.

Chang-Young Jang, G. Fang, J. Wong, 2008, Molecular biology of the cell.

HURP controls spindle dynamics to promote proper interkinetochore tension and efficient kinetochore capture

G. Fang, J. Wong, 2006, The Journal of cell biology.

Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry.

V. Dixit, Jinfeng Liu, Xiaodong Huang, 2011, Molecular cell.

PLK1 Phosphorylates Mitotic Centromere-associated Kinesin and Promotes Its Depolymerase Activity*

Xia Ding, Yuejia Huang, X. Yao, 2010, The Journal of Biological Chemistry.

Chang H. Park, D. Albert, Emily J. Faivre, 2017, Journal of medicinal chemistry.

DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement

J. Yates, Chang-Young Jang, G. Fang, 2008, The Journal of cell biology.

Abstract 4694: ABBV-075, a novel BET family inhibitor, disrupts critical transcription programs that drive prostate cancer growth to induce potent anti-tumor activity in vitro and in vivo

S. Rosenberg, P. Tapang, D. Albert, 2016 .