D. Lohse

发表

A Family of Putative Tumor Suppressors Is Structurally and Functionally Conserved in Humans and Yeast*

J. Dixon, L. Li, B. Ernsting, 1997, The Journal of Biological Chemistry.

Purification and characterization of heparin lyases from Flavobacterium heparinum.

R. Linhardt, D. Lohse, R. J. Linhardt, 1992, The Journal of biological chemistry.

Expression and characterization of catalytic and regulatory domains of rat tyrosine hydroxylase

D. Lohse, S. Daubner, P. Fitzpatrick, 1993, Protein science : a publication of the Protein Society.

Visualization of intermediate and transition-state structures in protein-tyrosine phosphatase catalysis.

J. Dixon, J. Denu, J. Dixon, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Insights derived from the structures of the Ser/Thr phosphatases calcineurin and protein phosphatase 1.

J. Dixon, J. Denu, J. Dixon, 1995, Structure.

The design and preliminary structure-activity relationship studies of benzotriazines as potent inhibitors of Abl and Abl-T315I enzymes.

G. Noronha, Xinshan Kang, J. Hood, 2007, Bioorganic & medicinal chemistry letters.

Microinjection of protein tyrosine phosphatases into fibroblasts disrupts focal adhesions and stress fibers.

L. Romer, A. Gilmore, D. Lohse, 1998, Cell adhesion and communication.

Identification of the intersubunit binding region in rat tyrosine hydroxylase.

D. Lohse, P. Fitzpatrick, 1993, Biochemical and biophysical research communications.

Metabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]- [4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methyl- benzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-py

G. Noronha, J. Hood, R. Soll, 2007 .

Discovery of 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol as an isozyme-selective inhibitor of PI3K for the treatment of ischemia reperfusion injury associated with myocardial infarction.

G. Noronha, Xinshan Kang, W. Wrasidlo, 2007, Journal of medicinal chemistry.

Structure and activity of a unique heparin-derived hexasaccharide.

R. Linhardt, K. Rice, D. Lohse, 1986, The Journal of biological chemistry.

Inhibitors of ABL and the ABL-T315I mutation.

G. Noronha, Xinshan Kang, J. Hood, 2008, Current topics in medicinal chemistry.

Expression, characterization, and crystallization of a member of the novel phospholipase D family of phosphodiesterases

J. Stuckey, J. Dixon, D. Lohse, 1997, Protein science : a publication of the Protein Society.

In Vitro and In Vivo Inhibition of the T315I Mutant BCR/ABL Kinase.

A. McPherson, G. Noronha, J. Hood, 2006 .

Development of prodrug 4-chloro-3-(5-methyl-3-{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}-1,2,4-benzotriazin-7-yl)phenyl benzoate (TG100801): a topically administered therapeutic candidate in clinical trials for the treatment of age-related macular degeneration.

Hong Zhu, Steven Hu, Joel Renick, 2008, Journal of medicinal chemistry.

Discovery of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine--a potent, orally active Src kinase inhibitor with anti-tumor activity in preclinical assays.

Hong Zhu, Feng Shi, Steven Hu, 2007, Bioorganic & medicinal chemistry letters.

Discovery and preliminary structure-activity relationship studies of novel benzotriazine based compounds as Src inhibitors.

Joel Renick, Kathy Barrett, Richard Soll, 2006, Bioorganic & medicinal chemistry letters.

Purification and Characterization Heparin Lyases from Flavobacterium heparinurn

D. Lohse, Robert J. Linhardtg, 1992 .

Metabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrro

Joel Renick, Richard Soll, G. Noronha, 2007, Drug Metabolism and Disposition.

Mapping and quantification of the major oligosaccharide components of heparin.

R. Linhardt, K. Rice, D. Lohse, 1988, The Biochemical journal.

Roles of aspartic acid-181 and serine-222 in intermediate formation and hydrolysis of the mammalian protein-tyrosine-phosphatase PTP1.

J. Dixon, J. Denu, J. Dixon, 1997, Biochemistry.

Design and selection of Toca 511 for clinical use: modified retroviral replicating vector with improved stability and gene expression.

D. Lohse, K. Hiraoka, N. Kasahara, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

Erratum: Design and selection of toca 511 for clinical use: Modified retroviral replicating vector with improved stability and gene expression (Molecular Therapy (2012) 20 (1689-1698) DOI:10.1038/mt.2012.83)

D. Lohse, K. Hiraoka, N. Kasahara, 2013 .

Development of an ASPEN Plus Model of a Chemical-Looping Reformer Reactor

D. Lohse, 2011 .