S. Cutts

发表

Defective chromosome segregation, microtubule bundling and nuclear bridging in inner centromere protein gene (Incenp)-disrupted mice.

K. Choo, B. Kile, S. Cutts, 1999, Human molecular genetics.

In vitro transcription assay for resolution of drug-DNA interactions at defined DNA sequences.

S. Cutts, D. Phillips, Benny J. Evison, 2010, Methods in molecular biology.

Impaired NHEJ repair in amyotrophic lateral sclerosis is associated with TDP-43 mutations

Z. Hořejší, I. Blair, G. Nicholson, 2020, Molecular neurodegeneration.

Formaldehyde-activated WEHI-150 induces DNA interstrand crosslinks with unique structural features.

J. Collins, S. Cutts, B. Sleebs, 2019, Bioorganic & medicinal chemistry.

Barminomycin, a model for the development of new anthracyclines.

K. Kimura, R. Brownlee, S. Cutts, 2010, Anti-cancer agents in medicinal chemistry.

Formaldehyde-Activated Pixantrone Is a Monofunctional DNA Alkylator That Binds Selectively to CpG and CpA Doublets

G. Pezzoni, S. Cutts, D. Phillips, 2008, Molecular Pharmacology.

Pixantrone can be activated by formaldehyde to generate a potent DNA adduct forming agent

S. Cutts, D. Phillips, Benny J. Evison, 2007, Nucleic acids research.

The cardio-protecting agent and topoisomerase II catalytic inhibitor sobuzoxane enhances doxorubicin-DNA adduct mediated cytotoxicity

A. Nudelman, S. Cutts, A. Rephaeli, 2008, Cancer Chemotherapy and Pharmacology.

Anticancer prodrugs of butyric acid and formaldehyde protect against doxorubicin-induced cardiotoxicity

A. Nudelman, S. Cutts, A. Rephaeli, 2007, British Journal of Cancer.

Barminomycin functions as a potent pre-activated analogue of Adriamycin.

K. Kimura, S. Cutts, D. Phillips, 2001, Chemico-biological interactions.

Formaldehyde activation of mitoxantrone yields CpG and CpA specific DNA adducts.

S. Cutts, C. Cullinane, D. Phillips, 2000, Nucleic acids research.

Mitoxantrone Mediates Demethylation and Re-Expression of Cyclin D2, Estrogen Receptor 14.3.3 Sigma In Breast Cancer Cells

S. Sukumar, A. Nudelman, S. Cutts, 2003, Cancer biology & therapy.

The selectivty and anti-metastatic activity of oral bioavailable butyric acid prodrugs

A. Nudelman, S. Cutts, A. Rephaeli, 2006, Investigational New Drugs.

Cytosine Methylation Enhances Mitoxantrone-DNA Adduct Formation at CpG Dinucleotides*

S. Cutts, D. Phillips, B. Parker, 2001, The Journal of Biological Chemistry.

Cloning, expression, and promoter structure of a mammalian Inner Centromere Protein (INCENP)

K. Choo, B. Kile, S. Cutts, 1999, Mammalian Genome.

High-resolution transcription assay for probing drug-DNA interactions at individual drug sites.

D. Crothers, S. Cutts, C. Cullinane, 2001, Methods in enzymology.

Disparate Impact of Butyroyloxymethyl Diethylphosphate (AN-7), a Histone Deacetylase Inhibitor, and Doxorubicin in Mice Bearing a Mammary Tumor

A. Nudelman, S. Cutts, A. Rephaeli, 2012, PloS one.

Chapter 45 – Anthracyclines

S. Cutts, D. Rayner, 2014 .

DNA repair in response to anthracycline-DNA adducts: a role for both homologous recombination and nucleotide excision repair.

S. Cutts, T. Koch, D. Phillips, 2008, Mutation research.

Processing of anthracycline-DNA adducts via DNA replication and interstrand crosslink repair pathways.

S. Cutts, D. Phillips, K. Kimura, 2012, Biochemical pharmacology.

Reversible and formaldehyde-mediated covalent binding of a bis-amino mitoxantrone analogue to DNA.

J. Collins, S. Cutts, B. Sleebs, 2016, Organic & biomolecular chemistry.

An evaluation of the interaction of pixantrone with formaldehyde-releasing drugs in cancer cells

A. Nudelman, S. Cutts, A. Rephaeli, 2022, Cancer Chemotherapy and Pharmacology.

Isolation and structural analysis of the covalent adduct formed between a bis-amino mitoxantrone analogue and DNA: a pathway to major-minor groove cross-linked adducts.

J. Collins, S. Cutts, B. Sleebs, 2016, Organic & biomolecular chemistry.

DNA binding by pixantrone.

J. Collins, S. Cutts, D. Phillips, 2010, Organic & biomolecular chemistry.

Construction of neocentromere-based human minichromosomes by telomere-associated chromosomal truncation

K. Choo, L. Wong, S. Cutts, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Formaldehyde-releasing prodrugs specifically affect cancer cells by depletion of intracellular glutathione and augmentation of reactive oxygen species

A. Nudelman, S. Cutts, A. Rephaeli, 2008, Cancer Chemotherapy and Pharmacology.

The role of intracellularly released formaldehyde and butyric acid in the anticancer activity of acyloxyalkyl esters.

A. Nudelman, S. Cutts, A. Rephaeli, 2005, Journal of medicinal chemistry.

Factors determining the stability, size distribution, and cellular accumulation of small, monodisperse chitosan nanoparticles as candidate vectors for anticancer drug delivery: application to the passive encapsulation of [14C]-doxorubicin [Corrigendum]

P. Pigram, G. Pietersz, S. Cutts, 2016, Nanotechnology, science and applications.

P. Pigram, M. J. Masarudin, S. Cutts, 2015, Nanotechnology, science and applications.

Mitoxantrone, More than Just Another Topoisomerase II Poison

S. Cutts, B. Sleebs, D. Phillips, 2016, Medicinal research reviews.

Doxorubicin-DNA adducts induce a non-topoisomerase II-mediated form of cell death.

A. Nudelman, S. Cutts, A. Rephaeli, 2006, Cancer research.

ToF-SIMS and machine learning for single-pixel molecular discrimination of an acrylate polymer microarray.

D. Ballabio, M. Alexander, A. Hook, 2020, Analytical chemistry.

The binding of [(en)Pt(mu-dpzm)2Pt(en)]4+ to G/C-rich regions of DNA.

J. Collins, J. Aldrich-Wright, S. Cutts, 2001, Journal of inorganic biochemistry.

Activation of clinically used anthracyclines by the formaldehyde-releasing prodrug pivaloyloxymethyl butyrate

A. Nudelman, S. Cutts, A. Rephaeli, 2007, Molecular Cancer Therapeutics.

Use of oligonucleotides to define the site of interstrand cross-links induced by Adriamycin

Suzanne M. Cutts, Don R. Phillips, S. Cutts, 1995, Nucleic Acids Res..

The histone deacetylase inhibitor butyroyloxymethyl diethylphosphate (AN-7) protects normal cells against toxicity of anticancer agents while augmenting their anticancer activity

A. Nudelman, S. Cutts, A. Rephaeli, 2012, Investigational New Drugs.

Mode of interaction between butyroyloxymethyl-diethyl phosphate (AN-7) and doxorubicin in MCF-7 and resistant MCF-7/Dx cell lines

A. Nudelman, S. Cutts, A. Rephaeli, 2006, Journal of Cancer Research and Clinical Oncology.

The Power and Potential of Doxorubicin‐DNA Adducts

A. Nudelman, S. Cutts, A. Rephaeli, 2005, IUBMB life.

Sequence specificity of adriamycin-DNA adducts in human tumor cells.

A. Nudelman, S. Cutts, A. Rephaeli, 2003, Molecular cancer therapeutics.

Effects of histone deacetylase inhibitory prodrugs on epigenetic changes and DNA damage response in tumor and heart of glioblastoma xenograft

A. Nudelman, S. Cutts, A. Rephaeli, 2017, Investigational New Drugs.

Centromere Protein B Null Mice are Mitotically and Meiotically Normal but Have Lower Body and Testis Weights

K. Choo, S. Cutts, K. Fowler, 1998, Journal of Cell Biology.

CpG methylation potentiates pixantrone and doxorubicin-induced DNA damage and is a marker of drug sensitivity

G. Pezzoni, S. Cutts, D. Phillips, 2009, Nucleic acids research.

Activation of adriamycin by the pH-dependent formaldehyde-releasing prodrug hexamethylenetetramine.

Abraham Nudelman, Ada Rephaeli, A. Nudelman, 2003, Molecular cancer therapeutics.

Binding of pixantrone to DNA at CpA dinucleotide sequences and bulge structures.

J. Collins, S. Cutts, D. Phillips, 2015, Organic & biomolecular chemistry.

M2, a novel anthracenedione, elicits a potent DNA damage response that can be subverted through checkpoint kinase inhibition to generate mitotic catastrophe.

S. Cutts, R. Forrest, B. Sleebs, 2011, Biochemical pharmacology.

A Molecular Understanding of Mitoxantrone-DNA Adduct Formation

S. Cutts, D. Phillips, Benny J. Evison, 2004, Journal of Biological Chemistry.

Activation of DNA damage response pathways as a consequence of anthracycline-DNA adduct formation.

A. Nudelman, S. Cutts, A. Rephaeli, 2012, Biochemical pharmacology.

Impaired NHEJ repair in amyotrophic lateral sclerosis is associated with TDP-43 mutations

Z. Hořejší, I. Blair, G. Nicholson, 2020, Molecular neurodegeneration.

Observation of non-glandular gastritis associated with Doxil chemotherapy treatment in NSG™ mice

S. Cutts, L. Rasmussen, Tina Robinson, 2021, Laboratory animals.

Molecular basis for the synergistic interaction of adriamycin with the formaldehyde-releasing prodrug pivaloyloxymethyl butyrate (AN-9).

A. Nudelman, S. Cutts, A. Rephaeli, 2001, Cancer research.

Interstrand cross-linking by adriamycin in nuclear and mitochondrial DNA of MCF-7 cells.

S. Cutts, C. Cullinane, D. Phillips, 2000, Nucleic acids research.

In Situ Hybridization

K. Choo, S. Cutts, J. Craig, 2001 .

A gel mobility shift assay for probing the effect of drug-DNA adducts on DNA-binding proteins.

P. Parsons, R. Sturm, S. Cutts, 1997, Methods in molecular biology.

In vivo and in vitro antitumor activity of butyroyloxymethyl‐diethyl phosphate (AN‐7), a histone deacetylase inhibitor, in human prostate cancer

Z. Malik, A. Nudelman, S. Cutts, 2005, International journal of cancer.

ABT-737 overcomes Bcl-2 mediated resistance to doxorubicin-DNA adducts.

A. Nudelman, S. Cutts, A. Rephaeli, 2010, Biochemical pharmacology.

Detection of Adriamycin–DNA adducts by accelerator mass spectrometry at clinically relevant Adriamycin concentrations

S. Cutts, T. Ognibene, D. Phillips, 2008, Nucleic acids research.

A novel valproic acid prodrug as an anticancer agent that enhances doxorubicin anticancer activity and protects normal cells against its toxicity in vitro and in vivo.

A. Nudelman, S. Cutts, A. Rephaeli, 2014, Biochemical pharmacology.

Formation of mitoxantrone adducts in human tumor cells: potentiation by AN-9 and DNA methylation.

A. Nudelman, S. Cutts, A. Rephaeli, 2004, Oncology research.

The hydroxyl epimer of doxorubicin controls the rate of formation of cytotoxic anthracycline-DNA adducts

A. Nudelman, S. Cutts, A. Rephaeli, 2013, Cancer Chemotherapy and Pharmacology.

Poly(ADP-ribose) polymerase at active centromeres and neocentromeres at metaphase.

L. Shaffer, A. Saxena, K. Choo, 2000, Human molecular genetics.

Design, synthesis, and DNA sequence selectivity of formaldehyde-mediated DNA-adducts of the novel N-(4-aminobutyl) acridine-4-carboxamide.

R. Brownlee, S. Cutts, D. Phillips, 2014, Bioorganic & medicinal chemistry letters.

Visualizing ToF-SIMS hyperspectral imaging data using color-tagged toroidal self-organizing maps.

Robert T. Jones, P. Pigram, S. Cutts, 2019, Analytical chemistry.

SOM-RPM for the accurate visualization of high-dimensional hyperspectral data.

D. Ballabio, D. Winkler, P. Pigram, 2020, Analytical chemistry.

Understanding mass spectrometry images: complexity to clarity with machine learning

P. Pigram, S. Cutts, D. Phillips, 2020, Biopolymers.

Self-Organizing Map and Relational Perspective Mapping for the Accurate Visualization of High-Dimensional Hyperspectral Data

D. Ballabio, D. Winkler, P. Pigram, 2020 .

Two-Dimensional and Three-Dimensional Time-of-Flight Secondary Ion Mass Spectrometry Image Feature Extraction Using a Spatially Aware Convolutional Autoencoder.

D. Winkler, P. Pigram, G. Pietersz, 2022, Analytical chemistry.

Fusing ToF‐SIMS Images for Spatial‐Spectral Resolution Enhancement using a Convolutional Neural Network

D. Winkler, P. Pigram, S. Cutts, 2022, Advanced Materials Interfaces.

Potential Therapeutic Advantages of Doxorubicin when Activated by Formaldehyde to Function as a DNA Adduct-Forming Agent.

A. Nudelman, S. Cutts, A. Rephaeli, 2015, Current topics in medicinal chemistry.

Formation of adriamycin--DNA adducts in vitro.

S. Cutts, C. Cullinane, D. Phillips, 1994, Nucleic acids research.

Development of pluronic micelle-encapsulated doxorubicin and formaldehyde-releasing prodrugs for localized anticancer chemotherapy.

A. Nudelman, C. Chan, S. Cutts, 2009, Oncology research.

Adriamycin-induced DNA Adducts Inhibit the DNA Interactions of Transcription Factors and RNA Polymerase (*)

P. Parsons, R. Sturm, S. Cutts, 1996, The Journal of Biological Chemistry.

Anthracyclines

S. Cutts, Alison Cheong, Sean McGrath, 2018, WikiJournal of Medicine.

A switch in mechanism of action prevents doxorubicin-mediated cardiac damage.

A. Nudelman, S. Cutts, A. Rephaeli, 2021, Biochemical pharmacology.

Inhibition of Bcl-2 or IAP proteins does not provoke mutations in surviving cells.

S. Cutts, D. Rayner, C. Hawkins, 2015, Mutation research.

Butyrate ( AN-9 ) with the Formaldehyde-releasing Prodrug Pivaloyloxymethyl Molecular Basis for the Synergistic Interaction of Adriamycin Updated

A. Nudelman, S. Cutts, A. Rephaeli, 2001 .

Identification of Macromolecular Targets for Formaldehyde-Activated Adriamycin

Don R. Phillips, Abraham Nudelman, Ada Rephaeli, 2002 .

Chapter 45 – Anthracyclines

S. Cutts, D. Rayner, 2014 .

Centromere Protein B Null Mice are Mitotically and Meiotically Normal but Have Lower Body and Testis Weights

K. Choo, S. Cutts, K. Fowler, 1998, The Journal of cell biology.

Binding of pixantrone to DNA at CpA dinucleotide sequences and bulge structures.

S. Cutts, Haiqiang Wang, Don R. Phillips, 2015, Organic & biomolecular chemistry.

Reversible and formaldehyde-mediated covalent binding of a bis-amino mitoxantrone analogue to DNA.

J. Collins, S. Cutts, B. Sleebs, 2016, Organic and biomolecular chemistry.

New anthracenedione derivatives with improved biological activity by virtue of stable drug-DNA adduct formation.

J. Collins, A. Nudelman, S. Cutts, 2010, Journal of medicinal chemistry.

P. Pigram, M. J. Masarudin, G. Pietersz, 2016, Nanotechnology, science and applications.

Nanotechnology, Science and Applications Dovepress

P. Pigram, S. Cutts, Benny J. Evison, 2022 .

Encapsulation of Mitoxantrone within Cucurbit[8]uril Decreases Toxicity and Enhances Survival in a Mouse Model of Cancer.

J. Collins, P. Pigram, S. Cutts, 2017, ACS medicinal chemistry letters.