P. Northcote

发表

The alkaline digestion of reject fibre in deinking sludge as a precursor to filler recovery by wet air oxidation

N. Wiseman, J. Johnston, C. B. Milestone, 2000 .

Marine natural products.

P. Northcote, J. Blunt, B. Copp, 2006, Natural product reports.

Effects of the microtubule stabilizing agent peloruside A on the proteome of HL-60 cells

J. Miller, A. Wilmes, P. Northcote, 2011, Investigational New Drugs.

Induction of apoptosis by the marine sponge (Mycale) metabolites, mycalamide A and pateamine

J. Miller, M. Berridge, P. Northcote, 2001, Apoptosis.

Spatial and Temporal Variability of Cytotoxic Metabolites in Populations of the New Zealand Sponge Mycale hentscheli

M. Page, P. Northcote, M. Kelly, 2005, Journal of Chemical Ecology.

Delaying the onset of experimental autoimmune encephalomyelitis with the microtubule‐stabilizing compounds, paclitaxel and Peloruside A

J. Miller, P. Northcote, A. L. La Flamme, 2009, Journal of leukocyte biology.

13C NMR analysis of 3,6-dihydro-2H-pyrans: assignment of remote stereochemistry using axial shielding effects.

P. Northcote, Mark J. Bartlett, M. Lein, 2014, The Journal of organic chemistry.

Synergistic Effects of Peloruside A and Laulimalide with Taxoid Site Drugs, but Not with Each Other, on Tubulin Assembly

Arun K. Ghosh, K. Nicolaou, J. Miller, 2006, Molecular Pharmacology.

Chemical genetic profiling of the microtubule-targeting agent peloruside A in budding yeast Saccharomyces cerevisiae.

D. Bellows, R. Heathcott, J. Miller, 2012, Gene.

Metagenomic Exploration of the Marine Sponge Mycale hentscheli Uncovers Multiple Polyketide-Producing Bacterial Symbionts

Alistair S Brown, Robert A. Keyzers, P. Northcote, 2020, mBio.

Peloruside A: a lead non-taxoid-site microtubule-stabilizing agent with potential activity against cancer, neurodegeneration, and autoimmune disease.

J. Miller, P. Northcote, Arun Kanakkanthara, 2016, Natural product reports.

Successes and pitfalls of the aquaculture of the sponge Mycale hentscheli

M. Page, S. Handley, R. Willan, 2011 .

Cellular effects of the microtubule-targeting agent peloruside A in hypoxia-conditioned colorectal carcinoma cells.

J. Miller, M. Hajdúch, P. Džubák, 2017, Biochimica et biophysica acta. General subjects.

Peloruside A enhances apoptosis in H-ras-transformed cells and is cytotoxic to proliferating T cells

J. Miller, M. Berridge, P. Northcote, 2004, Apoptosis.

High performance Raman spectroscopy with simple optical components

P. Etchegoin, P. Northcote, W. Somerville, 2010 .

Peloruside A inhibits microtubule dynamics in a breast cancer cell line MCF7

J. Miller, P. Northcote, Ariane Chan, 2011, Investigational New Drugs.

Functional mimicry revealed by the crystal structure of an eIF4A:RNA complex bound to the interfacial inhibitor, desmethyl pateamine A.

R. Cencic, J. Pelletier, P. Teesdale-Spittle, 2021, Cell chemical biology.

Characterizing the laulimalide-peloruside binding site using site-directed mutagenesis of TUB2 in S. cerevisiae.

P. Teesdale-Spittle, D. Bellows, J. Miller, 2014, Molecular bioSystems.

Preclinical Development Peloruside-and Laulimalide-Resistant Human Ovarian Carcinoma Cells Have b I-Tubulin Mutations and Altered Expression of b II-and b III-Tubulin Isotypes

J. Miller, A. Wilmes, P. Giannakakou, 2011 .

Peloruside- and Laulimalide-Resistant Human Ovarian Carcinoma Cells Have βI-Tubulin Mutations and Altered Expression of βII- and βIII-Tubulin Isotypes

J. Miller, A. Wilmes, P. Giannakakou, 2011, Molecular Cancer Therapeutics.

Synergistic interactions between peloruside A and other microtubule-stabilizing and destabilizing agents in cultured human ovarian carcinoma cells and murine T cells

J. Miller, A. Wilmes, P. Northcote, 2011, Cancer Chemotherapy and Pharmacology.

Marine natural products.

P. Northcote, J. Blunt, B. Copp, 2010, Natural product reports.

GLYCOTHIOHEXIDE α, A NOVEL ANTIBIOTIC PRODUCED BY "Sebekia" sp., LL-14E605

P. Northcote, M. Siegel, M. Lee, 1994 .

Methods for studying microtubule binding site interactions: zampanolide as a covalent binding agent.

K. Altmann, J. Díaz, J. Miller, 2013, Methods in cell biology.

Acquired Resistance to Peloruside A and Laulimalide is Associated with Downregulation of Vimentin in Human Ovarian Carcinoma Cells

J. Miller, P. Northcote, P. Rawson, 2012, Pharmaceutical Research.

Preclinical Development b II-Tubulin and b III-Tubulin Mediate Sensitivity to Peloruside A and Laulimalide , but not Paclitaxel or Vinblastine , in Human Ovarian Carcinoma Cells

J. Miller, P. Northcote, Arun Kanakkanthara, 2012 .

βII-Tubulin and βIII-Tubulin Mediate Sensitivity to Peloruside A and Laulimalide, but not Paclitaxel or Vinblastine, in Human Ovarian Carcinoma Cells

J. Miller, P. Northcote, Arun Kanakkanthara, 2011, Molecular Cancer Therapeutics.

Peloruside A Does Not Bind to the Taxoid Site on β-Tubulin and Retains Its Activity in Multidrug-Resistant Cell Lines

P. Teesdale-Spittle, J. Miller, R. Buey, 2004, Cancer Research.

Retains Its Activity in Multidrug-Resistant Cell Lines-Tubulin β Peloruside A Does Not Bind to the Taxoid Site on

P. Teesdale-Spittle, J. Miller, R. Buey, 2004 .

Advances in Brief Peloruside A Does Not Bind to the Taxoid Site on-Tubulin and Retains Its Activity in Multidrug-Resistant Cell Lines

P. Teesdale-Spittle, J. Miller, R. Buey, 2004 .

Peloruside A, a novel antimitotic agent with paclitaxel-like microtubule- stabilizing activity.

J. Miller, M. Berridge, P. Northcote, 2002, Cancer research.

Advances in Brief Peloruside A , a Novel Antimitotic Agent with Paclitaxel-like Microtubule-stabilizing Activity 1

J. Miller, M. Berridge, P. Northcote, 2002 .

Differential action of pateamine A on translation of genomic and subgenomic mRNAs from Sindbis virus.

Luis Carrasco, J. Pelletier, P. Northcote, 2015, Virology.

Microtubule‐stabilizing agents delay the onset of EAE through inhibition of migration

J. Miller, P. Northcote, A. L. La Flamme, 2013, Immunology and cell biology.

Induction of accelerated senescence by the microtubule-stabilizing agent peloruside A

J. Miller, P. Northcote, I. Paterson, 2017, Investigational New Drugs.

Chemical modulation of microtubule structure through the laulimalide/peloruside site.

M. Steinmetz, K. Altmann, F. Gago, 2022, Structure.

Pyrroindomycins, novel antibiotics produced by Streptomyces rugosporus sp. LL-42D005. I. Isolation and structure determination.

P. Northcote, M. Siegel, D. Williams, 1994, The Journal of antibiotics.

Pateamine: a potent cytotoxin from the New Zealand Marine sponge, mycale sp.

P. Northcote, J. Blunt, M. Munro, 1991 .

Polyhalogenated Indoles from the Red Alga Rhodophyllis membranacea: The First Isolation of Bromo-Chloro-Iodo Secondary Metabolites.

J. Miller, P. Northcote, A. Munkacsi, 2016, Journal of natural products.

Halogenated Meroditerpenoids from a South Pacific Collection of the Red Alga Callophycus serratus.

J. Miller, P. Northcote, M. Lein, 2018, Journal of natural products.

Az—a colourful azulene-derived protecting group

Mattie S. M. Timmer, P. Northcote, B. Burkett, 2009 .

The Nitrogenous Hamigerans: Unusual Amino Acid-Derivatized Aromatic Diterpenoid Metabolites from the New Zealand Marine Sponge Hamigera tarangaensis.

J. Miller, P. Northcote, J. Dattelbaum, 2015, The Journal of organic chemistry.

Terpenoids from Selected Marine Invertebrates

R. Andersen, P. Northcote, M. Tischler, 1990 .

Unusual sulfamate indoles and a novel indolo[3,2-a]carbazole from Ancorina sp.

L. Pannell, M. Boyd, P. Northcote, 2002, The Journal of organic chemistry.

Clathriol, a novel polyoxygenated 14beta steroid isolated from the New Zealand marine sponge Clathria lissosclera.

P. Northcote, V. Webb, R. Keyzers, 2002, Journal of natural products.

Mycalamide D, a new cytotoxic amide from the New Zealand marine sponge Mycale species.

J. Miller, M. Page, P. Northcote, 2000, Journal of natural products.

Glycothiohexide alpha, a novel antibiotic produced by "Sebekia" sp., LL-14E605. III. Structural elucidation.

P. Northcote, M. Siegel, D. Borders, 1994, The Journal of antibiotics.

Glycothiohexide alpha, a novel antibiotic produced by "Sebekia" sp., LL-14E605. II. Isolation and physical-chemical characterization.

P. Northcote, D. Williams, D. Borders, 1994, The Journal of antibiotics.

Zampanolide, a potent new microtubule-stabilizing agent, covalently reacts with the taxane luminal site in tubulin α,β-heterodimers and microtubules.

K. Altmann, I. Barasoain, J. Díaz, 2012, Chemistry & biology.

Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis.

J. Miller, P. Northcote, Arun Kanakkanthara, 2009, Journal of medicinal chemistry.

Genetic, morphological, and chemical divergence in the sponge genus Latrunculia (Porifera: Demospongiae) from New Zealand

P. Northcote, K. Miller, C. Battershill, 2001 .

Mitochondrial Genome-Knockout Cells Demonstrate a Dual Mechanism of Action for the Electron Transport Complex I Inhibitor Mycothiazole

J. Miller, M. Berridge, A. Tan, 2012, Marine drugs.

Marine natural products.

P. Northcote, J. Blunt, B. Copp, 2008, Natural product reports.

Xestenone, a new bycyclic C19 terpenoid from the marine sponge xestospongia vanilla

R. Andersen, P. Northcote, 1988 .

Peloruside A: a potent cytotoxic macrolide isolated from the new zealand marine sponge Mycale sp.

P. Northcote, L. West, C. Battershill, 2000, The Journal of organic chemistry.

Peloruside A: a potent cytotoxic macrolide isolated from the new zealand marine sponge Mycale sp.

P. Northcote, L. West, C. Battershill, 2000, The Journal of organic chemistry.

A colourful azulene-based protecting group for carboxylic acids

P. Northcote, J. Harvey, Thomas Bevan, 2018, Tetrahedron.

Marine natural products.

P. Northcote, J. Blunt, B. Copp, 2011, Natural product reports.

Lehualides E-K, cytotoxic metabolites from the Tongan marine sponge Plakortis sp.

Jacqueline M. Barber, D. Bellows, J. Miller, 2011, Journal of natural products.

The Oxeatamides: nitrogenous spongian diterpenes from the New Zealand marine sponge Darwinella oxeata.

K. Dowle, P. Northcote, J. Wojnar, 2014, Journal of natural products.

Spongian diterpenoids from marine sponges.

P. Northcote, M. Davies-Coleman, R. Keyzers, 2006, Natural product reports.

Natural Products from Tongan Marine Organisms

R. Subramani, P. Northcote, R. Keyzers, 2021, Molecules.

Marine natural products.

P. Northcote, J. Blunt, B. Copp, 2004, Natural product reports.

Clathriol B, a New 14β Marine Sterol from the New Zealand Sponge Clathria lissosclera

M. Berridge, P. Northcote, R. Keyzers, 2003 .

Lipophilic toxicity from the marine dinoflagellate Karenia brevisulcata: use of the brevetoxin neuroblastoma assay to assess toxin presence and concentration.

P. Northcote, P. Truman, N. Redshaw, 2005, Toxicon : official journal of the International Society on Toxinology.

Colensolide A: a new nitrogenous bromophenol from the New Zealand marine red alga Osmundaria colensoi

P. Northcote, W. Popplewell, 2009 .

Heptanosides from galactose-derived oxepenes via stereoselective addition reactions.

P. Northcote, J. O. Hoberg, J. Harvey, 2009, The Journal of organic chemistry.

The Cellular Target Specificity of Pateamine A

P. H. Atkinson, P. Northcote, D. Maass, 2013, Zeitschrift fur Naturforschung. C, Journal of biosciences.

The Cellular Target Specifi city of Pateamine A

P. H. Atkinson, P. Northcote, D. Maass, 2013 .

Marine Invertebrate Natural Products that Target Microtubules.

J. Miller, P. Northcote, J. Owen, 2018, Journal of natural products.

Aquaculture trials for the production of biologically active metabolites in the New Zealand sponge Mycale hentscheli (Demospongiae: Poecilosclerida)

M. Page, S. Handley, P. Northcote, 2005 .

The novel cytotoxic sponge metabolite peloruside A, structurally similar to bryostatin-1, has unique bioactivity independent of protein kinase C.

J. Miller, M. Berridge, P. Northcote, 2001, Anti-cancer drug design.

Peloruside E (22-Norpeloruside A), a Pelorusane Macrolide from the New Zealand Marine Sponge Mycale hentscheli, Retains Microtubule-Stabilizing Properties.

J. Miller, P. Northcote, Samantha Hong, 2018, Journal of natural products.

Peloruside A Inhibits Growth of Human Lung and Breast Tumor Xenografts in an Athymic nu/nu Mouse Model

J. Shay, J. Miller, M. Wick, 2015, Molecular Cancer Therapeutics.

Structure-activity studies of the pelorusides: new congeners and semi-synthetic analogues.

J. Goodman, J. Miller, A. Wilmes, 2011, Organic & biomolecular chemistry.

Spatial and temporal variability of the bacterial community in different chemotypes of the New Zealand marine sponge Mycale hentscheli.

M. Page, P. Northcote, S. Anderson, 2010, FEMS microbiology ecology.

Microtubule-Stabilizing Drugs from Marine Sponges: Focus on Peloruside A and Zampanolide

J. Miller, P. Northcote, A. J. Singh, 2010, Marine drugs.

Marine natural products

P. Northcote, J. Blunt, B. Copp, 2015, Natural product reports.

From Marine Organism to Potential Drug: Using Innovative Techniques to Identify and Characterize Novel Compounds − a Bottom‐Up Approach

J. Miller, P. H. Atkinson, P. Northcote, 2015 .

Studies in the Cycloproparene Series: Oxygen Transfer to 1-Diphenylmethylidene- 1 H-cyclopropabenzene

P. Northcote, A. Kay, B. Halton, 1999 .

Marine natural products.

P. Northcote, J. Blunt, B. Copp, 2003, Natural product reports.

Mollisosides A, B1, and B2: minor triterpene glycosides from the New Zealand and South Australian sea cucumber Australostichopus mollis.

V. Stonik, P. Northcote, V. Kalinin, 2005, Journal of natural products.

Peloruside A, a microtubule-stabilizing agent, induces aneuploidy in ovarian cancer cells

J. Miller, P. Northcote, Ariane Chan, 2016, Investigational New Drugs.

Marine natural products.

P. Northcote, J. Blunt, B. Copp, 2004, Natural product reports.

Insights into the Distinct Mechanisms of Action of Taxane and Non-Taxane Microtubule Stabilizers from Cryo-EM Structures.

Kenneth H. Downing, Eva Nogales, E. Nogales, 2017, Journal of molecular biology.

Zampanolides B-E from the Marine Sponge Cacospongia mycofijiensis: Potent Cytotoxic Macrolides with Microtubule-Stabilizing Activity.

J. Miller, P. Northcote, A. J. Singh, 2018, Journal of natural products.

Hamigeran G Does Not Affect Golgi Structure or Function in HEK293 Cells

J. Miller, P. Northcote, A. J. Singh, 2019, Drug and Drug Abuse.

Structurally diverse hamigerans from the New Zealand marine sponge Hamigera tarangaensis: NMR-directed isolation, structure elucidation and antifungal activity.

Jacqueline M. Barber, R. Heathcott, J. Miller, 2013, Organic & biomolecular chemistry.

Molecular basis for fungicidal action of neothyonidioside, a triterpene glycoside from the sea cucumber, Australostichopus mollis.

Jacqueline M. Barber, D. Bellows, R. Heathcott, 2012, Molecular bioSystems.

Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2alpha phosphorylation.

J. Pelletier, R. Sukarieh, R. Kaufman, 2006, Molecular biology of the cell.

Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation.

N. Sonenberg, J. Pelletier, P. Northcote, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Zampanolide, a Microtubule-Stabilizing Agent, Is Active in Resistant Cancer Cells and Inhibits Cell Migration

K. Altmann, J. Miller, P. Northcote, 2017, International journal of molecular sciences.

βI-tubulin mutations in the laulimalide/peloruside binding site mediate drug sensitivity by altering drug-tubulin interactions and microtubule stability.

J. Miller, P. Northcote, Arun Kanakkanthara, 2015, Cancer letters.

Molecular Recognition of Peloruside A by Microtubules. The C24 Primary Alcohol is Essential for Biological Activity

I. Barasoain, J. Díaz, P. Northcote, 2010, Chembiochem : a European journal of chemical biology.

Marine natural products.

P. Northcote, J. Blunt, B. Copp, 2007, Natural product reports.

Marine natural products.

P. Northcote, J. Blunt, B. Copp, 2005, Natural product reports.

Sized controlled synthesis, purification, and cell studies with silicon quantum dots.

P. Lai, R. Tilley, P. Northcote, 2011, Nanoscale.

The algal metabolite yessotoxin affects heterogeneous nuclear ribonucleoproteins in HepG2 cells

Robert A Keyzers, P. Northcote, T. W. Jordan, 2009, Proteomics.

The protein synthesis inhibitors mycalamides A and E have limited susceptibility toward the drug efflux network

D. Bellows, P. Northcote, A. J. Singh, 2012, Journal of biochemical and molecular toxicology.

Chemical reactions on surface molecules attached to silicon quantum dots.

R. Tilley, Kenji Yamamoto, P. Northcote, 2010, Journal of the American Chemical Society.

Determination of brevetoxins in shellfish by the neuroblastoma assay.

P. Northcote, D. Stirling, R. Lake, 2002, Journal of AOAC International.

Xestovanin A and secoxestovanin A, triterpenoid glycosides with new carbon skeletons from the sponge Xestospongia vanilla

R. Andersen, P. Northcote, 1989 .

Novel Anti‐Inflammatory Spongian Diterpenes from the New Zealand Marine Sponge Chelonaplysilla violacea

P. Northcote, O. A. Zubkov, R. Keyzers, 2004 .

Peloruside A synergizes with other microtubule stabilizing agents in cultured cancer cell lines.

J. Miller, A. Wilmes, P. Northcote, 2007, Molecular pharmaceutics.

Studies in the Cycloproparene Series: Formation of a New Dimer of 1H-Cyclopropa[b]naphthalene

P. Northcote, C. Jones, R. Boese, 1999 .

Hallmarks of Molecular Action of Microtubule Stabilizing Agents

V. Menon, R. Angeletti, A. Fiser, 2011, The Journal of Biological Chemistry.

Xestodiol, a new apocarotenoid from the sponge Xestospongia vanilla

R. Andersen, P. Northcote, 1987 .

Inhibition of human vascular endothelial cell migration and capillary-like tube formation by the microtubule-stabilizing agent peloruside A

J. Miller, P. Northcote, Ariane Chan, 2015, Investigational New Drugs.

Structural basis of microtubule stabilization by laulimalide and peloruside A.

M. Steinmetz, K. Altmann, J. Díaz, 2014, Angewandte Chemie.

Resistance to peloruside A and laulimalide: functional significance of acquired βI-tubulin mutations at sites important for drug-tubulin binding.

J. Miller, J. Eras, P. Northcote, 2014, Current cancer drug targets.

Acquired Resistance to Peloruside A and Laulimalide is Associated with Downregulation of Vimentin in Human Ovarian Carcinoma Cells

J. Miller, P. Northcote, P. Rawson, 2012, Pharmaceutical Research.

Peloruside B, a potent antitumor macrolide from the New Zealand marine sponge Mycale hentscheli: isolation, structure, total synthesis, and bioactivity.

Arun K. Ghosh, Xiaoming Xu, J. Miller, 2010, The Journal of organic chemistry.

Luakuliides A–C, cytotoxic labdane diterpenes from a Tongan dictyoceratid sponge

Jacqueline M. Barber, J. Miller, P. Northcote, 2015 .

Luakuliides A—C, Cytotoxic Labdane Diterpenes from a Tongan Dictyoceratid Sponge.

Jacqueline M. Barber, J. Miller, P. Northcote, 2016 .

NMR determination of the bioactive conformation of peloruside A bound to microtubules.

Jesús Jiménez-Barbero, R. Buey, P. Northcote, 2006, Journal of the American Chemical Society.

RNA-mediated sequestration of the RNA helicase eIF4A by Pateamine A inhibits translation initiation.

R. Cencic, J. Pelletier, G. Wagner, 2006, Chemistry & biology.

639 POSTER RTA 301 (peloruside): a novel microtubule stabilizer with potent in vivo activity against lung cancer and resistant breast cancer

M. Wick, D. Ferguson, P. Northcote, 2006 .

Clathriol B, a New 14β Marine Sterol from the New Zealand Sponge Clathria lissosclera.

M. Berridge, P. Northcote, R. Keyzers, 2003 .

Molecular Recognition of Peloruside A by Microtubules. The C24 Primary Alcohol is Essential for Biological Activity

I. Barasoain, J. Díaz, P. Northcote, 2010, Chembiochem : a European journal of chemical biology.

Stereochemical Control in Carbohydrate Chemistry.

P. Northcote, J. Harvey, Emma M. Dangerfield, 2008 .

Peloruside- and Laulimalide-Resistant Human Ovarian Carcinoma Cells Have βI-Tubulin Mutations and Altered Expression of βII- and βIII-Tubulin Isotypes

J. Miller, A. Wilmes, P. Giannakakou, 2011, Molecular Cancer Therapeutics.

Bi-analyte SERS with isotopically edited dyes.

B. Burkett, P. Etchegoin, P. Northcote, 2008, Physical chemistry chemical physics : PCCP.

Pyrroloquinoline derivatives from a Tongan specimen of the marine sponge Strongylodesma tongaensis

Muhammad Ali Hashmi, J. Miller, P. Northcote, 2019, Tetrahedron Letters.

Polyhalogenated Indoles from the Red Alga Rhodophyllis membranacea: The First Isolation of Bromo-Chloro-Iodo Secondary Metabolites.

J. Miller, P. Northcote, A. Munkacsi, 2016, Journal of natural products.

Two new 4-methylidene containing steroids, craterol A and B, from the New Zealand two sponge association between Stelletta crater and Desmacella dendyi

P. Northcote, R. Keyzers, Taitusi Taufa, 2019, Steroids.

Marine natural products.

P. Northcote, J. Blunt, B. Copp, 2007, Natural product reports.