W. Lehman

发表

Acetylation regulates tropomyosin function in the fission yeast Schizosaccharomyces pombe

Daniel P. Mulvihill, D. Mulvihill, A. Coulton, 2007, Journal of Cell Science.

Predicting Effects of Tropomyosin Mutations on Cardiac Muscle Contraction through Myofilament Modeling

Jeffrey R. Moore, W. Lehman, S. Campbell, 2016, Front. Physiol..

Direct observation of tropomyosin binding to actin filaments

Jeffrey R. Moore, W. Lehman, William M. Schmidt, 2015, Cytoskeleton.

Spontaneous transitions of actin-bound tropomyosin toward blocked and closed states

Stefan Fischer, M. Rynkiewicz, W. Lehman, 2018, The Journal of general physiology.

Electrostatic interaction map reveals a new binding position for tropomyosin on F-actin

Marek Orzechowski, Stefan Fischer, M. Rynkiewicz, 2015, Journal of Muscle Research and Cell Motility.

Electron microscopy and persistence length analysis of semi-rigid smooth muscle tropomyosin strands.

P. Graceffa, D. Sousa, A. Cammarato, 2010, Biophysical journal.

The shape and flexibility of tropomyosin coiled coils: implications for actin filament assembly and regulation.

Stefan Fischer, K. Holmes, H. Jung, 2010, Journal of molecular biology.

Altering the stability of the Cdc8 overlap region modulates the ability of this tropomyosin to bind co-operatively to actin and regulate myosin.

Daniel P. Mulvihill, D. Sousa, T. Edwards, 2011, The Biochemical journal.

A role for actin flexibility in thin filament-mediated contractile regulation and myopathy

D. Swank, M. Rynkiewicz, M. Preller, 2020, Nature Communications.

Modulation of cardiac thin filament structure by phosphorylated troponin-I analyzed by protein-protein docking and molecular dynamics simulation.

I. Gould, M. Rynkiewicz, W. Lehman, 2022, Archives of biochemistry and biophysics.

Energy landscapes reveal the myopathic effects of tropomyosin mutations.

Marek Orzechowski, Stefan Fischer, Jeffrey R. Moore, 2014, Archives of biochemistry and biophysics.

Genetic resiliency associated with dominant lethal TPM1 mutation causing atrial septal defect with high heritability

Ferhaan Ahmad, T. Wong, B. Keavney, 2021, Cell reports. Medicine.

FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets.

J. Hartwig, F. Nakamura, M. Plomann, 2015, Blood.

Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin

C. Yengo, M. Rynkiewicz, Jeffrey R. Moore, 2022, bioRxiv.

Venous thromboembolism prophylaxis in patients with traumatic Venous thromboembolism prophylaxis in patients with traumatic Venous thromboembolism prophylaxis in patients with traumatic Venous thromboembolism prophylaxis in patients with traumatic Venous thromboembolism prophylaxis in patients

W. Lehman, 2012 .

Tropomyosin Must Interact Weakly with Actin to Effectively Regulate Thin Filament Function.

S. Fischer, M. Rynkiewicz, K. Trybus, 2017, Biophysical journal.

Tropomyosin diffusion over actin subunits facilitates thin filament assembly

Stefan Fischer, M. Rynkiewicz, Jeffrey R. Moore, 2016, Structural dynamics.

Curvature variation along the tropomyosin molecule.

Stefan Fischer, K. Holmes, W. Lehman, 2010, Journal of structural biology.

Troponin organization on relaxed and activated thin filaments revealed by electron microscopy and three-dimensional reconstruction.

R Craig, W. Lehman, R. Craig, 2001, Journal of molecular biology.

Thin Filament Structure and the Steric Blocking Model.

W. Lehman, 2016, Comprehensive Physiology.

A new twist on tropomyosin binding to actin filaments: perspectives on thin filament function, assembly and biomechanics

M. Rynkiewicz, Jeffrey R. Moore, W. Lehman, 2019, Journal of Muscle Research and Cell Motility.

Structural Analysis of Smooth Muscle Tropomyosin α and β Isoforms*

R. Dominguez, J. N. Rao, W. Lehman, 2011, The Journal of Biological Chemistry.

Docking Troponin T onto the Tropomyosin Overlapping Domain of Thin Filaments.

M. Rynkiewicz, W. Lehman, Anita Ghosh, 2019, Biophysical journal.

Polymorphism in tropomyosin structure and function

W. Lehman, Worawit Suphamungmee, W. Lehman, 2013, Journal of Muscle Research and Cell Motility.

Three-dimensional organization of troponin on cardiac muscle thin filaments in the relaxed state.

John Trinick, Shixin Yang, Roger Craig, 2014, Biophysical journal.

Tropomyosin position on F-actin revealed by EM reconstruction and computational chemistry.

Stefan Fischer, W. Lehman, J. Mun, 2011, Biophysical journal.

Tropomyosin and the steric mechanism of muscle regulation.

W. Lehman, R. Craig, 2008, Advances in experimental medicine and biology.

Age-Onset Phosphorylation of a Minor Actin Variant Promotes Intestinal Barrier Dysfunction.

Peter M. Douglas, W. Lehman, R. S. Fonseca, 2019, Developmental cell.

Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation

M. Rynkiewicz, Jeffrey R. Moore, W. Lehman, 2021, The Journal of general physiology.

The structural elements responsible for contraction in the ciliateSpirostomum

L. Rebhun, W. Lehman, 2005, Protoplasma.

Switching Muscles On and Off in Steps: The McKillop-Geeves Three-State Model of Muscle Regulation.

W. Lehman, 2017, Biophysical journal.

The mechanism of thin filament regulation: Models in conflict?

W. Lehman, M. Geeves, S. Lehrer, 2019, The Journal of general physiology.

The recruitment of acetylated and unacetylated tropomyosin to distinct actin polymers permits the discrete regulation of specific myosins in fission yeast

Daniel P. Mulvihill, D. Mulvihill, A. Coulton, 2010, Journal of Cell Science.

A role for actin flexibility in thin filament-mediated contractile regulation and myopathy

D. Swank, M. Rynkiewicz, M. Preller, 2020, Nature Communications.

Ultra Short Yeast Tropomyosins Show Novel Myosin Regulation*

M. Konrad, W. Lehman, M. Geeves, 2008, Journal of Biological Chemistry.

Structural implications of conserved aspartate residues located in tropomyosin’s coiled-coil core

Jasmine A. Nirody, Stefan Fischer, J. Nirody, 2011, Bioarchitecture.

Protein-Protein Docking Reveals Dynamic Interactions of Tropomyosin on Actin Filaments.

M. Rynkiewicz, W. Lehman, Elumalai Pavadai, 2020, Biophysical journal.

Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments.

M. Regnier, M. Rynkiewicz, Jeffrey R. Moore, 2020, Biophysical journal.

Precise Binding of Tropomyosin on Actin Involves Sequence-Dependent Variance in Coiled-Coil Twisting.

S. Fischer, M. Rynkiewicz, Jeffrey R. Moore, 2018, Biophysical journal.

Electrostatic interaction map reveals a new binding position for tropomyosin on F-actin

Marek Orzechowski, Stefan Fischer, M. Rynkiewicz, 2015, Journal of Muscle Research and Cell Motility.

The relationship between curvature, flexibility and persistence length in the tropomyosin coiled-coil.

Stefan Fischer, W. Lehman, Xiaochuan Li, 2010, Journal of structural biology.

Cardiomyopathy Mutation Alters End-to-End Junction of Tropomyosin and Reduces Calcium Sensitivity.

M. Rynkiewicz, Jeffrey R. Moore, W. Lehman, 2019, Biophysical journal.

HCM and DCM cardiomyopathy-linked α-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments.

Marek Orzechowski, M. Rynkiewicz, Jeffrey R. Moore, 2018, Archives of biochemistry and biophysics.

Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation

C. Yengo, M. Rynkiewicz, Jeffrey R. Moore, 2022, The Journal of general physiology.

Tropomyosin movement on F-actin during muscle activation explained by energy landscapes.

Marek Orzechowski, S. Fischer, Jeffrey R. Moore, 2014, Archives of biochemistry and biophysics.

Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy

J. Katz, M. Rynkiewicz, A. Cammarato, 2017, Cell reports.

Modulation of actin mechanics by caldesmon and tropomyosin.

J. Moore, Jeffrey R. Moore, W. Lehman, 2008, Cell motility and the cytoskeleton.

Phosphorylation of Ser283 enhances the stiffness of the tropomyosin head-to-tail overlap domain.

Stefan Fischer, M. Regnier, Jeffrey R. Moore, 2015, Archives of biochemistry and biophysics.

An atomic model of the tropomyosin cable on F-actin.

Marek Orzechowski, S. Fischer, W. Lehman, 2014, Biophysical journal.

The structural dynamics of α-tropomyosin on F-actin shape the overlap complex between adjacent tropomyosin molecules.

Marek Orzechowski, Stefan Fischer, W. Lehman, 2014, Archives of biochemistry and biophysics.

Structure and flexibility of the tropomyosin overlap junction.

Marek Orzechowski, Stefan Fischer, W. Lehman, 2014, Biochemical and biophysical research communications.

The flexibility of two tropomyosin mutants, D175N and E180G, that cause hypertrophic cardiomyopathy.

Stefan Fischer, Worawit Suphamungmee, W. Lehman, 2012, Biochemical and biophysical research communications.

A Repeating Structural Motif in Tropomyosin that is Responsible for Multiple Gain of Function Skeletal Myopathy Mutations

W. Lehman, Steven B Marston, Xiaochuan Li, 2013 .

Influence of Actin Mutation on the Energy Landscape of Actin-Tropomyosin Filaments

Marek Orzechowski, S. Fischer, W. Lehman, 2013 .

Modeling Human Cardiac Thin Filament Structures

M. Rynkiewicz, W. Lehman, Elumalai Pavadai, 2022, Frontiers in Physiology.

C-terminal troponin-I residues trap tropomyosin in the muscle thin filament blocked-state.

M. Rynkiewicz, W. Lehman, Elumalai Pavadai, 2021, Biochemical and biophysical research communications.

Mechanisms of pathogenicity in the hypertrophic cardiomyopathy-associated TPM1 variant S215L

M. Rynkiewicz, Jeffrey R. Moore, W. Lehman, 2023, PNAS nexus.

The Effect of Tropomyosin Mutations on Actin-Tropomyosin Binding: In Search of Lost Time.

M. Rynkiewicz, Jeffrey R. Moore, W. Lehman, 2019, Biophysical journal.

Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1

E. Hardeman, P. Gunning, M. Rynkiewicz, 2019, Scientific Reports.

Structural determinants of muscle thin filament cooperativity.

Stuart G Campbell, Jeffrey R. Moore, W. Lehman, 2016, Archives of biochemistry and biophysics.

Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1

E. Hardeman, P. Gunning, M. Rynkiewicz, 2019, Scientific Reports.

Genetic resiliency associated with dominant lethal TPM1 mutation causing atrial septal defect with high heritability

Ferhaan Ahmad, T. Wong, B. Keavney, 2022, Cell Reports Medicine.

Structural Analysis of Smooth Muscle Tropomyosin α and β Isoforms*

R. Dominguez, J. N. Rao, W. Lehman, 2011, The Journal of Biological Chemistry.

Tropomyosin positions in regulated thin filaments revealed by cryoelectron microscopy.

W. Lehman, W. Lehman, R. Craig, 1999, Biophysical journal.

Drosophila muscle regulation characterized by electron microscopy and three-dimensional reconstruction of thin filament mutants.

A. Cammarato, J. Sparrow, W. Lehman, 2004, Biophysical journal.

Electron Microscopy and Molecular Dynamics on a D137L Mutant of Tropomyosin

Jasmine A. Nirody, Stefan Fischer, D. Sousa, 2010 .

Glutamate 139 of tropomyosin is critical for cardiac thin filament blocked-state stabilization.

M. Rynkiewicz, W. Lehman, Elumalai Pavadai, 2024, Journal of molecular and cellular cardiology.

A new twist on tropomyosin binding to actin filaments: perspectives on thin filament function, assembly and biomechanics

M. Rynkiewicz, Jeffrey R. Moore, W. Lehman, 2019, Journal of Muscle Research and Cell Motility.

The propensity for tropomyosin twisting in the presence and absence of F-actin.

Stefan Fischer, M. Rynkiewicz, W. Lehman, 2016, Archives of biochemistry and biophysics.

The Mouseion at the JAXlibrary The Mouseion at the JAXlibrary

Ferhaan Ahmad, M. Rynkiewicz, A. Bais, 2022 .

Myosin's powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin.

M. Rynkiewicz, M. Childers, W. Lehman, 2024, The Journal of general physiology.