J. W. Little

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Robustness of a gene regulatory circuit

J. W. Little, D. Shepley, D. Wert, 1999, The EMBO journal.

Airway hyperreactivity and peripheral airway dysfunction in influenza A infection.

G. S. Mudholkar, R. Douglas, J. W. Little, 2015, The American review of respiratory disease.

Regulatory circuit design and evolution using phage lambda.

S. Atsumi, J. W. Little, 2004, Genes & development.

A synthetic phage λ regulatory circuit

S. Atsumi, J. W. Little, 2006, Proceedings of the National Academy of Sciences.

RecA-dependent cleavage of LexA dimers.

John W. Little, J. W. Little, C. Michalowski, 2008, Journal of molecular biology.

LexA cleavage and other self-processing reactions

J. W. Little, 1993, Journal of bacteriology.

Efficacy of live attenuated influenza A/Scotland/74 (H3N2) virus vaccine against challenge with influenza A/Victoria/3/75 (H3N2) virus.

R. Douglas, R. Betts, J. W. Little, 1977, The Journal of infectious diseases.

Threshold effects in gene regulation: when some is not enough.

J. W. Little, John W Little, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Escherichia coli protein X is the recA gene product.

D. Kleid, J. W. Little, 1977, The Journal of biological chemistry.

LexA and λ Cl repressors as enzymes: Specific cleavage in an intermolecular reaction

J. W. Little, Baek Kim, 1993, Cell.

Nudeotide sequence of the lexA gene of Escherichia coli K-12

D. Mount, J. W. Little, B. Markham, 2005 .

Reaction of LexA repressor with diisopropyl fluorophosphate. A test of the serine protease model.

K. Roland, J. W. Little, 1990, The Journal of biological chemistry.

Cooperative DNA binding by CI repressor is dispensable in a phage lambda variant.

J. W. Little, A. Babić, Andrea C Babić, 2007, Proceedings of the National Academy of Sciences of the United States of America.

Regulatory circuit design and evolution using phage (cid:1)

S. Atsumi, J. W. Little, 2004 .

A xyloglucan in etiolated seedlings of Pinus radiata

J. W. Little, I. Andrew, 1997 .

Induction of protein X in Escherichia coli

P. Hanawalt, J. W. Little, 1977, Molecular and General Genetics MGG.

The effect of 5-bromouracil on recombination of phage lambda.

J. W. Little, 1976, Virology.

Defective Lambda Particles Whose DNA Carries Only a Single Cohesive End

M. Gottesman, J. W. Little, 1971 .

Isolation and characterization of noncleavable (Ind-) mutants of the LexA repressor of Escherichia coli K-12

J. W. Little, L. L. Lin, L. Lin, 1988, Journal of bacteriology.

Sequence Tolerance of the Phage (cid:2) P RM Promoter: Implications for Evolution of Gene Regulatory Circuitry†

J. W. Little, C. Michalowski, M. Short, 2004 .

Joining of DNA strands by DNA ligase of E. coli.

M. Gellert, S. Zimmerman, J. W. Little, 1968, Cold Spring Harbor symposia on quantitative biology.

Mutants of bacteriophage T4 which allow amber mutants of gene 32 to grow in ochre-suppressing hosts.

J. W. Little, 1973, Virology.

Lambda exonuclease.

J. W. Little, 1981, Gene amplification and analysis.

An exonuclease induced by bacteriophage lambda. I. Preparation of the crystalline enzyme.

I. Lehman, A. D. Kaiser, J. W. Little, 1967, The Journal of biological chemistry.

Highly cooperative DNA binding by the coliphage HK022 repressor.

J. W. Little, N. Carlson, 1993, Journal of molecular biology.

Construction and characterization of a plasmid coding for a fragment of the Escherichia coli recA protein

J. W. Little, 2004, Molecular and General Genetics MGG.

Cleavage of LexA repressor.

K. Roland, M. Smith, J. W. Little, 1994, Methods in enzymology.

Stability and Instability in the Lysogenic State of Phage Lambda (cid:1) §

J. W. Little, C. Michalowski, 2010 .

Influence of plasmids carrying the lexA gene on DNA repair and related processes in Escherichia coli K-12

D. Mount, J. W. Little, S. Edmiston, 1980, Molecular and General Genetics MGG.

The use of quantitative cultures and antibody coating of bacteria to diagnose bacterial pneumonia by fiberoptic bronchoscopy.

C. Thomas, J. W. Little, R. Winterbauer, 2015, The American review of respiratory disease.

UmuD and UmuD 0 Proteins

J. W. Little, 2012 .

UmuD and UmuD ′ proteins Databanks

J. W. Little, 2022 .

Creating new restriction sites by silent changes in coding sequences.

D. Mount, J. W. Little, 1984, Gene.

Role of the lytic repressor in prophage induction of phage lambda as analyzed by a module-replacement approach.

S. Atsumi, J. W. Little, 2006, Proceedings of the National Academy of Sciences of the United States of America.

The excystment, growth and reproduction of Acanthoparyphiutn spinulosum Johnston, 1917 (Trematoda) in chicks fed various diets

J. W. Little, 1970, Parasitology.

Mechanism of specific LexA cleavage: autodigestion and the role of RecA coprotease.

J. W. Little, 1991, Biochimie.

The SOS regulatory system: control of its state by the level of RecA protease.

J. W. Little, Martin Gellert, J. W. Little, 1983, Journal of molecular biology.

The SOS regulatory system of Escherichia coli

D. Mount, J. W. Little, 1982, Cell.

Intramolecular cleavage of LexA and phage lambda repressors: dependence of kinetics on repressor concentration, pH, temperature, and solvent.

J. A. Rupley, J. W. Little, S. N. Slilaty, 1986, Biochemistry.

Acanthoparyphium spinulosum (Trematoda: Echinostomatidae) in oysters at Port Isabel, Texas.

S. H. Hopkins, J. W. Little, F. Schlicht, 1966 .

Effect of abx, bx and pbx mutations on expression of homeotic genes in Drosophila larvae.

J. W. Little, D. Brower, C. Byrd, 1990, Genetics.

Gene synthesis, bacterial expression, and 1H NMR spectroscopic studies of the rat outer mitochondrial membrane cytochrome b5.

M. Rivera, F. Walker, J. W. Little, 1992, Biochemistry.

The viability of an echinostome metacercaria in the American oyster

S. H. Hopkins, J. W. Little, J. G. Mackin, 1969 .

Crystal Structure of LexA A Conformational Switch for Regulation of Self-Cleavage

Richard A. Pfuetzner, John W. Little, R. Pfuetzner, 2001, Cell.

An exonuclease induced by bacteriophage lambda. II. Nature of the enzymatic reaction.

J. W. Little, 1967, The Journal of biological chemistry.

Cleavage of the Escherichia coli lexA protein by the recA protease.

D. Mount, J. W. Little, J W Little, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Family values in the age of genomics: comparative analyses of temperate bacteriophage HK022.

R. Weisberg, R. Hendrix, J. W. Little, 1999, Annual review of genetics.

LexA and lambda Cl repressors as enzymes: specific cleavage in an intermolecular reaction.

J. W. Little, B. Kim, 1993, Cell.

Role of cis-Acting Sites in Stimulation of the Phage λ PRM Promoter by CI-Mediated Looping

J. W. Little, C. Michalowski, 2013, Journal of bacteriology.

Stability and Instability in the Lysogenic State of Phage Lambda

J. W. Little, C. Michalowski, 2010, Journal of bacteriology.

Cooperative DNA binding by CI repressor is dispensable in a phage λ variant

John W. Little, J. W. Little, Andrea C. Babic, 2007, Proceedings of the National Academy of Sciences.

Conservation and diversity in the immunity regions of wild phages with the immunity specificity of phage λ

P. Degnan, J. W. Little, M. Cordes, 2007, Molecular microbiology.

Role of the lytic repressor in prophage induction of phage λ as analyzed by a module-replacement approach

S. Atsumi, J. W. Little, 2006 .

Sequence Tolerance of the Phage λ PRM Promoter: Implications for Evolution of Gene Regulatory Circuitry

J. W. Little, C. Michalowski, M. Short, 2004 .

Regulatory circuit design and evolution using phage λ

S. Atsumi, J. W. Little, 2004 .

Evolution of Complex Gene Regulatory Circuits by Addition of Refinements

J. W. Little, 2010, Current Biology.

LexA protein inhibits transcription of the E. coli uvrA gene in vitro

Aziz Sancar, David W. Mount, W. Dean Rupp, 1982, Nature.

The uvrB gene of Escherichia coli has both lexA-repressed and lexA-independent promoters

Aziz Sancar, W. Dean Rupp, John W. Little, 1982, Cell.

The SOS Regulatory System

J. W. Little, 1996 .

Lysine-156 and serine-119 are required for LexA repressor cleavage: a possible mechanism.

J. W. Little, S. N. Slilaty, John W. LITTLEtt, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Autodigestion of lexA and Phage 1 Repressors

J. W. Little, 1984 .

Allele replacement in Escherichia coli by use of a selectable marker for resistance to spectinomycin: replacement of the lexA gene

J. W. Little, S. Hill, 1988, Journal of bacteriology.

Purified lexA protein is a repressor of the recA and lexA genes.

D. Mount, C. Yanisch-Perron, J. W. Little, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Chapter 772 – Repressor LexA

J. W. Little, 2013 .

Autodigestion of lexA and phage lambda repressors.

J. W. Little, J W Little, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Identification of the lexA gene product of Escherichia coli K-12.

J. W. Little, J. Harper, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Enzymatic joining of DNA strands: a novel reaction of diphosphopyridine nucleotide.

M. Gellert, S. Zimmerman, J. W. Little, 1967, Proceedings of the National Academy of Sciences of the United States of America.

Nucleotide sequence of the lexA gene of Escherichia coli K-12.

D. Mount, J. W. Little, B. Markham, 1981, Nucleic acids research.

Sequence tolerance of the phage lambda PRM promoter: implications for evolution of gene regulatory circuitry.

J. W. Little, C. Michalowski, M. Short, 2004, Journal of bacteriology.

Novel mechanism for UV sensitivity and apparent UV nonmutability of recA432 mutants: persistent LexA cleavage following SOS induction

D. Mount, J. W. Little, D. G. Ennis, 1993, Journal of bacteriology.

Positive Autoregulation of cI Is a Dispensable Feature of the Phage λ Gene Regulatory Circuitry

J. W. Little, C. Michalowski, 2005 .

Positive autoregulation of cI is a dispensable feature of the phage lambda gene regulatory circuitry.

J. W. Little, C. Michalowski, 2005, Journal of bacteriology.

CHAPTER 22 THE SOS REGULATORY SYSTEM

J. W. Little, 1996 .

A novel antivirulence element in the temperate bacteriophage HK022

J. W. Little, N. Carlson, 1993, Journal of bacteriology.

Control of the SOS regulatory system by the level of RecA protease.

J. W. Little, 1982, Biochimie.

Isolation of recombinant plasmids and phage carrying the lexA gene of Escherichia coli K-12.

J. W. Little, 1980, Gene.

A synthetic phage lambda regulatory circuit.

S. Atsumi, J. W. Little, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Repression of the E coli recA gene requires at least two LexA protein monomers.

D. Mount, J. W. Little, A. Thliveris, 1991, Biochimie.

A study on the susceptibility of triatomid bugs to some Mexican strains of Trypanosoma cruzi.

J. W. Little, F. Biagi, J. Tay, 1966, Journal of medical entomology.

Mutations affecting cooperative DNA binding of phage HK022 CI repressor.

J. W. Little, C. Mao, 1998, Journal of molecular biology.

Analysis of Escherichia coli RecA Interactions with LexA, λ CI, and UmuD by Site-Directed Mutagenesis of recA

J. Mustard, J. W. Little, 2000, Journal of bacteriology.

In vitro analysis of mutant LexA proteins with an increased rate of specific cleavage.

J. A. Rupley, K. Roland, M. Smith, 1992, Journal of molecular biology.

Dimerization of a specific DNA-binding protein on the DNA.

J. W. Little, Baek Kim, B. Kim, 1992, Science.

Mutant LexA proteins with an increased rate of in vivo cleavage.

M. Smith, J. W. Little, M. Cavenagh, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Autodigestion and RecA-dependent cleavage of Ind- mutant LexA proteins.

J. W. Little, J W Little, L L Lin, 1989, Journal of molecular biology.

Lysogeny, Prophage Induction, and Lysogenic Conversion

J. W. Little, 2005 .

Attenuated influenza produced by experimental intranasal inoculation

J. W. Little, W. Hall, R. Gordon, 1979, Journal of medical virology.

Enzymatic joining of DNA strands, II. An enzyme-adenylate intermediate in the dpn-dependent DNA ligase reaction.

M. Gellert, S. Zimmerman, J. W. Little, 1967, Proceedings of the National Academy of Sciences of the United States of America.

[34a] An exonuclease induced by bacteriophage lambda

J. W. Little, 1967 .

Rapid mutational analysis of regulatory loci in Escherichia coli K-12 using bacteriophage M13.

D. Mount, K. Wertman, J. W. Little, 1984, Proceedings of the National Academy of Sciences of the United States of America.

P. mirabilis RecA protein catalyses cleavage of E. coli LexA protein and the λ repressor in vitro

S. West, J. W. Little, 2004, Molecular and General Genetics MGG.

Amantadine effect on peripheral airways abnormalities in influenza. A study in 15 students with natural influenza A infection.

R. Douglas, J. W. Little, W. Hall, 1976, Annals of Internal Medicine.

Mutant LexA proteins with specific defects in autodigestion.

J. W. Little, D. Shepley, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Deletions within a hinge region of a specific DNA-binding protein.

J. W. Little, S. Hill, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Preferential cleavage of phage lambda repressor monomers by recA protease.

D. Mount, J. W. Little, S. Cohen, 1981, Nature.

Saturation mutagenesis of specific codons: elimination of molecules with stop codons from mixed pools of DNA.

J. W. Little, 1990, Gene.

The spacing between binding sites controls the mode of cooperative DNA-protein interactions: implications for evolution of regulatory circuitry.

J. W. Little, J W Little, Z Liu, 1998, Journal of molecular biology.

SMALL AIRWAYS DYSFUNCTION IN INFLUENZA A VIRUS INFECTION: THERAPEUTIC ROLE AND POTENTIAL MODE OF ACTION OF AMANTADINE *

R. Douglas, J. W. Little, W. Hall, 1977, Annals of the New York Academy of Sciences.

Preferential cleavage of phage λ repressor monomers by recA protease

D. Mount, J. W. Little, B. Knoll, 1981, Nature.