A. Polverino

发表

Complex formation between RAS and RAF and other protein kinases.

M. Wigler, M. Barr, L. Van Aelst, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Design, synthesis, and evaluation of orally active benzimidazoles and benzoxazoles as vascular endothelial growth factor-2 receptor tyrosine kinase inhibitors.

Daniel Elbaum, P. Gallant, A. Coxon, 2007, Journal of medicinal chemistry.

Selective Activation of Caspases During Apoptotic Induction in HL-60 Cells

S. Patterson, A. Polverino, 1997, The Journal of Biological Chemistry.

Oncogenic ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes.

M. Wigler, J. Ruderman, E. Chang, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Safety, pharmacokinetics, and efficacy of AMG 706, an oral multikinase inhibitor, in patients with advanced solid tumors.

R. Herbst, C. Ng, R. Kurzrock, 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Evaluation of a series of naphthamides as potent, orally active vascular endothelial growth factor receptor-2 tyrosine kinase inhibitors.

A. Coxon, D. Whittington, A. Tasker, 2008, Journal of medicinal chemistry.

Angiopoietin-2 Antagonists for Anti-Angiogenic Therapy

J. Oliner, R. Kendall, A. Polverino, 2008 .

Discovery of novel 1,2,3,4-tetrahydroisoquinolines and 3,4-dihydroisoquinoline-1(2H)-ones as potent and selective inhibitors of KDR: synthesis, SAR, and pharmacokinetic properties.

A. Polverino, J. Harmange, Y. Teffera, 2008, Bioorganic & medicinal chemistry letters.

The highly conserved skb1 gene encodes a protein that interacts with Shk1, a fission yeast Ste20/PAK homolog.

J. Frost, M. Cobb, S. Marcus, 1996, Proceedings of the National Academy of Sciences of the United States of America.

A Conserved Cascade of Protein Kinases : RAS Effector Function

L. Rodgers, M. Barr, J. Camonis, 2013 .

Fas-induced apoptosis of T cells occurs independently of ceramide generation.

R. Aebersold, J. Watts, S. Patterson, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Complexes between STE5 and components of the pheromone-responsive mitogen-activated protein kinase module.

M. Wigler, M. Barr, S. Marcus, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Inhibition of Ca2+ inflow causes an abrupt cessation of growth-factor-induced repetitive free Ca2+ transients in single NIH-3T3 cells.

B. P. Hughes, G. Barritt, A. Polverino, 1991, The Biochemical journal.

On the complexities of ceramide changes in cells undergoing apoptosis: lack of evidence for a second messenger function in apoptotic induction

R. Aebersold, J. Watts, S. Patterson, 1999, Cell Death and Differentiation.

Ceramide second messengers and ceramide assays.

R. Aebersold, J. Watts, S. Patterson, 1999, Trends in biochemical sciences.

Naphthamides as novel and potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: design, synthesis, and evaluation.

Ling Wang, Kelly Regal, Sesha Neervannan, 2008, Journal of medicinal chemistry.

Multiple ras functions can contribute to mammalian cell transformation

M. Wigler, M. White, M. Karin, 1995, Cell.

Mammalian Genes That Interact with Yeast Signaling Pathways

L. Rodgers, M. Barr, J. Camonis, 2013 .

Novel 2,3-dihydro-1,4-benzoxazines as potent and orally bioavailable inhibitors of tumor-driven angiogenesis.

M. Morrison, A. Coxon, D. Whittington, 2008, Journal of medicinal chemistry.

Osteoprotegerin ligand modulates murine osteoclast survival in vitro and in vivo.

D L Lacey, D. Lacey, M. Kelley, 2000, The American journal of pathology.

Synthesis, structural analysis, and SAR studies of triazine derivatives as potent, selective Tie-2 inhibitors.

P. Gallant, M. Morrison, P. Rose, 2007, Bioorganic & medicinal chemistry letters.

Activation of Mitogen-activated Protein Kinase Cascades by p21-activated Protein Kinases in Cell-free Extracts of Xenopus Oocytes (*)

J. Frost, A. Neiman, Peirong Yang, 1995, Journal of Biological Chemistry.

RAS function and protein kinase cascades.

M. Wigler, R. Ballester, H. -. Xu, 1993, Ciba Foundation symposium.

Augmentation of Radiation Response by Motesanib, a Multikinase Inhibitor that Targets Vascular Endothelial Growth Factor Receptors

J. Bussink, P. Harari, A. Coxon, 2010, Clinical Cancer Research.

AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts.

Ling Wang, Sesha Neervannan, Richard Kendall, 2006, Cancer research.

Antitumor activity of motesanib alone and in combination with cisplatin or docetaxel in multiple human non–small-cell lung cancer xenograft models

A. Coxon, A. Polverino, S. Kaufman, 2012, Molecular Cancer.

ResearchMotesanib inhibits Kit mutations associated with gastrointestinal stromal tumors

T. Bush, A. Tasker, T. Juan, 2015 .

Motesanib inhibits Kit mutations associated with gastrointestinal stromal tumors

Todd Juan, Will Baron, T. Bush, 2010, Journal of experimental & clinical cancer research : CR.

Broad Antitumor Activity in Breast Cancer Xenografts by Motesanib, a Highly Selective, Oral Inhibitor of Vascular Endothelial Growth Factor, Platelet-Derived Growth Factor, and Kit Receptors

Paul Hughes, Richard Kendall, T. Bush, 2009, Clinical Cancer Research.

BroadAntitumorActivity inBreastCancerXenograftsbyMotesanib , aHighly Selective , Oral Inhibitorof Vascular Endothelial Growth Factor , Platelet-DerivedGrowth Factor , andKit Receptors

T. Bush, K. Rex, A. Coxon, 2008 .

Anti-tumor activity of motesanib in a medullary thyroid cancer model

A. Coxon, J. Canon, R. Radinsky, 2011, Journal of Endocrinological Investigation.

Discovery of N-phenyl nicotinamides as potent inhibitors of Kdr.

A. Coxon, T. Harvey, R. Syed, 2007, Bioorganic & medicinal chemistry letters.

Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe.

M. Wigler, M. Cobb, D. Robbins, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor.

Richard Kendall, P. Gallant, M. Morrison, 2007, Journal of medicinal chemistry.

Antitumor activity of motesanib alone and in combination with cisplatin or docetaxel in multiple human non–small-cell lung cancer xenograft models

A. Coxon, A. Polverino, Man Xu, 2012, Molecular Cancer.

Vasopressin Decreases Total Free Fatty Acids but Enhances Release of Radioactivity from Isolated Hepatocytes Labelled with [3H]Arachidonic Acid

B. P. Hughes, G. Barritt, A. Polverino, 1987, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Evaluation of indazole-based compounds as a new class of potent KDR/VEGFR-2 inhibitors.

A. Coxon, D. Whittington, A. Polverino, 2008, Bioorganic & medicinal chemistry letters.

Alkynylpyrimidine amide derivatives as potent, selective, and orally active inhibitors of Tie-2 kinase.

David Powers, Paul Hughes, Richard Kendall, 2007, Journal of medicinal chemistry.

On the source of the vasopressin-induced increases in diacylglycerol in hepatocytes.

G. Barritt, A. Polverino, 1988, Biochimica et biophysica acta.