Masakazu Atobe

发表

Increase of enzyme activity through specific covalent modification with fragments

James D. Firth, R. Hubbard, G. Davies, 2017, Chemical science.

Design and Synthesis of 56 Shape‐Diverse 3D Fragments

James D. Firth, Hanna F. Klein, R. Hubbard, 2020, Chemistry.

Design, synthesis and SAR investigation of thienosultam derivatives as ADAMTS-5 (aggrecanase-2) inhibitors.

Masakazu Atobe, Eiichi Tanaka, Naomi Maekawara, 2013, Bioorganic & medicinal chemistry letters.

A series of thiazole derivatives bearing thiazolidin-4-one as non-competitive ADAMTS-5 (aggrecanase-2) inhibitors.

Masakazu Atobe, Eiichi Tanaka, N. Jinno, 2013, Bioorganic & medicinal chemistry letters.

Discovery of Novel Transient Receptor Potential Vanilloid 4 (TRPV4) Agonists as Regulators of Chondrogenic Differentiation: Identification of Quinazolin-4(3 H)-ones and in Vivo Studies on a Surgically Induced Rat Model of Osteoarthritis.

Masakazu Atobe, M. Ishiguro, Shuji Muramatsu, 2019, Journal of medicinal chemistry.

SAR-based optimization of 2-(1H-pyrazol-1-yl)-thiazole derivatives as highly potent EP1 receptor antagonists.

Masakazu Atobe, Ken-ichi Kasahara, M. Kawanishi, 2013, Bioorganic & medicinal chemistry letters.

Discovery of a novel 2-(1H-pyrazolo[3,4-b]pyridin-1-yl)thiazole derivative as an EP1 receptor antagonist and in vivo studies in a bone fracture model.

Masakazu Atobe, M. Kawanishi, Hiroko Suzuki, 2018, Bioorganic & medicinal chemistry letters.

New Entry to the Asymmetric Synthesis of (–)-Lasubine I and (+)-Subcosine I

Masakazu Atobe, N. Yamazaki, C. Kibayashi, 2009 .

Asymmetric synthesis of (+)-abresoline

Masakazu Atobe, N. Yamazaki, C. Kibayashi, 2005 .

Hit-to-lead optimization of 2-(1H-pyrazol-1-yl)-thiazole derivatives as a novel class of EP1 receptor antagonists.

Masakazu Atobe, Ken-ichi Kasahara, M. Kawanishi, 2013, Bioorganic & medicinal chemistry letters.

Discovery of 2-(1H-indazol-1-yl)-thiazole derivatives as selective EP(1) receptor antagonists for treatment of overactive bladder by core structure replacement.

Masakazu Atobe, Ken-ichi Kasahara, M. Kawanishi, 2014, Bioorganic & medicinal chemistry letters.

Nucleophilic addition of methyllithium to chiral oxime ethers: asymmetric preparation of 1-(aryl)ethylamines and application to a synthesis of calcimimetics (+)-NPS R-568 and its thio analogue

Masakazu Atobe, N. Yamazaki, C. Kibayashi, 2001 .

Enantioselective synthesis of primary 1-(aryl)alkylamines by nucleophilic 1,2-addition of organolithium reagents to hydroxyoxime ethers and application to asymmetric synthesis of G-protein-coupled receptor ligands.

Masakazu Atobe, N. Yamazaki, C. Kibayashi, 2004, The Journal of organic chemistry.

Enantioselective synthesis of primary 1-(aryl)alkylamines by nucleophilic 1,2-addition of organolithium reagents to hydroxyoxime ethers and application to asymmetric synthesis of G-protein-coupled receptor ligands.

Masakazu Atobe, N. Yamazaki, C. Kibayashi, 2004, The Journal of organic chemistry.

Enantioselective synthesis of NK-1 receptor antagonists (+)-CP-99,994 and (+)-CP-122,721

Masakazu Atobe, N. Yamazaki, C. Kibayashi, 2002 .

Discovery of a benzimidazole series of ADAMTS-5 (aggrecanase-2) inhibitors by scaffold hopping.

Masakazu Atobe, Eiichi Tanaka, M. Kawanishi, 2014, European journal of medicinal chemistry.

Increase of enzyme activity through speci ﬁ c covalent modi ﬁ cation with fragments †

James D. Firth, R. Hubbard, G. Davies, 2022 .

Activation of Transient Receptor Potential Vanilloid (TRPV) 4 as a Therapeutic Strategy in Osteoarthritis.

Masakazu Atobe, 2019, Current topics in medicinal chemistry.

Discovery of 4,6- & 5,7-Disubstituted Isoquinoline Derivatives as a Novel Class of Protein Kinase C ζ Inhibitors with Fragment-Merging Strategy.

K. Takaba, Masakazu Atobe, Toshiaki Yamaura, 2020, Journal of medicinal chemistry.

A series of novel indazole derivatives of Sirt 1 activator as osteogenic regulators.

Masakazu Atobe, M. Kawanishi, M. Takeda, 2017, Bioorganic & medicinal chemistry letters.

Lead-oriented synthesis: Investigation of organolithium-mediated routes to 3-D scaffolds and 3-D shape analysis of a virtual lead-like library.

Peter O'Brien, Roderick E Hubbard, R. Hubbard, 2015, Bioorganic & medicinal chemistry.