S. Jacobson

S. Jacobson, 1996, Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association.

Detection of human T‐lymphotropic virus type I (HTLV‐I) tax RNA in the central nervous system of HTLV‐I–associated myelopathy/tropical spastic paraparesis patients by in situ hybridization

C. Fox, T. Lehky, S. Koenig, 1995, Annals of neurology.

Induction of HLA class II in HTLV-I infected neuronal cell lines.

T. Lehky, S. Jacobson, Tanya J Lehky, 1995, Journal of neurovirology.

Circulating CD8+ cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological disease

A. Fauci, D. McFarlin, S. Koenig, 1990, Nature.

Induction of CD4+, human T lymphotropic virus type-1-specific cytotoxic T lymphocytes from patients with HAM/TSP. Recognition of an immunogenic region of the gp46 envelope glycoprotein of human T lymphotropic virus type-1.

R. Streilein, J. Reuben, S. Jacobson, 1991, Journal of immunology.

HTLV-1 Infection and Neuropathogenesis in the Context of Rag1-/-γc-/- (RAG1-Hu) and BLT Mice

M. Corley, S. Jacobson, L. Ndhlovu, 2017, Journal of Neuroimmune Pharmacology.

Do herpesviruses play a role in Alzheimer’s disease pathogenesis?

S. Jacobson, Mary Alice Allnutt, 2019 .

BK virus-specific T cells for immunotherapy of progressive multifocal leukoencephalopathy: an open-label, single-cohort pilot study

Bryan R. Smith, D. Reich, Omar Al-Louzi, 2021, The Lancet Neurology.

Nucleotide sequence analysis of a provirus derived from an individual with tropical spastic paraparesis.

A. Haase, D. McFarlin, E. Retzel, 1990, Microbial pathogenesis.

Infection with HHV-6 and its role in epilepsy

W. Gaillard, W. Theodore, S. Jacobson, 2019, Epilepsy Research.

Viral Triggers and Inflammatory Mechanisms in Pediatric Epilepsy

W. Gaillard, J. Libbey, R. Fujinami, 2018, Molecular Neurobiology.

Dysregulation of TGF-beta signaling and regulatory and effector T-cell function in virus-induced neuroinflammatory disease.

S. Jacobson, Y. Yamano, U. Oh, 2008, Blood.

Lymphotropic Virus-Associated Myelopathy Complexes in Patients with Human T Cell with Soluble HLA-A 2 / Tax 11-19 Tetramer T Cells + Direct Analysis of Viral-Specific CD 8

D. Hafler, J. Altman, T. Greten, 1999 .

The Immune Response to Viruses

H. McFarland, S. Jacobson, 1989 .

Cytokine Therapies in Neurological Disease

S. Jacobson, S. Azodi, 2016, Neurotherapeutics.

Oligoclonal bands in multiple sclerosis reactive against two herpesviruses and association with magnetic resonance imaging findings

D. Reich, D. Reich, S. Jacobson, 2014, Multiple sclerosis.

Inhibition of human immunodeficiency virus and growth of infected T cells by the immunosuppressive drugs cyclosporin A and FK 506.

M. Lowdell, S. Jacobson, A. Karpas, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Direct visualization of antigen-specific T cells: HTLV-1 Tax11-19- specific CD8(+) T cells are activated in peripheral blood and accumulate in cerebrospinal fluid from HAM/TSP patients.

E. Jaffee, T. Greten, D. Pardoll, 1998, Proceedings of the National Academy of Sciences of the United States of America.

The formation of inflammatory demyelinated lesions in cerebral white matter

D. Reich, Afonso C. Silva, S. Westmoreland, 2014, Annals of neurology.

Co-purification of soluble membrane cofactor protein (CD46) and human herpesvirus 6 variant A genome in serum from multiple sclerosis patients.

S. Jacobson, A. Fogdell-Hahn, S. Soldan, 2005, Virus research.

Imaging spinal cord atrophy in progressive myelopathies: HTLV‐I‐associated neurological disease (HAM/TSP) and multiple sclerosis (MS)

D. Reich, G. Nair, S. Jacobson, 2017, Annals of neurology.

Clinical trial of a humanized anti‐IL‐2/IL‐15 receptor β chain in HAM/TSP

T. Waldmann, S. Jacobson, I. Cortese, 2019, Annals of clinical and translational neurology.

HHV‐6 and hippocampal volume in patients with mesial temporal sclerosis

K. Zaghloul, S. Inati, W. Theodore, 2020, Annals of clinical and translational neurology.

Association of Human Herpesvirus-6B with Mesial Temporal Lobe Epilepsy

S. Weinstein, A. Vortmeyer, W. Gaillard, 2007, PLoS medicine.

Human herpesvirus 6 and epilepsy

K. Zaghloul, S. Inati, W. Gaillard, 2021, Epilepsia open.

Direct Phenotypic Analysis of Human MHC Class I Antigen Presentation: Visualization, Quantitation, and In Situ Detection of Human Viral Epitopes Using Peptide-Specific, MHC-Restricted Human Recombinant Antibodies1

S. Jacobson, Y. Yamano, Y. Reiter, 2003, The Journal of Immunology.

A novel multivalent human CTL peptide construct elicits robust cellular immune responses in HLA-A*0201 transgenic mice: implications for HTLV-1 vaccine design.

F. Lemonnier, C. Walker, S. Jacobson, 2003, Vaccine.

Targeting the Binding Interface on a Shared Receptor Subunit of a Cytokine Family Enables the Inhibition of Multiple Member Cytokines with Selectable Target Spectrum*

S. Jacobson, N. Azimi, Y. Tagaya, 2015, The Journal of Biological Chemistry.

Human T-lymphotropic virus type 1 (HTLV-1) and cellular immune response in HTLV-1-associated myelopathy/tropical spastic paraparesis

S. Jacobson, R. Kubota, S. Nozuma, 2020, Journal of Neurovirology.

Essential Role of Human T Cell Leukemia Virus Type 1 orf-I in Lethal Proliferation of CD4+ Cells in Humanized Mice

C. Pise-Masison, M. Vaccari, J. Zack, 2019, Journal of Virology.

Human T-Cell Lymphotropic Virus Type 1 Infection

S. Jacobson, R. Massoud, 2013 .

HTLV-1 Infected CD4 + CD25 + CCR4 + T-Cells Disregulate Balance of Inflammation and Tolerance in HTLV-1 Associated Neuroinflammatory Disease

S. Jacobson, Y. Yamano, 2011 .

HTLV-1 propels untransformed CD4 lymphocytes into the cell cycle while protecting CD8 cells from death.

E. Wattel, C. Pinatel, S. Jacobson, 2006, The Journal of clinical investigation.

HPRT mutations, TCR gene rearrangements, and HTLV‐1 integration sites define in vivo T‐cell clonal lineages

R. Albertini, E. Wattel, S. Jacobson, 2005, Environmental and molecular mutagenesis.

How does interleukin 15 contribute to the pathogenesis of HTLV type 1-associated myelopathy/tropical spastic paraparesis?

T. Waldmann, S. Jacobson, N. Azimi, 2000, AIDS research and human retroviruses.

Immunologic analysis of a spinal cord-biopsy specimen from a patient with human T-cell lymphotropic virus type I-associated neurologic disease.

E. Jaffe, J. Heiss, N. Patronas, 1997, The New England journal of medicine.

Atypical human T‐cell lymphotropic virus type‐I‐associated T‐cell lymphoma in a low‐prevalence alaska native population. Implications for Disease Surveillance

R. Braziel, P. Levine, S. Jacobson, 1993, Cancer.

Multicenter Comparison of PCR Assays for Detection of Human Herpesvirus 6 DNA in Serum

D. Boutolleau, T. Yoshikawa, Yi-Wei Tang, 2008, Journal of Clinical Microbiology.

Cytotoxic T cells are induced in mice infected with lymphocytic choriomeningitis virus strains of markedly different pathogenicities

S. Jacobson, C. Pfau, J. Valenti, 1982, Infection and immunity.

Viral pathogenesis and resistance to defective interfering particles

S. Jacobson, C. Pfau, 1980, Nature.

Determinants of spontaneous recovery and persistance in MDCK cells infected with lymphocytic choriomeningitis virus.

S. Jacobson, C. Pfau, F. Dutko, 1979, The Journal of general virology.

Measles virus persistence in human lymphocytes: a role for virus-induced interferon.

H. McFarland, S. Jacobson, 1982, The Journal of general virology.

Neuroaxonal dystrophy in HTLV-1-associated myelopathy/tropical spastic paraparesis: neuropathologic and neuroimmunologic correlations

D. Dickson, C. Raine, S. Jacobson, 2004, Acta Neuropathologica.

Detection of HHV-6B in post-mortem central nervous system tissue of a post-bone marrow transplant recipient: a multi-virus array analysis

F. Kashanchi, E. Ghedin, Naomi A. Sengamalay, 2006, Journal of Clinical Virology.

Chemokines in chronic progressive neurological diseases: HTLV-1 associated myelopathy and multiple sclerosis.

P. Calabresi, R. Martin, S. Jacobson, 1999, Journal of neurovirology.

Chemokines in chronic progressive neurological associated myelopathy and diseases: mu1 t ip le HTLV-1 sclerosis

P. Calabresi, Roland Martin, S. Jacobson, 1999 .

Chemokines in chronic progressive neurological multiple sclerosis

P. Calabresi, Roland Martin, S. Jacobson, 1999 .

Infection and Multiple Sclerosis

S. Jacobson, S. Soldan, 2004, Infection and Autoimmunity.

Viruses and multiple sclerosis.

S. Jacobson, C. Cermelli, 2012, Viral immunology.

Memory lineage relationships in HTLV-1-specific CD8+ cytotoxic T cells

P. Calabresi, S. Jacobson, Karen Yao, 2006, Journal of Neuroimmunology.

Vaccinations for Neuroinfectious Disease: A Global Health Priority

S. Jacobson, E. Leibovitch, 2016, Neurotherapeutics.

High Expression of CD244 and SAP Regulated CD8+ T Cell Responses of Patients with HTLV-I Associated Neurologic Disease

E. Matsuura, S. Jacobson, Yoshimi Enose-Akahata, 2009, PLoS pathogens.

Correction in trans for Fabry disease: expression, secretion and uptake of alpha-galactosidase A in patient-derived cells driven by a high-titer recombinant retroviral vector.

R. Brady, J. Medin, M. Tudor, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Human T-Lymphotropic Virus Type 1 (HTLV-1) and Regulatory T Cells in HTLV-1-Associated Neuroinflammatory Disease

A. Utsunomiya, N. Araya, S. Jacobson, 2011, Viruses.

Role of Wild-type and Recombinant Human T-cell Leukemia Viruses in Lymphoproliferative Disease in Humanized NSG Mice.

L. Ratner, S. Jacobson, P. Green, 2018, Comparative medicine.

Reduced Foxp3 protein expression is associated with inflammatory disease during human t lymphotropic virus type 1 Infection.

S. Jacobson, U. Oh, K. Fugo, 2006, The Journal of infectious diseases.

Nanomedicine in Demyelinating Disease: Application to Diagnosis and Therapy in Multiple Sclerosis

S. Jacobson, Emily Leibovitch, 2013 .

Variant-Specific Tropism of Human Herpesvirus 6 in Human Astrocytes

E. Major, J. Hou, E. Martinelli, 2005, Journal of Virology.

DNA restriction fragment length polymorphism of HLA-DR2: Correlation with HLA-DR2-associated functions

J. Strominger, D. McFarlin, G. Nepom, 1986, Journal of Neuroimmunology.

Quiescent phenotype of tumor-speciﬁc CD8 (cid:1) T cells following immunization

F. Marincola, S. Migueles, M. Connors, 2004 .

HTLV-I/II

S. Jacobson, K. Fugo, C. Grant, 2008 .

Immunopathogensis of HTLV-I associated neurologic disease: molecular, histopathologic, and immunologic approaches.

S. Jacobson, N. Takenouchi, Karen Yao, 2004, Frontiers in bioscience : a journal and virtual library.

Increased Expression of Human T Lymphocyte Virus Type I (HTLV-I) Tax11-19 Peptide–Human Histocompatibility Leukocyte Antigen A*201 Complexes on CD4+ CD25+T Cells Detected by Peptide-specific, Major Histocompatibility Complex–restricted Antibodies in Patients with HTLV-I–associated Neurologic Disease

S. Jacobson, Hong-Chuan Li, Y. Yamano, 2004, The Journal of experimental medicine.

Abnormally High Levels of Virus-Infected IFN-γ+CCR4+CD4+CD25+ T Cells in a Retrovirus-Associated Neuroinflammatory Disorder

A. Utsunomiya, S. Aratani, T. Nakajima, 2009, PloS one.

Dysregulation of TGF- (cid:1) signaling and regulatory and effector T-cell function in virus-induced neuroinﬂammatory disease

S. Jacobson, Y. Yamano, U. Oh, 2008 .

Foxp3 Represses Retroviral Transcription by Targeting Both NF-κB and CREB Pathways

L. Ratner, S. Jacobson, U. Oh, 2006, PLoS pathogens.

Translocator Protein PET Imaging for Glial Activation in Multiple Sclerosis

V. Ikonomidou, I. Evangelou, S. Zoghbi, 2011, Journal of Neuroimmune Pharmacology.

Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases

E. Aronica, Jiabin Tang, S. Chandran, 2022, bioRxiv.

Human herpesvirus 6 and multiple sclerosis: potential mechanisms for virus-induced disease.

S. Jacobson, J. Fotheringham, 2005, Herpes : the journal of the IHMF.

Mechanism of Neuroinflammation: Enhanced Cytotoxicity and IL-17 Production via CD46 Binding

S. Jacobson, U. Oh, Jhanelle Graham, 2010, Journal of Neuroimmune Pharmacology.

Elevated serum and cerebrospinal fluid levels of soluble human herpesvirus type 6 cellular receptor, membrane cofactor protein, in patients with multiple sclerosis

H. McFarland, L. Massacesi, S. Jacobson, 2001, Annals of neurology.

Measles virus-specific T4+ human cytotoxic T cell clones are restricted by class II HLA antigens.

H. McFarland, R. Hartzman, S. Jacobson, 1984, Journal of immunology.

T cell receptor repertoire analysis in HTLV-1-associated diseases

S. Jacobson, Yoshimi Enose-Akahata, Annaliese Clauze, 2022, Frontiers in Immunology.

Increased activated human T cell lymphotropic virus type I (HTLV-I) Tax11-19-specific memory and effector CD8+ cells in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis: correlation with HTLV-I provirus load.

T. Greten, Masahiro Nagai, S. Jacobson, 2001, The Journal of infectious diseases.

Free Major Histocompatibility Complex Class I Heavy Chain Is Preferentially Targeted for Degradation by Human T-Cell Leukemia/Lymphotropic Virus Type 1 p12I Protein

S. Jacobson, J. Mulloy, C. Nicot, 2001, Journal of Virology.

Virus-specific HLA Class II-restricted Cytotoxic T Cells

S. Jacobson, W. Biddison, 1986 .

An Altered Peptide Ligand Antagonizes Antigen-Specific T Cells of Patients with Human T Lymphotropic Virus Type I-Associated Neurological Disease

R. Martin, S. Jacobson, S. Soldan, 2000, The Journal of Immunology.

I-Associated Neurological Disease Human T Lymphotropic Virus Type Antigen-Specific T Cells of Patients with An Altered Peptide Ligand Antagonizes

Roland Martin, S. Jacobson, S. Soldan, 2000 .

Neuronal molecular mimicry in immune‐mediated neurologic disease

M. Rosenfeld, J. Dalmau, J. Posner, 1998, Annals of neurology.

Quantitative differences in HTLV-I antibody responses: classification and relative risk assessment for asymptomatic carriers and ATL and HAM/TSP patients from Jamaica.

S. Jacobson, Kory R. Johnson, Yoshimi Enose-Akahata, 2012, Blood.

Common Sense Paths Follow Brain Injuries

S. Jacobson, 2012, Journal of Neuroimmune Pharmacology.

Immunostimulation by induced expression of NKG2D and its MIC ligands in HTLV-1-associated neurologic disease

L. Corey, Yuetsu Tanaka, T. Spies, 2006, Immunogenetics.

Association of Chlamydia pneumoniae and multiple sclerosis: Stage two?

A. Cross, S. Jacobson, 2001, Neurology.

Transcriptomic architecture of nuclei in the marmoset CNS

D. Geschwind, D. Reich, R. Kawaguchi, 2022, Nature Communications.

Human herpesvirus multiplex ddPCR detection in brain tissue from low- and high-grade astrocytoma cases and controls

S. Jacobson, E. Leibovitch, M. I. almira-suarez, 2016, Infectious Agents and Cancer.

Classification of HHV-6A and HHV-6B as distinct viruses

H. Agut, U. Gompels, P. Pellett, 2014, Archives of Virology.

Antigen presentation to HLA class II-restricted measles virus-specific T-cell clones can occur in the absence of the invariant chain.

Eric O Long, H. McFarland, R. Sékaly, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Isolation of human T-cell lymphotropic virus type 2 from Guaymi Indians in Panama.

W. Blattner, P. Levine, B. De, 1990, Proceedings of the National Academy of Sciences of the United States of America.

CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSP.

T. Waldmann, J. Chen, J. Janik, 2011, Blood.

Effect of treatment of Strongyloides infection on HTLV‐1 expression in a patient with adult T‐cell leukemia

L. Ratner, G. Weil, S. Jacobson, 2007, American journal of hematology.

Effect of Teriflunomide on Cells From Patients With Human T-cell Lymphotropic Virus Type 1–Associated Neurologic Disease

S. Jacobson, J. Ohayon, Yoshimi Enose-Akahata, 2021, Neurology: Neuroimmunology & Neuroinflammation.

Dynamic acquisition of HTLV-1 tax protein by mononuclear phagocytes: Role in neurologic disease

Yuetsu Tanaka, E. Matsuura, S. Jacobson, 2017, Journal of Neuroimmunology.

Humoral immune response to HTLV-1 basic leucine zipper factor (HBZ) in HTLV-1-infected individuals

S. Jacobson, P. Green, Kory R. Johnson, 2013, Retrovirology.

Selected cytotoxic T lymphocytes with high specificity for HTLV-I in cerebrospinal fluid from a HAM/TSP patient

Roland Martin, S. Jacobson, S. Soldan, 2011, Journal of NeuroVirology.

Immunopathogenesis of human T cell lymphotropic virus type I-associated myelopathy

S. Jacobson, M. Nagai, 2001, Current opinion in neurology.

Astrocyte-specific expression of human T-cell lymphotropic virus type 1 (HTLV-1) Tax: induction of tumor necrosis factor alpha and susceptibility to lysis by CD8+ HTLV-1-specific cytotoxic T cells

P. Calabresi, J. Brady, H. Siomi, 1997, Journal of virology.

Induction of Tumor Necrosis Factor Alpha and Lymphotropic Virus Type 1 (htlv-1) Tax: Astrocyte-specific Expression of Human T-cell

P. Calabresi, J. Brady, H. Siomi, 2022 .

Immune response to retroviruses in the central nervous system

S. Jacobson, 1992 .

Immunological studies in tropical spastic paraparesis

D. Mattson, D. McFarlin, S. Jacobson, 1990, Annals of neurology.

Increased HTLV type 1 tax specific CD8+ cells in HTLV type 1-asociated myelopathy/tropical spastic paraparesis: correlation with HTLV type 1 proviral load.

S. Jacobson, M. Nagai, M. Osame, 2000, AIDS research and human retroviruses.

Sequence comparisons of HTLV‐I from HAM/TSP patients and their asymptomatic spouses

D. McFarlin, S. Jacobson, M. Nishimura, 1993, Neurology.

HTLV-II infection in Florida Indians.

J. Drummond, P. Levine, S. Jacobson, 1993, AIDS research and human retroviruses.

Differential activation of neuroinflammatory pathways in children with seizures: A cross-sectional study

W. Gaillard, J. Chamberlain, W. Theodore, 2019, Seizure.

Animal Models of Alzheimer's Disease Should Be Controlled for Roseolovirus.

R. Tanzi, S. Jacobson, J. Denner, 2020, Journal of Alzheimer's disease : JAD.

Limited T cell receptor usage by HTLV-I tax-specific, HLA class I restricted cytotoxic T lymphocytes from patients with HTLV-I associated neurological disease

U. Utz, I. Elovaara, S. Jacobson, 1995, Journal of Neuroimmunology.

Inflammatory manifestations of HTLV-1 and their therapeutic options

S. Jacobson, F. Martin, G. Taylor, 2014, Expert review of clinical immunology.

Changes in leukocyte recirculation, NK cell activity, and HLA-DR expression in peripheral blood mononuclear cells of MS patients treated with Poly ICLC.

C. Bever, D. McFarlin, S. Jacobson, 1991, International journal of immunopharmacology.

Human T lymphotropic virus, type-I myelopathy: an immunopathologically mediated chronic progressive disease of the central nervous system.

S. Jacobson, 1995, Current opinion in neurology.

MEASLES VIRUS INFECTION OF HUMAN PERIPHERAL BLOOD LYMPHOCYTES: IMPORTANCE OF THE OKT4+ T-CELL SUBSET1

H. McFarland, S. Jacobson, 1984 .

Prevalence of salivary human herpesviruses in pediatric multiple sclerosis cases and controls

E. Waubant, S. Jacobson, J. Graves, 2019, Multiple sclerosis.

Tumor necrosis factor alpha expression in the spinal cord of human T-cell lymphotrophic virus type I associated myelopathy/tropical spastic paraparesis patients.

R. Fox, M. Levin, S. Jacobson, 1996, Journal of neurovirology.

Virus‐Specific Cytotoxic T Cells in Multiple Sclerosis

H. McFarland, A. Goodman, S. Jacobson, 1988, Annals of the New York Academy of Sciences.

Natalizumab and immune cells.

H. McFarland, S. Jacobson, 2006, Archives of neurology.

Increased lymphoproliferative response to human herpesvirus type 6A variant in multiple sclerosis patients

H. McFarland, S. Jacobson, S. Soldan, 2000, Annals of neurology.

HHV-6 and the Central Nervous System

A. Goodman, S. Jacobson, S. Soldan, 2006 .

Major histocompatibility complex molecules as virus receptors.

S. Jacobson, W. Biddison, 1984, Immunology today.

Brief Definitive Report Identification of a Specific Hla Dr2 Ia Molecule as a Restriction Element for Measles Virus- Specific Hla Class Ii-restricted Cytotoxic T Cell Clones

H. McFarland, G. Nepom, S. Jacobson, 2003 .

Brief Definitive Report Identification of a Specific Hla Dr2 Ia Molecule as a Restriction Element for Measles Virus- Specific Hla Class Ii-restricted Cytotoxic T Cell Clones

H. McFarland, G. Nepom, S. Jacobson, 2022 .

Virus-specific cytotoxic T lymphocytes in multiple sclerosis: a normal mumps virus response adds support for a distinct impairment in the measles virus response

H. McFarland, A. Goodman, S. Jacobson, 1989, Journal of Neuroimmunology.

Neuroimmunology of Human T-Lymphotropic Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis

S. Jacobson, S. Nozuma, 2019, Front. Microbiol..

Role of HTLV-1 Tax and HBZ in the Pathogenesis of HAM/TSP

S. Jacobson, Yoshimi Enose-Akahata, A. Vellucci, 2017, Front. Microbiol..

Common γ-chain blocking peptide reduces in vitro immune activation markers in HTLV-1-associated myelopathy/tropical spastic paraparesis

S. Jacobson, N. Azimi, Y. Tagaya, 2015, Proceedings of the National Academy of Sciences.

Humoral immune response to HTLV-1 basic leucine zipper factor (HBZ) in HTLV-1-infected individuals

S. Jacobson, P. Green, Kory R. Johnson, 2013, Retrovirology.

Minocycline modulates antigen-specific CTL activity through inactivation of mononuclear phagocytes in patients with HTLV-I associated neurologic disease

Yuetsu Tanaka, E. Matsuura, S. Jacobson, 2012, Retrovirology.

Involvement of IL-15 in the pathogenesis of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: implications for therapy with a monoclonal antibody directed to the IL-2/15R beta receptor.

T. Waldmann, S. Jacobson, N. Azimi, 1999, Journal of immunology.

HTLV-I/II seroindeterminate Western blot reactivity in a cohort of patients with neurological disease.

T. Lehky, M. Levin, S. Jacobson, 1999, The Journal of infectious diseases.

Receptor β IL-2 / 15 R Monoclonal Antibody Directed to the Paraparesis : Implications for Therapy with a I-Associated Myelopathy / Tropical Spastic Human T Lymphotropic Virus Type Involvement of IL-15 in the Pathogenesis of

T. Waldmann, S. Jacobson, N. Azimi, 1999 .

Reduction in HTLV‐I proviral load and spontaneous lymphoproliferation in HTLV‐I–associated myelopathy/tropical spastic paraparesis patients treated with humanized anti‐tac

J. D. White, T. Waldmann, H. McFarland, 1998, Annals of neurology.

Cellular and Humoral Immune Responses Associated with HTLV‐I Associated Myelopathy/Tropical Spastic Paraparesis

M. Levin, S. Jacobson, 1997, Annals of the New York Academy of Sciences.

Extensive latent retroviral infection in bone marrow of patients with HTLV-I-associated neurologic disease.

C. Fox, N. Young, R. Fox, 1997, Blood.

Human T‐cell lymphotropic virus type II–associated myelopathy: Clinical and immunologic profiles

H. McFarland, T. Lehky, S. Jacobson, 1996, Annals of neurology.

In Situ PCR for the Detection of HTLV‐I in HAM/TSP Patients

M. Walter, C. Fox, T. Lehky, 1994, Annals of the New York Academy of Sciences.

Induction of HLA class I and class II expression in human T-lymphotropic virus type I-infected neuroblastoma cells

T. Lehky, S. Jacobson, L. Lampson, 1994, Journal of virology.

High human T cell lymphotropic virus type 1 (HTLV-1)-specific precursor cytotoxic T lymphocyte frequencies in patients with HTLV-1-associated neurological disease

I. Elovaara, T. Lehky, R. Woods, 1993, The Journal of experimental medicine.

High Human T Cell Lymphotropic Virus Type 1 (HTLV-1)-specific Precursor Cytotoxic T Lymphocyte Frequencies in Patients with HTLV-l-associated Neurological Disease By Irina Elovaara,* Scott Koenig,~ A. Yambusu Brewah,~

T. Lehky, R. Woods, S. Jacobson, 1993 .

Isolation of an HTLV-1-like retrovirus from patients with tropical spastic paraparesis

D. McFarlin, C. Raine, S. Jacobson, 1988, Nature.

In vivo immunogenicity of Tax (11-19) epitope in HLA-A2/DTR transgenic mice: implication for dendritic cell-based anti-HTLV-1 vaccine.

R. Philip, B. Wigdahl, S. Jacobson, 2015, Retrovirology.

Immunological findings in neurological diseases associated with antibodies to HTLV‐I: Activated lymphocytes in tropical spastic paraparesis

D. McFarlin, W. Sheremata, D. Gajdusek, 1988, Annals of neurology.

Translocator Protein 18 kDa (TSPO) Expression in Multiple Sclerosis Patients

D. Datta, S. Jacobson, Erin M. Harberts, 2012, Journal of Neuroimmune Pharmacology.

Recognition of Intracellular Measles Virus Antigens by HLA Class II Restricted Measles Virus‐Specific Cytotoxic T Lymphocytes

W. Bellini, H. McFarland, R. Sékaly, 1988 .

Evidence linking HHV-6 with multiple sclerosis: an update.

S. Jacobson, E. Leibovitch, 2014, Current opinion in virology.

Herpesvirus trigger accelerates neuroinflammation in a nonhuman primate model of multiple sclerosis

D. Reich, Afonso C. Silva, C. Yen, 2018, Proceedings of the National Academy of Sciences.

Viruses in chronic progressive neurologic disease

S. Jacobson, E. Leibovitch, 2018, Multiple sclerosis.

Human Herpesvirus 6A, 6B, and 7 Encephalitis

S. Jacobson, J. Ongrádi, D. Ablashi, 2013 .

Human herpesvirus-6 entry into the central nervous system through the olfactory pathway

R. Henkin, S. Jacobson, Erin M. Harberts, 2011, Proceedings of the National Academy of Sciences.

Differential tropism of human herpesvirus 6 (HHV-6) variants and induction of latency by HHV-6A in oligodendrocytes

S. Jacobson, A. Fogdell-Hahn, N. Akhyani, 2005, Journal of NeuroVirology.

Differential HHV‐6A gene expression in T cells and primary human astrocytes based on multi‐virus array analysis

F. Kashanchi, E. Ghedin, Naomi A. Sengamalay, 2006, Glia.

Extended observations on the association of HHV-6 and multiple sclerosis.

H. McFarland, S. Jacobson, S. Soldan, 2000, Journal of neurovirology.

Reply to “HHV-6 and multiple sclerosis”

S. Jacobson, S. Soldan, R. Berti, 1998, Nature Medicine.

In situ analysis of microvascular pericytes in hypertensive rat brains.

I. Herman, S. Jacobson, 1988, Tissue & cell.

Selection of transduced CD34+ progenitors and enzymatic correction of cells from Gaucher patients, with bicistronic vectors.

S. Karlsson, J. Nagle, J. Medin, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Co-dependence of HTLV-1 p12 and p8 Functions in Virus Persistence

D. Venzon, C. Pise-Masison, L. Alcântara, 2014, PLoS pathogens.

GLUT 1 Is Not the Primary Binding Receptor but Is Associated with Cell-to-Cell Transmission of Human T-Cell Leukemia Virus Type 1

F. Ruscetti, S. Cushman, S. Jacobson, 2007 .

GLUT1 Is Not the Primary Binding Receptor but Is Associated with Cell-to-Cell Transmission of Human T-Cell Leukemia Virus Type 1

F. Ruscetti, S. Cushman, S. Jacobson, 2006, Journal of Virology.

Human T-Cell Leukemia Virus Type 1 (HTLV-1) and HTLV-2 Use Different Receptor Complexes To Enter T Cells

F. Ruscetti, D. Bertolette, S. Cushman, 2006, Journal of Virology.

CD46 on glial cells can function as a receptor for viral glycoprotein‐mediated cell–cell fusion

Roland Martin, E. Martinelli, S. Jacobson, 2005, Glia.

GLUT 1 Is Not The Primary Binding Receptor But Is Associated With Cell-Cell Transmission Of HTLV-1

F. Ruscetti, S. Cushman, S. Jacobson, 2006 .

Recognition of intracellular measles virus antigens by HLA class II-restricted measles virus-specific cytotoxic T lymphocytes

Eric O Long, W. Bellini, R. Sékaly, 1987, Journal of Neuroimmunology.

Cytotoxic T cells in paramyxovirus infection of humans.

S. Jacobson, S. Dhib-jalbut, S. Dhib-Jalbut, 1994, Current topics in microbiology and immunology.

Translocator Protein 18 kDa (TSPO) Expression in Multiple Sclerosis Patients

D. Datta, S. Jacobson, Erin M. Harberts, 2013, Journal of Neuroimmune Pharmacology.

Reducing the global burden of HTLV‐1 infection: An agenda for research and action

M. Matsuoka, E. Murphy, L. Willems, 2017, Antiviral research.

Dose-adjusted EPOCH chemotherapy with bortezomib and raltegravir for human T-cell leukemia virus-associated adult T-cell leukemia lymphoma

H. Abel, L. Ratner, J. Harding, 2016, Blood Cancer Journal.

Localization of retrovirus in the central nervous system of a patient co-infected with HTLV-1 and HIV with HAM/TSP and HIV-associated dementia

M. Rosenblum, C. Fox, M. Levin, 2011, Journal of NeuroVirology.

The NK cell as a new player in the pathogenesis of HTLV-I associated neurologic disease

S. Jacobson, 2010, Virulence.

Detection of HHV-6 and EBV and Cytokine Levels in Saliva From Children With Seizures: Results of a Multi-Center Cross-Sectional Study

E. Waubant, W. Gaillard, J. Chamberlain, 2018, Front. Neurol..

Viral Triggers and Inflammatory Mechanisms in Pediatric Epilepsy

W. Gaillard, J. Libbey, R. Fujinami, 2018, Molecular Neurobiology.

Title Detection of HHV-6 and EBV and cytokine levels in saliva from children with seizures : Results of a multi-center cross-sectional study

E. Waubant, W. Gaillard, J. Chamberlain, 2018 .

CD8 1 T cells are an in vivo reservoir for human T-cell lymphotropic virus type I

Masahiro Nagai, S. Jacobson, M. Brennan, 2001 .

Myelin basic protein specific TCR-engineered regulatory T cells from multiple sclerosis patients are suppressive to MBP-specific T effector cells

D. Scott, S. Jacobson, Y. Kim, 2019, Journal of Immunology.

CD8(+) T cells are an in vivo reservoir for human T-cell lymphotropic virus type I.

Masahiro Nagai, S. Jacobson, M. Brennan, 2001, Blood.

Minocycline modulates antigen-specific CTL activity through inactivation of mononuclear phagocytes in patients with HTLV-I associated neurologic disease

Yuetsu Tanaka, E. Matsuura, S. Jacobson, 2012, Retrovirology.

Prediagnostic human T lymphotropic virus type I provirus loads were highest in Jamaican children who developed seborrheic dermatitis and severe anemia.

M. Carrington, S. Jacobson, M. Brennan, 2004, The Journal of infectious diseases.

Digital droplet PCR (ddPCR) for the precise quantification of human T-lymphotropic virus 1 proviral loads in peripheral blood and cerebrospinal fluid of HAM/TSP patients and identification of viral mutations

Steven Jacobson, Joan Ohayon, Irene Cortese, 2014, Journal of NeuroVirology.

Analyses of HTLV-1 sequences suggest interaction between ORF-I mutations and HAM/TSP outcome.

C. Pise-Masison, R. Khouri, L. Alcântara, 2016, Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases.

Parkinsonism in the course of HTLV‐I‐associated myelopathy

S. Jacobson, R. Papais-Alvarenga, M. Puccioni-Sohler, 2005, Movement disorders : official journal of the Movement Disorder Society.

Characterization Of Antigen‐specific T Cells in Multiple Sclerosis Twins with Elevated Responses to Measles Virus

S. Jacobson, J. Greenstein, J. R. RICHERT, 1984, Annals of the New York Academy of Sciences.

Impaired human leukocyte antigen–restricted measles virus–specific cytotoxic T‐cell response in subacute sclerosing panencephalitis

D. McFarlin, H. McFarland, S. Jacobson, 1989, Annals of neurology.

Impaired Measles‐Specific Cytotoxic T‐Cell Response in Subacute Sclerosing Panencephalitis

D. McFarlin, H. McFarland, S. Jacobson, 1988, Annals of the New York Academy of Sciences.

Discrete serum protein signatures discriminate between human retrovirus-associated hematologic and neurologic disease

M. Trosset, S. Gygi, M. Ward, 2005, Leukemia.

Interferon induction by lymphocytic choriomeningitis viruses correlates with maximum virulence.

R. Friedman, S. Jacobson, C. Pfau, 1981, The Journal of general virology.

A bicistronic therapeutic retroviral vector enables sorting of transduced CD34+ cells and corrects the enzyme deficiency in cells from Gaucher patients.

S. Karlsson, R. Brady, J. Medin, 1996, Blood.

Kinetics and intracellular compartmentalization of HTLV-1 gene expression: nuclear retention of HBZ mRNAs.

A. Corradin, G. Toffolo, Yuetsu Tanaka, 2011, Blood.

Real-time polymerase chain reaction assay for cell-associated HTLV type I DNA viral load.

J. Lifson, S. Jacobson, A. Manns, 2000, AIDS research and human retroviruses.

Effect of (r)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine (H2G) and AZT-lipid-PFA on human herpesvirus-6B infected cells.

S. Jacobson, T. Schott, C. Hoest, 2009, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

Role of viruses in etiology and pathogenesis of multiple sclerosis

S. Jacobson, S. Soldan, 2001, Advances in Virus Research.

TGF-β signaling is altered in the peripheral blood of subjects with multiple sclerosis

S. Jacobson, U. Oh, E. Meoli, 2011, Journal of Neuroimmunology.

In Vivo MRI of Endogenous Remyelination in a Nonhuman Primate Model of Multiple Sclerosis

D. Reich, Afonso C. Silva, C. Yen, 2021 .

Progressive multifocal leukoencephalopathy lesion and brain parenchymal segmentation from MRI using serial deep convolutional neural networks

Bryan R. Smith, D. Reich, Omar Al-Louzi, 2020, NeuroImage: Clinical.

The spectrum of spinal cord lesions in a primate model of multiple sclerosis

Stéphane Lehéricy, Pascal Sati, Daniel S Reich, 2020, Multiple sclerosis.

Role of Exosomes in Human Retroviral Mediated Disorders

F. Kashanchi, S. Jacobson, Monique R. Anderson, 2018, Journal of Neuroimmune Pharmacology.

Virus-Induced Demyelination: The Case for Virus(es) in Multiple Sclerosis

S. Jacobson, S. Soldan, 2016, Neurotropic Viral Infections.

HHV-6 and Multiple Sclerosis

S. Jacobson, Bridgette Jeanne Billioux, R. Álvarez Lafuente, 2014, Human Herpesviruses HHV-6A, HHV-6B & HHV-7.

Role of Viral Infection in the Aetiology of Multiple Sclerosis

S. Jacobson, R. Berti, 1999, CNS Drugs.

Impaired measles virus-specific cytotoxic T cell responses in multiple sclerosis

H. McFarland, S. Jacobson, M. Flerlage, 1985, The Journal of experimental medicine.

Viruses and multiple sclerosis.

S. Jacobson, Steve Jacobson, Jussi Oskari Virtanen, 2012, CNS & neurological disorders drug targets.

Association of human herpes virus 6 (HHV-6) with multiple sclerosis: Increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA

P. Calabresi, H. McFarland, P. Secchiero, 1997, Nature Medicine.

Human Herpesviruses 6A and 6B in Brain Diseases: Association versus Causation

A. Komaroff, P. Pellett, S. Jacobson, 2020, Clinical Microbiology Reviews.

Correlation of human T-cell lymphotropic virus type 1 (HTLV-1) mRNA with proviral DNA load, virus-specific CD8(+) T cells, and disease severity in HTLV-1-associated myelopathy (HAM/TSP).

S. Jacobson, M. Brennan, Y. Yamano, 2002, Blood.

Direct analysis of viral-specific CD8+ T cells with soluble HLA-A2/Tax11-19 tetramer complexes in patients with human T cell lymphotropic virus-associated myelopathy.

D. Hafler, J. Altman, T. Greten, 1999, Journal of immunology.

Gene Expression Profile of Herpesvirus-Infected T Cells Obtained Using Immunomicroarrays: Induction of Proinflammatory Mechanisms

D. Taub, K. Becker, C. Cheadle, 2001, Journal of Virology.

CSF CXCL10, CXCL9, and Neopterin as Candidate Prognostic Biomarkers for HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis

Takahiko Ueno, E. Inoue, A. Utsunomiya, 2013, PLoS neglected tropical diseases.

Human Herpesvirus 6 Detection in Alzheimer’s Disease Cases and Controls across Multiple Cohorts

Sonja W. Scholz, D. Bennett, S. Resnick, 2020, Neuron.

High frequency of human herpesvirus 6 DNA in multiple sclerosis plaques isolated by laser microdissection.

S. Ludwin, S. Jacobson, S. Soldan, 2003, The Journal of infectious diseases.

Use of a multi-virus array for the study of human viral and retroviral pathogens: gene expression studies and ChIP-chip analysis

John Quackenbush, F. Kashanchi, E. Ghedin, 2004, Retrovirology.

Human Herpesvirus 6 (HHV-6) Induces Dysregulation of Glutamate Uptake and Transporter Expression in Astrocytes

S. Jacobson, N. Akhyani, J. Fotheringham, 2008, Journal of Neuroimmune Pharmacology.

Detection of human herpesvirus-6 in mesial temporal lobe epilepsy surgical brain resections

S. Sato, A. Vortmeyer, W. Gaillard, 2003, Neurology.

Positive feedback loop via astrocytes causes chronic inflammation in virus-associated myelopathy.

A. Utsunomiya, K. Yudoh, T. Nakajima, 2013, Brain : a journal of neurology.

Conventional magnetic resonance imaging features in patients with tropical spastic paraparesis

H. McFarland, J. Butman, F. Bagnato, 2005, Journal of NeuroVirology.

Reactivation of Human Herpesvirus-6 in Natalizumab Treated Multiple Sclerosis Patients

E. Frohman, O. Stuve, S. Jacobson, 2008, PloS one.

Molecular tracking of antigen-specific T cell clones in neurological immune-mediated disorders.

U. Utz, Roland Martin, H. McFarland, 2003, Brain : a journal of neurology.

Immunovirological markers in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)

S. Jacobson, Yoshimi Enose-Akahata, 2019, Retrovirology.

The Prevalence and Significance of HTLV-I/II Seroindeterminate Western Blot Patterns

S. Jacobson, Anna Abrams, Yoshimi Akahata, 2011, Viruses.

Helminthic infection down-regulates type 1 immune responses in human T cell lymphotropic virus type 1 (HTLV-1) carriers and is more prevalent in HTLV-1 carriers than in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis.

S. Jacobson, E. Carvalho, A. Muniz, 2005, The Journal of infectious diseases.

Using Droplet Digital PCR to Detect Coinfection of Human Herpesviruses 6A and 6B (HHV-6A and HHV-6B) in Clinical Samples.

S. Jacobson, E. Leibovitch, A. Vellucci, 2018, Methods in molecular biology.

Development of neurologic diseases in a patient with primate T lymphotropic virus type 1 (PTLV-1)

G. Nair, S. Jacobson, W. Switzer, 2016, Retrovirology.

Efficacy of antiviral compounds in human herpesvirus-6-infected glial cells

S. Jacobson, N. Akhyani, J. Fotheringham, 2006, Journal of NeuroVirology.

An evaluation of HHV-6 as an etiologic agent in Hodgkin lymphoma and brain cancer using IARC criteria for oncogenicity

P. Levine, S. Jacobson, Michael J. Wells, 2019, Infectious Agents and Cancer.

Epstein-Barr Virus and MS:Causality or Association?

S. Jacobson, S. Ludwin, 2011, International MS journal.

Unstable EBV latency drives inflammation in multiple sclerosis patient derived spontaneous B cells

Noam Auslander, P. Lieberman, S. Jacobson, 2023, Research square.

Human herpesvirus multiplex ddPCR detection in brain tissue from low- and high-grade astrocytoma cases and controls

S. Jacobson, E. Leibovitch, C. Lin, 2016, Infectious Agents and Cancer.

An evaluation of HHV-6 as an etiologic agent in Hodgkin lymphoma and brain cancer using IARC criteria for oncogenicity

P. Levine, S. Jacobson, Michael J. Wells, 2019, Infectious Agents and Cancer.

Detection of human herpesvirus-6 variants in pediatric brain tumors: association of viral antigen in low grade gliomas.

M. Santi, T. MacDonald, E. Rushing, 2009, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

Vaccinations for Neuroinfectious Disease: A Global Health Priority

S. Jacobson, E. Leibovitch, 2016, Neurotherapeutics.

Human herpes virus 6B: A possible role in epilepsy?

W. Gaillard, S. Shinnar, W. Theodore, 2008, Epilepsia.

Detection of human herpesvirus‐6 in cerebrospinal fluid of patients with encephalitis

C. Glaser, S. Jacobson, N. Akhyani, 2009, Annals of neurology.

Pathways of viral antigen processing and presentation to CTL: defined by the mode of virus entry?

Eric O Long, S. Jacobson, 1989, Immunology today.

Induction of measles virus-specific human cytotoxic T cells by purified measles virus nucleocapsid and hemagglutinin polypeptides.

D. McFarlin, H. McFarland, S. Jacobson, 1987, Viral immunology.

Atomic structure of the human herpesvirus 6B capsid and capsid-associated tegument complexes

G. Bi, Z. Zhou, S. Jacobson, 2019, Nature Communications.

Microenvironment Impacts the Molecular Architecture and Interactivity of Resident Cells in Marmoset Brain

D. Geschwind, D. Reich, R. Kawaguchi, 2021, bioRxiv.

In vivo immunogenicity of Tax (11-19) epitope in HLA-A2/DTR transgenic mice: implication for dendritic cell-based anti-HTLV-1 vaccine.

R. Philip, B. Wigdahl, S. Jacobson, 2014, Retrovirology.

Viral antigens detectable in CSF exosomes from patients with retrovirus associated neurologic disease: functional role of exosomes

F. Kashanchi, Yuetsu Tanaka, Jennifer Jones, 2018, Clinical and Translational Medicine.

Exosomes in Viral Disease

F. Kashanchi, S. Jacobson, Monique R. Anderson, 2016, Neurotherapeutics.

Detection of active human herpesvirus-6 infection in the brain: correlation with polymerase chain reaction detection in cerebrospinal fluid.

A. Vortmeyer, J. Gea-Banacloche, S. Jacobson, 2007, The Journal of infectious diseases.

Extracellular Vesicles and Ebola Virus: A New Mechanism of Immune Evasion

J. Dye, F. Kashanchi, M. Aman, 2019, Viruses.

Immunophenotypic characterization of CSF B cells in virus-associated neuroinflammatory diseases

Bryan R. Smith, A. Nath, Yuetsu Tanaka, 2018, PLoS pathogens.

Differentiation of HAM/TSP from patients with multiple sclerosis infected with HTLV-I

S. Jacobson, Y. Yamano, C. Vasconcelos, 2007, Neurology.

Multicenter Comparison of PCR Assays for Detection of Human Herpesvirus 6 DNA in Serum

D. Boutolleau, T. Yoshikawa, Yi-Wei Tang, 2009, Journal of Clinical Microbiology.

Etiologies of rash and fever illnesses in Campinas, Brazil.

B. Kemp, P. Strebel, J. C. de Moraes, 2011, The Journal of infectious diseases.

Quiescent phenotype of tumor-specific CD8+ T cells following immunization.

Mark Connors, Steven Jacobson, Francesco M Marincola, 2004, Blood.

ELI-spot of Th-1 cytokine secreting PBMC's in multiple sclerosis: correlation with MRI lesions

P. Calabresi, J. Frank, H. McFarland, 1998, Journal of Neuroimmunology.

Pembrolizumab Treatment for Progressive Multifocal Leukoencephalopathy

Bryan R. Smith, Daniel S Reich, Seung-Kwon Ha, 2019, The New England journal of medicine.

Immunopathogenesis of HTLV-I associated neurologic disease: massive latent HTLV-I infection in bone marrow of HAM/TSP patients.

M. Levin, S. Jacobson, N. Flerlage, 1997, Leukemia.

Analysis of the T-cell receptor repertoire of human T-cell leukemia virus type 1 (HTLV-1) Tax-specific CD8+ cytotoxic T lymphocytes from patients with HTLV-1-associated disease: evidence for oligoclonal expansion

U. Utz, S. Jacobson, W. Biddison, 1996, Journal of virology.

Virus-induced dysfunction of CD4+CD25+ T cells in patients with HTLV-I-associated neuroimmunological disease.

S. Jacobson, Hong-Chuan Li, Y. Yamano, 2005, The Journal of clinical investigation.

Human T cell leukemia virus type I and neurologic disease: Events in bone marrow, peripheral blood, and central nervous system during normal immune surveillance and neuroinflammation

B. Wigdahl, S. Jacobson, T. Alefantis, 2002, Journal of cellular physiology.

Regulatory T cells are reduced during anti-CD25 antibody treatment of multiple sclerosis.

H. McFarland, N. Richert, S. Jacobson, 2009, Archives of neurology.

Regulatory T Cells Are Reduced During Anti-CD 25 Antibody Treatment of Multiple Sclerosis

H. McFarland, N. Richert, S. Jacobson, 2009 .

Comprehensive Analysis of TCR-β Repertoire in Patients with Neurological Immune-mediated Disorders

Jun Zhu, S. Jacobson, P. Muraro, 2019, Scientific Reports.

Retrovirally induced CTL degranulation mediated by IL-15 expression and infection of mononuclear phagocytes in patients with HTLV-I-associated neurologic disease.

S. Jacobson, Yoshimi Enose-Akahata, U. Oh, 2008, Blood.

Detection of virus-specific T cells and CD8+ T-cell epitopes by acquisition of peptide–HLA-GFP complexes: analysis of T-cell phenotype and function in chronic viral infections

D. Maric, S. Jacobson, Y. Yamano, 2003, Nature Medicine.

The Effect of Human β2-Microglobulin on Major Histocompatibility Complex I Peptide Loading and the Engineering of a High Affinity Variant

Ryuji Kubota, Steven Jacobson, S. Jacobson, 1998, The Journal of Biological Chemistry.

Treatment of HTLV-I-associated myelopathy/tropical spastic paraparesis: toward rational targeted therapy.

S. Jacobson, U. Oh, 2008, Neurologic clinics.

IL-15 plays a major role in the persistence of Tax-specific CD8 cells in HAM/TSP patients

T. Waldmann, S. Jacobson, N. Azimi, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Immunopathogenesis of human T cell lymphotropic virus type I-associated neurologic disease.

S. Jacobson, 2002, The Journal of infectious diseases.

Characterization of MHC class I restricted cytotoxic T cell responses to tax in HTLV-1 infected patients with neurologic disease.

M. Baseler, J. Adelsberger, E. Boone, 1993, Journal of immunology.

Increased HTLV‐I proviral load and preferential expansion of HTLV‐I tax‐specific CD8+ T cells in cerebrospinal fluid from patients with HAM/TSP

Masahiro Nagai, S. Jacobson, M. Brennan, 2001, Annals of neurology.

Demonstration of human T‐cell lymphotrophic virus type I (HTLV‐I) from an HTLV‐I seronegative South Indian patient with chronic, progessive spastic paraparesis

D. McFarlin, S. Jacobson, M. Nishimura, 1993, Annals of neurology.

Natural history of viral markers in children infected with human T lymphotropic virus type I in Jamaica.

Elizabeth M. Maloney, S. Jacobson, P. Vanveldhuisen, 2006, The Journal of infectious diseases.

HTLV-1 induces a Th1-like state in CD4+CCR4+ T cells.

A. Hasegawa, Yuetsu Tanaka, A. Utsunomiya, 2014, The Journal of clinical investigation.

Pathological and virological assessment of acute HTLV-I-associated myelopathy complicated with encephalopathy and systemic inflammation

L. Chimelli, S. Jacobson, C. Bianco, 2003, Journal of the Neurological Sciences.

Human T Cell Leukemia Virus Reactivation with Progression of Adult T-Cell Leukemia-Lymphoma

J. Sparano, L. Ratner, Jeannette Y Lee, 2009, PloS one.

Clinical trial of raltegravir, an integrase inhibitor, in HAM/TSP

S. Jacobson, I. Cortese, J. Ohayon, 2021, Annals of clinical and translational neurology.

C2H2-546: a zinc finger protein differentially expressed in HTLV-1 infected T cells.

A. Dehejia, M. Polymeropoulos, K. Becker, 1997, Journal of neurovirology.

Inhibition of immune activation by a novel nuclear factor-kappa B inhibitor in HTLV-I-associated neurologic disease.

Yuetsu Tanaka, D. Datta, S. Jacobson, 2011, Blood.

Human T lymphotropic virus types I and II western blot seroindeterminate status and its association with exposure to prototype HTLV-I.

R. Wilks, S. Jacobson, Y. Yamano, 2006, The Journal of infectious diseases.

International Retrovirology Association brings together scientists and clinicians to bridge discoveries about human T-lymphotropic viruses from the laboratory to clinical trials

E. Murphy, S. Jacobson, M. Lairmore, 2005, Retrovirology.

Introduction to the Special Issue

D. Reich, H. McFarland, S. Jacobson, 2017, Journal of Neuroimmunology.

Interferon‐β1a therapy in human T‐lymphotropic virus type I–associated neurologic disease

H. McFarland, J. Butman, F. Bagnato, 2005, Annals of neurology.

Utilizing 3D Printing Technology to Merge MRI with Histology: A Protocol for Brain Sectioning

Daniel S. Reich, Pascal Sati, Wen-Yang Chiang, 2016, Journal of visualized experiments : JoVE.

Custom fit 3D-printed brain holders for comparison of histology with MRI in marmosets

Daniel S. Reich, Pascal Sati, Steven Jacobson, 2016, Journal of Neuroscience Methods.

Preexisting Infection with Human T-Cell Lymphotropic Virus Type 2 neither Exacerbates nor Attenuates Simian Immunodeficiency Virus SIVmac251 Infection in Macaques

D. Venzon, J. Héraud, E. Murphy, 2010, Journal of Virology.

Peptide/HLA-GFP Complexes

S. Jacobson, Y. Yamano, U. Tomaru, 2005 .

Comparison of [11C]-(R)-PK 11195 and [11C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: Implications for positron emission tomographic imaging of this inflammation biomarker

Masahiro Fujita, Cheryl L. Morse, Robert B. Innis, 2010, NeuroImage.

In vitro spontaneous lymphoproliferation in patients with human T-cell lymphotropic virus type I-associated neurologic disease: predominant expansion of CD8+ T cells.

S. Jacobson, M. Brennan, M. Nagai, 2001, Blood.

In vivo imaging of spinal cord atrophy in neuroinflammatory diseases

D. Reich, G. Nair, S. Jacobson, 2014, Annals of neurology.

Brain volume measurements in patients with human T-cell lymphotropic virus-1-associated tropical spastic paraparesis

F. Bagnato, M. McAuliffe, S. Jacobson, 2006, Journal of NeuroVirology.

Novel Marmoset (Callithrix jacchus) Model of Human Herpesvirus 6A and 6B Infections: Immunologic, Virologic and Radiologic Characterization

D. Reich, S. Westmoreland, S. Jacobson, 2013, PLoS pathogens.

Paramagnetic Rim Lesions are Specific to Multiple Sclerosis: An International Multicenter 3T MRI Study

Bryan R. Smith, D. Reich, M. Filippi, 2020, Annals of neurology.

4: Complete replication cycle and acquisition of tegument in nucleus of human herpesvirus 6A (HHV-6A) in astrocytes and in T-cells

E. Major, J. Hou, E. Martinelli, 2006 .

Complete replication cycle and acquisition of tegument in nucleus of human herpesvirus 6A in astrocytes and in T‐cells

E. Major, J. Hou, E. Martinelli, 2006, Journal of medical virology.

In vivo quantification of T2 ⁎ anisotropy in white matter fibers in marmoset monkeys

Jeff H. Duyn, Daniel S. Reich, Peter van Gelderen, 2012, NeuroImage.

Characterization of microvascular cell cultures from normotensive and hypertensive rat brains: pericyte-endothelial cell interactions in vitro.

I. Herman, S. Jacobson, J. Coughlin, 1987, Tissue & cell.

Cortical neuronal cytoskeletal changes associated with FIV infection.

F. Bloom, O. Prospero-Garcia, S. Henriksen, 1997, Journal of neurovirology.

Increased detection of serum HHV-6 DNA sequences during multiple sclerosis (MS) exacerbations and correlation with parameters of MS disease progression

H. McFarland, S. Jacobson, M. Brennan, 2002, Journal of NeuroVirology.

HTLV‐I‐specific cytotoxic T lymphocytes in the cerebrospinal fluid of patients with HTLV‐I‐associated neurological disease

D. McFarlin, R. Martin, R. Voskuhl, 1992, Annals of neurology.

Immunopathogenic CSF TCR repertoire signatures in virus-associated neurologic disease

A. Elkahloun, S. Jacobson, Kory R. Johnson, 2021, JCI insight.

Purification of infectious human herpesvirus 6A virions and association of host cell proteins

H. Garoff, S. Jacobson, A. Fogdell-Hahn, 2007, Virology Journal.

Cytokine Therapies in Neurological Disease

S. Jacobson, S. Azodi, 2016, Neurotherapeutics.

Deep Phenotyping of Neurologic Postacute Sequelae of SARS-CoV-2 Infection

Bryan R. Smith, D. Goldstein, D. Hammoud, 2023, Neurology: Neuroimmunology & Neuroinflammation.

Viral Infections of the Central Nervous System: Pathogenesis to Therapeutics

S. Jacobson, S. Soldan, 2010, Journal of Neuroimmune Pharmacology.

Opinion and Special Articles: Cerebellar Ataxia and Liver Failure Complicating IPEX Syndrome

L. Notarangelo, A. Soldatos, K. Werner, 2020, Neurology.

Polypeptide specificities of measles virus-reactive T cell lines and clones derived from a patient with multiple sclerosis.

D. McFarlin, H. McFarland, R. Hartzman, 1986, Journal of immunology.

S. Jacobson, I. Cortese, K. Fenton, 2014, Journal of NeuroVirology.

Serum proteomic analysis of a pre‐symptomatic multiple sclerosis cohort

T. Kislinger, S. Jacobson, U. Oh, 2015, European journal of neurology.

Human T-Cell Lymphotropic Virus Types 1 and 2

S. Jacobson, R. Massoud, B. Caruso, 2016 .

Human T cell leukemia virus type I (HTLV-I)-specific CD8+ CTL clones from patients with HTLV-I-associated neurologic disease secrete proinflammatory cytokines, chemokines, and matrix metalloproteinase.

D. Taub, E. Connor, U. Utz, 1997, Journal of immunology.

Utility of HTLV proviral load quantification in diagnosis of HTLV-1-associated myelopathy requires international standardization.

S. Jacobson, Y. Yamano, F. Martin, 2013, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

Epigenetic Modification of the FoxP3 TSDR in HAM/TSP Decreases the Functional Suppression of Tregs

Yuetsu Tanaka, S. Jacobson, Monique R. Anderson, 2014, Journal of Neuroimmune Pharmacology.

Humoral immune response to HTLV-1 basic leucine zipper factor (HBZ) in HTLV-1-infected individuals

S. Jacobson, P. Green, Kory R. Johnson, 2014, Retrovirology.

Creation and validation of a bladder dysfunction symptom score for HTLV-1-associated myelopathy/tropical spastic paraparesis

J. Kira, H. Yonezawa, Takahiko Ueno, 2020, Orphanet Journal of Rare Diseases.

Human T Lymphotropic Virus Type I (Htlv-I)-Specific T Helper Cell Responses from Htlv-I Seronegative Patients with Chronic Myelopathy and Ms in Japan

S. Jacobson, M. Nishimura, T. Saida, 1996, Multiple sclerosis.

Chimeric peptide vaccine composed of B- and T-cell epitopes of human T-cell leukemia virus type 1 induces humoral and cellular immune responses and reduces the proviral load in immunized squirrel monkeys (Saimiri sciureus).

J. Héraud, G. de Thé, S. Jacobson, 2006, The Journal of general virology.

A multi-cytokine inhibitory peptide (BNZ 132-1) that is a potential therapeutic agent for HAMTSP and other necrotizing diseases.

S. Jacobson, N. Azimi, Y. Tagaya, 2015, Retrovirology.

Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD

M. Nalls, N. Staff, L. Petrucelli, 2023, bioRxiv.

Cervical and thoracic cord atrophy in multiple sclerosis phenotypes: Quantification and correlation with clinical disability

D. Reich, G. Nair, Tianxia Wu, 2021, NeuroImage: Clinical.

Intrathecal T‐cell clonal expansions in patients with multiple sclerosis

D. Douek, S. Darko, R. Nicholas, 2016, Annals of clinical and translational neurology.

Accumulation of human T lymphotropic virus (HTLV)-I-specific T cell clones in HTLV-I-associated myelopathy/tropical spastic paraparesis patients.

S. Jacobson, K. Nishioka, T. Kato, 1997, Journal of immunology.

Serum neurofilament light-chain levels and long-term treatment outcomes in relapsing-remitting multiple sclerosis patients: A post hoc analysis of the randomized CombiRx trial

F. Lublin, J. Wolinsky, R. Rudick, 2023, Multiple sclerosis journal - experimental, translational and clinical.

Timed walk as primary outcome measure of treatment response in clinical trials for HTLV-1-associated myelopathy: a feasibility study

E. Inoue, M. Bland, S. Jacobson, 2015, Pilot and Feasibility Studies.

The elusive role of herpesviruses in Alzheimer’s disease: current evidence and future directions

S. Jacobson, S. Piotrowski, Allison Tucker, 2023, NeuroImmune pharmacology and therapeutics.

Haploinsufficiency of immune checkpoint receptor CTLA4 induces a distinct neuroinflammatory disorder.

D. Reich, S. Pittaluga, G. Uzel, 2020, The Journal of clinical investigation.

The repertoire of CSF antiviral antibodies in patients with neuroinflammatory diseases

S. Jacobson, J. Ohayon, Kory R. Johnson, 2023, Science advances.

Quantitative differences in antibody responses between normal donors HAM/TSP patients, asymptomatic carriers, and ATL patients from Jamaica: can they be used to estimate risk of disease?

J. Goedert, S. Jacobson, Anna Abrams, 2011, Retrovirology.

Site-specific immune response to implanted gliomas.

E. Oldfield, M. Proescholdt, S. Jacobson, 2001, Journal of neurosurgery.

Human T-Cell Lymphotropic Viruses (HTLVs)

S. Jacobson, R. Massoud, 2014 .

Highly Sensitive 3-Tesla Real Inversion Recovery MRI Detects Leptomeningeal Contrast Enhancement in Chronic Active Multiple Sclerosis.

D. Reich, M. Absinta, D. Pham, 2023, Investigative Radiology.

HTLV‐I‐Associated Myelopathy/Tropical Spastic Paraparesis: Semiautomatic Quantification of Spinal Cord Atrophy from 3‐Dimensional MR Images

I. Evangelou, S. Jacobson, R. Massoud, 2014, Journal of neuroimaging : official journal of the American Society of Neuroimaging.

Multiple Autoimmune-Associated Variants Confer Decreased IL-2R Signaling in CD4+CD25hi T Cells of Type 1 Diabetic and Multiple Sclerosis Patients

Elizabeth Whalen, Ian Frank, I. Frank, 2013, PloS one.

Clinicopathologic correlations in 172 cases of rapid eye movement sleep behavior disorder with or without a coexisting neurologic disorder.

C. Adler, M. Mahowald, E. Tolosa, 2013, Sleep medicine.

Viral Immune signatures from cerebrospinal fluid extracellular vesicles and particles in HAM and other chronic neurological diseases

D. Reich, A. Nath, S. Jacobson, 2023, Frontiers in immunology.

Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases

E. Aronica, Jiabin Tang, S. Chandran, 2023, Nature communications.

Impaired Carbohydrate Digestion and Transport and Mucosal Dysbiosis in the Intestines of Children with Autism and Gastrointestinal Disturbances

W. Lipkin, D. L. Hirschberg, M. Bauman, 2011, PloS one.

HLA Class11-Restricted Presentation ofCytoplasmic MeaslesVirus Antigens toCytotoxic T Cells

S. Jacobson, Neuroimmunology Branch, F. Henry, 1989 .

Immunovirological markers in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)

S. Jacobson, Yoshimi Enose-Akahata, 2019, Retrovirology.

Molecular analysis of HTLV-I proviral integration and T cell receptor arrangement indicates that T cells in tropical spastic paraparesis are polyclonal.

T. Waldmann, D. McFarlin, S. Jacobson, 1989, The Journal of infectious diseases.

Role of Exosomes in Human Retroviral Mediated Disorders

F. Kashanchi, S. Jacobson, Monique R. Anderson, 2018, Journal of Neuroimmune Pharmacology.

Human T-Cell Leukemia Virus Type 1 (HTLV-1) and HTLV-2 Use Different Receptor Complexes To Enter T Cells

F. Ruscetti, D. Bertolette, S. Cushman, 2006, Journal of Virology.

Correlations of diffusion tensor imaging and clinical measures with spinal cord cross-sectional area measurements in pediatric spinal cord injury patients

M. Mulcahey, F. Mohamed, S. Faro, 2021, The journal of spinal cord medicine.

Review part 2: Human herpesvirus‐6 in central nervous system diseases

A. Komaroff, S. Jacobson, J. Crawford, 2010, Journal of medical virology.

Immunophenotypic characterization of CSF B cells in virus-associated neuroinflammatory diseases

Bryan R. Smith, A. Nath, Yuetsu Tanaka, 2018, PLoS pathogens.

EBNA1 Inhibitors Block Proliferation of Spontaneous Lymphoblastoid Cell Lines From Patients With Multiple Sclerosis and Healthy Controls

P. Lieberman, S. Jacobson, J. Ohayon, 2023, Neurology: Neuroimmunology & Neuroinflammation.

Human herpes virus 6B: A possible role in epilepsy?

W. Gaillard, S. Shinnar, W. Theodore, 2008, Epilepsia.

Herpesvirus trigger accelerates neuroinflammation in a nonhuman primate model of multiple sclerosis

D. Reich, Afonso C. Silva, C. Yen, 2018, Proceedings of the National Academy of Sciences.

Viruses in chronic progressive neurologic disease

S. Jacobson, E. Leibovitch, 2018, Multiple sclerosis.

Isolation of HTLV‐II from a patient with chronic, progressive neurological disease clinically indistinguishable from HTLV‐I‐associated myelopathy/tropical spastic paraparesis

D. McFarlin, T. Lehky, S. Jacobson, 1993, Annals of Neurology.

Utility of HTLV proviral load quantification in diagnosis of HTLV-1-associated myelopathy requires international standardization.

S. Jacobson, Y. Yamano, F. Martin, 2013, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

Common Sense Paths Follow Brain Injuries

S. Jacobson, 2012, Journal of Neuroimmune Pharmacology.