S. Charman

David M. Shackleford, S. Charman, David M Shackleford, 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Weak base dispiro-1,2,4-trioxolanes: potent antimalarial ozonides.

J. Karle, J. Chollet, S. Charman, 2007, Bioorganic & medicinal chemistry letters.

First-in-man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials

C. Siethoff, S. Charman, S. Duparc, 2012, British journal of clinical pharmacology.

System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion

S. Charman, D. Creek, G. Siddiqui, 2020, bioRxiv.

Structure-Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439).

David M. Shackleford, J. Chollet, S. Charman, 2017, Journal of medicinal chemistry.

In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in Plasmodium models

David M. Shackleford, S. Charman, R. Brun, 2013, Drug design, development and therapy.

Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs: relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity.

J. K. Wood, J. Chollet, S. Charman, 2009, Bioorganic & medicinal chemistry letters.

Discovery and Structure-Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials.

David M. Shackleford, Laura M Sanz, K. Dechering, 2021, Journal of medicinal chemistry.

Analysis of bovine immunoglobulin G by capillary gel electrophoresis.

S. Charman, L. Bennett, W. Charman, 1994, Journal of pharmaceutical and biomedical analysis.

Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as Plasmodium Cytoplasmic Prolyl-tRNA Synthetase Inhibitors

David M. Shackleford, D. Fidock, Laura M Sanz, 2021, ACS infectious diseases.

Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria.

David M. Shackleford, Brice Campo, M. Belén, 2018, Bioorganic & medicinal chemistry.

Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle.

E. Winzeler, S. Meister, K. Chibale, 2016, Journal of medicinal chemistry.

Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: part 1.

K. Chibale, Dale Taylor, M. Witty, 2014, Journal of medicinal chemistry.

Comparison of the Exposure Time Dependence of the Activities of Synthetic Ozonide Antimalarials and Dihydroartemisinin against K13 Wild-Type and Mutant Plasmodium falciparum Strains

L. Tilley, Pengxing Cao, J. McCaw, 2016, Antimicrobial Agents and Chemotherapy.

Assessing the utility of an anti-malarial pharmacokinetic-pharmacodynamic model for aiding drug clinical development

R. Price, J. McCaw, J. Simpson, 2012, Malaria Journal.

Lymphatic Absorption Is a Significant Contributor to the Subcutaneous Bioavailability of Insulin in a Sheep Model

G. Edwards, C. Porter, S. Charman, 2001, Pharmaceutical Research.

Effects of backbone cyclization on the pharmacokinetics and drug ef ﬁ ciency of the orally active analgesic conotoxin cVc1.1 in Drug

D. Craik, T. Durek, D. Venter, 2021 .

Preclinical Activity and Pharmacokinetic/Pharmacodynamic Relationship for a Series of Novel Benzenesulfonamide Perforin Inhibitors

J. A. Spicer, J. Trapani, K. Gartlan, 2022, ACS pharmacology & translational science.

Brain uptake of diazepam and phenytoin in a genetic animal model of absence epilepsy

S. Petrou, S. Charman, J. Nicolazzo, 2010, Clinical and experimental pharmacology & physiology.

Spiro- and dispiro-1,2-dioxolanes: contribution of iron(II)-mediated one-electron vs two-electron reduction to the activity of antimalarial peroxides.

J. Chollet, S. Charman, D. Creek, 2007, Journal of medicinal chemistry.

Kinetics of iron-mediated artemisinin degradation: effect of solvent composition and iron salt.

R. Prankerd, S. Charman, W. Charman, 2005, Journal of pharmaceutical sciences.

Ozonide Antimalarial Activity in the Context of Artemisinin-Resistant Malaria.

J. Simpson, S. Charman, D. Creek, 2019, Trends in parasitology.

Trioxolane-Mediated Delivery of Mefloquine Limits Brain Exposure in a Mouse Model of Malaria.

M. Bogyo, J. Gut, P. Rosenthal, 2015, ACS medicinal chemistry letters.

Iron-mediated degradation kinetics of substituted dispiro-1,2,4-trioxolane antimalarials.

R. Prankerd, S. Charman, W. Charman, 2007, Journal of pharmaceutical sciences.

Biopharmaceutical characterisation of a low-dose (75 mg) controlled-release aspirin formulation.

G. Fitzgerald, S. Charman, W. Charman, 1993, British journal of clinical pharmacology.

Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Plasmodium falciparum.

E. Winzeler, D. Fidock, M. Phillips, 2021, Journal of medicinal chemistry.

Efficacy, metabolism and pharmacokinetics of Ro 15-5458, a forgotten schistosomicidal 9-acridanone hydrazone.

J. Keiser, D. Siegel, C. Caffrey, 2020, The Journal of antimicrobial chemotherapy.

Progress in antischistosomal N,N'-diaryl urea SAR.

David M. Shackleford, J. Keiser, S. Charman, 2017, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of 5′ alkyl ester prodrugs of zidovudine for directed lymphatic delivery

C. Porter, S. Charman, W. Charman, 1996 .

Lymphatic Absorption Is the Primary Contributor to the Systemic Availability of Epoetin Alfa following Subcutaneous Administration to Sheep

Steven W. Martin, G. Edwards, C. Porter, 2005, Journal of Pharmacology and Experimental Therapeutics.

Synthesis and antimalarial evaluation of amide and urea derivatives based on the thiaplakortone A natural product scaffold.

S. Charman, R. Quinn, P. Healy, 2015, Organic & biomolecular chemistry.

Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes.

J. Karle, J. Chollet, S. Charman, 2005, Journal of medicinal chemistry.

Effect of dietary fatty acids on the intestinal permeability of marker drug compounds in excised rat jejunum

P. Gibson, C. Porter, S. Charman, 2002, The Journal of pharmacy and pharmacology.

An evaluation of the relative roles of the unstirred water layer and receptor sink in limiting the in‐vitro intestinal permeability of drug compounds of varying lipophilicity

C. Porter, S. Charman, K. Katneni, 2008 .

Derivatives of a benzoquinone acyl hydrazone with activity against Toxoplasma gondii

X. Wang, S. Charman, T. T. Schulze, 2018, International journal for parasitology. Drugs and drug resistance.

The Absorption of Darbepoetin Alfa Occurs Predominantly via the Lymphatics Following Subcutaneous Administration to Sheep

Steven W. Martin, G. Edwards, C. Porter, 2006, Pharmaceutical Research.

Lipid-based Systems, Drug Exposure and Lead Optimization

C. Porter, S. Charman, W. Charman, 2006 .

Pharmacokinetics and brain uptake of AM‐36, a novel neuroprotective agent, following intravenous administration to rats

S. Charman, J. Nicolazzo, J. Callaway, 2008, The Journal of pharmacy and pharmacology.

Design, structure-activity relationship and in vivo efficacy of piperazine analogues of fenarimol as inhibitors of Trypanosoma cruzi.

David M. Shackleford, Paul W. Alexander, E. Chatelain, 2013, Bioorganic & medicinal chemistry.

Analogues of fenarimol are potent inhibitors of Trypanosoma cruzi and are efficacious in a murine model of Chagas disease.

M. J. Abbott, Paul W. Alexander, E. Chatelain, 2012, Journal of medicinal chemistry.

Pharmacological Characterization, Structural Studies, and In Vivo Activities of Anti-Chagas Disease Lead Compounds Derived from Tipifarnib

David M. Shackleford, M. Gelb, F. Buckner, 2012, Antimicrobial Agents and Chemotherapy.

Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities.

F. Diederich, T. Mietzner, C. Pinthong, 2015, Journal of medicinal chemistry.

The structure-activity relationship of the antimalarial ozonide arterolane (OZ277).

J. Chollet, S. Charman, W. Charman, 2010, Journal of medicinal chemistry.

Structure-activity-relationship studies around the 2-amino group and pyridine core of antimalarial 3,5-diarylaminopyridines lead to a novel series of pyrazine analogues with oral in vivo activity.

K. Chibale, M. Witty, S. Charman, 2013, Journal of medicinal chemistry.

3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential.

David M. Shackleford, K. Chibale, M. Witty, 2012, Journal of medicinal chemistry.

Metabolic, Pharmacokinetic, and Activity Profile of the Liver Stage Antimalarial (RC-12)

D. Kyle, S. Charman, C. Kocken, 2022, ACS omega.

Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ

C. Masters, R. Tanzi, A. Bush, 2008, Neuron.

Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres.

J. Chollet, S. Charman, E. Ryan, 2013, Journal of medicinal chemistry.

ELQ-300 Prodrugs for Enhanced Delivery and Single-Dose Cure of Malaria

David M. Shackleford, Galen P. Miley, M. Mather, 2015, Antimicrobial Agents and Chemotherapy.

Discovery, Synthesis, and Optimization of Antimalarial 4(1H)-Quinolone-3-Diarylethers

Galen P. Miley, M. Mather, A. Vaidya, 2014, Journal of medicinal chemistry.

Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity

David M. Shackleford, P. Rathod, John White, 2018, ACS omega.

Structure–Activity Relationship Studies of Pyrrolone Antimalarial Agents

Marcel Kaiser, Susan A Charman, Ian H Gilbert, 2013, ChemMedChem.

Discovery and Structure–Activity Relationships of Pyrrolone Antimalarials

Ian H. Gilbert, Marcel Kaiser, David M. Shackleford, 2013, Journal of medicinal chemistry.

Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors

Jeremy N. Burrows, Werner Kaminsky, Margaret A. Phillips, 2014, Journal of medicinal chemistry.

Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice.

David M. Shackleford, Pradipsinh K Rathod, Karen L White, 2009, Journal of medicinal chemistry.

Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice.

David M. Shackleford, Susan A Charman, Pradipsinh K Rathod, 2011, Journal of medicinal chemistry.

2,4-Diaminothienopyrimidines as orally active antimalarial agents.

K. Chibale, Dale Taylor, M. Witty, 2014, Journal of medicinal chemistry.

Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase.

P. Rathod, F. Buckner, John White, 2012, Journal of medicinal chemistry.

Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential.

David M. Shackleford, Francisco-Javier Gamo, Xiaoyi Deng, 2011, Journal of medicinal chemistry.

Novel orally active antimalarial thiazoles.

K. Chibale, M. Witty, S. Charman, 2011, Journal of medicinal chemistry.

Pyridyl benzamides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei.

Christel A. S. Bergström, J. Baell, V. Avery, 2014, Journal of medicinal chemistry.

Discovery of Potent and Fast-Acting Antimalarial Bis-1,2,4-triazines.

David M. Shackleford, J. Baell, V. Avery, 2021, Journal of medicinal chemistry.

3,3'-Disubstituted 5,5'-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity.

Jayme L. Dahlin, R. Price, S. Ralph, 2019, Journal of medicinal chemistry.

Novel Toxoplasma gondii inhibitor chemotypes.

X. Wang, S. Charman, T. T. Schulze, 2018, Parasitology international.

Hit-to-Lead Optimization of a Novel Class of Potent, Broad-Spectrum Trypanosomacides.

Ana Rodriguez, K. Read, J. Baell, 2016, Journal of medicinal chemistry.

The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson’s disease

David M. Shackleford, C. Masters, A. Bush, 2017, Acta neuropathologica communications.

2,5-Dimethyl-2,4-hexadiene induced photodechlorination of 9,10-dichloroanthracene

K. Schanze, S. Charman, J. Saltiel, 2009, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

Alteration of the intravenous pharmacokinetics of a synthetic ozonide antimalarial in the presence of a modified cyclodextrin.

Susan A Charman, R. Prankerd, S. Charman, 2006, Journal of pharmaceutical sciences.

The binding interaction of synthetic ozonide antimalarials with natural and modified beta-cyclodextrins.

Susan A Charman, Martin J Scanlon, R. Prankerd, 2006, Journal of pharmaceutical sciences.

Strategies to Address Low Drug Solubility in Discovery and Development

Hywel D Williams, Christopher J H Porter, Colin W Pouton, 2013, Pharmacological Reviews.

Preclinical comparison of intravenous melphalan pharmacokinetics administered in formulations containing either (SBE)7 m-β-cyclodextrin or a co-solvent system.

David M. Shackleford, Susan A Charman, S. Charman, 2010, Biopharmaceutics & drug disposition.

Degradation of recombinant porcine growth hormone in the presence of guanidine hydrochloride

S. Charman, W. Charman, Louise E. McCrossin, 1998 .

Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum

Sandhya Kortagere, Thomas D. Otto, Vicky M. Avery, 2014, Nature Communications.

Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions.

Shailesh N Mistry, S. McGowan, A. Paiardini, 2016, European journal of medicinal chemistry.

Novel inhibitors of Plasmodium falciparum based on 2,5-disubstituted furans.

S. Charman, E. Ryan, L. Dias, 2017, European journal of medicinal chemistry.

Self-Emulsifying Drug Delivery Systems: Formulation and Biopharmaceutic Evaluation of an Investigational Lipophilic Compound

Colin W. Pouton, Susan A. Charman, C. Pouton, 2004, Pharmaceutical Research.

Transformation of poorly water-soluble drugs into lipophilic ionic liquids enhances oral drug exposure from lipid based formulations.

Hywel D Williams, Christopher J H Porter, Susan A Charman, 2015, Molecular pharmaceutics.

Identification of an antimalarial synthetic trioxolane drug development candidate

Christian Scheurer, Jonathan L. Vennerstrom, Susan A. Charman, 2004, Nature.

UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria

R. Price, K. Chibale, Dale Taylor, 2018, Antimicrobial Agents and Chemotherapy.

A novel prodrug approach for tertiary amines. 3. In vivo evaluation of two N-phosphonooxymethyl prodrugs in rats and dogs.

V. Stella, S. Charman, W. Charman, 1999, Journal of pharmaceutical sciences.

Lymphatic Absorption of Subcutaneously Administered Proteins: Influence of Different Injection Sites on the Absorption of Darbepoetin Alfa Using a Sheep Model

G. Edwards, C. Porter, S. Charman, 2007, Drug Metabolism and Disposition.

Evaluation of emulsifiable glasses for the oral administration of cyclosporin in beagle dogs

Rachel Williams, Susan A. Charman, Rachel L. Williams, 1996 .

Computational Prediction of CNS Drug Exposure Based on a Novel In Vivo Dataset

Christel A. S. Bergström, S. Charman, J. Nicolazzo, 2012, Pharmaceutical Research.

Systemic availability and lymphatic transport of human growth hormone administered by subcutaneous injection.

G. Edwards, C. Porter, S. Charman, 2000, Journal of pharmaceutical sciences.

Synthesis and biological evaluation of polysulfated oligosaccharide glycosides as inhibitors of angiogenesis and tumor growth.

David M. Shackleford, T. Gonda, S. Charman, 2010, Journal of medicinal chemistry.

Re-evaluating pretomanid analogues for Chagas disease: Hit-to-lead studies reveal both in vitro and in vivo trypanocidal efficacy.

K. Read, W. Denny, A. M. Thompson, 2020, European journal of medicinal chemistry.

Use of plasma proteins as solubilizing agents in in vitro permeability experiments: correction for unbound drug concentration using the reciprocal permeability approach.

C. Porter, S. Charman, K. Katneni, 2008, Journal of pharmaceutical sciences.

Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.

David M. Shackleford, D. Chalmers, D. Grobelny, 2011, Journal of medicinal chemistry.

Inhibition of Cytomegalovirus Replication with Extended-Half-Life Synthetic Ozonides

S. Charman, Xiaofang Wang, J. Vennerstrom, 2018, Antimicrobial Agents and Chemotherapy.

S-glycosyl primary sulfonamides--a new structural class for selective inhibition of cancer-associated carbonic anhydrases.

C. Supuran, A. Innocenti, D. Vullo, 2009, Journal of medicinal chemistry.

Intestinal Lymph Flow, and Lipid and Drug Transport Scale Allometrically From Pre-clinical Species to Humans

J. Windsor, C. Porter, A. Phillips, 2020, Frontiers in Physiology.

Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors

Chin Wee Tan, J. Visvader, Maohui Luo, 2021, Cell Death & Disease.

Lymphatic transport of halofantrine in the conscious rat when administered as either the free base or the hydrochloride salt: effect of lipid class and lipid vehicle dispersion.

C. Porter, S. Charman, W. Charman, 1996, Journal of pharmaceutical sciences.

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

David M. Shackleford, R. Price, D. Fidock, 2017, Nature Communications.

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

Nghi Nguyen, Thomas S. Peat, Olan Dolezal, 2018, Nature.

Discovery of Acylsulfonohydrazide-Derived Lysine Acetyltransferase (KAT6A) Inhibitors as Potent Senescence-Inducing Anti-Cancer Agents.

Jayme L. Dahlin, David M. Shackleford, J. Baell, 2020, Journal of medicinal chemistry.

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

Farah El Mazouni, T. Laird, P. Rathod, 2015, Science Translational Medicine.

Development of Diaminoquinazoline Histone Lysine Methyltransferase Inhibitors as Potent Blood‐Stage Antimalarial Compounds

N. A. Malmquist, F. Liu, M. Fuchter, 2014, ChemMedChem.

Metallocene-based inhibitors of cancer-associated carbonic anhydrase enzymes IX and XII.

C. Supuran, D. Vullo, S. Charman, 2012, Journal of medicinal chemistry.

Quinolone-3-Diarylethers: A New Class of Antimalarial Drug

Yuexin Li, David M. Shackleford, Susan A Charman, 2013, Science Translational Medicine.

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium

Hongshen Ma, Zheng Wang, Jeremy Horst, 2014, Proceedings of the National Academy of Sciences.

In Vitro and In Vivo Antischistosomal Activity Profiling and Pharmacokinetics of Ozonide Carboxylic Acids.

J. Keiser, S. Charman, Xiaofang Wang, 2023, ACS infectious diseases.

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

Christian Scheurer, Lukas Stingelin, David M. Shackleford, 2011, Proceedings of the National Academy of Sciences.

Biphasic Drug Absorption from the Epidural Space of the Dog May Limit the Utility of a Slow Release Medium Molecular Weight Hyaluronic Acid-Lidocaine Ionic Complex Formulation

S. Charman, W. Charman, P. Hughes, 1996, Anesthesia and analgesia.

Probing a potential in vivo drug-excipient interaction: temporal effects of a modified β-cyclodextrin on the intravenous pharmacokinetics of a model high-affinity drug ligand.

David M. Shackleford, S. Charman, Anne Mannila, 2012, Journal of Pharmacy and Science.

Chemical kinetics and aqueous degradation pathways of a new class of synthetic ozonide antimalarials.

R. Prankerd, S. Charman, W. Charman, 2006, Journal of pharmaceutical sciences.

Phenylaminopyrimidines as inhibitors of Janus kinases (JAKs).

David M. Shackleford, Christopher J Burns, Susan A Charman, 2009, Bioorganic & medicinal chemistry letters.

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase

David M. Shackleford, G. Drewes, M. Bantscheff, 2017, Science Translational Medicine.

Computational Prediction of CNS Drug Exposure Based on a Novel In Vivo Dataset

Christel A. S. Bergström, Susan A. Charman, S. Charman, 2012, Pharmaceutical Research.

Methods to assess drug permeability across the blood‐brain barrier

Susan A Charman, S. Charman, W. Charman, 2006, The Journal of pharmacy and pharmacology.

Antimalarial activity of pyrroloiminoquinones from the Australian marine sponge Zyzzya sp.

David M. Shackleford, V. Avery, S. Charman, 2012, Journal of medicinal chemistry.

Novel Human Aminopeptidase N Inhibitors: Discovery and Optimization of Subsite Binding Interactions.

C. Overall, Wei Yang, S. McGowan, 2019, Journal of medicinal chemistry.

Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target

Yongyuth Yuthavong, Sumalee Kamchonwongpaisan, Jarunee Vanichtanankul, 2012, Proceedings of the National Academy of Sciences.

Revisiting the SAR of the Antischistosomal Aryl Hydantoin (Ro 13-3978)

David M. Shackleford, J. Keiser, Jeremy O. Jones, 2016, Journal of medicinal chemistry.

Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins

L. Tilley, E. Hanssen, N. Klonis, 2016, Journal of Cell Science.

Techniques for Assessing the Effects of Pharmaceutical Excipients on the Aggregation of Porcine Growth Hormone

S. Charman, W. Charman, Kaye L. Mason, 1993, Pharmaceutical Research.

Systematic evaluation of structure-property relationships and pharmacokinetics in 6-(hetero)aryl-substituted matched pair analogs of amiloride and 5-(N,N-hexamethylene)amiloride.

David M. Shackleford, M. Ranson, S. Charman, 2021, Bioorganic & medicinal chemistry.

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

A. Strasser, G. Smyth, J. Baell, 2018, Nature.

Antimalarial Inhibitors Targeting Serine Hydroxymethyltransferase (SHMT) with in Vivo Efficacy and Analysis of their Binding Mode Based on X-ray Cocrystal Structures.

F. Diederich, R. Aponte, P. Chaiyen, 2017, Journal of medicinal chemistry.

Analytical methods and stability assessment of liquid yeast derived sucrase.

S. Charman, W. Charman, L. Borgen, 1998, Journal of pharmaceutical and biomedical analysis.

Selection and optimization of hits from a high-throughput phenotypic screen against Trypanosoma cruzi.

M. J. Abbott, Paul W. Alexander, S. Cornwall, 2013, Future medicinal chemistry.

The application of capillary electrophoresis for monitoring effects of excipients on protein conformation.

S. Charman, W. Charman, K. McIntosh, 1998, Journal of pharmaceutical and biomedical analysis.

Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors

J. Newman, D. Komander, B. C. Lechtenberg, 2022, Frontiers in Chemistry.

Parasite-Mediated Degradation of Synthetic Ozonide Antimalarials Impacts In Vitro Antimalarial Activity

L. Tilley, L. Stingelin, S. Charman, 2017, Antimicrobial Agents and Chemotherapy.

Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles

Julie Clark, George Papadatos, Jeremy N. Burrows, 2016, ACS central science.

Total synthesis of thiaplakortone a: derivatives as metabolically stable leads for the treatment of malaria.

S. Charman, R. Quinn, K. Andrews, 2014, ACS medicinal chemistry letters.

6-Arylpyrazine-2-carboxamides: A New Core for Trypanosoma brucei Inhibitors.

J. Baell, V. Avery, S. Charman, 2015, Journal of medicinal chemistry.

Synthetic Sansanmycin Analogues as Potent Mycobacterium tuberculosis Translocase I Inhibitors.

Roger G. Linington, E. Rubin, R. Payne, 2021, Journal of medicinal chemistry.

Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis

Roger G. Linington, R. Payne, T. Bugg, 2017, Nature Communications.

The involvement of a Na⁺- and Cl⁻-dependent transporter in the brain uptake of amantadine and rimantadine.

P. Couraud, I. Romero, B. Weksler, 2012, Molecular pharmaceutics.

Impact of cremophor-EL and polysorbate-80 on digoxin permeability across rat jejunum: delineation of thermodynamic and transporter related events using the reciprocal permeability approach.

Christopher J H Porter, Susan A Charman, C. Porter, 2007, Journal of pharmaceutical sciences.

Comparative Antimalarial Activities of Six Pairs of 1,2,4,5-Tetraoxanes (Peroxide Dimers) and 1,2,4,5,7,8-Hexaoxonanes (Peroxide Trimers)

J. K. Wood, James K. Wood, J. Chollet, 2007, Antimicrobial Agents and Chemotherapy.

Presystemic acetylation of platelets by aspirin: reduction in rate of drug delivery to improve biochemical selectivity for thromboxane A2.

G. FitzGerald, S. Charman, W. Charman, 1991, The Journal of pharmacology and experimental therapeutics.

Drug delivery: A key factor in realising the full therapeutic potential of drugs

S. Charman, H. Chan, W. Charman, 1999 .

Long-Lasting and Fast-Acting in Vivo Efficacious Antiplasmodial Azepanylcarbazole Amino Alcohol.

P. Hewitt, D. Picard, S. Charman, 2017, ACS medicinal chemistry letters.

Medicinal Chemistry Case History: Discovery of the Dihydroorate Dehydrogenase Inhibitor DSM265 as an Antimalarial Drug Candidate

P. Rathod, M. Phillips, S. Charman, 2017 .

Antimalarial activity of N-alkyl amine, carboxamide, sulfonamide, and urea derivatives of a dispiro-1,2,4-trioxolane piperidine.

J. Chollet, S. Charman, W. Charman, 2006, Bioorganic & medicinal chemistry letters.

Modulation of Lymphocyte Potassium Channel KV1.3 by Membrane-Penetrating, Joint-Targeting Immunomodulatory Plant Defensin.

K. Chandy, R. Norton, J. Lescar, 2020, ACS pharmacology & translational science.

Permeability assessment of poorly water-soluble compounds under solubilizing conditions: the reciprocal permeability approach.

C. Porter, S. Charman, K. Katneni, 2006, Journal of pharmaceutical sciences.

Therapeutic efficacy of antimalarial drugs targeting DosRS signaling in Mycobacterium abscessus

K. Malcolm, J. Nick, M. Zimmerman, 2022, Science Translational Medicine.

Evidence for the in vitro bioactivation of aminopyrazole derivatives: trapping reactive aminopyrazole intermediates using glutathione ethyl ester in human liver microsomes.

S. Charman, J. Pinson, E. Ryan, 2015, Chemical research in toxicology.

Discovery of benzoylsulfonohydrazides as potent inhibitors of the histone acetyltransferase KAT6A.

Jayme L. Dahlin, J. Baell, M. Walters, 2019, Journal of medicinal chemistry.

Ozonide antimalarials alkylate heme in the malaria parasite Plasmodium falciparum.

S. Charman, D. Creek, Dovile Anderson, 2019, ACS infectious diseases.

The development process for discovery and clinical advancement of modern antimalarials.

Shane M. Devine, S. Charman, D. Creek, 2019, Journal of medicinal chemistry.

Using Human Plasma as an Assay Medium in Caco-2 Studies Improves Mass Balance for Lipophilic Compounds

David M. Shackleford, S. Charman, Nada Abla, 2018, Pharmaceutical Research.

Structure-Activity Relationship of Antischistosomal Ozonide Carboxylic Acids.

David M. Shackleford, J. Keiser, S. Charman, 2020, Journal of medicinal chemistry.

Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439.

David M. Shackleford, S. Charman, Qingjie Zhao, 2021, ACS infectious diseases.

Lead optimization of a pyrrole-based dihydroorotate dehydrogenase inhibitor series for the treatment of Malaria.

David M. Shackleford, P. Rathod, John White, 2020, Journal of medicinal chemistry.

Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277.

A. Ruf, S. Charman, W. Charman, 2008, Bioorganic & medicinal chemistry letters.

In vitro assessment of the pharmacodynamic properties and the partitioning of OZ277/RBx-11160 in cultures of Plasmodium falciparum.

S. Charman, R. Brun, H. Matile, 2006, The Journal of antimicrobial chemotherapy.

The comparative antimalarial properties of weak base and neutral synthetic ozonides.

J. Chollet, S. Charman, W. Charman, 2010, Bioorganic & medicinal chemistry letters.

Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes.

J. Chollet, S. Charman, W. Charman, 2006, Bioorganic & medicinal chemistry.

Erratum: (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium (Proceedings of the National Academy of Sciences of the United States of America (2014) 111 (E5455-E5462) 1 DOI: 10.1073/pnas.1414221111)

Anang A. Shelat, Zheng Wang, Jeremy A. Horst, 2015 .

Chapter 2:Semisynthetic Artemisinin and Synthetic Peroxide Antimalarials

L. Tilley, S. Charman, J. Vennerstrom, 2011 .

Potent in Vitro and in Vivo Antimalarials

J. Gut, R. Payne, N. Hunt, 2019 .

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis

E. Winzeler, S. Meister, J. Rayner, 2016, Nature.

Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice

David M. Shackleford, S. Norval, K. Read, 2011, Malaria Journal.

Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series.

David M. Shackleford, E. Winzeler, P. Rathod, 2021, Journal of medicinal chemistry.

Effects of backbone cyclization on the pharmacokinetics and drug efficiency of the orally active analgesic conotoxin cVc1.1

David M. Shackleford, D. Craik, T. Durek, 2021 .

Repurposed dihydroorotate dehydrogenase inhibitors with efficacy against drug-resistant Acinetobacter baumannii

P. Rathod, M. Phillips, B. Posner, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Evaluation of 4-Amino 2-Anilinoquinazolines against Plasmodium and Other Apicomplexan Parasites In Vitro and in a P. falciparum Humanized NOD-scid IL2Rγnull Mouse Model of Malaria

Christopher J. Tonkin, A. Cowman, F. Gamo, 2018, Antimicrobial Agents and Chemotherapy.

Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer.

Chin Wee Tan, Dharmesh D. Bhuva, Eric C Greenwald, 2023, Cell chemical biology.

Abstract 5371: PRMT5 inhibitors as novel treatment for cancers

T. Peat, P. Pilling, S. Jane, 2015 .

SAR of a new antischistosomal urea carboxylic acid.

David M. Shackleford, J. Keiser, S. Charman, 2018, Bioorganic & medicinal chemistry letters.

Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions.

Shailesh N Mistry, S. McGowan, A. Paiardini, 2016, European journal of medicinal chemistry.

6-Arylpyrazine-2-carboxamides: A New Core for Trypanosoma brucei Inhibitors.

J. Baell, V. Avery, S. Charman, 2015, Journal of medicinal chemistry.

Novel orally active antimalarial thiazoles.

K. Chibale, M. Witty, S. Charman, 2011, Journal of medicinal chemistry.

Increased In Vivo Exposure of N-(4-Hydroxyphenyl) Retinamide (4-HPR) to Achieve Plasma Concentrations Effective against Dengue Virus

David M. Shackleford, D. Jans, K. Wagstaff, 2023, Pharmaceutics.

Development and application of a PBPK modeling strategy to support antimalarial drug development

S. Charman, E. Howgate, K. Rowland-Yeo, 2023, CPT: pharmacometrics & systems pharmacology.