B. Poulain

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Adaptation of Granule Cell to Purkinje Cell Synapses to High-Frequency Transmission

B. Barbour, P. Isope, Antoine M Valera, 2012, The Journal of Neuroscience.

Clusters of cerebellar Purkinje cells control their afferent climbing fiber discharge

M. Barrot, G. Dugué, D. Popa, 2013, Proceedings of the National Academy of Sciences.

Stereotyped spatial patterns of functional synaptic connectivity in the cerebellar cortex

Jean-Luc Dupont, Philippe Isope, J. Rothstein, 2015, eLife.

Short-term plasticity at cerebellar granule cell to molecular layer interneuron synapses expands information processing

P. Isope, Y. Bailly, F. Doussau, 2019, eLife.

Molecular and functional heterogeneity of cerebellar granule cell terminals expands temporal coding in molecular layer interneurons

P. Isope, Y. Bailly, F. Doussau, 2018, bioRxiv.

Molecular Mechanism of Action of Botulinal Neurotoxins and the Synaptic Remodeling They Induce In Vivo at the Skeletal Neuromuscular Junction

G. Schiavo, F. Meunier, B. Poulain, 2002 .

How botulinum and tetanus neurotoxins block neurotransmitter release.

Y. Humeau, N. Grant, F. Doussau, 2000, Biochimie.

Evidence for a functional link between Rab3 and the SNARE complex.

J. Henry, A. Clabecq, F. Doussau, 1996, Journal of cell science.

The metallo-proteinase activity of tetanus and botulism neurotoxins

C. Montecucco, B. Poulain, R. Pellizzari, 1995, Journal of Physiology-Paris.

Neurotransmitter release is blocked intracellularly by botulinum neurotoxin, and this requires uptake of both toxin polypeptides by a process mediated by the larger chain.

L. Tauc, J. Dolly, B. Poulain, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Light chain of tetanus toxin intracellularly inhibits acetylcholine release at neuro‐neuronal synapses, and its internalization is mediated by heavy chain

L. Tauc, B. Poulain, S. Mochida, 1989, FEBS letters.

Minimal essential domains specifying toxicity of the light chains of tetanus toxin and botulinum neurotoxin type A.

L. Tauc, H. Kurazono, H. Niemann, 1992, The Journal of biological chemistry.

Tetanus toxin is a zinc protein and its inhibition of neurotransmitter release and protease activity depend on zinc.

F. Benfenati, L. Tauc, G. Schiavo, 1992, EMBO Journal.

Factors Underlying the Characteristic Inhibition of the Neuronal Release of Transmitters by Tetanus and Various Botulinum Toxins

L. Tauc, J. Dolly, B. Poulain, 1993 .

Antibodies Against Rat Brain Vesicle‐Associated Membrane Protein (Synaptobrevin) Prevent Inhibition of Acetylcholine Release by Tetanus Toxin or Botulinum Neurotoxin Type B

L. Tauc, G. Schiavo, C. Montecucco, 1993, Journal of neurochemistry.

A role for the interchain disulfide or its participating thiols in the internalization of botulinum neurotoxin A revealed by a toxin derivative that binds to ecto-acceptors and inhibits transmitter release intracellularly.

L. Tauc, J. Dolly, B. Poulain, 1993, The Journal of biological chemistry.

Novel targets and catalytic activities of bacterial protein toxins.

F. Benfenati, G. Schiavo, C. Montecucco, 1993, Trends in microbiology.

Neuronal selectivity of botulinum neurotoxins.

E. Lemichez, B. Poulain, M. Popoff, 2018, Toxicon : official journal of the International Society on Toxinology.

Why Are Botulinum Neurotoxin-Producing Bacteria So Diverse and Botulinum Neurotoxins So Toxic?

B. Poulain, M. Popoff, 2019, Toxins.

Organotypic cultures of cerebellar slices as a model to investigate demyelinating disorders

F. Doussau, B. Poulain, J. Dupont, 2017, Expert opinion on drug discovery.

Tetanus and Botulinum Neurotoxins Are Zinc Proteases Specific for Components of the Neuroexocytosis Apparatus a

F. Benfenati, G. Schiavo, C. Montecucco, 1994, Annals of the New York Academy of Sciences.

[Molecular mechanism of action of tetanus toxin and botulinum neurotoxins].

B. Poulain, 1994, Pathologie-biologie.

Transglutaminase participates in the blockade of neurotransmitter release by tetanus toxin: evidence for a novel biological function

A. Luini, F. Benfenati, F. Facchiano, 2010, Amino Acids.

Tetanus Toxin Inhibits Neuroexocytosis Even When Its Zn-dependent Protease Activity Is Removed (*)

G. Dougan, J. Dolly, F. Doussau, 1995, The Journal of Biological Chemistry.

A role for phospholipase D1 in neurotransmitter release

Y. Humeau, S. Chasserot-Golaz, N. Vitale, 2001, Proceedings of the National Academy of Sciences of the United States of America.

How Do Bacterial Neurotoxins Affect Neurosecretion?

F. Doussau, B. Poulain, 2020 .

Quantal neurotransmitter release and the clostridial neurotoxins' targets.

B. Poulain, J. Molgó, S. Thesleff, 1995, Current topics in microbiology and immunology.

Heterologous combinations of heavy and light chains from botulinum neurotoxin A and tetanus toxin inhibit neurotransmitter release in Aplysia.

L. Tauc, J. Dolly, B. Poulain, 1991, Journal of Biological Chemistry.

[Mechanisms of action of botulinum toxins and neurotoxins].

B. Poulain, J. Molgó, M. Popoff, 2009, Annales de dermatologie et de venereologie.

Botulinal Neurotoxins: Mode of Action on Neurotransmitter Release

B. Poulain, J. Molgó, 1992 .

[Botulinum neurotoxin].

B. Poulain, 2010, Revue neurologique.

Antagonism of the intracellular action of botulinum neurotoxin type A with monoclonal antibodies that map to light-chain epitopes.

L. Tauc, J. Dolly, B. Poulain, 1994, European journal of biochemistry.

Ca2+ Dependent Evoked Quantal Neurotransmitter Release does Not Necessarily Involve Exocytosis of Synaptic Vesicles

L. Tauc, B. Poulain, 1993 .

Exogenous mRNA encoding tetanus or botulinum neurotoxins expressed in Aplysia neurons.

L. Tauc, H. Kurazono, H. Niemann, 1990, Proceedings of the National Academy of Sciences of the United States of America.

High sensitivity of mouse neuronal cells to tetanus toxin requires a GPI-anchored protein.

P. Boquet, B. Poulain, J. Dupont, 2001, Biochemical and biophysical research communications.

Functional Roles of Domains of Clostridial Neurotoxins: The Contribution from Studies on Aplysia

L. Tauc, J. Dolly, H. Niemann, 1993 .

Differences in the temperature dependencies of uptake of botulinum and tetanus toxins in Aplysia neurons

L. Tauc, J. Dolly, B. Poulain, 1992, Neuroscience Letters.

Involvement of the constituent chains of botulinum neurotoxins A and B in the blockade of neurotransmitter release.

L. Tauc, J. Dolly, B. Poulain, 1988, European journal of biochemistry.

Inhibition of transmitter release by botulinum neurotoxin A. Contribution of various fragments to the intoxication process.

L. Tauc, J. Dolly, B. Poulain, 1989, European journal of biochemistry.

Inhibition of neurotransmitter release by botulinum neurotoxins and tetanus toxin at Aplysia synapses: role of the constituent chains.

L. Tauc, J. Dolly, B. Poulain, 1990, Journal de physiologie.

Clostridial neurotoxins: from toxins to therapeutic tools?

L. Tauc, H. Kurazono, H. Niemann, 1991, Behring Institute Mitteilungen.

Multiple domains of botulinum neurotoxin contribute to its inhibition of transmitter release in Aplysia neurons.

L. Tauc, J. Dolly, B. Poulain, 1989, The Journal of biological chemistry.

Internalization of staphylococcal leukotoxins that bind and divert the C5a receptor is required for intracellular Ca2+ mobilization by human neutrophils

C. Potrich, B. Poulain, T. Bourcier, 2015, Cellular microbiology.

Presynaptic transmitter content controls the number of quanta released at a neuro-neuronal cholinergic synapse.

L. Tauc, B. Poulain, G. Baux, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Clostridial neurotoxins: from the cellular and molecular mode of action to their therapeutic use

B. Poulain, J. Molgó, M. Popoff, 2015 .

Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin

F. Benfenati, G. Schiavo, P. P. Laureto, 1992, Nature.

Marine Toxins Affecting Quantal Acetylcholine Release and Transmission at the Vertebrate Neuromuscular Junction

F. Meunier, B. Poulain, J. Molgó, 1997 .

Functional roles of synapsin: lessons from invertebrates.

Y. Humeau, M. Ghirardi, B. Poulain, 2011, Seminars in cell & developmental biology.

Staphylococcal leukotoxins trigger free intracellular Ca2+ rise in neurones, signalling through acidic stores and activation of store-operated channels

B. Poulain, G. Prévost, E. Jover, 2012, Cellular microbiology.

Botulinum and Tetanus Neurotoxins

L. Tauc, H. Kurazono, H. Niemann, 1993, Springer US.

How do the Botulinum Neurotoxins block neurotransmitter release: from botulism to the molecular mechanism of action

B. Poulain, J. Molgó, M. Popoff, 2008 .

CHAPTER 19 – Attack of the nervous system by clostridial toxins: physical findings, cellular and molecular actions

B. Poulain, J. Molgó, M. Popoff, 2006 .

Epsilon toxin from Clostridium perfringens acts on oligodendrocytes without forming pores, and causes demyelination

P. Isope, F. Doussau, B. Poulain, 2015, Cellular microbiology.

Attack of the nervous system by Clostridium perfringens Epsilon toxin: from disease to mode of action on neural cells.

B. Poulain, M. Popoff, J. Dupont, 2013, Toxicon : official journal of the International Society on Toxinology.

Clostridium perfringens Epsilon Toxin: Structural and Mechanistic Insights

B. Poulain, M. Popoff, B. Stiles, 2016 .

Hemicholinium-3 facilitates the release of acetylcholine by acting on presynaptic nicotinic receptors at a central synapse in Aplysia

P. Fossier, L. Tauc, B. Poulain, 1987, Brain Research.

[Validity of the two species O. lienalis and O. gutturosa from bovines (author's transl)].

B. Poulain, G. Petit, O. Bain, 1978, Annales de parasitologie humaine et comparee.

Quantal analysis of action of hemicholinium‐3 studied at a central cholinergic synapse of Aplysia.

L. Tauc, B. Poulain, G. Baux, 1986, The Journal of physiology.

12 Botulism and Tetanus

B. Poulain, M. Popoff, C. Mazuet, 2013 .

Botulism and Tetanus

B. Poulain, M. Popoff, C. Mazuet, 2013 .

Both presynaptic nicotinic-like and muscarinic-like autoreceptors regulate acetylcholine release at an identified neuro-neuronal synapse ofAplysia

P. Fossier, L. Tauc, B. Poulain, 1988, Pflügers Archiv.

SNARE motif and neurotoxins

Giampietro Schiavo, Cesare Montecucco, G. Schiavo, 1994, Nature.

Frequency-dependent mobilization of heterogeneous pools of synaptic vesicles shapes presynaptic plasticity

P. Isope, F. Doussau, B. Poulain, 2017, eLife.

Pore-forming epsilon toxin causes membrane permeabilization and rapid ATP depletion-mediated cell death in renal collecting duct cells.

J. de Barry, A. Vandewalle, M. Bens, 2007, American journal of physiology. Renal physiology.

Role of Rab3a in neurotransmitter and hormone release: a discussion of recent data.

J. Henry, B. Poulain, F. Darchen, 1996, Biochemical Society transactions.

IL1-receptor accessory protein-like 1 (IL1RAPL1), a protein involved in cognitive functions, regulates N-type Ca2+-channel and neurite elongation

Y. Humeau, N. Vitale, J. Chelly, 2007, Proceedings of the National Academy of Sciences.

IL1RAPL1 controls inhibitory networks during cerebellar development in mice

Y. Humeau, P. Billuart, N. Vitale, 2009, The European journal of neuroscience.

Rac GTPase Plays an Essential Role in Exocytosis by Controlling the Fusion Competence of Release Sites

Y. Humeau, F. Doussau, B. Poulain, 2002, The Journal of Neuroscience.

Synaptic organization of the mouse cerebellar cortex in organotypic slice cultures

B. Poulain, J. Dupont, J. Bossu, 2008, The Cerebellum.

Inhibition promotes long-term potentiation at cerebellar excitatory synapses

M. Kano, K. Sakimura, P. Isope, 2016, Scientific Reports.

Bacterial Toxins and the Nervous System: Neurotoxins and Multipotential Toxins Interacting with Neuronal Cells

B. Poulain, M. Popoff, 2010, Toxins.

Clinical equivalence of conventional OnabotulinumtoxinA (900 KDa) and IncobotulinumtoxinA (neurotoxin free from complexing proteins - 150 KDa): 2012 multidisciplinary French consensus in aesthetics.

S. Dahan, P. Humbert, H. Cartier, 2013, Journal of drugs in dermatology : JDD.

Differences in the multiple step process of inhibition of neurotransmitter release induced by tetanus toxin and botulinum neurotoxins type A and B atAplysia synapses

L. Tauc, J. Dolly, F. Doussau, 1996, Neuroscience.

Micro carbon electrode for intracellular voltammetry

L. Tauc, B. Poulain, D. Henzel, 1986 .

Changes in serotonin concentration in a living neurone: a study by on-line intracellular voltammetry

L. Tauc, B. Poulain, G. Baux, 1987, Brain Research.

Synapsin Controls Both Reserve and Releasable Synaptic Vesicle Pools during Neuronal Activity and Short-Term Plasticity inAplysia

P. Greengard, Y. Humeau, F. Benfenati, 2001, The Journal of Neuroscience.

Cellular and Molecular Mode of Action of Botulinum and Tetanus Neurotoxins

F. Doussau, B. Poulain, J. Molgó, 1997 .

Inhibition of Neurotransmitter Release by Synthetic Proline-rich Peptides Shows That the N-terminal Domain of Vesicle-associated Membrane Protein/Synaptobrevin Is Critical for Neuro-exocytosis (*)

B. Roques, B. Poulain, M. Fournié-Zaluski, 1995, The Journal of Biological Chemistry.

cAMP/PKA signaling and RIM1α mediate presynaptic LTP in the lateral amygdala

Y. Humeau, H. Shaban, A. Lüthi, 2008, Proceedings of the National Academy of Sciences.

Petrobart vs. The Kyrgyz Republic - a few reservations regarding the Tribunal’s constructions of the material, temporal and spatial application of the Treaty

B. Poulain, 2005 .

Fast changes in the functional status of release sites during short‐term plasticity: involvement of a frequency‐dependent bypass of Rac at Aplysia synapses

Y. Humeau, F. Benfenati, F. Doussau, 2007, The Journal of physiology.

A Rho-related GTPase Is Involved in Ca2+-dependent Neurotransmitter Exocytosis*

Y. Humeau, M. Bader, P. Boquet, 2000, The Journal of Biological Chemistry.

Cerebellar connectivity maps embody individual adaptive behavior in mice

I. Sugihara, Demian Battaglia, P. Isope, 2022, Nature communications.

Maturation of GABAergic Transmission in Cerebellar Purkinje Cells Is Sex Dependent and Altered in the Valproate Model of Autism

Y. Ben-Ari, A. Lohof, S. Roux, 2018, Front. Cell. Neurosci..

L-type voltage-dependent Ca2+ channels mediate expression of presynaptic LTP in amygdala

Andreas Lüthi, Y. Humeau, A. Lüthi, 2009, Nature Neuroscience.

Synaptic Maturation at Cortical Projections to the Lateral Amygdala in a Mouse Model of Rett Syndrome

Y. Humeau, J. Chelly, T. Bienvenu, 2010, PloS one.

In Vitro Physiological Studies on Clostridial Neurotoxins

M. Bader, B. Poulain, J. Molgó, 2000 .

Epsilon Toxin from Clostridium perfringens Causes Inhibition of Potassium inward Rectifier (Kir) Channels in Oligodendrocytes

P. Isope, F. Doussau, B. Poulain, 2020, Toxins.

Clostridium perfringens Epsilon Toxin Targets Granule Cells in the Mouse Cerebellum and Stimulates Glutamate Release

J. de Barry, F. Doussau, B. Poulain, 2010, PloS one.

A Novel Form of Presynaptic Plasticity Based on the Fast Reactivation of Release Sites Switched Off during Low-Frequency Depression

Y. Humeau, F. Benfenati, F. Doussau, 2010, The Journal of Neuroscience.

Deletion of Cav2.1(α1A) subunit of Ca2+‐channels impairs synaptic GABA and glutamate release in the mouse cerebellar cortex in cultured slices

F. Doussau, B. Poulain, Hee-Sup Shin, 2009, The European journal of neuroscience.

A frequency-dependent mobilization of heterogeneous pools of synaptic vesicles shapes presynaptic plasticity

P. Isope, F. Doussau, B. Poulain, 2017, bioRxiv.

[Analysis of synaptic neurotransmitter release mechanisms using bacterial toxins].

Y. Humeau, F. Doussau, B. Poulain, 1999, Journal de la Societe de biologie.

Dissecting the L Chains of Clostridial Neurotoxins

L. Tauc, H. Kurazono, H. Niemann, 1993 .

[Mode of action of botulinum neurotoxin: pathological, cellular and molecular aspect].

Y. Humeau, B. Poulain, 2003, Annales de readaptation et de medecine physique : revue scientifique de la Societe francaise de reeducation fonctionnelle de readaptation et de medecine physique.

The mouse cerebellar cortex in organotypic slice cultures: an in vitro model to analyze the consequences of mutations and pathologies on neuronal survival, development, and function.

B. Poulain, J. Dupont, J. Bossu, 2006, Critical reviews in neurobiology.

Lack of the presynaptic RhoGAP protein oligophrenin1 leads to cognitive disabilities through dysregulation of the cAMP/PKA signalling pathway

Y. Humeau, A. Lüthi, P. Billuart, 2014, Philosophical Transactions of the Royal Society B: Biological Sciences.

Clues to the multi-phasic inhibitory action of botulinum neurotoxins on release of transmitters.

L. Tauc, J. Dolly, B. Poulain, 1990, Journal de physiologie.

Receptor-mediated presynaptic facilitation of quantal release of acetylcholine induced by pralidoxime inAplysia

P. Fossier, L. Tauc, B. Poulain, 1990, Cellular and Molecular Neurobiology.

Pre and Post Synaptic NMDA Effects Targeting Purkinje Cells in the Mouse Cerebellar Cortex

F. Doussau, B. Poulain, F. Gambino, 2012, PloS one.

The mechanism of action of tetanus and botulinum neurotoxins.

G. Schiavo, C. Montecucco, B. Poulain, 1995, Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement.

Synaptic Efficacy Is Controlled by the Concentration of Transmitter in the Nerve Ending

P. Fossier, L. Tauc, B. Poulain, 1988 .

Cerebellar connectivity maps embody individual adaptive behavior

I. Sugihara, Demian Battaglia, P. Isope, 2021, bioRxiv.

Calcium-Dependent Regulation of Rab3 in Short-Term Plasticity

F. Doussau, B. Poulain, F. Darchen, 1998, The Journal of Neuroscience.

[Botulinum neurotoxin].

B. Poulain, B. Poulain, 2010, Revue neurologique.