S. Jensen

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Insights into positive and negative requirements for protein-protein interactions by crystallographic analysis of the beta-lactamase inhibitory proteins BLIP, BLIP-I, and BLP.

D. Lim, N. Strynadka, M. Gretes, 2009, Journal of molecular biology.

Structural and kinetic characterization of a β-lactamase-inhibitor protein

André Matagne, J. Frère, M. Page, 1994, Nature.

A potent new mode of β-lactamase inhibition revealed by the 1.7 Å X-ray crystallographic structure of the TEM-1–BLIP complex

Pedro M. Alzari, M. James, P. Alzari, 1996, Nature Structural Biology.

Minimum Information about a Biosynthetic Gene cluster.

Carla S. Jones, M. Smanski, Jan Claesen, 2015, Nature chemical biology.

Molecular structure of the acyl-enzyme intermediate in β-lactam hydrolysis at 1.7 Å resolution

C. Betzel, M. James, K. Sutoh, 1992, Nature.

Nutritional factors controlling exocellular protease production by Pseudomonas aeruginosa

S. Jensen, I. T. Fecycz, J. N. Campbell, 1980, Journal of bacteriology.

β-Lactam synthetase: implications for β-lactamase evolution

C. Schofield, S. Jensen, Heather J. McNaughton, 1998 .

Crystal structure and kinetic analysis of beta-lactamase inhibitor protein-II in complex with TEM-1 beta-lactamase.

K J Lee, D. Lim, N. Strynadka, 2001, Nature structural biology.

Carboxyethylarginine Synthase Genes Show Complex Cross-Regulation in Streptomyces clavuligerus

S. Jensen, C. Anders, K. Tahlan, 2012, Applied and Environmental Microbiology.

A comparison of the clavam biosynthetic gene clusters in Streptomyces antibioticus Tü1718 and Streptomyces clavuligerus.

S. Jensen, Sarah Goomeshi Nobary, 2012, Canadian journal of microbiology.

Clavulanic acid biosynthesis and genetic manipulation for its overproduction

S. Jensen, Kye-Joon Lee, J. Song, 2010, Applied Microbiology and Biotechnology.

Alanylclavam Biosynthetic Genes Are Clustered Together with One Group of Clavulanic Acid Biosynthetic Genes in Streptomyces clavuligerus

S. Jensen, N. Zelyas, H. Cai, 2008, Journal of bacteriology.

5S clavam biosynthetic genes are located in both the clavam and paralog gene clusters in Streptomyces clavuligerus.

S. Jensen, C. Anders, K. Tahlan, 2007, Chemistry & biology.

Biosynthesis and Molecular Genetics of Clavulanic Acid

S. Jensen, A. Paradkar, 2004, Antonie van Leeuwenhoek.

Construction and analysis of ss-lactamase-inhibitory protein (BLIP) non-producer mutants of Streptomyces clavuligerus.

S. Jensen, A. Paradkar, W. Thai, 2001, Microbiology.

Functional analysis of the gene encoding the clavaminate synthase 2 isoenzyme involved in clavulanic acid biosynthesis in Streptomyces clavuligerus

S. Jensen, A. Paradkar, 1995, Journal of bacteriology.

Deacetoxycephalosporin C synthetase and deacetoxycephalosporin C hydroxylase are two separate enzymes in Streptomyces clavuligerus.

D. Westlake, S. Jensen, S. Wolfe, 1985, The Journal of antibiotics.

Purification of isopenicillin N synthetase from Streptomyces clavuligerus.

D. Westlake, S. Jensen, L. Vining, 1986, Canadian journal of microbiology.

Production of the penicillin precursor δ‐(L‐α‐aminoadipyl)‐L‐cysteinyl‐D‐valine (ACV) by cell‐free extracts from Streptomyces clavuligerus

D. Westlake, S. Jensen, S. Wolfe, 1988 .

Investigation of the Streptomyces clavuligerus Cephamycin C Gene Cluster and Its Regulation by the CcaR Protein

S. Jensen, D. Alexander, 1998, Journal of bacteriology.

Production of δ-(l-α-aminoadipyl)-l-cysteinyl-d-valine by entrapped ACV-synthetase fromStreptomyces clavuligerus

M. Pickard, S. Jensen, T. A. Kadima, 2005, Journal of Industrial Microbiology.

Expression of ccaR, Encoding the Positive Activator of Cephamycin C and Clavulanic Acid Production in Streptomyces clavuligerus, Is Dependent on bldG

S. Jensen, K. Tahlan, D. Bignell, 2005, Antimicrobial Agents and Chemotherapy.

Applications of Gene Replacement Technology toStreptomyces clavuligerus Strain Development for Clavulanic Acid Production

S. Jensen, C. Anders, J. Griffin, 2001, Applied and Environmental Microbiology.

A gene located downstream of the clavulanic acid gene cluster in Streptomyces clavuligerus ATCC 27064 encodes a putative response regulator that affects clavulanic acid production

S. Jensen, Kye-Joon Lee, Dae-Wi Kim, 2009, Journal of Industrial Microbiology & Biotechnology.

Paenibacillus polymyxa produces fusaricidin-type antifungal antibiotics active against Leptosphaeria maculans, the causative agent of blackleg disease of canola.

S. Jensen, P. H. Beatty, P. Beatty, 2002, Canadian journal of microbiology.

Amidase activity involved in peptidoglycan biosynthesis in membranes of Micrococcus luteus (sodonensis)

S. Jensen, J. N. Campbell, 1976, Journal of bacteriology.

Peptidoglycan biosynthesis in Micrococcus luteus (sodonensis): transglycosidase and phosphodiesterase activities in membrane preparations

S. Jensen, J. N. Campbell, 1976, Journal of bacteriology.

Peptidoglycan Biosynthesis inMicrococcus luteus (sodonensis): Transglycosidase andPhosphodiesterase Activities inMembranePreparations

S. Jensen, J. N. Campbell, 1976 .

Structure-based design of a potent transition state analogue for TEM-1 beta-lactamase.

J. B. Jones, N. Strynadka, S. Jensen, 1996, Nature structural biology.

Enzymatic approach to syntheses of unnatural beta-lactams.

A. Demain, D. Westlake, S. Jensen, 1984, Science.

Enzymatic synthesis of the penicillin and cephalosporin nuclei from an acyclic peptide containing carboxymethylcysteine.

D. Westlake, S. Jensen, S. Wolfe, 1984, Biochemical and biophysical research communications.

Penicillin formation by cell-free extracts of Streptomycesclavuligerus. Behaviour of aminoadipyl-modified analogs of the natural peptide precursor δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine (ACV)

D. Westlake, S. Jensen, S. Wolfe, 1984 .

Production of penicillins and cephalosporins in an immobilized enzyme reactor

D. Westlake, S. Jensen, S. Wolfe, 1984, Applied Microbiology and Biotechnology.

Paenibacillus polymyxa PKB1 produces variants of polymyxin B-type antibiotics.

J. Vederas, S. Jensen, A. Ross, 2011, Chemistry & biology.

CHAPTER 8 – Beta-Lactams

A. Demain, S. Jensen, 1995 .

Production ofStreptomyces clavuligerus isopenicillin N synthase inEscherichia coli using two-cistron expression systems

D. Westlake, S. Jensen, B. Leskiw, 1990, Journal of Industrial Microbiology.

Three unlinked gene clusters are involved in clavam metabolite biosynthesis in Streptomyces clavuligerus.

H. Park, S. Jensen, K. Tahlan, 2004, Canadian journal of microbiology.

The Paralogous Pairs of Genes Involved in Clavulanic Acid and Clavam Metabolite Biosynthesis Are Differently Regulated in Streptomyces clavuligerus

S. Jensen, C. Anders, K. Tahlan, 2004, Journal of bacteriology.

Enzymes Catalyzing the Early Steps of Clavulanic Acid Biosynthesis Are Encoded by Two Sets of Paralogous Genes inStreptomyces clavuligerus

S. Jensen, A. Paradkar, K. A. Aidoo, 2000, Antimicrobial Agents and Chemotherapy.

and Streptomyces clavuligerus by Two Sets of Paralogous Genes in Clavulanic Acid Biosynthesis Are Encoded Enzymes Catalyzing the Early Steps of

S. Jensen, A. Paradkar, K. A. Aidoo, 2000 .

Giant linear plasmids of β‐lactam antibiotic producing Streptomyces

S. Jensen, K. Roy, D. Netolitzky, 1995 .

pcd Mutants of Streptomyces clavuligerus Still Produce Cephamycin C

S. Jensen, C. Anders, D. Alexander, 2007, Journal of bacteriology.

Demonstration of a cell-associated, inactive precursor of an exocellular protease produced by Pseudomonas aeruginosa.

S. Jensen, I. T. Fecycz, J. N. Campbell, 1980, Canadian journal of microbiology.

3-Lactamase-Inhibitory Protein from Streptomyces clavuligerus and Cloning and Analysis of the Corresponding Gene

S. Jensen, B. Leskiw, S. Aippersbach, 2022 .

Five Additional Genes Are Involved in Clavulanic Acid Biosynthesis in Streptomyces clavuligerus

S. Jensen, C. Anders, P. H. Beatty, 2004, Antimicrobial Agents and Chemotherapy.

Origins of the β-lactam rings in natural products

S. Jensen, K. Tahlan, 2013, The Journal of Antibiotics.

Structure-based design guides the improved efficacy of deacylation transition state analogue inhibitors of TEM-1 beta-Lactamase(,).

J. B. Jones, M. Paetzel, N. Strynadka, 2000, Biochemistry.

Characterization of Bacteroides asaccharolyticus and B. melaninogenicus oral isolates.

S. Jensen, B. McBride, D. Mayrand, 1980, Canadian journal of microbiology.

Genetic Engineering To Regulate Production of Secondary Metabolites in Streptomyces clavuligerus

S. Jensen, 2010 .

COMPARATIVE GENETICS AND MOLECULAR BIOLOGY OF BETA -LACTAM BIOSYNTHESIS

S. Jensen, R. H. Mosher, A. Paradkar, 1997 .

Structure-based design of a potent transition state analogue for TEM-1 β-lactamase

S. E. Jensen, Marvin Gold, J. B. Jones, 1996, Nature Structural Biology.

Bactericidal action of carbon dioxide laser radiation in experimental dental root canals.

K L Zakariasen, J. Tulip, S. Jensen, 1986, Canadian journal of microbiology.

Isolation and characterization of a beta-lactamase-inhibitory protein from Streptomyces clavuligerus and cloning and analysis of the corresponding gene

S. Jensen, B. Leskiw, B K Leskiw, 1990, Journal of bacteriology.

Effect of dissolved oxygen level on ACV synthetase synthesis and activity during growth of Streptomyces clavuligerus

D. Westlake, S. Jensen, M. Rollins, 1991, Applied Microbiology and Biotechnology.

Regulation of antibiotic production by iron and oxygen during defined medium fermentations of Streptomyces clavuligerus

D. Westlake, S. Jensen, M. Rollins, 1989, Applied Microbiology and Biotechnology.

Analysis of penicillin N ring expansion activity from Streptomyces clavuligerus by ion-pair high-pressure liquid chromatography

D. Westlake, S. Jensen, S. Wolfe, 1983, Antimicrobial Agents and Chemotherapy.

Transcriptional analysis and regulation of carnobacteriocin production in Carnobacterium piscicola LV17.

L. Frost, S. Jensen, M. Stiles, 1997, Gene.

Early Cephamycin Biosynthetic Genes Are Expressed from a Polycistronic Transcript in Streptomyces clavuligerus

S. Jensen, D. Alexander, M. Brumlik, 2000, Journal of bacteriology.

Cyclization of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine to penicillins by cell-free extracts of Streptomyces clavuligerus.

D. Westlake, S. Jensen, S. Wolfe, 1982, The Journal of antibiotics.

Nonribosomal biosynthesis of fusaricidins by Paenibacillus polymyxa PKB1 involves direct activation of a D-amino acid.

S. Jensen, Jingru Li, 2008, Chemistry & biology.

Transcriptional and translational analysis of the ccaR gene from Streptomyces clavuligerus.

S. Jensen, K. Tahlan, D. Alexander, 2004, Microbiology.

A pathway‐specific transcriptional activator regulates late steps of clavulanic acid biosynthesis in Streptomyces clavuligerus

S. Jensen, A. Paradkar, K. A. Aidoo, 1998, Molecular microbiology.

The positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus is mistranslated in a bldA mutant.

S. Jensen, B. Leskiw, D. Alexander, 2002, Microbiology.

Draft Genome Sequence of Streptomyces clavuligerus NRRL 3585, a Producer of Diverse Secondary Metabolites

M. Fischbach, Haeyoung Jeong, Jae Jong Kim, 2010, Journal of bacteriology.

Molecular analysis of a beta-lactam resistance gene encoded within the cephamycin gene cluster of Streptomyces clavuligerus

S. Jensen, A. Wong, A. Paradkar, 1996, Journal of bacteriology.

Transcriptional mapping of the genes encoding the early enzymes of the cephamycin biosynthetic pathway of Streptomyces clavuligerus.

S. Jensen, B. Leskiw, A. Petrich, 1994, Gene.

Transcriptional analysis of the isopenicillin N synthase-encoding gene of Streptomyces clavuligerus.

X. Wu, S. Jensen, K. Roy, 1992, Gene.

5S Clavam Biosynthesis Is Controlled by an Atypical Two-Component Regulatory System in Streptomyces clavuligerus

S. Jensen, K. Tahlan, N. Zelyas, 2012, Antimicrobial Agents and Chemotherapy.

Two Sets of Paralogous Genes Encode the Enzymes Involved in the Early Stages of Clavulanic Acid and Clavam Metabolite Biosynthesis in Streptomyces clavuligerus

H. Park, S. Jensen, K. Tahlan, 2004, Antimicrobial Agents and Chemotherapy.

Genes Specific for the Biosynthesis of Clavam Metabolites Antipodal to Clavulanic Acid Are Clustered with the Gene for Clavaminate Synthase 1 in Streptomyces clavuligerus

S. Jensen, C. Anders, B. Barton, 1999, Antimicrobial Agents and Chemotherapy.

Cephalosporin formation by cell-free extracts from Streptomyces clavuligerus.

D. Westlake, S. Jensen, S. Wolfe, 1982, The Journal of antibiotics.

Two small linear plasmids of Streptomyces jumonjinensis

S. Jensen, K. Roy, D. Netolitzky, 1997 .

Cloning and comparative sequence analysis of the gene coding for isopenicillin N synthase in Streptomyces

D. Shiffman, S. Jensen, G. Cohen, 1988, Molecular and General Genetics MGG.

Resistance to β-Lactamase Inhibitor Protein Does Not Parallel Resistance to Clavulanic Acid in TEM β-Lactamase Mutants

S. Jensen, Troy R Locke, W. Schroeder, 2002, Antimicrobial Agents and Chemotherapy.

Structure-Based Design Guides the Improved Efficacy of Deacylation Transition State Analogue Inhibitors of TEM-1 â-Lactamase

J. B. Jones, M. Paetzel, N. Strynadka, 2022 .

δ-(l-α-aminoadipyl)-l-cysteinyl-d-valine synthetase (ACVS): discovery and perspectives

S. Jensen, M. Moore, K. Tahlan, 2017, Journal of Industrial Microbiology & Biotechnology.

Genetic and biochemical analysis of the cysteinyl residues of isopenicillin N synthase from Streptomyces clavuligerus.

S. Jensen, B. Leskiw, M. Durairaj, 1996, Canadian journal of microbiology.

Biosynthesis of clavam metabolites

S. Jensen, 2012, Journal of Industrial Microbiology & Biotechnology.

Cloning, sequencing and disruption of a gene from Streptomyces clavuligerus involved in clavulanic acid biosynthesis.

S. Jensen, D. Alexander, A. Wong, 1994, Gene.

Biosynthesis of Cephalosporins

S. Jensen, L. Vining, 1985 .

Use of PCR-Targeted Mutagenesis To Disrupt Production of Fusaricidin-Type Antifungal Antibiotics in Paenibacillus polymyxa

Saleh Shah, S. Jensen, P. Beatty, 2007, Applied and Environmental Microbiology.

Purification and characterization of recombinantStreptomyces clavuligerus isopenicillin N synthase produced inEscherichia coli

S. Jensen, M. Durairaj, 1996, Journal of Industrial Microbiology.

Oxygen derepresses deacetoxycephalosporin C synthase and increases the conversion of penicillin N to cephamycin C in Streptomyces clavuligerus.

D. Westlake, S. Jensen, D W Westlake, 1990, Enzyme and microbial technology.

Giant linear plasmids of beta-lactam antibiotic producing Streptomyces.

X. Wu, S. Jensen, K. Roy, 1995, FEMS microbiology letters.

cluster of Streptomyces clavuligerus . gene encoded within the cephamycin gene Molecular analysis of a beta-lactam resistance

S. Jensen, A. Wong, A. Paradkar, 1996 .

Use of the native flp gene to generate in-frame unmarked mutations in Streptomyces spp.

S. Jensen, K. Tahlan, N. Zelyas, 2009, Gene.

Discovery of an insertion sequence, IS116, from Streptomyces clavuligerus and its relatedness to other transposable elements from actinomycetes.

K. Chater, S. Jensen, D. Hopwood, 1990, Journal of general microbiology.

Production kinetics and stability properties of ϖ(l-α-aminoadipyl)-l-cysteinyl-d-valine synthetase fromStreptomyces clavuligerus

M. Pickard, S. Jensen, T. A. Kadima, 2005, Journal of Industrial Microbiology.

Purification and partial characterization of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Streptomyces clavuligerus

D. Westlake, S. Jensen, M. Rollins, 1990, Journal of bacteriology.

Crystal structures of an oligopeptide-binding protein from the biosynthetic pathway of the beta-lactamase inhibitor clavulanic acid.

I. Andersson, A. Mackenzie, C. Schofield, 2010, Journal of molecular biology.

Purification and initial characterization of deacetoxycephalosporin C synthase from Streptomyces clavuligerus.

D. Westlake, S. Jensen, M. Rollins, 1988, Canadian journal of microbiology.

Dissolved oxygen control of a maltose feed to batch fermentations ofStreptomyces clavuligerus: Effect on cephamycin C biosynthesis

D. Westlake, S. Jensen, M. Rollins, 1988, Biotechnology Letters.

Crystal structure and kinetic analysis of β-lactamase inhibitor protein-II in complex with TEM-1 β-lactamase

Susan Jensen, Sung Gyun Kang, Hyeon Ung Park, 2001, Nature Structural Biology.

Prediction and functional analysis of the replication origin of the linear plasmid pSCL2 in Streptomyces clavuligerus.

Shannon K D Leblanc, S. Jensen, Wei Wu, 2006, Canadian journal of microbiology.

High performance liquid chromatographic assay of cyclization activity in cell-free systems from Streptomyces clavuligerus.

D. Westlake, S. Jensen, S. Wolfe, 1982, The Journal of antibiotics.

High-level expression of the Streptomyces clavuligerus isopenicillin N synthase gene in Escherichia coli

S. Jensen, M. Durairaj, J. L. Doran, 1992, Applied and Environmental Microbiology.

Cephamycin production and isopenicillin N synthetase activity in cultures of Streptomyces clavuligerus

D. Westlake, S. Jensen, L. Vining, 1987, Applied Microbiology and Biotechnology.

Cloning and nucleotide sequence determination of the isopenicillin N synthetase gene from Streptomyces clavuligerus.

D. Westlake, S. Jensen, L. Vining, 1988, Gene.

Prevention of phosphate inhibition of cephalosporin synthetases by ferrous ion

A. Demain, S. Jensen, C. Lübbe, 1984 .

Partial purification and characterization of isopenicillin N epimerase activity from Streptomyces clavuligerus.

D. Westlake, S. Jensen, S. Wolfe, 1983, Canadian journal of microbiology.

A longitudinal study of serum TSH, and total and free iodothyronines during normal pregnancy.

P. Laurberg, S. Jensen, J. Weeke, 1982, Acta endocrinologica.

Minimum Information about a Biosynthetic Gene cluster.

M. Smanski, Jan Claesen, B. Shen, 2015, Nature chemical biology.