I. Foltz

发表

A Novel Antibody Engineering Strategy for Making Monovalent Bispecific Heterodimeric IgG Antibodies by Electrostatic Steering Mechanism*

Rutilio H. Clark, Haruki Hasegawa, K. Gunasekaran, 2015, The Journal of Biological Chemistry.

MEDI0639: A Novel Therapeutic Antibody Targeting Dll4 Modulates Endothelial Cell Function and Angiogenesis In Vivo

S. Barry, J. Kendrew, V. Bedian, 2012, Molecular Cancer Therapeutics.

Hemopoietic Growth Factors with the Exception of Interleukin-4 Activate the p38 Mitogen-activated Protein Kinase Pathway*

John C. Lee, P. Young, J. Schrader, 1997, The Journal of Biological Chemistry.

A fully human anti-hepcidin antibody modulates iron metabolism in both mice and nonhuman primates.

C. Begley, S. Steavenson, I. Foltz, 2013, Blood.

Ceramide and cyclic adenosine monophosphate (cAMP) induce cAMP response element binding protein phosphorylation via distinct signaling pathways while having opposite effects on myeloid cell survival.

P. Young, M. Scheid, V. Duronio, 1999, Blood.

Treating Diabetes and Obesity with an FGF21-Mimetic Antibody Activating the βKlotho/FGFR1c Receptor Complex

T. Arora, Zhulun Wang, L. Sekirov, 2012, Science Translational Medicine.

The serum protein transthyretin as a platform for dimerization and tetramerization of antibodies and Fab fragments to enable target clustering

Zhulun Wang, I. Foltz, K. Walker, 2020, The Journal of Biological Chemistry.

AMG 655, a fully human agonistic antibody against TRAIL receptor-2, induces apoptosis via caspase activation in vitro and in vivo

A. Coxon, D. Branstetter, I. Foltz, 2007 .

Activation of the stress-activated protein kinases by multiple hematopoietic growth factors with the exception of interleukin-4.

J. Schrader, I. Foltz, John W. Schrader, 1997, Blood.

Molecular mechanism of hepcidin-mediated ferroportin internalization requires ferroportin lysines, not tyrosines or JAK-STAT.

T. Ganz, T. Arvedson, E. Nemeth, 2012, Cell metabolism.

Identification and Characterization of MEDI4736, an Antagonistic Anti–PD-L1 Monoclonal Antibody

V. Bedian, R. Wilkinson, I. Foltz, 2015, Cancer Immunology Research.

Kinetic analysis of unpurified native antigens available in very low quantities and concentrations.

K. Manchulenko, I. Foltz, P. Rathanaswami, 2011, Analytical biochemistry.

Pharmacology of AMG 181, a human anti‐α4β7 antibody that specifically alters trafficking of gut‐homing T cells

L. Wienkers, H. Hsu, K. Manchulenko, 2013, British journal of pharmacology.

Impact of antibody subclass and disulfide isoform differences on the biological activity of CD200R and βklotho agonist antibodies.

T. Dillon, L. Sekirov, K. Manchulenko, 2017, Biochemical and biophysical research communications.

The p38 mitogen-activated protein kinase is activated by ligation of the T or B lymphocyte antigen receptors, Fas or CD40, but suppression of kinase activity does not inhibit apoptosis induced by antigen receptors.

P. Young, J. Schrader, I. Foltz, 1997, Journal of immunology.

AMG 595, an Anti-EGFRvIII Antibody–Drug Conjugate, Induces Potent Antitumor Activity against EGFRvIII-Expressing Glioblastoma

T. Arora, C. Kozlosky, Hua Liu, 2015, Molecular Cancer Therapeutics.

Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer’s disease

M. van Lookeren Campagne, M. Colonna, Daniel C. Ellwanger, 2021, Proceedings of the National Academy of Sciences.

Human Mitogen-activated Protein Kinase Kinase 7 (MKK7) Is a Highly Conserved c-Jun N-terminal Kinase/Stress-activated Protein Kinase (JNK/SAPK) Activated by Environmental Stresses and Physiological Stimuli*

J. Schrader, J. Wieler, I. Foltz, 1998, The Journal of Biological Chemistry.

Conatumumab, a fully human agonist antibody to death receptor 5, induces apoptosis via caspase activation in multiple tumor types

A. Coxon, D. Branstetter, I. Foltz, 2010, Cancer biology & therapy.

Regulation of the stress-activated protein kinase pathways in hematopoietic cells

I. Foltz, 1999 .

Development of a potent high-affinity human therapeutic antibody via novel application of recombination signal sequence–based affinity maturation

I. D'Angelo, Xiaoshan Min, I. Foltz, 2021, The Journal of biological chemistry.

Evolution and emergence of therapeutic monoclonal antibodies: what cardiologists need to know.

M. Karow, I. Foltz, S. Wasserman, 2013, Circulation.

TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant Trem2R47H on murine myeloid cell function

Qingwen Cheng, D. Chui, I. Foltz, 2018, The Journal of Biological Chemistry.

Functional and Nonclinical Similarity of ABP 980, a Biosimilar of Trastuzumab

J. Ferbas, P. Kanakaraj, I. Foltz, 2019, Pharmaceutical Research.

Asymmetrical Fc Engineering Greatly Enhances Antibody-dependent Cellular Cytotoxicity (ADCC) Effector Function and Stability of the Modified Antibodies*

K. Gunasekaran, C. Kozlosky, L. Sekirov, 2013, The Journal of Biological Chemistry.

Apo2L/TRAIL and the death receptor 5 agonist antibody AMG 655 cooperate to promote receptor clustering and antitumor activity.

T. Bush, Tzu-Hsuan Huang, D. Branstetter, 2014, Cancer cell.

Molecular basis for the loss-of-function effects of the Alzheimer's disease–associated R47H variant of the immune receptor TREM2

A. Lim, Zhongqi Zhang, Zhulun Wang, 2018, The Journal of Biological Chemistry.

An Antibody Targeted to VEGFR-2 Ig Domains 4-7 Inhibits VEGFR-2 Activation and VEGFR-2–Dependent Angiogenesis without Affecting Ligand Binding

S. Barry, S. Wedge, J. Kendrew, 2011, Molecular Cancer Therapeutics.

A human monoclonal antibody 264RAD targeting αvβ6 integrin reduces tumour growth and metastasis, and modulates key biomarkers in vivo

S. Barry, J. Kendrew, V. Bedian, 2013, Oncogene.

Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models

D. Bates, C. Murawsky, Zhulun Wang, 2018, Science Translational Medicine.

Enhancing Antibody Fc Heterodimer Formation through Electrostatic Steering Effects

M. Wittekind, K. Gunasekaran, M. Retter, 2010, The Journal of Biological Chemistry.