S. Thompson

发表

Rational design, synthesis, and crystallographic analysis of a hydroxyethylene-based HIV-1 protease inhibitor containing a heterocyclic P1'--P2' amide bond isostere.

R. DesJarlais, K. Murthy, E. Winborne, 1994, Journal of medicinal chemistry.

The discovery of tertiary-amine LXR agonists with potent cholesterol efflux activity in macrophages.

M. Jaye, S. Thompson, Dennis Lee, 2009, Bioorganic & medicinal chemistry letters.

Synthetic LXR agonists increase LDL in CETP species Published, JLR Papers in Press, July 16, 2005. DOI 10.1194/jlr.M500116-JLR200

M. Jaye, C. Doe, R. Willette, 2005, Journal of Lipid Research.

Topical Application of ASN008, a Permanently Charged Sodium Channel Blocker, Shows Robust Efficacy, a Rapid Onset, and Long Duration of Action in a Mouse Model of Pruritus

T. Yaksh, S. Thompson, R. Ramachandran, 2020, The Journal of Pharmacology and Experimental Therapeutics.

Rational design of orally-active, pyrrolidine-based progesterone receptor partial agonists.

C. Duraiswami, N. Laping, Shawn P. Williams, 2009, Bioorganic & medicinal chemistry letters.

Structure and Design of Potent and Selective Cathepsin K Inhibitors

S. Carr, R. DesJarlais, Baoguang Zhao, 1997 .

Design and synthesis of orally bioavailable serum and glucocorticoid-regulated kinase 1 (SGK1) inhibitors.

Baoguang Zhao, M. Head, N. Laping, 2009, Bioorganic & medicinal chemistry letters.

Proteolytic Activity of Human Osteoclast Cathepsin K

D. Mcnulty, B. Amegadzie, T. Tomaszek, 1996, The Journal of Biological Chemistry.

Design and synthesis of diaminopyrrolidinone inhibitors of human osteoclast cathepsin K.

R. DesJarlais, D. Veber, K. Duffy, 1999, Bioorganic & medicinal chemistry letters.

Structure-based design of non-peptide, carbohydrazide-based cathepsin K inhibitors.

R. DesJarlais, D. Veber, D. Tew, 1999, Bioorganic & medicinal chemistry.

Procede d'inhibition de la cathepsine k

Baoguang Zhao, Y. Ru, D. Veber, 1996 .

Steady-state kinetic characterization of substrates and metal-ion specificities of the full-length and N-terminally truncated recombinant human methionine aminopeptidases (type 2).

M. Doyle, D. Tew, D. Casper, 2001, Biochemistry.

Identification of a loop outside the active site cavity of the human immunodeficiency virus proteases which confers inhibitor specificity.

C. Debouck, T. Tomaszek, S. Thompson, 1997, Biochemistry.

Total synthesis of some marasmane and lactarane sesquiterpenes

S. Thompson, C. Heathcock, 1992 .

2-Amino-9-aryl-3-cyano-4-methyl-7-oxo-6,7,8,9-tetrahydropyrido[2',3':4,5]thieno[2,3-b]pyridine derivatives as selective progesterone receptor agonists.

C. Duraiswami, Yonghui Wang, T. Graybill, 2009, Bioorganic & medicinal chemistry letters.

4-Aryl-1,2,3-triazole: a novel template for a reversible methionine aminopeptidase 2 inhibitor, optimized to inhibit angiogenesis in vivo.

Guang Yang, Keith W Ward, D. Veber, 2005, Journal of medicinal chemistry.

Synthesis and antiviral activity of a novel class of HIV-1 protease inhibitors containing a heterocyclic P1′-P2′ amide bond isostere

R. Lum, M. Darcy, D. Lambert, 1994 .

Discovery of non-steroidal mifepristone mimetics: pyrazoline-based PR antagonists.

Shawn P. Williams, S. Thompson, E. Stewart, 2005, Bioorganic & medicinal chemistry letters.

Effect of cation, temperature, and solvent on the stereoselectivity of the Horner-Emmons reaction of trimethyl phosphonoacetate with aldehydes

S. Thompson, C. Heathcock, 1990 .

Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic.

N. Laping, D. Kazmin, S. Thompson, 2008, Cancer research.

Design and evaluation of small peptides mapping the exposed surface of IL-8.

C. E. Peishoff, D. Veber, J. White, 2009, International journal of peptide and protein research.

Peptide Aldehyde Inhibitors of Cathepsin K Inhibit Bone Resorption Both In Vitro and In Vivo

D. Veber, A. Badger, I. James, 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore.

Keizo Yamashita, Guang Yang, D. Veber, 2007, Journal of medicinal chemistry.

A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator.

Shawn P Williams, N. Laping, Shawn P. Williams, 2007, Molecular endocrinology.

Design of potent and selective human cathepsin K inhibitors that span the active site.

J G Gleason, S. Carr, R. DesJarlais, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis and SAR of potent LXR agonists containing an indole pharmacophore.

Angela Smallwood, Michael Jaye, Chaya Duraiswami, 2009, Bioorganic & medicinal chemistry letters.

Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure.

Angela Smallwood, Ping Wang, David Haigh, 2005, Journal of medicinal chemistry.

Use of papain as a model for the structure-based design of cathepsin K inhibitors: crystal structures of two papain-inhibitor complexes demonstrate binding to S'-subsites.

R. DesJarlais, D. Veber, S. Abdel-Meguid, 1999, Journal of medicinal chemistry.

Structure-based design of cathepsin K inhibitors containing a benzyloxy-substituted benzoyl peptidomimetic.

R. DesJarlais, D. Veber, S. Abdel-Meguid, 1998, Journal of medicinal chemistry.

Improving the developability profile of pyrrolidine progesterone receptor partial agonists.

C. Duraiswami, N. Laping, Shawn P. Williams, 2010, Bioorganic & medicinal chemistry letters.

Azepanone-based inhibitors of human cathepsin L.

Y. Ru, M. Head, D. Veber, 2005, Journal of medicinal chemistry.