J. Guichou

发表

In-plate protein crystallization, in situ ligand soaking and X-ray diffraction.

G. Labesse, S. Pochet, J. Ferrer, 2011, Acta crystallographica. Section D, Biological crystallography.

Combining 'dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography.

G. Labesse, J. Ferrer, F. Hoh, 2015, Acta crystallographica. Section D, Biological crystallography.

TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM

Y. Kohara, J. Reboul, J. Guichou, 2004, Nature Immunology.

Toward the Design of Ligands Selective for the C-Terminal Domain of TEADs.

F. Allemand, M. Gelin, J. Guichou, 2022, Journal of medicinal chemistry.

Discovery of a cryptic site at the interface 2 of TEAD - Towards a new family of YAP/TAZ-TEAD inhibitors.

X. Thuru, F. Bailly, F. Allemand, 2021, European journal of medicinal chemistry.

Toward the Discovery of a Novel Class of YAP–TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP–TEAD Protein–Protein Interface

G. Huet, X. Thuru, P. Chavatte, 2018, Cancers.

Crosslinking photosensitized by a ruthenium chelate as a tool for labeling and topographical studies of G-protein-coupled receptors.

B. Mouillac, E. Richard, J. Guichou, 2005, Chemistry & biology.

Discovery of a Highly Active Ligand of Human Pregnane X Receptor: A Case Study from Pharmacophore Modeling and Virtual Screening to “In Vivo” Biological Activity

Virginie Nahoum, William Bourguet, Jean-François Guichou, 2007, Molecular Pharmacology.

A Histone Deacetylase (HDAC) Inhibitor with Pleiotropic In Vitro Anti-Toxoplasma and Anti-Plasmodium Activities Controls Acute and Chronic Toxoplasma Infection in Mice

G. Labesse, D. Jublot, C. Loeuillet, 2022, International journal of molecular sciences.

A Tiny Change Makes a Big Difference in the Anti-Parasitic Activities of an HDAC Inhibitor

G. Labesse, C. Loeuillet, D. Sereno, 2019, International journal of molecular sciences.

Pseudo-prolines (ΨPro): direct insertion of ΨPro systems into cysteine containing peptides

M. Mutter, J. Guichou, L. Patiny, 2002 .

Inhibition of RNA binding to hepatitis C virus RNA-dependent RNA polymerase: a new mechanism for antiviral intervention

J. Pawlotsky, J. Guichou, E. Hernández, 2014, Nucleic acids research.

Characterization of the Anti-Hepatitis C Virus Activity of New Nonpeptidic Small-Molecule Cyclophilin Inhibitors with the Potential for Broad Anti-Flaviviridae Activity

J. Pawlotsky, N. Jouvenet, P. Bruscella, 2018, Antimicrobial Agents and Chemotherapy.

Synthetic routes to NEtXaa4-cyclosporin A derivatives as potential anti-HIV I drugs

M. Mutter, T. Ruckle, J. Guichou, 2000 .

A Phenyl-Pyrrolidine Derivative Reveals a Dual Inhibition Mechanism of Myocardial Mitochondrial Permeability Transition Pore, Which Is Limited by Its Myocardial Distribution

J. Pawlotsky, J. Guichou, D. Morin, 2020, The Journal of Pharmacology and Experimental Therapeutics.

Structure-activity relationships of Bak derived peptides: affinity and specificity modulations by amino acid replacement.

G. Grassy, J. Guichou, A. Chavanieu, 2008, European journal of medicinal chemistry.

Structural basis for chemically-induced homodimerization of a single domain antibody

A. Barducci, G. Labesse, J. Bonnet, 2019, Scientific Reports.

Design, Synthesis and Evaluation of a Series of 1,5‐Diaryl‐1,2,3‐triazole‐4‐carbohydrazones as Inhibitors of the YAP‐TAZ/TEAD Complex

B. Rubin, F. Bailly, A. Pobbati, 2021, ChemMedChem.

The ellagitannin metabolite urolithin C is a glucose‐dependent regulator of insulin secretion through activation of L‐type calcium channels

A. Crozier, D. Del Rio, J. Guichou, 2019, British journal of pharmacology.

New imidazoquinoxaline derivatives: Synthesis, biological evaluation on melanoma, effect on tubulin polymerization and structure-activity relationships.

N. Bec, C. Larroque, P. Cuq, 2016, Bioorganic & medicinal chemistry.

Nuclear receptor ligand-binding domains: reduction of helix H12 dynamics to favour crystallization.

Efrén Pérez, W. Bourguet, A. D. de Lera, 2008, Acta crystallographica. Section F, Structural biology and crystallization communications.

A Tripartite Complex HIV-1 Tat-Cyclophilin A-Capsid Protein Enables Tat Encapsidation That Is Required for HIV-1 Infectivity

P. Milhiet, M. Blaise, J. Guichou, 2022, bioRxiv.

Novel and selective TLR7 antagonists among the imidazo[1,2-a]pyrazines, imidazo[1,5-a]quinoxalines and pyrazolo[1,5-a]quinoxalines series.

P. Cuq, J. Guichou, I. Kassab, 2019, Journal of medicinal chemistry.

Aminoglycoside binding and catalysis specificity of aminoglycoside 2″-phosphotransferase IVa: A thermodynamic, structural and kinetic study

E. Serpersu, C. Lionne, L. Chaloin, 2016, Biochimica et biophysica acta.

New IKK inhibitors: Synthesis of new imidazo[1,2-a]quinoxaline derivatives using microwave assistance and biological evaluation as IKK inhibitors.

P. Cuq, J. Guichou, P. Bonnet, 2016, European journal of medicinal chemistry.

Purification and crystallization of the heterodimeric complex of RARβ and RXRα ligand-binding domains in the active conformation

W. Bourguet, V. Pogenberg, J. Guichou, 2004 .

Imidazo[1,2-a]quinoxalines for melanoma treatment with original mechanism of action.

Romain M. Larive, P. Cuq, J. Guichou, 2020, European journal of medicinal chemistry.

Polymerization-induced enhancement of binding and binding-induced polymerization

J. Guichou, A. Chavanieu, F. Sánchez, 2004 .

Proceedings of the Frontiers of Retrovirology Conference 2016

R. König, D. Elleder, R. Sachidanandam, 2016, Retrovirology.

Small-molecule inhibitors of cyclophilins block opening of the mitochondrial permeability transition pore and protect mice from hepatic ischemia-reperfusion injury.

J. Pawlotsky, J. Calderaro, F. Allemand, 2019, Gastroenterology.

Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities

J. Pawlotsky, D. Douguet, W. Bourguet, 2016, Nature Communications.

Vpr expression abolishes the capacity of HIV-1 infected cells to repair uracilated DNA

J. Guichou, L. Briant, P. Eldin, 2013, Nucleic acids research.

Homodimerization of RBPMS2 through a new RRM-interaction motif is necessary to control smooth muscle plasticity

G. Labesse, F. Allemand, J. Guichou, 2014, Nucleic acids research.

Circulating Tumor DNA Genomics Reveal Potential Mechanisms of Resistance to BRAF-Targeted Therapies in Patients with BRAF-Mutant Metastatic Non–Small Cell Lung Cancer

J. Blay, D. Planchard, J. Mazières, 2020, Clinical Cancer Research.

Characterization of the Interaction between Retinoic Acid Receptor/Retinoid X Receptor (RAR/RXR) Heterodimers and Transcriptional Coactivators through Structural and Fluorescence Anisotropy Studies*

H. Gronemeyer, C. Royer, Efrén Pérez, 2005, Journal of Biological Chemistry.

Nuclear Envelope Protein SUN2 Promotes Cyclophilin-A-Dependent Steps of HIV Replication

J. Pawlotsky, N. Manel, M. Gentili, 2016, Cell reports.

Crystal structure of the coiled-coil dimerization motif of geminin: structural and functional insights on DNA replication regulation.

C. Dumas, A. Padilla, M. Méchali, 2004, Journal of molecular biology.

Structural basis for the interaction between focal adhesion kinase and CD4.

Jean-François Guichou, Jonathan McNally, S. Arold, 2008, Journal of molecular biology.

The Leishmania nicotinamidase is essential for NAD+ production and parasite proliferation

G. Labesse, D. Sereno, E. Gazanion, 2011, Molecular microbiology.

Synthesis and characterization of constrained cyclosporin A derivatives containing a pseudo-proline group

M. Mutter, M. Keller, J. Guichou, 2003 .

AB668, a novel highly selective protein kinase CK2 inhibitor with a distinct anti-tumor mechanism as compared to CX-4945 and SGC-CK2-1

J. Delcros, J. Guichou, I. Krimm, 2022, bioRxiv.

Synthesis of aminophenylhydroxamate and aminobenzylhydroxamate derivatives and in vitro screening for antiparasitic and histone deacetylase inhibitory activity

G. Labesse, C. Loeuillet, B. Oury, 2018, International journal for parasitology. Drugs and drug resistance.

Structural determinants of the catalytic mechanism of Plasmodium CCT, a key enzyme of malaria lipid biosynthesis

H. Vial, F. Hoh, B. Vértessy, 2018, Scientific Reports.

Structural basis for chemically-induced homodimerization of a single domain antibody

A. Barducci, G. Labesse, J. Bonnet, 2019, Scientific Reports.

Protein–ligand structure guided by backbone and side-chain proton chemical shift perturbations

J. Guichou, I. Krimm, O. Cala, 2014, Journal of Biomolecular NMR.

Protein–ligand structure guided by backbone and side-chain proton chemical shift perturbations

J. Guichou, I. Krimm, O. Cala, 2014, Journal of Biomolecular NMR.

e-Drug3D: 3D structure collections dedicated to drug repurposing and fragment-based drug design

Lionel Colliandre, Dominique Douguet, Emilie Pihan, 2012, Bioinform..

Fragment linking strategies for structure-based drug design.

J. Guichou, I. Krimm, M. Le Borgne, 2020, Journal of medicinal chemistry.

N-1H-benzimidazol-5-ylbenzenesulfonamide derivatives as potent hPXR agonists.

J. Pascussi, A. Mallavialle, W. Bourguet, 2008, Bioorganic & medicinal chemistry.

MA21.07 Circulating Tumor DNA Analysis Depicts Potential Mechanisms of Resistance to BRAF-Targeted Therapies in BRAF+ Non-Small Cell Lung Cancer

D. Planchard, J. Mazières, P. Saintigny, 2019, Journal of Thoracic Oncology.

Characterization of Aspartic Acid and β-Aspartic Acid in Peptides by Fast-atom Bombardment Mass Spectrometry and Tandem Mass Spectrometry

C. Enjalbal, Jean Martínez, J. Guichou, 1996 .

Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.

Jean-François Guichou, Alain Chavanieu, Julien Viaud, 2006, Journal of medicinal chemistry.

Two crystal structures of the FK506-binding domain of Plasmodium falciparum FKBP35 in complex with rapamycin at high resolution.

A. Bell, A. Chubb, F. Allemand, 2015, Acta crystallographica. Section D, Biological crystallography.

Cyclophilin A Isomerisation of Septin 2 Mediates Abscission during Cytokinesis

D. Matallanas, J. Guichou, M. M. Mc Gee, 2023, International journal of molecular sciences.

Proceedings of the Frontiers of Retrovirology Conference 2016

Sebastian A. Wagner, R. König, D. Elleder, 2016, Retrovirology.

Linkers in fragment-based drug design: an overview of the literature

J. Preto, J. Guichou, I. Krimm, 2023, Expert opinion on drug discovery.

Small-Molecule Cyclophilin Inhibitors Potently Reduce Platelet Procoagulant Activity

C. Maas, J. Pawlotsky, J. Guichou, 2023, International journal of molecular sciences.

1184 FRAGMENT BASED DRUG DISCOVERY OF NEW CYCLOPHILIN INHIBITORS UNRELATED TO CYCLOSPORINE A THAT POTENTLY INHIBIT HCV REPLICATION

J. Pawlotsky, D. Douguet, P. Barthe, 2013 .

New imidazoquinoxaline derivatives: Synthesis, biological evaluation on melanoma, effect on tubulin polymerization and structure-activity relationships.

N. Bec, C. Larroque, P. Cuq, 2016, Bioorganic & medicinal chemistry.

N-1H-benzimidazol-5-ylbenzenesulfonamide derivatives as potent hPXR agonists.

J. Pascussi, W. Bourguet, J. Guichou, 2008, Bioorganic & medicinal chemistry.

Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings.

Simon S. Woo, M. Vedadi, B. Annabi, 2023, Bioorganic & medicinal chemistry letters.

Comparing Binding Modes of Analogous Fragments Using NMR in Fragment-Based Drug Design: Application to PRDX5

J. Guichou, I. Krimm, O. Cala, 2014, PloS one.