A. Soares

发表

Using sound pulses to solve the crystal-harvesting bottleneck

Sean McSweeney, Alexei S Soares, Kazimierz Gofron, 2017, Acta crystallographica. Section D, Structural biology.

High throughput screening using acoustic droplet ejection to combine protein crystals and chemical libraries on crystallization plates at high density.

Robert M Sweet, Alexei S Soares, R. Sweet, 2014, Journal of structural biology.

Acoustic methods for high-throughput protein crystal mounting at next-generation macromolecular crystallographic beamlines.

Alexei S Soares, Anthony Kuczewski, Marc Allaire, 2013, Journal of synchrotron radiation.

Maintaining Microclimates during Nanoliter Chemical Dispensations Using Custom-Designed Source Plate Lids

R. Sweet, S. McSweeney, M. Bollard, 2016, Journal of laboratory automation.

Acoustically mounted microcrystals yield high-resolution X-ray structures.

M. Allaire, A. Héroux, A. Orville, 2011, Biochemistry.

Hitting the target: fragment screening with acoustic in situ co-crystallization of proteins plus fragment libraries on pin-mounted data-collection micromeshes

R. Sweet, M. Allaire, A. Orville, 2014, Acta crystallographica. Section D, Biological crystallography.

A Linear Relationship between Crystal Size and Fragment Binding Time Observed Crystallographically: Implications for Fragment Library Screening Using Acoustic Droplet Ejection

R. Sweet, M. Allaire, A. Orville, 2014, PloS one.

Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking

A. Ashworth, J. Irwin, B. Shoichet, 2020, Science Advances.

High-speed raster-scanning synchrotron serial microcrystallography with a high-precision piezo-scanner

H. Bernstein, S. McSweeney, Qun Liu, 2018, Journal of synchrotron radiation.

Getting the Most Out of Your Crystals: Data Collection at the New High-Flux, Microfocus MX Beamlines at NSLS-II

Michelle S. Miller, L. Amzel, S. Gabelli, 2019, Molecules.

An Acrobatic Substrate Metamorphosis Reveals a Requirement for Substrate Conformational Dynamics in Trypsin Proteolysis*

N. Papo, E. Radisky, A. Soares, 2016, The Journal of Biological Chemistry.

Acoustic Methods to Monitor Protein Crystallization and to Detect Protein Crystals in Suspensions of Agarose and Lipidic Cubic Phase

R. Sweet, Yasmin N Samara, A. Soares, 2016, Journal of laboratory automation.

Nd isotope composition of the terrigenous component of sediments as a tracer for the Heinrich events: a study in the NW Iberian continental margin

A. Mackensen, J. Dias, F. Rocha, 2011 .

A Simple Technique to Improve Microcrystals Using Gel Exclusion of Nucleation Inducing Elements

S. McSweeney, Haley M. Brennan, A. Soares, 2018, Crystals.

Expression, purification and preliminary diffraction studies of PhnP.

Shu-mei He, Z. Jia, D. Zechel, 2008, Acta crystallographica. Section F, Structural biology and crystallization communications.

Mail-in crystallography program at Brookhaven National Laboratory's National Synchrotron Light Source.

Michael Becker, Alexei S Soares, Robert Sweet, 2006, Acta crystallographica. Section D, Biological crystallography.

Remote Access to the PXRR Macromolecular Crystallography Facilities at the NSLS

R. Sweet, A. Soares, J. Skinner, 2008 .

Acoustic Injectors for Drop-On-Demand Serial Femtosecond Crystallography.

A. Kuczewski, Diling Zhu, A. Cohen, 2016, Structure.

Small molecule inhibitors of mesotrypsin from a structure-based docking screen

A. Bode, Z. Dong, Zunnan Huang, 2017, PloS one.

Crystal structures of the nitrite and nitric oxide complexes of horse heart myoglobin.

Alexei S Soares, A. West, A. Soares, 2006, Journal of inorganic biochemistry.

Synthesis, structure and imaging of oligodeoxyribonucleotides with tellurium-nucleobase derivatization

Wen Zhang, Bingqian Xu, A. Soares, 2011, Nucleic acids research.

Mesotrypsin Has Evolved Four Unique Residues to Cleave Trypsin Inhibitors as Substrates*

E. Radisky, A. Soares, O. Kayode, 2015, The Journal of Biological Chemistry.

Sequence and Conformational Specificity in Substrate Recognition

M. Kazanov, E. Radisky, A. Soares, 2014, The Journal of Biological Chemistry.

The P(2)' residue is a key determinant of mesotrypsin specificity: engineering a high-affinity inhibitor with anticancer activity.

D. Radisky, Moh’d A. Salameh, E. Radisky, 2011, The Biochemical journal.

Determinants of Affinity and Proteolytic Stability in Interactions of Kunitz Family Protease Inhibitors with Mesotrypsin*

D. Sinha, P. Walsh, Moh’d A. Salameh, 2010, The Journal of Biological Chemistry.

Structural Basis for Accelerated Cleavage of Bovine Pancreatic Trypsin Inhibitor (BPTI) by Human Mesotrypsin*

Moh’d A. Salameh, E. Radisky, A. Soares, 2008, Journal of Biological Chemistry.

Long-range Electrostatic Complementarity Governs Substrate Recognition by Human Chymotrypsin C, a Key Regulator of Digestive Enzyme Activation*

J. Batra, E. Radisky, A. Szabó, 2013, The Journal of Biological Chemistry.

Structural insights of non-canonical U•U pair and Hoogsteen interaction probed with Se atom

J. Gan, A. Soares, J. Saloň, 2013, Nucleic acids research.

Hydrogen bond formation between the naturally modified nucleobase and phosphate backbone

J. Gan, Wen Zhang, A. Soares, 2012, Nucleic acids research.

Quantitative assessment of peptide sequence diversity in M13 combinatorial peptide phage display libraries.

Lee Makowski, Alexei S Soares, L. Makowski, 2002, Journal of molecular biology.

Crystal structure of a complex between the phosphorelay protein YPD1 and the response regulator domain of SLN1 bound to a phosphoryl analog.

A. West, A. Soares, Xiao-Fei Zhao, 2008, Journal of molecular biology.

Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking

A. Ashworth, J. Irwin, B. Shoichet, 2021, Science Advances.

Structural basis for NADH/NAD+ redox sensing by a Rex family repressor.

A. Soares, M. Paget, C. Strain-Damerell, 2010, Molecular cell.

Matrix Metalloproteinase-10 (MMP-10) Interaction with Tissue Inhibitors of Metalloproteinases TIMP-1 and TIMP-2

D. Radisky, A. Fields, J. Batra, 2012, The Journal of Biological Chemistry.

Estimating the diversity of peptide populations from limited sequence data

Lee Makowski, Alexei Soares, L. Makowski, 2003, Bioinform..

Fragment-based identification of determinants of conformational and spectroscopic change at the ricin active site

J. Carra, A. Soares, C. A. McHugh, 2007, BMC Structural Biology.

Structure of the catalytic chain of Methanococcus jannaschii aspartate transcarbamoylase in a hexagonal crystal form: insights into the path of carbamoyl phosphate to the active site of the enzyme.

J. Vitali, A. Singh, M. Colaneri, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

The structures of penicillin-binding protein 4 (PBP4) and PBP5 from Enterococci provide structural insights into β-lactam resistance

Mónica A. García-Solache, L. Rice, W. Peti, 2018, The Journal of Biological Chemistry.

Macromolecular crystallography beamline X25 at the NSLS

Robert M. Sweet, John M. Skinner, Lonny E. Berman, 2014, Journal of synchrotron radiation.

Structural analysis and biochemical properties of laccase enzymes from two Pediococcus species

P. Casino, R. Collins, A. Soares, 2021, Microbial biotechnology.

Acoustic transfer of protein crystals from agarose pedestals to micromeshes for high-throughput screening

R. Sweet, M. Allaire, A. Orville, 2015, Acta crystallographica. Section D, Biological crystallography.

A simple technique to reduce evaporation of crystallization droplets by using plate lids with apertures for adding liquids

B. M. Santiago, R. Sweet, A. Soares, 2014, Acta crystallographica. Section F, Structural biology communications.

Solvent minimization induces preferential orientation and crystal clustering in serial micro-crystallography on micro-meshes, in situ plates and on a movable crystal conveyor belt

R. Sweet, M. Allaire, A. Orville, 2014, Journal of synchrotron radiation.

The structure of NAD+ consuming protein Acinetobacter baumannii TIR domain shows unique kinetics and conformations

E. Eisenmesser, J. Milbrandt, J. Redzic, 2023, bioRxiv.

Matrix Metalloproteinase-10/TIMP-2 Structure and Analyses Define Conserved Core Interactions and Diverse Exosite Interactions in MMP/TIMP Complexes

J. Batra, E. Radisky, A. Soares, 2013, PloS one.

Three-beam interference is a sensitive measure of the efficacy of macromolecular refinement techniques.

E. Weckert, R. Sweet, A. Soares, 2003, Acta crystallographica. Section D, Biological crystallography.

Crystallographic characterization of the nitric oxide derivative of R-state human hemoglobin.

A. Soares, G. B. Richter‐Addo, J. Yi, 2014, Nitric oxide : biology and chemistry.

Structure of the dihydrolipoamide succinyltransferase catalytic domain from Escherichia coli in a novel crystal form: a tale of a common protein crystallization contaminant

S. McSweeney, Qun Liu, A. Soares, 2019, Acta crystallographica. Section F, Structural biology communications.

Crystal Structure of SARS-CoV-2 Main Protease (3CLpro/Mpro) in Complex with Covalent Inhibitor Narlaprevir

S. McSweeney, D. Kumaran, J. Jakoncic, 2020 .

A simple technique to classify diffraction data from dynamic proteins according to individual polymorphs

L. C. Andrews, H. Bernstein, D. Kozakov, 2020, bioRxiv.

Best practices for high data-rate macromolecular crystallography (HDRMX)

Justin Y Wei, Mario A Xerri, L. C. Andrews, 2019, Structural dynamics.

Migrating the fast_dp software package for Python 2 and 3 compatibility

H. Bernstein, A. Soares, Jorge Diaz, 2019, Acta Crystallographica Section A Foundations and Advances.

Serial Crystallography with Multi-stage Merging of 1000s of Images

Herbert J. Bernstein, Sean McSweeney, Yusuke Yamada, 2017, bioRxiv.

Computing infrastructure, software optimization, and real time analysis for high data-rate MX

Herbert J. Bernstein, Robert M. Sweet, Sean McSweeney, 2016, 2016 New York Scientific Data Summit (NYSDS).

X-ray diffraction measurement of cosolvent accessible volume in rhombohedral insulin crystals.

A. Soares, D. Caspar, 2017, Journal of structural biology.

Structural basis for NADH/NAD+ redox sensing by a Rex family repressor.

A. Soares, M. Paget, C. Strain-Damerell, 2010, Molecular cell.

Integrated software for macromolecular crystallography synchrotron beamlines II: revision, robots and a database.

Matt Cowan, Robert M Sweet, Alexei S Soares, 2006, Acta crystallographica. Section D, Biological crystallography.

RapiData: a practical course in macromolecular X-ray diffraction data measurement and structure solving at the NSLS

R. M. Sweet, A. Soares, R. Sweet, 2010, Journal of applied crystallography.

First Results of Digital Topography Applied to Macromolecular Crystals

Robert M. Sweet, Edward H. Snell, Jeffrey J. Lovelace, 2004 .

Acoustic methods for high-throughput protein crystal mounting at next-generation macromolecular crystallographic beamlines.

A. Kuczewski, M. Allaire, A. Orville, 2013, Journal of synchrotron radiation.

Serial Crystallography with Multi-stage Merging of 1000s of Images

L. C. Andrews, H. Bernstein, R. Sweet, 2017, bioRxiv.

Determinants of Affinity and Proteolytic Stability in Interactions of Kunitz Family Protease Inhibitors with Mesotrypsin*

D. Sinha, P. Walsh, Moh’d A. Salameh, 2010, The Journal of Biological Chemistry.

Acoustic Injectors for Drop-On-Demand Serial Femtosecond Crystallography.

A. Kuczewski, A. Cohen, C. Wilmot, 2016, Structure.