M. Walsh

发表

Structure of ribose 5-phosphate isomerase from the probiotic bacterium Lactobacillus salivarius UCC118.

Carina M. C. Lobley, R. Owens, L. Bird, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

iNEXT: a European facility network to stimulate translational structural biology

J. Ellenberg, H. Schwalbe, D. Stuart, 2018, FEBS letters.

Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

James D. Firth, Hanna F. Klein, M. Noble, 2020, Nature Communications.

SARS-CoV-2 main protease with unliganded active site (2019-nCoV, coronavirus disease 2019, COVID-19)

D. Stuart, D. Hall, F. von Delft, 2020 .

A novel ADP- and zinc-binding fold from function-directed in vitro evolution

M. Walsh, P. L. Surdo, M. Sollazzo, 2004, Nature Structural &Molecular Biology.

The nsp9 Replicase Protein of SARS-Coronavirus, Structure and Functional Insights

David I Stuart, David Alderton, Lester G. Carter, 2004, Structure.

Taking MAD to the extreme: ultrafast protein structure determination.

M A Walsh, A. Joachimiak, G. Evans, 1999, Acta crystallographica. Section D, Biological crystallography.

Fucosidases from the human gut symbiont Ruminococcus gnavus

S. Monaco, N. Juge, J. Angulo, 2020, Cellular and Molecular Life Sciences.

High-throughput sample handling and data collection at synchrotrons: embedding the ESRF into the high-throughput gene-to-structure pipeline.

A Beteva, F Cipriani, S Cusack, 2006, Acta crystallographica. Section D, Biological crystallography.

ATOMIC RESOLUTION REFINEMENT OF TRICLINIC HEW LYSOZYME AT 295K

Z. Dauter, L. Sieker, K. Wilson, 1998 .

Structure of the equine arteritis virus nucleocapsid protein reveals a dimer–dimer arrangement

T. Dokland, M. Walsh, Sifang Wang, 2007, Acta crystallographica. Section D, Biological crystallography.

Elucidation of a unique sialic acid metabolism pathway in mucus-foraging Ruminococcus gnavus unravels mechanisms of bacterial adaptation to the gut

Jan Claesen, G. Thomas, N. Juge, 2019, Nature Microbiology.

Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092

D. Hall, M. Walsh, S. Culurgioni, 2017, Journal of visualized experiments : JoVE.

Crystal Structure of Human Edc3 and Its Functional Implications

R. Parker, Haiwei Song, M. Walsh, 2008, Molecular and Cellular Biology.

A complete structural characterization of the desferrioxamine E biosynthetic pathway from the fire blight pathogen Erwinia amylovora.

N. Demitri, M. Walsh, S. Benini, 2018, Journal of structural biology.

Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint

S. Mohammed, P. Roversi, N. Zitzmann, 2017, Proceedings of the National Academy of Sciences.

An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 Mpro inhibitor

F. von Delft, J. Prilusky, N. London, 2020, bioRxiv.

The Royal Society of C spectroscopy reveals water-mediated coherent dynamics in an enzyme active site †

G. M. Greetham, M. Towrie, N. T. Hunt, 2014 .

Sulfur Single-wavelength Anomalous Diffraction Crystal Structure of a Pheromone-Binding Protein from the Honeybee Apis mellifera L*

C. Cambillau, A. Gruez, L. Briand, 2004, Journal of Biological Chemistry.

Structure of cyanase reveals that a novel dimeric and decameric arrangement of subunits is required for formation of the enzyme active site.

A. Joachimiak, Z. Otwinowski, A. Perrakis, 2000, Structure.

Dimerisation induced formation of the active site and the identification of three metal sites in EAL-phosphodiesterases

R. Strange, I. Tews, A. Wagner, 2017, Scientific Reports.

Crystal structure of an HD‐GYP domain cyclic‐di‐GMP phosphodiesterase reveals an enzyme with a novel trinuclear catalytic iron centre

J. M. Dow, M. Bumann, R. Ryan, 2013, Molecular microbiology.

Penicillin Derivatives Inhibit the SARS-CoV-2 Main Protease by Reaction with Its Nucleophilic Cysteine

E. Salah, C. Schofield, A. Tumber, 2022, Journal of medicinal chemistry.

Crystallization and preliminary crystallographic analysis of an NADH oxidase that functions in peroxide reduction in Thermus aquaticus YT-1.

A. D'arcy, M. Walsh, A. Mac Sweeney, 1999, Acta crystallographica. Section D, Biological crystallography.

Crystal structure of a human VH: requirements for maintaining a monomeric fragment.

T. Dottorini, M. Walsh, C. Vaughan, 2004, Biochemistry.

Crystal Structure of Human Edc3 and Its Functional Implications (cid:1)

R. Parker, Haiwei Song, M. Walsh, 2008 .

SARS-CoV-2 main protease with unliganded active site (2019-nCoV, coronavirus disease 2019, COVID-19).

D. Stuart, D. Hall, F. von Delft, 2020 .

Mass Spectrometric Assays Reveal Discrepancies in Inhibition Profiles for the SARS‐CoV‐2 Papain‐Like Protease

C. Schofield, A. Tumber, P. Lukacik, 2022, ChemMedChem.

Lipase-assisted preparation of enantiopure ferrocenyl sulfides possessing planar chirality and their use in the synthesis of chiral sulfoxides

M. Walsh, A. Patti, M. Piattelli, 1997 .

Unusual chromophore and cross-links in ranasmurfin: a blue protein from the foam nests of a tropical frog.

Lester G. Carter, M. F. White, L. Carter, 2008, Angewandte Chemie.

Crystal structures of penicillin acylase enzyme-substrate complexes: structural insights into the catalytic mechanism.

K. Wilson, J. Brannigan, M. Walsh, 2001, Journal of molecular biology.

The Structural Biology Center 19ID undulator beamline: facility specifications and protein crystallographic results.

Gwyndaf Evans, Ruslan Sanishvili, Edwin Westbrook, 2006, Journal of synchrotron radiation.

Comparison of the Structure and Activity of Glycosylated and Aglycosylated Human Carboxylesterase 1

R. Owens, M. Charlton, J. Nettleship, 2015, PloS one.

Crystal Structure of Human Kynurenine Aminotransferase II, a Drug Target for the Treatment of Schizophrenia*

F. Rossi, M. Rizzi, M. Walsh, 2008, Journal of Biological Chemistry.

Structural basis of the sensor-synthase interaction in autoinduction of the quorum sensing signal DSF biosynthesis.

Lian-Hui Zhang, Haiwei Song, M. Walsh, 2010, Structure.

Streptococcus pneumoniae NanC

G. Taylor, P. Lukacik, M. Walsh, 2015, The Journal of Biological Chemistry.

The human gut symbiont Ruminococcus gnavus shows specificity to blood group A antigen during mucin glycan foraging: Implication for niche colonisation in the gastrointestinal tract

S. Monaco, N. Juge, J. Angulo, 2021, PLoS biology.

Crystal structure and functional analysis of the eukaryotic class II release factor eRF3 from S. pombe.

Haiwei Song, Yoshikazu Nakamura, Martin A Walsh, 2004, Molecular cell.

Phylogenetic Analysis with Prediction of Cofactor or Ligand Binding for Pseudomonas aeruginosa PAS and Cache Domains

I. Tews, M. Walsh, J. Webb, 2021, Microbiology spectrum.

Crystallization and preliminary X-ray diffraction analysis of bacteriophage varphi12 packaging factor P7.

P. Gottlieb, R. Tuma, D. Bamford, 2004, Acta crystallographica. Section D, Biological crystallography.

Allelic Variation of Bile Salt Hydrolase Genes in Lactobacillus salivarius Does Not Determine Bile Resistance Levels

Yin Li, M. Bumann, P. O’Toole, 2009, Journal of bacteriology.

Structural insights into the molecular mechanisms of the Mycobacterium evolvability factor Mfd

V. Nagaraja, D. Rao, R. Natesh, 2019, bioRxiv.

Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping.

R. Parker, Haiwei Song, M. Walsh, 2005, Journal of molecular biology.

Crystal structure of MboIIA methyltransferase.

Martin A Walsh, Andrzej Joachimiak, A. Joachimiak, 2003, Nucleic acids research.

Who checks the checkers? Four validation tools applied to eight atomic resolution structures. EU 3-D Validation Network.

Chris Sander, Shoshana J. Wodak, Jean Richelle, 1998, Journal of molecular biology.

Diamond Light Source: contributions to SARS-CoV-2 biology and therapeutics

D. Stuart, J. Grimes, M. Walsh, 2020, Biochemical and Biophysical Research Communications.

West Nile Virus Core Protein

T. Dokland, J. Mackenzie, M. Walsh, 2004, Structure.

Reduced flavin reductase PheA2 in complex with NAD

A. Heck, W. Berkel, A. Mattevi, 2004 .

Structural Studies on Flavin Reductase PheA2 Reveal Binding of NAD in an Unusual Folded Conformation and Support Novel Mechanism of Action*

A. Heck, A. Mattevi, A. Westphal, 2004, Journal of Biological Chemistry.

Ultrafast infrared spectroscopy reveals water-mediated coherent dynamics in an enzyme active site

G. M. Greetham, A. Parker, M. Towrie, 2014, Chemical science.

A structural and dynamic investigation of the inhibition of catalase by nitric oxide.

N. Tucker, G. M. Greetham, A. Parker, 2013, Organic & biomolecular chemistry.

Structure of RsrI methyltransferase, a member of the N6-adenine beta class of DNA methyltransferases.

M A Walsh, A. Joachimiak, R. Gumport, 2000, Nucleic acids research.

Structure and Regulation of EAL Domain Proteins

I. Tews, M. Walsh, J. Webb, 2020 .

Structural and functional analysis of Erwinia amylovora SrlD. The first crystal structure of a sorbitol-6-phosphate 2-dehydrogenase.

M. Rejžek, R. Field, M. Walsh, 2018, Journal of structural biology.

A thermophilic mini-chaperonin contains a conserved polypeptide-binding surface: combined crystallographic and NMR studies of the GroEL apical domain with implications for substrate interactions.

A. Joachimiak, M. Weiss, K. Hallenga, 2001, Journal of molecular biology.

Structural basis for translational inhibition by the tumour suppressor Pdcd4

Haiwei Song, M. Walsh, Xiaoxing Wang, 2009, The EMBO journal.

Targeting cyclic di-GMP signalling: a strategy to control biofilm formation?

J. M. Dow, R. Ryan, M. Walsh, 2014, Current pharmaceutical design.

Measuring protein dynamics with ultrafast two-dimensional infrared spectroscopy

Anthony W. Parker, Neil T. Hunt, Nicholas P. Tucker, 2012 .

Mass spectrometry reveals potential of β-lactams as SARS-CoV-2 Mpro inhibitors† †Electronic supplementary information (ESI) available: Experimental details and inhibition data. See DOI: 10.1039/d0cc06870e

E. Salah, Z. Rao, C. Schofield, 2021, Chemical communications.

The 2-Å Crystal Structure of 6-Oxo Camphor Hydrolase

C. Verma, J. Turkenburg, J. Whittingham, 2003, The Journal of Biological Chemistry.

Crystallographic investigation of the role of aspartate 95 in the modulation of the redox potentials of Desulfovibrio vulgaris flavodoxin.

Chandra S Verma, Andrew A McCarthy, Gerrit Voordouw, 2002, Biochemistry.

Automation of sample mounting for macromolecular crystallography.

F Cipriani, S Cusack, M Guijarro, 2006, Acta crystallographica. Section D, Biological crystallography.

Structural basis for Streptococcus pneumoniae NanA inhibition by influenza antivirals zanamivir and oseltamivir carboxylate.

G. Taylor, Guogang Xu, H. Gut, 2011, Journal of molecular biology.

The structure of nontypeable Haemophilus influenzae SapA in a closed conformation reveals a constricted ligand-binding cavity and a novel RNA binding motif

R. Owens, P. Biggin, C. Robinson, 2021, PloS one.

Differential impact on motility and biofilm dispersal of closely related phosphodiesterases in Pseudomonas aeruginosa

I. Tews, M. Walsh, J. Webb, 2019, Scientific Reports.

MAD data collection - current trends.

A. Joachimiak, G. Evans, R. Sanishvili, 1999, Acta crystallographica. Section D, Biological crystallography.

Structural Basis for Regulation and Specificity of Fructooligosaccharide Import in Streptococcus pneumoniae

G. Harris, M. Walsh, Anirudh K. Singh, 2017, Structure.

Discovery of SARS-CoV-2 Mpro peptide inhibitors from modelling substrate and ligand binding

Helen M. Deeks, Rebecca K. Walters, Rebecca M. Twidale, 2021, bioRxiv.

Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19

M. Swindells, D. Stuart, A. Hopkins, 2021, Scientific Reports.

High-resolution structures of Lactobacillus salivarius transketolase in the presence and absence of thiamine pyrophosphate

Carina M. C. Lobley, R. Owens, M. Bumann, 2015, Acta crystallographica. Section F, Structural biology communications.

Application of in situ diffraction in high-throughput structure determination platforms.

Gwyndaf Evans, Mark Williams, Marco Mazzorana, 2015, Methods in molecular biology.

Sulfur Single-wavelength Anomalous Diffraction Crystal Structure of a Pheromone-Binding Protein from the Honeybee Apis mellifera L

C. Cambillau, A. Gruez, L. Briand, 2003 .

Refinement of triclinic hen egg-white lysozyme at atomic resolution.

V S Lamzin, K S Wilson, Z Dauter, 1998, Acta crystallographica. Section D, Biological crystallography.

The structure of Erwinia amylovora AvrRpt2 provides insight into protein maturation and induced resistance to fire blight by Malus × robusta 5.

N. Demitri, M. Walsh, S. Benini, 2019, Journal of structural biology.

Structure of a new crystal form of human Hsp70 ATPase domain.

A. Joachimiak, R. Morimoto, B. Freeman, 1999, Acta crystallographica. Section D, Biological crystallography.

Going soft and SAD with manganese.

D. Stuart, J. Grimes, M. Walsh, 2005, Acta crystallographica. Section D, Biological crystallography.

Inhibition of the Hepatitis C Virus NS3/4A Protease

R. De Francesco, M. Rizzi, F. Narjes, 2000, The Journal of Biological Chemistry.

The crystal structure of Erwinia amylovora AmyR, a member of the YbjN protein family, shows similarity to type III secretion chaperones but suggests different cellular functions

Youfu Zhao, A. Schmitt, N. Demitri, 2017, PloS one.

Super-Resolution Fluorescence Microscopy Reveals Clustering Behaviour of Chlamydia pneumoniae’s Major Outer Membrane Protein

K. Watson, M. Martin-Fernandez, I. Moraes, 2020, Biology.

The metabolism of avermectins B1a, H2B1a, and H2B1b by liver microsomes.

A. Y. Lu, M. Walsh, J. Walsh, 1982, Drug metabolism and disposition: the biological fate of chemicals.

Structural characterization of the Streptococcus pneumoniae carbohydrate substrate-binding protein SP0092

M. Walsh, S. Culurgioni, Minzhe Tang, 2017, Acta crystallographica. Section F, Structural biology communications.

Expression, purification, crystallization and preliminary crystallographic analysis of the calponin-homology domain of Rng2.

T. Dokland, M. Balasubramanian, M. Walsh, 2003, Acta crystallographica. Section D, Biological crystallography.

Allelic Variation of Bile Salt Hydrolase Genes in Lactobacillus salivarius Does Not Determine Bile Resistance Levels

Yin Li, M. Bumann, P. O’Toole, 2009, Journal of bacteriology.

An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 Mpro inhibitor

F. von Delft, J. Prilusky, N. London, 2021, Cell Chemical Biology.

Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping.

R. Parker, Haiwei Song, M. Walsh, 2005, Journal of molecular biology.