E. Fry

发表

Exploiting fast detectors to enter a new dimension in room-temperature crystallography

D. Stuart, C. Schulze-Briese, G. Evans, 2014, Acta crystallographica. Section D, Biological crystallography.

In situ macromolecular crystallography using microbeams

Gwyndaf Evans, Jun Aishima, David I. Stuart, 2012, Acta crystallographica. Section D, Biological crystallography.

A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71

Gwyndaf Evans, Zihe Rao, David I. Stuart, 2012, Nature Structural &Molecular Biology.

Plant-made polio type 3 stabilized VLPs—a candidate synthetic polio vaccine

D. Stuart, D. Rowlands, G. Lomonossoff, 2017, Nature Communications.

The structure of foot-and-mouth disease virus.

D. Stuart, D. Rowlands, E. Fry, 2005, Current topics in microbiology and immunology.

Fitness Cost of Escape Mutations in p24 Gag in Association with Control of Human Immunodeficiency Virus Type 1

B. Walker, J. Mullins, D. Stuart, 2006, Journal of Virology.

Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike

R. Owens, D. Stuart, G. Screaton, 2020, Cell Host & Microbe.

Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike

R. Owens, D. Stuart, G. Screaton, 2020, SSRN Electronic Journal.

Structure of Ljungan virus provides insight into genome packaging of this picornavirus

Zihe Rao, David I Stuart, Ling Zhu, 2015, Nature Communications.

Seneca Valley virus attachment and uncoating mediated by its receptor anthrax toxin receptor 1

D. Stuart, Z. Rao, Lingpeng Cheng, 2018 .

Seneca Valley virus attachment and uncoating mediated by its receptor anthrax toxin receptor 1

D. Stuart, Yuna Sun, M. Hu, 2018, Proceedings of the National Academy of Sciences.

The nsp9 Replicase Protein of SARS-Coronavirus, Structure and Functional Insights

David I Stuart, David Alderton, Lester G. Carter, 2004, Structure.

Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus

D. Stuart, T. Springer, N. Abrescia, 2017, Nature Communications.

Glutathione facilitates enterovirus assembly by binding at a druggable pocket

D. Stuart, T. Walter, E. Fry, 2020, Communications Biology.

Hepatitis A Virus Capsid Structure.

D. Stuart, Z. Rao, Xiangxi Wang, 2018, Cold Spring Harbor perspectives in medicine.

More powerful virus inhibitors from structure-based analysis of HEV71 capsid-binding molecules

D. Stuart, D. Rowlands, Z. Rao, 2014, Nature Structural &Molecular Biology.

Rational Engineering of Recombinant Picornavirus Capsids to Produce Safe, Protective Vaccine Antigen

D. Stuart, B. Charleston, T. Jackson, 2013, PLoS pathogens.

Structure determination from a single high-pressure-frozen virus crystal.

D. Stuart, A. Meents, R. Reimer, 2013, Acta crystallographica. Section D, Biological crystallography.

Methods used in the structure determination of foot-and-mouth disease virus.

D. Stuart, E. Fry, R. Acharya, 1993, Acta crystallographica. Section A, Foundations of crystallography.

Evaluation and Use of In-Silico Structure-Based Epitope Prediction with Foot-and-Mouth Disease Virus

D. Stuart, R. Esnouf, E. Fry, 2013, PloS one.

Potent cross-reactive antibodies following Omicron breakthrough in vaccinees

D. Stuart, P. Klenerman, G. Screaton, 2022, Cell.

Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10

D. Stuart, Z. Rao, E. Jones, 2020, Nature Communications.

Structure of human Aichi virus and implications for receptor binding

D. Stuart, Z. Rao, T. Walter, 2016, Nature Microbiology.

Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum

P. Klenerman, G. Screaton, A. Mentzer, 2022, Cell.

The SARS-CoV-2 Spike harbours a lipid binding pocket which modulates stability of the prefusion trimer

D. Stuart, T. Walter, J. Radecke, 2020, bioRxiv.

Structure and receptor binding.

A. King, E. Fry, Terry Jackson, 2003, Virus research.

Generation and characterisation of recombinant FMDV antibodies: Applications for advancing diagnostic and laboratory assays

R. Owens, D. Stuart, S. Berryman, 2018, PloS one.

Specificity of the VP1 GH Loop of Foot-and-Mouth Disease Virus for αv Integrins

D. Stuart, N. Abrescia, T. Jackson, 2006, Journal of Virology.

A conserved glutathione binding site in poliovirus is a target for antivirals and vaccine stabilisation

D. Stuart, D. Rowlands, K. Grehan, 2022, bioRxiv.

Specific Interactions between Human Integrin αvβ3and Chimeric Hepatitis B Virus Core Particles Bearing the Receptor-Binding Epitope of Foot-and-Mouth Disease Virus

D. Stuart, D. Rowlands, Z. Rao, 1997 .

Structures of Ebola Virus Glycoprotein Complexes with Tricyclic Antidepressant and Antipsychotic Drugs.

D. Stuart, A. Townsend, Yuguang Zhao, 2018, Journal of medicinal chemistry.

Production and Characterisation of Stabilised PV-3 Virus-like Particles Using Pichia pastoris

D. Stuart, D. Rowlands, K. Grehan, 2022, bioRxiv.

Nonlytic cellular release of hepatitis A virus requires dual capsid recruitment of the ESCRT-associated Bro1 domain proteins HD-PTP and ALIX

Xian Chen, Ling Xie, S. Lemon, 2022, bioRxiv.

Further antibody escape by Omicron BA.4 and BA.5 from vaccine and BA.1 serum

P. Klenerman, G. Screaton, A. Mentzer, 2022, bioRxiv.

The Antigenic Anatomy of SARS-CoV-2 Receptor Binding Domain

D. Stuart, P. Klenerman, J. Knight, 2020, SSRN Electronic Journal.

Speciﬁcity of the VP1 GH Loop of Foot-and-Mouth Disease Virus for (cid:2) v Integrins

D. Stuart, N. Abrescia, T. Jackson, 2006 .

Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera

D. Stuart, P. Klenerman, J. Knight, 2021, Cell.

Genome-first detection of emerging resistance to novel therapeutic agents for SARS-CoV-2

P. Klenerman, G. Screaton, J. Sutton, 2022, bioRxiv.

Reduced Neutralization of SARS-CoV-2 B.1.1.7 Variant from Naturally Acquired and Vaccine Induced Antibody Immunity

D. Stuart, P. Klenerman, J. Knight, 2021, Social Science Research Network.

Preliminary crystallographic analysis of bovine enterovirus.

D. Stuart, S. Martin, E. Fry, 1993, Journal of molecular biology.

The structure and function of a foot‐and‐mouth disease virus–oligosaccharide receptor complex

D. Stuart, T. Jackson, A. King, 1999, The EMBO journal.

Switching of Receptor Binding Poses between Closely Related Enteroviruses

D. Stuart, L. Qin, Kuan-Ying A. Huang, 2022, Viruses.

Crystallization and preliminary X-ray analysis of three serotypes of foot-and-mouth disease virus.

D. Stuart, S. Curry, T. Jackson, 1992, Journal of molecular biology.

A delicate balance between antibody evasion and ACE2 affinity for Omicron BA.2.75

P. Klenerman, D. Hall, G. Screaton, 2022, Cell Reports.

Sequence-Based Prediction for Vaccine Strain Selection and Identification of Antigenic Variability in Foot-and-Mouth Disease Virus

Richard Reeve, Tjaart A. P. de Beer, Louise Matthews, 2010, PLoS Comput. Biol..

Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability

D. Stuart, Z. Rao, J. Huiskonen, 2017, Nature Communications.

Structure-based energetics of protein interfaces guides foot-and-mouth disease virus vaccine design

D. Stuart, R. Esnouf, C. A. Siebert, 2015, Nature Structural &Molecular Biology.

Structure of a major immunogenic site on foot-and-mouth disease virus

D. Stuart, R. Lewis, S. Curry, 1993, Nature.

Efficient production of foot-and-mouth disease virus empty capsids in insect cells following down regulation of 3C protease activity

D. Stuart, Yanmin Li, S. Curry, 2013, Journal of virological methods.

Perturbations in the surface structure of A22 Iraq foot-and-mouth disease virus accompanying coupled changes in host cell specificity and antigenicity.

D. Stuart, S. Curry, D. Rowlands, 1996, Structure.

SAT2 Foot-and-Mouth Disease Virus Structurally Modified for Increased Thermostability

D. Stuart, J. Seago, B. Charleston, 2017, Journal of Virology.

Viral RNA modulates the acid sensitivity of foot-and-mouth disease virus capsids

D I Stuart, D. Stuart, S. Curry, 1995, Journal of virology.

The three-dimensional structure of foot-and-mouth disease virus at 2.9 Å resolution

David Rowlands, D. Stuart, D. Rowlands, 1989, Nature.

Structural and functional analysis of protective antibodies targeting the threefold plateau of enterovirus 71

D. Stuart, K. Tsao, Kuan-Ying A. Huang, 2020, Nature Communications.

Structures of Coxsackievirus A16 Capsids with Native Antigenicity: Implications for Particle Expansion, Receptor Binding, and Immunogenicity

D. Stuart, Z. Rao, Xiangxi Wang, 2015, Journal of Virology.

Unexpected mode of engagement between enterovirus 71 and its receptor SCARB2

D. Stuart, D. Rowlands, Z. Rao, 2018, Nature Microbiology.

The structure of foot-and-mouth disease virus: implications for its physical and biological properties.

D. Stuart, D. Rowlands, F. Brown, 1990, Veterinary microbiology.

Atomic resolution structure of Moloney murine leukemia virus matrix protein and its relationship to other retroviral matrix proteins.

D. Stuart, A. Kingsman, Z. Rao, 2002, Structure.

Role of Glycoproteins in Virus-Human Cell Interactions

T. Bowden, E. Fry, 2010 .

Crystal structure of SIV matrix antigen and implications for virus assembly

D. Stuart, Z. Rao, P. Roy, 1995, Nature.

Tandem Fusion of Hepatitis B Core Antigen Allows Assembly of Virus-Like Particles in Bacteria and Plants with Enhanced Capacity to Accommodate Foreign Proteins

D. Stuart, D. Rowlands, R. Gilbert, 2015, PloS one.

Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike

David I Stuart, Raymond J Owens, Tomas Malinauskas, 2020, bioRxiv.

Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera

D. Stuart, P. Klenerman, J. Knight, 2021, Cell.

SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

S. Madhi, D. Stuart, P. Klenerman, 2022, Cell.

Hepatitis A virus and the origins of picornaviruses

Qiang Gao, Zihe Rao, David I. Stuart, 2014, Nature.

Unexpected mode of engagement between enterovirus 71 and its receptor SCARB2

D. Stuart, D. Rowlands, Z. Rao, 2018, Nature Microbiology.

Equine Rhinitis A Virus and Its Low pH Empty Particle: Clues Towards an Aphthovirus Entry Mechanism?

D. Stuart, D. Rowlands, K. Harlos, 2009, PLoS pathogens.

Outrunning free radicals in room-temperature macromolecular crystallography

Gwyndaf Evans, David I. Stuart, Danny Axford, 2012, Acta crystallographica. Section D, Biological crystallography.

Neutralization Mechanisms of Two Highly Potent Antibodies against Human Enterovirus 71

D. Stuart, Ling Zhu, Z. Rao, 2018, mBio.

Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site

D. Stuart, Z. Rao, T. Walter, 2017, Proceedings of the National Academy of Sciences.

Picornavirus uncoating intermediate captured in atomic detail

D. Stuart, Mark A. Williams, D. Rowlands, 2013, Nature Communications.

Redundant Late Domain Functions of Tandem VP2 YPX3L Motifs in Nonlytic Cellular Egress of Quasi-enveloped Hepatitis A Virus

D. Stuart, F. Hu, S. Lemon, 2018, Journal of Virology.

Target Identification and Mode of Action of Four Chemically Divergent Drugs against Ebolavirus Infection

D. Stuart, Yuguang Zhao, E. Fry, 2017, Journal of medicinal chemistry.

Toremifene interacts with and destabilizes the Ebola virus glycoprotein

D. Stuart, K. Harlos, S. Padilla-Parra, 2016, Nature.

The antigenic anatomy of SARS-CoV-2 receptor binding domain

D. Stuart, P. Klenerman, J. Knight, 2021, Cell.

High-speed fixed-target serial virus crystallography

Nicholas K Sauter, David I Stuart, Bernd Reime, 2017, Nature Methods.

Mammalian expression of virus-like particles as a proof of principle for next generation polio vaccines

D. Stuart, M. Bahar, E. Fry, 2021, npj Vaccines.

Application of the thermofluor PaSTRy technique for improving foot-and-mouth disease virus vaccine formulation

D. Stuart, J. Seago, N. Juleff, 2016, The Journal of general virology.

Structures of foot and mouth disease virus pentamers: Insight into capsid dissociation and unexpected pentamer reassociation

D. Stuart, J. Huiskonen, S. Gold, 2017, PLoS pathogens.

Tracking the Antigenic Evolution of Foot-and-Mouth Disease Virus

William T. Harvey, R. Reeve, F. Maree, 2016, PloS one.

The structure and antigenicity of a type C foot-and-mouth disease virus.

D. Stuart, E. Domingo, S. Curry, 1994, Structure.

Structures and therapeutic potential of anti-RBD human monoclonal antibodies against SARS-CoV-2

D. Stuart, Che Ma, M. Carroll, 2022, Theranostics.

Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient

R. Owens, D. Stuart, G. Screaton, 2020, Nature Structural & Molecular Biology.

Structural comparison of two strains of foot-and-mouth disease virus subtype O1 and a laboratory antigenic variant, G67.

D. Stuart, S. Curry, T. Jackson, 1995, Structure.

The role of the light chain in the structure and binding activity of two cattle antibodies that neutralize bovine respiratory syncytial virus

R. Owens, D. Stuart, G. Harris, 2019, Molecular immunology.

Mammalian expression of virus-like particles as a proof of principle for next generation polio vaccines

D. Stuart, M. Bahar, E. Fry, 2021, NPJ vaccines.

Specificity of the VP1 GH loop of Foot-and-Mouth Disease virus for alphav integrins.

D. Stuart, N. Abrescia, T. Jackson, 2006, Journal of virology.

Specific interactions between human integrin alpha v beta 3 and chimeric hepatitis B virus core particles bearing the receptor-binding epitope of foot-and-mouth disease virus.

D. Stuart, D. Rowlands, Z. Rao, 1997, Virology.

Foot-and-mouth disease virus (FMDV) with a stable FLAG epitope in the VP1 G-H loop as a new tool for studying FMDV pathogenesis.

J. Hollister, J. Pacheco, A. Kotecha, 2013, Virology.

Characterization of epitope-tagged foot-and-mouth disease virus

D. Stuart, J. Seago, N. Juleff, 2012, The Journal of general virology.

Structural and serological evidence for a novel mechanism of antigenic variation in foot-and-mouth disease virus

D. Stuart, D. Rowlands, F. Brown, 1990, Nature.

Rapid escape of new SARS-CoV-2 Omicron variants from BA.2-directed antibody responses

P. Klenerman, G. Screaton, A. Mentzer, 2023, Cell Reports.

Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

S. Madhi, P. Klenerman, G. Screaton, 2021, bioRxiv.

The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variants

D. Stuart, M. Diamond, P. Goulder, 2021, Cell Host & Microbe.

Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum

S. Madhi, D. Stuart, P. Klenerman, 2021, Cell.

Antibody evasion by the P.1 strain of SARS-CoV-2

D. Stuart, P. Klenerman, J. Knight, 2021, Cell.

Antibody evasion by the Brazilian P.1 strain of SARS-CoV-2

D. Stuart, P. Klenerman, J. Knight, 2021, bioRxiv.

Structure-Based in Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library

D. Stuart, S. Padilla-Parra, C. Schofield, 2019, Journal of medicinal chemistry.

Structure of Foot-and-mouth disease virus serotype A10 61 alone and complexed with oligosaccharide receptor: receptor conservation in the face of antigenic variation.

David I Stuart, Terry Jackson, Susan M Lea, 2005, The Journal of general virology.

Crystal Structure of Swine Vesicular Disease Virus and Implications for Host Adaptation

D. Stuart, Z. Rao, A. King, 2003, Journal of Virology.

Structure of Equine Infectious Anemia Virus Matrix Protein

D. Stuart, A. Kingsman, Z. Rao, 2002, Journal of Virology.

The crystal structure of coxsackievirus A9: new insights into the uncoating mechanisms of enteroviruses.

D. Stuart, T. Hyypiä, H. Hatanaka, 1999, Structure.

Kelp Fly Virus: a Novel Group of Insect Picorna-Like Viruses as Defined by Genome Sequence Analysis and a Distinctive Virion Structure

D. Stuart, R. Gilbert, P. Scotti, 2005, Journal of Virology.

Receptor Binding and Escape From Beta Antibody Responses Drive Omicron-B.1.1.529 Evolution

D. Stuart, G. Screaton, J. Zahradník, 2021, SSRN Electronic Journal.

The Structure of Foot and Mouth Disease Virus Serotype SAT1

D. Stuart, A. King, S. Lea, 2010 .

12 – Structure of Foot-and-Mouth Disease Virus

D. Stuart, E. Fry, D. Logan, 1990 .

Symmetrical arrangement of positively charged residues around the 5-fold axes of SAT type foot-and-mouth disease virus enhances cell culture of field viruses

D. Stuart, F. Maree, J. Theron, 2020, PLoS pathogens.

Virus crystallography

D. Stuart, J. Grimes, E. Fry, 1999, Molecular biotechnology.

PREDICTING ANTIGENIC SITES ON THE FMDV CAPSID FROM CROSS-REACTIVITY DATA

D. Haydon, R. Reeve, F. Maree, 2008 .

Chimeric O1K foot-and-mouth disease virus with SAT2 outer capsid as an FMD vaccine candidate

Corey W. Hecksel, D. Stuart, S. Ilca, 2018, Scientific Reports.

Structure Elucidation of Coxsackievirus A16 in Complex with GPP3 Informs a Systematic Review of Highly Potent Capsid Binders to Enteroviruses

D. Stuart, Z. Rao, J. Grimes, 2015, PLoS pathogens.

Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability

D. Stuart, Z. Rao, J. Huiskonen, 2017, Nature Communications.

Lysosome sorting of β-glucocerebrosidase by LIMP-2 is targeted by the mannose 6-phosphate receptor

D. Stuart, S. Padilla-Parra, Yuguang Zhao, 2014, Nature Communications.

A plate-based high-throughput assay for virus stability and vaccine formulation

David I. Stuart, Elizabeth E. Fry, D. Stuart, 2012, Journal of virological methods.

Glutathione facilitates enterovirus assembly by binding at a druggable pocket

D. Stuart, T. Walter, E. Fry, 2020, Communications Biology.

Potent antiviral agents fail to elicit genetically-stable resistance mutations in either enterovirus 71 or Coxsackievirus A16

D. Stuart, D. Rowlands, L. De Colibus, 2015, Antiviral research.

Sample Preparation and Data Collection for High-Speed Fixed-Target Serial Femtosecond Crystallography

C. David, D. Stuart, B. Reime, 2017 .

MS1-O5 High Pressure Freezing of Macromolecular Crystals

Armin, Carina, D. Stuart, 2012 .

Crystal structure of equine rhinitis A virus in complex with its sialic acid receptor.

D. Stuart, D. Rowlands, K. Harlos, 2010, The Journal of general virology.

Antigenic characterization of SARS-CoV-2 Omicron subvariant BA.4.6

G. Screaton, A. Mentzer, Jingshan Ren, 2022, Cell Discovery.

Universal detection of foot and mouth disease virus based on the conserved VP0 protein

D. Stuart, B. Charleston, I. Jones, 2018, Wellcome Open Research.

Generation of SARS-CoV-2 escape mutations by monoclonal antibody therapy

P. Klenerman, G. Screaton, M. Bahar, 2023, Nature communications.

Foot-and Mouth Disease Virus Serotype A1061

D. Stuart, S. Curry, T. Jackson, 2005 .

Crystallization and preliminary X-ray diffraction analysis of foot-and-mouth disease virus.

D. Stuart, D. Rowlands, F. Brown, 1987, Journal of molecular biology.

Rules of engagement between alpha v beta 6 integrin and foot-and-mouth disease virus.

D. Stuart, T. Springer, N. Abrescia, 2017 .

Broadly neutralizing antibodies against COVID-19

Jingshan Ren, E. Fry, David I. Stuart, 2023, Current opinion in virology.

What Does it Take to Make a Virus: The Concept of the Viral 'Self'

D. Stuart, J. Grimes, D. Bamford, 2010 .

Efficient production of foot-and-mouth disease virus empty capsids in insect cells following down regulation of 3C protease activity

D. Stuart, Yanmin Li, S. Curry, 2013, Journal of virological methods.

Dissecting the roles of VP0 cleavage and RNA packaging in picornavirus capsid stabilization: the structure of empty capsids of foot-and-mouth disease virus

S. Curry, T. Jackson, A. King, 1997, Journal of virology.

Structure of the SARS-CoV-2 spike S1 protein in complex with CR3022 Fab

R. Owens, D. Stuart, Yuguang Zhao, 2020 .