J. Hubbuch

发表

Application of Empirical Phase Diagrams for Multidimensional Data Visualization of High-Throughput Microbatch Crystallization Experiments.

Marieke E. Klijn, J. Hubbuch, 2018, Journal of pharmaceutical sciences.

3D‐Printed Phenacrylate Decarboxylase Flow Reactors for the Chemoenzymatic Synthesis of 4‐Hydroxystilbene

K. Rabe, C. Niemeyer, M. Engqvist, 2019, Chemistry.

High‐throughput computational pipeline for 3‐D structure preparation and in silico protein surface property screening: A case study on HBcAg dimer structures

Marieke E. Klijn, J. Hubbuch, Philipp Vormittag, 2019, International journal of pharmaceutics.

Monitoring of antibody-drug conjugation reactions with UV/Vis spectroscopy.

M. Wendeler, J. Hubbuch, Sebastian Andris, 2018, Journal of biotechnology.

Kinetic reaction modeling for antibody-drug conjugate process development.

J. Hubbuch, Sebastian Andris, Jonathan Seidel, 2019, Journal of biotechnology.

Modifying an ÄKTApurifier System for the Automated Acquisition of Samples for Kinetic Modeling of Batch Reactions

J. Hubbuch, A. Sanden, S. Haas, 2019, SLAS technology.

Selective high throughput protein quantification based on UV absorption spectra

J. Hubbuch, S. Hansen, B. Jamali, 2013, Biotechnology and bioengineering.

A tool for selective inline quantification of co‐eluting proteins in chromatography using spectral analysis and partial least squares regression

J. Hubbuch, Nina Brestrich, Till Briskot, 2014, Biotechnology and bioengineering.

Advances in downstream processing of biologics - Spectroscopy: An emerging process analytical technology.

J. Hubbuch, Matthias Rüdt, Till Briskot, 2017, Journal of chromatography. A.

In-line Fourier-transform infrared spectroscopy as a versatile process analytical technology for preparative protein chromatography.

S. Heissler, J. Hubbuch, Steffen Großhans, 2018, Journal of chromatography. A.

Multi-step high-throughput conjugation platform for the development of antibody-drug conjugates.

M. Wendeler, Xiangyang Wang, J. Hubbuch, 2018, Journal of biotechnology.

Evaluation of the Reproducibility and Robustness of Extrusion-Based Bioprinting Processes Applying a Flow Sensor

J. Hubbuch, Svenja Strauß, Bianca Schroth, 2022, Frontiers in Bioengineering and Biotechnology.

On the analysis of chromatographic biopharmaceutical data by curve resolution techniques in the framework of the area of feasible solutions.

K. Neymeyr, M. Sawall, J. Hubbuch, 2020, Journal of chromatography. A.

Application of spectral deconvolution and inverse mechanistic modelling as a tool for root cause investigation in protein chromatography.

J. Hubbuch, Nina Brestrich, Tobias Hahn, 2016, Journal of chromatography. A.

A novel two-zone protein uptake model for affinity chromatography and its application to the description of elution band profiles of proteins fused to a family 9 cellulose binding module affinity tag.

Jürgen Hubbuch, Florian Dismer, Mojgan Kavoosi, 2007, Journal of chromatography. A.

Cross‐scale quality assessment of a mechanistic cation exchange chromatography model

G. Wang, J. Hubbuch, J. Studts, 2020, Biotechnology progress.

The Biomaker: an entry‐level bioprinting device for biotechnological applications

Carsten P Radtke, J. Hubbuch, Nils Hillebrandt, 2018 .

High‐throughput characterization of an insect cell‐free expression

J. Hubbuch, A. Osberghaus, F. Bickel, 2014 .

Precipitation of complex antibody solutions: influence of contaminant composition and cell culture medium on the precipitation behavior

J. Hubbuch, Steffen Großhans, Susanna Suhm, 2019, Bioprocess and Biosystems Engineering.

actorization of preparative protein chromatograms with ard-constraint multivariate curve resolution and second-derivative retreatment

J. Hubbuch, Sebastian Andris, atthias Rüdt, 2019 .

Process monitoring of virus‐like particle reassembly by diafiltration with UV/Vis spectroscopy and light scattering

J. Hubbuch, Philipp Vormittag, Matthias Rüdt, 2019, Biotechnology and bioengineering.

Factorization of preparative protein chromatograms with hard-constraint multivariate curve resolution and second-derivative pretreatment.

J. Hubbuch, Sebastian Andris, Matthias Rüdt, 2019, Journal of chromatography. A.

Characterization of aqueous two phase systems by combining lab-on-a-chip technology with robotic liquid handling stations.

J. Hubbuch, Sven Amrhein, Marie-Luise Schwab, 2014, Journal of chromatography. A.

Integrated development of up- and downstream processes supported by the Cherry-Tag™ for real-time tracking of stability and solubility of proteins.

J. Hubbuch, Nicolai Bluthardt, A. Osberghaus, 2015, Journal of biotechnology.

A mechanistic model of ion-exchange chromatography on polymer fiber stationary phases.

J. Hubbuch, Tobias Hahn, Johann Winderl, 2016, Journal of chromatography. A.

High-throughput process development of an alternative platform for the production of virus-like particles in Escherichia coli.

A. Middelberg, J. Hubbuch, Philipp Vormittag, 2016, Journal of biotechnology.

Investigation and prediction of protein precipitation by polyethylene glycol using quantitative structure-activity relationship models.

J. Hubbuch, Sebastian Andris, Christopher Ladd Effio, 2017, Journal of biotechnology.

Adsorption of colloidal proteins in ion-exchange chromatography under consideration of charge regulation.

J. Hubbuch, Till Briskot, Tobias Hahn, 2020, Journal of chromatography. A.

Systematic generation of buffer systems for pH gradient ion exchange chromatography and their application.

J. Hubbuch, Frieder Kröner, F. Kröner, 2013, Journal of chromatography. A.

Determination of protein phase diagrams by microbatch experiments: exploring the influence of precipitants and pH.

Jürgen Hubbuch, Stefan A Oelmeier, J. Hubbuch, 2015, International journal of pharmaceutics.

Preparative Protein Crystallization

H. Nirschl, J. Hubbuch, M. Kind, 2019, Chemical Engineering & Technology.

Correlating multidimensional short‐term empirical protein properties to long‐term protein physical stability data via empirical phase diagrams

Marieke E. Klijn, J. Hubbuch, 2019, International journal of pharmaceutics.

A phase diagram-based toolbox to assess the impact of freeze/thaw ramps on the phase behavior of proteins

J. Hubbuch, A. Wöll, Monika Desombre, 2019, Bioprocess and Biosystems Engineering.

Redesigning food protein formulations with empirical phase diagrams: A case study on glycerol-poor and glycerol-free formulations.

Marieke E. Klijn, J. Hubbuch, 2019, Food research international.

Impact of Polymer Bioconjugation on Protein Stability and Activity Investigated with Discrete Conjugates: Alternatives to PEGylation.

G. Delaittre, A. Beloqui, J. Hubbuch, 2018, Biomacromolecules.

Prediction and characterization of the stability enhancing effect of the Cherry-Tag™ in highly concentrated protein solutions by complex rheological measurements and MD simulations.

J. Hubbuch, P. Baumann, H. Burghardt, 2017, International journal of pharmaceutics.

Model-Based Investigation on the Mass Transfer and Adsorption Mechanisms of Mono-Pegylated Lysozyme in Ion-Exchange Chromatography.

J. Hubbuch, Josefine Morgenstern, P. Baumann, 2017, Biotechnology journal.

Effect of PEG molecular weight and PEGylation degree on the physical stability of PEGylated lysozyme.

J. Hubbuch, Josefine Morgenstern, P. Baumann, 2017, International journal of pharmaceutics.

The influence of mixed salts on the capacity of HIC adsorbers: A predictive correlation to the surface tension and the aggregation temperature

J. Hubbuch, Sven Amrhein, K. Baumgartner, 2016, Biotechnology progress.

Prediction of salt effects on protein phase behavior by HIC retention and thermal stability.

J. Hubbuch, Steffen Großhans, Susanna Suhm, 2016, Journal of pharmaceutical and biomedical analysis.

Squeeze flow rheometry as a novel tool for the characterization of highly concentrated protein solutions

J. Hubbuch, C. Oelschlaeger, Marie-Therese Schermeyer, 2016, Biotechnology and bioengineering.

Cell Separation in Aqueous Two-Phase Systems - Influence of Polymer Molecular Weight and Tie-Line Length on the Resolution of Five Model Cell Lines.

Philipp K Zimmermann, J. Hubbuch, S. Zimmermann, 2018, Biotechnology journal.

Streamlined process development procedure incorporating the selection of various stationary phase types established in a mAb aggregate reduction study with different mixed mode ligands

J. Hubbuch, V. Thom, D. Stein, 2021, Biotechnology progress.

Ensembles of Hydrophobicity Scales as Potent Classifiers for Chimeric Virus-Like Particle Solubility – An Amino Acid Sequence-Based Machine Learning Approach

J. Hubbuch, Philipp Vormittag, T. Klamp, 2020, Frontiers in Bioengineering and Biotechnology.

Optimization of a Soft Ensemble Vote Classifier for the Prediction of Chimeric Virus-Like Particle Solubility and Other Biophysical Properties

J. Hubbuch, Philipp Vormittag, T. Klamp, 2020, Frontiers in Bioengineering and Biotechnology.

Machine-assisted cultivation and analysis of biofilms

Carsten P Radtke, K. Rabe, C. Niemeyer, 2019, Scientific Reports.

Cell‐free expression of recombinant antigens of Borrelia burgdorferi and microarray‐based multiplex detection using different patient sera

J. Hubbuch, K. Konstantinidis, R. Kneusel, 2014 .

Process monitoring framework for cross‐flow diafiltration‐based virus‐like particle disassembly: Tracing product properties and filtration performance

J. Hubbuch, Philipp Vormittag, Nils Hillebrandt, 2022, Biotechnology and bioengineering.

A sub-two minutes method for monoclonal antibody-aggregate quantification using parallel interlaced size exclusion high performance liquid chromatography.

J. Hubbuch, S. Hansen, S. A. Oelmeier, 2011, Journal of chromatography. A.

Defined polymer shells on nanoparticles via a continuous aerosol-based process

Stephanie E. Sigmund, Jörg Meyer, M. Wörner, 2014, Journal of Nanoparticle Research.

Packing characteristics of winged shaped polymer fiber supports for preparative chromatography.

J. Hubbuch, Johann Winderl, Tamara Spies, 2018, Journal of chromatography. A.

An orientation sensitive approach in biomolecule interaction quantitative structure-activity relationship modeling and its application in ion-exchange chromatography.

M. Ottens, J. Hubbuch, J. Kittelmann, 2017, Journal of chromatography. A.

Orientation of monoclonal antibodies in ion-exchange chromatography: A predictive quantitative structure-activity relationship modeling approach.

M. Ottens, J. Hubbuch, J. Kittelmann, 2017, Journal of chromatography. A.

Downstream processing of virus-like particles: single-stage and multi-stage aqueous two-phase extraction.

J. Hubbuch, L. Wenger, R. Kneusel, 2015, Journal of chromatography. A.

Influence of binding pH and protein solubility on the dynamic binding capacity in hydrophobic interaction chromatography.

J. Hubbuch, P. Baumann, K. Baumgartner, 2015, Journal of chromatography. A.

Process development exploiting competitive adsorption‐based displacement effects in monoclonal antibody aggregate removal—A new high‐throughput screening procedure for membrane chromatography

J. Hubbuch, V. Thom, D. Stein, 2021, Biotechnology and applied biochemistry.

Structured Data Storage for Data-Driven Process Optimisation in Bioprinting

J. Hubbuch, M. Selzer, B. Schmieg, 2022, Applied Sciences.

PAT concepts for chromatography: Real-time monitoring, real-time control, and cause of error diagnostics

Jürgen Hubbuch, Tobias Hahn, Nina Brestrich, 2015 .

High‐throughput micro‐scale cultivations and chromatography modeling: Powerful tools for integrated process development

Jürgen Hubbuch, Tobias Hahn, Pascal Baumann, 2015, Biotechnology and bioengineering.

Antibody fingerprints in lyme disease deciphered with high density peptide arrays

F. Breitling, J. Hubbuch, F. Loeffler, 2017, Engineering in life sciences.

An integrated precipitation and ion-exchange chromatography process for antibody manufacturing: Process development strategy and continuous chromatography exploration.

Gang Wang, Jürgen Hubbuch, G. Wang, 2018, Journal of chromatography. A.

Water on hydrophobic surfaces: mechanistic modeling of polyethylene glycol-induced protein precipitation

J. Hubbuch, Steffen Großhans, Gang Wang, 2018, Bioprocess and Biosystems Engineering.

Light extinction and scattering by agarose based resin beads and applications in high-throughput screening.

J. Hubbuch, Moritz Ebeler, Frank Hämmerling, 2015, Journal of chromatography. A.

High-throughput characterization of virus-like particles by interlaced size-exclusion chromatography.

J. Hubbuch, Christopher Ladd Effio, S. A. Oelmeier, 2016, Vaccine.

Integrated process model for the prediction of biopharmaceutical manufacturing chromatography and adjustment steps.

J. Hubbuch, Till Briskot, J. Studts, 2022, Journal of chromatography. A.

HIGH‐THROUGHPUT SCREENING AND MODELING TECHNOLOGIES FOR PROCESS DEVELOPMENT IN ANTIBODY PURIFICATION

J. Hubbuch, Tobias Hahn, Thiemo C Huuk, 2016 .

Perspectives of aerosol-photopolymerization: organic-inorganic hybrid nanoparticles

M. Wörner, J. Hubbuch, E. Akgün, 2014, Colloid and Polymer Science.

Magnetic resonance imaging as a tool for quality control in extrusion‐based bioprinting

J. Hubbuch, G. Guthausen, B. Schmieg, 2022, Biotechnology journal.

Calibration-free PAT: Locating selective crystallization or precipitation sweet spot in screenings with multi-way PARAFAC models

J. Hubbuch, C. H. Wegner, 2022, Frontiers in Bioengineering and Biotechnology.

Robust high-throughput batch screening method in 384-well format with optical in-line resin quantification.

M. Ottens, J. Hubbuch, J. Kittelmann, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Investigation of the reversibility of freeze/thaw stress-induced protein instability using heat cycling as a function of different cryoprotectants

J. Hubbuch, A. Wöll, 2020, Bioprocess and Biosystems Engineering.

Strategy for assessment of the colloidal and biological stability of H1N1 influenza A viruses.

J. Hubbuch, P. Baumann, Frank Hämmerling, 2017, International journal of pharmaceutics.

High‐throughput process development of purification alternatives for the protein avidin

J. Hubbuch, M. Hoffmann, P. Diederich, 2015, Biotechnology progress.

Next generation vaccines and vectors: Designing downstream processes for recombinant protein‐based virus‐like particles

Jürgen Hubbuch, Christopher Ladd Effio, J. Hubbuch, 2015, Biotechnology journal.

Alternative separation steps for monoclonal antibody purification: combination of centrifugal partitioning chromatography and precipitation.

Jürgen Hubbuch, Stefan A Oelmeier, J. Hubbuch, 2013, Journal of chromatography. A.

High throughput screening based selection of phases for aqueous two-phase system-centrifugal partitioning chromatography of monoclonal antibodies.

Jürgen Hubbuch, Stefan A Oelmeier, J. Hubbuch, 2012, Journal of chromatography. A.

Molecular dynamics simulations on aqueous two-phase systems - Single PEG-molecules in solution

Jürgen Hubbuch, Stefan A Oelmeier, Florian Dismer, 2012, BMC biophysics.

Perspectives of Aerosol-Photopolymerization: Nanostructured Polymeric Particles

M. Wörner, J. Hubbuch, E. Akgün, 2014 .

Thiol-Functional Polymer Nanoparticles via Aerosol Photopolymerization

M. Wörner, J. Hubbuch, I. Perner-Nochta, 2021, Polymers.

Automated image processing as an analytical tool in cell cryopreservation for bioprocess development

Jürgen Hubbuch, Sarah Gretzinger, Stefanie Limbrunner, 2019, Bioprocess and Biosystems Engineering.

Impact of additives on the formation of protein aggregates and viscosity in concentrated protein solutions.

Jürgen Hubbuch, J. Hubbuch, Katharina Christin Bauer, 2017, International journal of pharmaceutics.

Impact of polymer surface characteristics on the microrheological measurement quality of protein solutions - A tracer particle screening.

J. Hubbuch, Jonathan Seidel, Marie-Therese Schermeyer, 2016, International journal of pharmaceutics.

Mid‐UV Protein Absorption Spectra and Partial Least Squares Regression as Screening and PAT Tool

J. Hubbuch, A. Staby, S. Hansen, 2017 .

Advances in inline quantification of co‐eluting proteins in chromatography: Process‐data‐based model calibration and application towards real‐life separation issues

Jürgen Hubbuch, Axel Kraft, Joseph Bertolini, 2015, Biotechnology and bioengineering.

Photoinitiated miniemulsion polymerization in microfluidic chips on automated liquid handling stations: Proof of concept

M. Wörner, J. Hubbuch, C. P. Radtke, 2016 .

Influence of image analysis strategy, cooling rate, and sample volume on apparent protein cloud-point temperature determination

Marieke E. Klijn, J. Hubbuch, 2020, Bioprocess and Biosystems Engineering.

Moving through three‐dimensional phase diagrams of monoclonal antibodies

J. Hubbuch, Natalie Rakel, M. Baum, 2014, Biotechnology progress.

A Novel MATLAB®-Algorithm-Based Video Analysis to Quantitatively Determine Solution Creeping in Intact Pharmaceutical Glass Vials.

J. Hubbuch, K. Schindowski, Ingo Presser, 2022, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Soluble full-length expression and characterization of snRNP protein U1-68/70K.

G. Brenner-Weiss, J. Hubbuch, Carolin G. Richter, 2014, Protein expression and purification.

Process development for cross‐flow diafiltration‐based VLP disassembly: A novel high‐throughput screening approach

J. Hubbuch, Philipp Vormittag, Nils Hillebrandt, 2021, Biotechnology and bioengineering.

Manipulation of lysozyme phase behavior by additives as function of conformational stability.

Jürgen Hubbuch, J. Hubbuch, Josefine Morgenstern, 2015, International journal of pharmaceutics.

Isoform separation and binding site determination of mono-PEGylated lysozyme with pH gradient chromatography.

G. Brenner-Weiss, J. Hubbuch, Florian Dismer, 2012, Journal of chromatography. A.

Rapid quantification of protein-polyethylene glycol conjugates by multivariate evaluation of chromatographic data.

J. Hubbuch, S. Hansen, Benjamin Maiser, 2012, Journal of chromatography. A.

Downstream process development strategies for effective bioprocesses: Trends, progress, and combinatorial approaches

Jürgen Hubbuch, Pascal Baumann, J. Hubbuch, 2017, Engineering in life sciences.

Quantification of PEGylated proteases with varying degree of conjugation in mixtures: An analytical protocol combining protein precipitation and capillary gel electrophoresis.

J. Hubbuch, Josefine Morgenstern, P. Baumann, 2016, Journal of chromatography. A.

High-throughput downstream process development for cell-based products using aqueous two-phase systems.

Jürgen Hubbuch, Stefan A. Oelmeier, Sarah Zimmermann, 2016, Journal of chromatography. A.

Non‐invasive high throughput approach for protein hydrophobicity determination based on surface tension

J. Hubbuch, Sven Amrhein, Lara Galm, 2015, Biotechnology and bioengineering.

Automated and dynamic extrusion pressure adjustment based on real-time flow rate measurements for precise ink dispensing in 3D bioprinting

J. Hubbuch, L. Wenger, Svenja Strauß, 2022, Bioprinting.

Integrated bioprocesses.

Jürgen Hubbuch, Karl Schügerl, K. Schügerl, 2005, Current opinion in microbiology.

High‐throughput screening of packed‐bed chromatography coupled with SELDI‐TOF MS analysis: monoclonal antibodies versus host cell protein

Jürgen Hubbuch, J. Hubbuch, Ralf Bogumil, 2007, Biotechnology and bioengineering.

High Throughput Screening of Chromatographic Phases for Rapid Process Development

Jürgen Hubbuch, Matthias Bensch, E. von Lieres, 2005 .

Molecular dynamics simulations approach for the characterization of peptides with respect to hydrophobicity.

J. Hubbuch, Florian Dismer, Sven Amrhein, 2014, The journal of physical chemistry. B.

High‐throughput methods for miniaturization and automation of monoclonal antibody purification processes

Jürgen Hubbuch, Katrin Treier, Patrick Diederich, 2012, Biotechnology progress.

Steric exclusion chromatography of lentiviral vectors using hydrophilic cellulose membranes.

J. Hubbuch, K. Pflanz, F. Bollmann, 2022, Journal of chromatography. A.

Computational study of elements of stability of a four-helix bundle protein biosurfactant

Jürgen Hubbuch, Anton P. J. Middelberg, Natalie K. Connors, 2014, Journal of Computer-Aided Molecular Design.

A critical review of recent trends, and a future perspective of optical spectroscopy as PAT in biopharmaceutical downstream processing

Jürgen Hubbuch, Matthias Rüdt, Laura Rolinger, 2020, Analytical and Bioanalytical Chemistry.

Integrated Process for Capture and Purification of Virus-Like Particles: Enhancing Process Performance by Cross-Flow Filtration

J. Hubbuch, Philipp Vormittag, Nicolai Bluthardt, 2020, Frontiers in Bioengineering and Biotechnology.

Rational and systematic protein purification process development: the next generation.

Jürgen Hubbuch, Marcel Ottens, Beckley K Nfor, 2009, Trends in biotechnology.

Modeling the Gibbs-Donnan effect during ultrafiltration and diafiltration processes using the Poisson–Boltzmann theory in combination with a basic Stern model

J. Hubbuch, Till Briskot, J. Studts, 2022, Journal of Membrane Science.

A comprehensive molecular dynamics approach to protein retention modeling in ion exchange chromatography.

J. Hubbuch, A. Osberghaus, J. Kittelmann, 2015, Journal of chromatography. A.

Influence of structure properties on protein–protein interactions—QSAR modeling of changes in diffusion coefficients

J. Hubbuch, Frank Hämmerling, J. Kittelmann, 2017, Biotechnology and bioengineering.

Molecular dynamics simulations of aqueous two-phase systems: Understanding phase formation and protein partitioning

Jürgen Hubbuch, Florian Dismer, Stefan A. Oelmeier, 2013 .

Real‐time monitoring and control of the load phase of a protein A capture step

Jürgen Hubbuch, Matthias Rüdt, Nina Brestrich, 2016, Biotechnology and bioengineering.

Single amino acid fingerprinting of the human antibody repertoire with high density peptide arrays.

F. Breitling, S. Dübel, O. Armant, 2017, Journal of immunological methods.

Examination of a genetic algorithm for the application in high-throughput downstream process development.

Jürgen Hubbuch, Katrin Treier, Annette Berg, 2012, Biotechnology journal.

Rapid Analysis for Multicomponent High-Throughput Crystallization Screening: Combination of UV–Vis Spectroscopy and Chemometrics

J. Hubbuch, I. Zimmermann, C. H. Wegner, 2022, Crystal Growth & Design.

Apparent protein cloud point temperature determination using a low volume high-throughput cryogenic device in combination with automated imaging

Marieke E. Klijn, J. Hubbuch, A. Wöll, 2019, Bioprocess and Biosystems Engineering.

UV absorption‐based inverse modeling of protein chromatography

Jürgen Hubbuch, Vincent Heuveline, Pascal Baumann, 2016 .

Calibration‐free inverse modeling of ion‐exchange chromatography in industrial antibody purification

Jürgen Hubbuch, Vincent Heuveline, Anna Osberghaus, 2016 .

Adjoint-based estimation and optimization for column liquid chromatography models

Jürgen Hubbuch, Vincent Heuveline, Tobias Hahn, 2014, Comput. Chem. Eng..

Detection, Quantification, and Propagation of Uncertainty in High‐Throughput Experimentation by Monte Carlo Methods

Jürgen Hubbuch, M. Haindl, Anna Osberghaus, 2012 .

Multi-attribute PAT for UF/DF of Proteins—Monitoring Concentration, particle sizes, and Buffer Exchange

Jürgen Hubbuch, Matthias Rüdt, Martin Heitmann, 2020, Analytical and Bioanalytical Chemistry.

Application of ultraviolet, visible, and infrared light imaging in protein-based biopharmaceutical formulation characterization and development studies.

Marieke E. Klijn, J. Hubbuch, 2021, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Identification of a Tetanus Toxin Specific Epitope in Single Amino Acid Resolution

F. Breitling, J. Hubbuch, Martyna Sedlmayr, 2017, Biotechnology journal.

Determination of parameters for the steric mass action model--a comparison between two approaches.

E. von Lieres, J. Hubbuch, E. Lieres, 2012, Journal of chromatography. A.

Effects of ionic strength and mobile phase pH on the binding orientation of lysozyme on different ion-exchange adsorbents.

Jürgen Hubbuch, Martin Petzold, Florian Dismer, 2008, Journal of chromatography. A.

On the analysis of chromatographic biopharmaceutical data with multivariate curve resolution methods and FACPACK

K. Neymeyr, M. Sawall, J. Hubbuch, 2019 .

Exploration of fiber-based cation exchange adsorbents for the removal of monoclonal antibody aggregates.

J. Hubbuch, Johann Winderl, E. Neumann, 2021, Journal of chromatography. A.

Root cause investigation of deviations in protein chromatography based on mechanistic models and artificial neural networks.

Jürgen Hubbuch, Pascal Baumann, Till Briskot, 2017, Journal of chromatography. A.

Estimation of adsorption isotherm and mass transfer parameters in protein chromatography using artificial neural networks.

Jürgen Hubbuch, Pascal Baumann, Till Briskot, 2017, Journal of chromatography. A.

Optimizing a chromatographic three component separation: a comparison of mechanistic and empiric modeling approaches.

E. von Lieres, J. Hubbuch, E. Lieres, 2012, Journal of chromatography. A.

High Throughput Screening for the Design and Optimization of Chromatographic Processes: Automated Optimization of Chromatographic Phase Systems

Jürgen Hubbuch, Katrin Treier, E. von Lieres, 2009 .

Piezoelectric Silicon Micropump for Drug Delivery Applications

M. Richter, M. Wackerle, J. Hubbuch, 2021, Applied Sciences.

High‐throughput screening of aqueous biphasic systems with ionic liquids as additives for extraction and purification of enveloped virus‐like particles

I. Marrucho, A. S. Coroadinha, J. Hubbuch, 2019, Engineering Reports.

Characterization of highly concentrated antibody solution - A toolbox for the description of protein long-term solution stability

Jürgen Hubbuch, Marie-Therese Schermeyer, M. Eppink, 2017, mAbs.

Concentration-dependent changes in apparent diffusion coefficients as indicator for colloidal stability of protein solutions.

Jürgen Hubbuch, Marie-Therese Schermeyer, J. Hubbuch, 2016, International journal of pharmaceutics.

Microfluidic Cell Transport with Piezoelectric Micro Diaphragm Pumps

M. Richter, J. Hubbuch, Leopold Daum, 2021, Micromachines.

Analytical characterization of complex, biotechnological feedstocks by pH gradient ion exchange chromatography for purification process development.

Jürgen Hubbuch, Marcel Ottens, Beckley K Nfor, 2013, Journal of chromatography. A.

Machine-assisted cultivation and analysis of biofilms

Silla H. Hansen, Kersten S. Rabe, C. Niemeyer, 2017, bioRxiv.

Prediction uncertainty assessment of chromatography models using Bayesian inference.

Jürgen Hubbuch, Till Briskot, Stefan Hepbildikler, 2019, Journal of chromatography. A.

Application of an aqueous two‐phase systems high‐throughput screening method to evaluate mAb HCP separation

Jürgen Hubbuch, Stefan A Oelmeier, Florian Dismer, 2011, Biotechnology and bioengineering.

A high-throughput 2D-analytical technique to obtain single protein parameters from complex cell lysates for in silico process development of ion exchange chromatography.

Jürgen Hubbuch, D. Elsässer, J. Hubbuch, 2013, Journal of chromatography. A.

On-Demand Production of Flow-Reactor Cartridges by 3D Printing of Thermostable Enzymes.

Jürgen Hubbuch, Christof M Niemeyer, Kersten S Rabe, 2018, Angewandte Chemie.

Development and characterization of an automated high throughput screening method for optimization of protein refolding processes.

J. Hubbuch, Florian Dismer, J. Kittelmann, 2012, Journal of separation science.

Modeling of hydrophobic interaction chromatography for the separation of antibody-drug conjugates and its application towards quality by design.

Jürgen Hubbuch, Sebastian Andris, J. Hubbuch, 2020, Journal of biotechnology.

Process monitoring of virus‐like particle reassembly by diafiltration with UV/Vis spectroscopy and light scattering

Jürgen Hubbuch, Matthias Rüdt, J. Hubbuch, 2019, Biotechnology and bioengineering.

Evaluation of PEG/phosphate aqueous two-phase systems for the purification of the chicken egg white protein avidin by using high-throughput techniques

J. Hubbuch, Sven Amrhein, Frank Hämmerling, 2013 .

Temperature Based Process Characterization of Pharmaceutical Freeze-Thaw Operations

J. Hubbuch, Dennis Weber, 2021, Frontiers in Bioengineering and Biotechnology.

Raman spectroscopy as a process analytical technology to investigate biopharmaceutical freeze concentration processes

J. Hubbuch, Dennis Weber, 2021, Biotechnology and bioengineering.

Impact of freeze–thaw processes on monoclonal antibody platform process development

J. Hubbuch, Dennis Weber, Christian Sittig, 2021, Biotechnology and bioengineering.

Analysis of phase behavior and morphology during freeze‐thaw applications of lysozyme

Jürgen Hubbuch, J. Hubbuch, Anna Katharina Wöll, 2019, International journal of pharmaceutics.

Fourier-transform infrared spectroscopy as a process analytical technology for near real time in-line estimation of the degree of PEGylation in chromatography.

Jürgen Hubbuch, Matthias Rüdt, Adrian Sanden, 2019, Journal of chromatography. A.

Predictive approach for protein aggregation: Correlation of protein surface characteristics and conformational flexibility to protein aggregation propensity

J. Hubbuch, Lara Galm, Sven Amrhein, 2017, Biotechnology and bioengineering.

Selective protein quantification for preparative chromatography using variable pathlength UV/Vis spectroscopy and partial least squares regression

Jürgen Hubbuch, Matthias Rüdt, Nina Brestrich, 2018 .

Cationic Aerosol Photopolymerization

M. Sangermano, M. Wörner, J. Hubbuch, 2015 .

Perspectives of aerosol-photopolymerization: Nanoscale polymer particles

M. Wörner, J. Hubbuch, E. Akgün, 2013 .

Image analysis as PAT-Tool for use in extrusion-based bioprinting

Jürgen Hubbuch, Sarah Gretzinger, Svenja Strauß, 2021, Bioprinting.

Editorial: High‐throughput process development

Jürgen Hubbuch, J. Hubbuch, 2012 .

Automated Microscale High‐Throughput Screening for Chromatography Resins

J. Hubbuch, M. Bensch, T. Schroeder, 2005 .

Optimization of random PEGylation reactions by means of high throughput screening

J. Hubbuch, Florian Dismer, Benjamin Maiser, 2014, Biotechnology and bioengineering.

Effect of lysozyme solid-phase PEGylation on reaction kinetics and isoform distribution.

J. Hubbuch, Florian Dismer, K. Baumgartner, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

High throughput screening techniques in downstream processing: Preparation, characterization and optimization of aqueous two-phase systems

Jürgen Hubbuch, Matthias Bensch, Björn Selbach, 2007 .

A novel approach to characterize the binding orientation of lysozyme on ion-exchange resins.

Jürgen Hubbuch, Florian Dismer, J. Hubbuch, 2007, Journal of chromatography. A.

3D-Printable and Enzymatically Active Composite Materials Based on Hydrogel-Filled High Internal Phase Emulsions

M. Wörner, J. Hubbuch, L. Wenger, 2020, Frontiers in Bioengineering and Biotechnology.

3D bioprinting – Flow cytometry as analytical strategy for 3D cell structures

Jürgen Hubbuch, Andrew Gleadall, Sarah Gretzinger, 2018, Bioprinting.

Comparison of UV‐ and Raman‐based monitoring of the Protein A load phase and evaluation of data fusion by PLS models and CNNs

J. Hubbuch, Matthias Rüdt, Laura Rolinger, 2021, Biotechnology and bioengineering.

A multiscale modeling method for therapeutic antibodies in ion exchange chromatography

T. Schwab, J. Hubbuch, Jan-Hendrik Grosch, 2022, Biotechnology and bioengineering.

Modeling the impact of amino acid substitution in a monoclonal antibody on cation exchange chromatography

M. Blech, J. Hubbuch, J. Studts, 2021, Biotechnology and bioengineering.

A multisensor approach for improved protein A load phase monitoring by conductivity‐based background subtraction of UV spectra

Jürgen Hubbuch, Matthias Rüdt, Laura Rolinger, 2020, Biotechnology and bioengineering.

Feasibility of using continuous chromatography in downstream processing: Comparison of costs and product quality for a hybrid process vs. a conventional batch process.

Jürgen Hubbuch, Ozan Ötes, Hendrik Flato, 2017, Journal of biotechnology.

Process monitoring of virus‐like particle reassembly by diafiltration with UV/Vis spectroscopy and light scattering

J. Hubbuch, Philipp Vormittag, Matthias Rüdt, 2019, Biotechnology and bioengineering.

In silico process characterization for biopharmaceutical development following the quality by design concept

G. Wang, J. Hubbuch, J. Studts, 2021, Biotechnology progress.

Analysis of complex protein elution behavior in preparative ion exchange processes using a colloidal particle adsorption model.

G. Wang, G. Malmquist, J. Hubbuch, 2021, Journal of chromatography. A.

Protein adsorption on ion exchange adsorbers: A comparison of a stoichiometric and non-stoichiometric modeling approach.

J. Hubbuch, Till Briskot, Tobias Hahn, 2021, Journal of chromatography. A.

Straightforward method for calibration of mechanistic cation exchange chromatography models for industrial applications.

Gang Wang, Jürgen Hubbuch, David Saleh, 2020, Biotechnology progress.

A versatile noninvasive method for adsorber quantification in batch and column chromatography based on the ionic capacity

Jürgen Hubbuch, Till Briskot, J. Hubbuch, 2016, Biotechnology progress.

Simulating and Optimizing Preparative Protein Chromatography with ChromX

Jürgen Hubbuch, Vincent Heuveline, Thiemo Huuk, 2015 .

Standardized method for mechanistic modeling of multimodal anion exchange chromatography in flow through operation.

T. Schwab, J. Hubbuch, Jan-Hendrik Grosch, 2023, Journal of chromatography. A.

Modeling of complex antibody elution behavior under high protein load densities in ion exchange chromatography using an asymmetric activity coefficient.

Jürgen Hubbuch, Stefan Hepbildikler, J. Hubbuch, 2017, Biotechnology journal.

Model-based integrated optimization and evaluation of a multi-step ion exchange chromatography

Jürgen Hubbuch, Tobias Hahn, Anna Osberghaus, 2014 .

Monitoring of ultra- and diafiltration processes by Kalman-filtered Raman measurements

J. Hubbuch, Matthias Rüdt, Laura Rolinger, 2023, Analytical and Bioanalytical Chemistry.

High throughput screening of fiber-based adsorbents for material and process development.

J. Hubbuch, Johann Winderl, Stephan Bürkle, 2021, Journal of Chromatography A.

Modeling of biopharmaceutical UF/DF from laboratory to manufacturing scale

J. Hubbuch, Till Briskot, J. Studts, 2023, Comput. Chem. Eng..

High-throughput downstream process development for cell-based products using aqueous two-phase systems (ATPS) - A case study.

Jürgen Hubbuch, Sarah Zimmermann, Christian Scheeder, 2017, Biotechnology journal.

Rapid quantification of protein-polyethylene glycol conjugates by multivariate evaluation of chromatographic data.

J. Hubbuch, S. Hansen, Benjamin Maiser, 2012, Journal of chromatography. A.

Downstream processing of virus-like particles: single-stage and multi-stage aqueous two-phase extraction.

J. Hubbuch, L. Wenger, R. Kneusel, 2015, Journal of chromatography. A.

Analytics in Extrusion-Based Bioprinting: Standardized Methods Improving Quantification and Comparability of the Performance of Bioinks

J. Hubbuch, Svenja Strauß, David Grijalva Garces, 2023, Polymers.

Mechanical Properties of Protein-Based Hydrogels Derived from Binary Protein Mixtures—A Feasibility Study

J. Hubbuch, S. Haas, 2023, Polymers.

Connected mechanistic process modeling to predict a commercial biopharmaceutical downstream process

J. Hubbuch, Till Briskot, J. Studts, 2023, Computers and Chemical Engineering.

Standardized method for mechanistic modeling of multimodal anion exchange chromatography in flow through operation.

T. Schwab, J. Hubbuch, Jan-Hendrik Grosch, 2023, Journal of chromatography. A.

High Throughput Screening for the Design and Optimization of Chromatographic Processes - Miniaturization, Automation and Parallelization of Breakthrough and Elution Studies

Jürgen Hubbuch, Jens Nielsen, Matthias Wiendahl, 2008 .

Model-integrated process development demonstrated on the optimization of a robotic cation exchange step

Jürgen Hubbuch, M. Haindl, Anna Osberghaus, 2012 .

High Throughput Screening for the Design and Optimization of Chromatographic Processes: Assessment of Model Parameter Determination from High Throughput Compatible Data

Jürgen Hubbuch, E. von Lieres, A. Susanto, 2008 .

An adaptive soft‐sensor for advanced real‐time monitoring of an antibody‐drug conjugation reaction

J. Hubbuch, R. Schiemer, Jan Tobias Weggen, 2023, Biotechnology and bioengineering.

High throughput screening setup of a scale‐down device for membrane chromatography‐aggregate removal of monoclonal antibodies

Jürgen Hubbuch, Volkmar Thom, Dominik Stein, 2020, Biotechnology progress.

Custom-tailored adsorbers: A molecular dynamics study on optimal design of ion exchange chromatography material.

J. Hubbuch, J. Kittelmann, Katharina M H Lang, 2015, Journal of chromatography. A.

Optimization of random PEGylation reactions by means of high throughput screening

J. Hubbuch, Florian Dismer, Benjamin Maiser, 2014, Biotechnology and bioengineering.

A novel method to evaluate protein solubility using a high throughput screening approach

Jürgen Hubbuch, Stephan Scholl, Matthias Wiendahl, 2009 .

Generative data augmentation and automated optimization of convolutional neural networks for process monitoring

J. Hubbuch, Matthias Rüdt, R. Schiemer, 2024, Frontiers in Bioengineering and Biotechnology.

A label‐free methodology for selective protein quantification by means of absorption measurements

Jürgen Hubbuch, Sigrid K Hansen, Arne Staby, 2011, Biotechnology and bioengineering.

On the reproducibility of extrusion-based bioprinting: round robin study on standardization in the field

L. Meinel, M. Gelinsky, T. Ahlfeld, 2023, Biofabrication.

Kinetic studies and CFD-based reaction modeling for insights into the scalability of ADC conjugation reactions

Richard Bean, M. Wendeler, J. Hubbuch, 2023, Frontiers in Bioengineering and Biotechnology.

Estimation of adsorption isotherm and mass transfer parameters in protein chromatography using artificial neural networks.

J. Hubbuch, Till Briskot, Tobias Hahn, 2017, Journal of chromatography. A.

An integrated precipitation and ion-exchange chromatography process for antibody manufacturing: Process development strategy and continuous chromatography exploration.

G. Wang, J. Hubbuch, Steffen Großhans, 2018, Journal of chromatography. A.