E. Nuti

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Discovery of a new selective inhibitor of A Disintegrin And Metalloprotease 10 (ADAM-10) able to reduce the shedding of NKG2D ligands in Hodgkin's lymphoma cell models.

Armando Rossello, Tiziano Tuccinardi, Elisa Nuti, 2016, European journal of medicinal chemistry.

N-O-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in Vivo Antiangiogenic Activity.

Armando Rossello, Tiziano Tuccinardi, Adriano Martinelli, 2015, Journal of medicinal chemistry.

Matrix metalloproteinase inhibitors: new challenges in the era of post broad-spectrum inhibitors.

T. Tuccinardi, E. Nuti, A. Rossello, 2007, Current pharmaceutical design.

Targeting ADAM17 Sheddase Activity in Cancer.

S. Ferrini, E. Nuti, A. Rossello, 2016, Current drug targets.

N-O-isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis.

E. Novellino, Valeria La Pietra, L. Marinelli, 2009, Journal of medicinal chemistry.

Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhibitors.

Armando Rossello, Tiziano Tuccinardi, Adriano Martinelli, 2009, Journal of medicinal chemistry.

Ionic liquid-promoted green synthesis of biologically relevant diaryl thioethers

E. Nuti, A. Rossello, C. Chiappe, 2020 .

Synthesis and preliminary evaluation in tumor bearing mice of new (18)F-labeled arylsulfone matrix metalloproteinase inhibitors as tracers for positron emission tomography.

L. Tei, A. Maiocchi, A. Quattrini, 2013, Journal of medicinal chemistry.

Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: synthesis and biological evaluation.

E. Novellino, F. Da Settimo, S. Taliani, 2013, European journal of medicinal chemistry.

Immobilization of matrix metalloproteinase 8 (MMP-8) for online drug screening.

E. Nuti, A. Rossello, A. Petri, 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors.

E. Novellino, F. Da Settimo, C. Martini, 2011, European journal of medicinal chemistry.

Discovery of 1,1'-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors.

C. Supuran, A. Coluccia, D. Vullo, 2015, Journal of medicinal chemistry.

Synthesis and in vitro Evaluation of ADAM10 and ADAM17 Highly Selective Bioimaging Probes

Caterina Camodeca, E. Nuti, A. Poggi, 2018, ChemMedChem.

Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with sulfonylated hydroxamates.

C. Supuran, A. Scozzafava, A. Innocenti, 2007, Bioorganic & medicinal chemistry.

Vascular ADAM17 as a Novel Therapeutic Target in Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin II

H. Kwok, S. Eguchi, E. Nuti, 2016, Hypertension.

Development of a fluorogenic ADAMTS-7 substrate

A. Snijders, Steven A. Howell, T. Tuccinardi, 2021, Journal of enzyme inhibition and medicinal chemistry.

Inhibitors of ADAM10 reduce Hodgkin lymphoma cell growth in 3D microenvironments and enhance brentuximab-vedotin effect

M. Gobbi, Roberta Pece, Caterina Camodeca, 2021, Haematologica.

ADAM10 new selective inhibitors reduce NKG2D ligand release sensitizing Hodgkin lymphoma cells to NKG2D-mediated killing

Caterina Camodeca, E. Nuti, A. Poggi, 2015, Oncoimmunology.

The metalloproteinase ADAM10 requires its activity to sustain surface expression

M. Tomlinson, E. Nuti, A. Rossello, 2020, Cellular and Molecular Life Sciences.

Exosite inhibition of ADAMTS-5 by a glycoconjugated arylsulfonamide

T. Tuccinardi, L. Ciccone, E. Nuti, 2021, Scientific reports.

Exosite inhibition of A Disintegrin And Metalloproteinase with Thrombospondin motif (ADAMTS)-5 by a glycoconjugated arylsulfonamide

T. Tuccinardi, L. Ciccone, E. Nuti, 2020, bioRxiv.

Targeting Aggrecanases for Osteoarthritis Therapy: From Zinc Chelation to Exosite Inhibition

L. Ciccone, E. Nuti, A. Rossello, 2022, Journal of medicinal chemistry.

A new D₂ dopamine receptor agonist allosterically modulates A(2A) adenosine receptor signalling by interacting with the A(2A)/D₂ receptor heteromer.

M. Trincavelli, C. Martini, C. Lluis, 2012, Cellular signalling.

Inhibition of matrix degrading enzymes and invasion in rat glioblastoma (C6) Cells

C. Martini, E. Nuti, A. Rossello, 2009 .

Hepatitis C virus-induced NK cell activation causes metzincin-mediated CD16 cleavage and impaired antibody-dependent cytotoxicity.

S. Ludovisi, M. Mondelli, E. Nuti, 2017, Journal of hepatology.

The metalloproteinase ADAM10 requires its activity to sustain surface expression

M. Tomlinson, E. Nuti, A. Rossello, 2020, Cellular and Molecular Life Sciences.

Inhibition of metalloproteinases derived from tumours: new insights in the treatment of human glioblastoma

E. Novellino, C. Martini, E. Orlandini, 2010, Neuroscience.

Identification of a Novel p53 Modulator Endowed with Antitumoural and Antibacterial Activity through a Scaffold Repurposing Approach

C. Martini, A. Carotenuto, Valeria La Pietra, 2022, Pharmaceuticals.

New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2).

A. Albini, S. Rapposelli, E. Orlandini, 2004, Bioorganic & medicinal chemistry.

New bifunctional metalloproteinase inhibitors: an integrated approach towards biological improvements and cancer therapy.

E. Nuti, A. Rossello, S. Marques, 2013, Journal of Inorganic Biochemistry.

Synthesis and antimicrobial activity of new 7 beta-(benzo[a]dihydrocarbazolyloxyacetyl)-substituted cephalosporins.

S. Rapposelli, E. Orlandini, E. Nuti, 2004, Il Farmaco.

Synthesis and Antimicrobial Activity of New 7β-(Benzo[a]dihydrocarbazolyloxyacetyl)-Substituted Cephalosporins.

S. Rapposelli, E. Orlandini, E. Nuti, 2005 .

Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: a first round of lead optimization.

E. Novellino, F. Da Settimo, S. Taliani, 2012, European journal of medicinal chemistry.

Structural insights on carbonic anhydrase inhibitory action, isoform selectivity, and potency of sulfonamides and coumarins incorporating arylsulfonylureido groups.

C. Supuran, A. Scozzafava, E. Masini, 2014, Journal of medicinal chemistry.

Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies.

C. Supuran, A. Scozzafava, M. Ferraroni, 2014, Bioorganic & medicinal chemistry.

Methotrexate γ-hydroxamate derivatives as potential dual target antitumor drugs

S. Krupenko, E. Nuti, A. Rossello, 2007 .

Synthesis and cycloxygenase inhibitory properties of new naphthalene-methylsulfonamido, naphthalene-methylsulfonyl and tetrahydronaphthalen-methylsulfonamido compounds

S. Nencetti, L. Ciccone, E. Orlandini, 2015, Journal of enzyme inhibition and medicinal chemistry.

Synthesis, SAR, and Biological Evaluation of α‐Sulfonylphosphonic Acids as Selective Matrix Metalloproteinase Inhibitors

Cristina Campestre, Mariangela Agamennone, E. Nuti, 2009, ChemMedChem.

An overview of carbohydrate-based carbonic anhydrase inhibitors

E. Nuti, A. Rossello, Doretta Cuffaro, 2020, Journal of enzyme inhibition and medicinal chemistry.

Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibit α- and β-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms.

F. Da Settimo, S. Taliani, C. La Motta, 2012, Journal of medicinal chemistry.

Developments in Carbohydrate-Based Metzincin Inhibitors

E. Nuti, A. Rossello, F. D’Andrea, 2020, Pharmaceuticals.

alpha-Biphenylsulfonylamino 2-methylpropyl phosphonates: enantioselective synthesis and selective inhibition of MMPs.

Cristina Campestre, Mariangela Agamennone, E. Nuti, 2007, Bioorganic & medicinal chemistry.

Design and Synthesis of Ionic Liquid‐Based Matrix Metalloproteinase Inhibitors (MMPIs): A Simple Approach to Increase Hydrophilicity and to Develop MMPI‐Coated Gold Nanoparticles

V. Cappello, M. Gemmi, S. Nencetti, 2019, ChemMedChem.

Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamides.

Armando Rossello, Tiziano Tuccinardi, Adriano Martinelli, 2006, Bioorganic & medicinal chemistry.

N-i-Propoxy-N-biphenylsulfonylaminobutylhydroxamic acids as potent and selective inhibitors of MMP-2 and MT1-MMP.

Armando Rossello, Marco Macchia, Federica Balzano, 2005, Bioorganic & medicinal chemistry letters.

Synthesis and antiangiogenic activity study of new hop chalcone Xanthohumol analogues.

Armando Rossello, Elisabetta Orlandini, Elisa Nuti, 2017, European journal of medicinal chemistry.

MMP‐8 Is Critical for Dexamethasone Therapy in Alkali‐Burned Corneas Under Dry Eye Conditions

Changjun Wang, Caterina Camodeca, E. Nuti, 2016, Journal of cellular physiology.

G. Vozzi, S. Nencetti, E. Orlandini, 2019, Current drug targets.

Sugar‐Based Arylsulfonamide Carboxylates as Selective and Water‐Soluble Matrix Metalloproteinase‐12 Inhibitors

Armando Rossello, Marina Fabbi, Lidia Ciccone, 2016, ChemMedChem.

Strategies to Target ADAM17 in Disease: From Its Discovery to the iRhom Revolution

E. Nuti, A. Rossello, S. D. Scilabra, 2021, Molecules.

Activation of carbonic anhydrases from human brain by amino alcohol oxime ethers: towards human carbonic anhydrase VII selective activators

C. Supuran, S. Nencetti, L. Ciccone, 2020, Journal of enzyme inhibition and medicinal chemistry.

Dual inhibitors of matrix metalloproteinases and carbonic anhydrases: iminodiacetyl-based hydroxamate-benzenesulfonamide conjugates.

C. Supuran, T. Tuccinardi, A. Martinelli, 2008, Journal of medicinal chemistry.

Identification of histone deacetylase inhibitors with (arylidene)aminoxy scaffold active in uveal melanoma cell lines

G. Marshall, F. Ballante, S. Nencetti, 2020, Journal of enzyme inhibition and medicinal chemistry.

Metalloprotease inhibitor profiles of human ADAM8 in vitro and in cell-based assays

T. Tuccinardi, E. Nuti, A. Rossello, 2019, Biological chemistry.

Identification of Broad-Spectrum MMP Inhibitors by Virtual Screening

M. Mulero, S. Garcia-Vallvé, G. Pujadas, 2021, Molecules.

Kinetic characterization of 4,4′-biphenylsulfonamides as selective non-zinc binding MMP inhibitors

C. Supuran, R. Silvestri, G. La Regina, 2015, Journal of enzyme inhibition and medicinal chemistry.

Novel folate-hydroxamate based antimetabolites: synthesis and biological evaluation.

S. Krupenko, T. Tuccinardi, A. Martinelli, 2011, Medicinal chemistry (Shariqah (United Arab Emirates)).

Monoaryl derivatives as transthyretin fibril formation inhibitors: Design, synthesis, biological evaluation and structural analysis.

W. Shepard, S. Nencetti, L. Ciccone, 2020, Bioorganic & medicinal chemistry.

ADAM metalloproteinases as potential drug targets.

Caterina Camodeca, E. Nuti, A. Rossello, 2019, Current medicinal chemistry.

Specific ADAM10 inhibitors localize in exosome-like vesicles released by Hodgkin lymphoma and stromal cells and prevent sheddase activity carried to bystander cells

Caterina Camodeca, E. Nuti, A. Poggi, 2017, Oncoimmunology.

Crystallization of bi-functional ligand protein complexes.

Armando Rossello, Elisa Nuti, E. Stura, 2013, Journal of structural biology.

Matrix metalloproteinase-12 inhibitors: synthesis, structure-activity relationships and intestinal absorption of novel sugar-based biphenylsulfonamide carboxylates.

E. Orlandini, Caterina Camodeca, E. Nuti, 2018, Bioorganic & medicinal chemistry.

Bivalent Inhibitor with Selectivity for Trimeric MMP-9 Amplifies Neutrophil Chemotaxis and Enables Functional Studies on MMP-9 Proteoforms

G. Opdenakker, Caterina Camodeca, E. Nuti, 2020, Cells.

Design, synthesis and biological evaluation of bifunctional inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP).

N. Ito, Y. Itoh, T. Tuccinardi, 2019, Bioorganic & medicinal chemistry.

Development of a receptor-based 3D-QSAR study for the analysis of MMP2, MMP3, and MMP9 inhibitors.

T. Tuccinardi, A. Martinelli, E. Nuti, 2008, Bioorganic & medicinal chemistry.

Peptidyl 3-substituted 1-hydroxyureas as isosteric analogues of succinylhydroxamate MMP inhibitors.

Cristina Campestre, Mariangela Agamennone, E. Nuti, 2008, European journal of medicinal chemistry.

Analysis of Human Carbonic Anhydrase II: Docking Reliability and Receptor-Based 3D-QSAR Study

Claudiu T. Supuran, Armando Rossello, Tiziano Tuccinardi, 2007, J. Chem. Inf. Model..

Selective arylsulfonamide inhibitors of ADAM-17: hit optimization and activity in ovarian cancer cell models.

E. Novellino, S. Ferrini, Valeria La Pietra, 2013, Journal of medicinal chemistry.

Matrix metalloproteinase inhibitors prevent the release and proteolytic activity of monocyte/macrophage-derived microparticles

S. Fogli, Caterina Camodeca, E. Nuti, 2019, Pharmacological reports : PR.

Synthesis, experimental evaluation and molecular modelling of hydroxamate derivatives as zinc metalloproteinase inhibitors.

I. Sylte, Stian Sjøli, O. A. Adekoya, 2016, European journal of medicinal chemistry.

In Vivo Imaging of Matrix Metalloproteinase 12 and Matrix Metalloproteinase 13 Activities in the Mouse Model of Collagen‐Induced Arthritis

V. Dive, M. Meldal, George Bou-Gharios, 2014, Arthritis & rheumatology.

N-O-isopropyl sulfonamido-based hydroxamates: kinetic characterisation of a series of MMP-12/MMP-13 dual target inhibitors.

E. Novellino, Valeria La Pietra, L. Marinelli, 2012, Biochemical pharmacology.

Novel 1-hydroxypiperazine-2,6-diones as new leads in the inhibition of metalloproteinases.

Armando Rossello, Tiziano Tuccinardi, Adriano Martinelli, 2011, Journal of medicinal chemistry.

N-(Aroyl)-N-(arylmethyloxy)-α-alanines: Selective inhibitors of aldose reductase.

C. La Motta, S. Sartini, S. Nencetti, 2017, Bioorganic & medicinal chemistry.

Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, NMR, and Crystallographic Studies.

E. Stura, L. Vera, V. Dive, 2018, Journal of medicinal chemistry.

Bacterial Zinc Metalloenzyme Inhibitors: Recent Advances and Future Perspectives

E. Nuti, A. Rossello, Riccardo Di Leo, 2023, Molecules.

New isoxazolidinyl-based N-alkylethanolamines as new activators of human brain carbonic anhydrases

C. Supuran, L. Ciccone, E. Nuti, 2023, Journal of enzyme inhibition and medicinal chemistry.

Identification of N-Acyl Hydrazones as New Non-Zinc-Binding MMP-13 Inhibitors by Structure-Based Virtual Screening Studies and Chemical Optimization

G. Pujadas, S. Nencetti, E. Nuti, 2023, International journal of molecular sciences.

A new development of matrix metalloproteinase inhibitors: twin hydroxamic acids as potent inhibitors of MMPs.

S. Rapposelli, T. Tuccinardi, E. Orlandini, 2005, Bioorganic & medicinal chemistry letters.

Inhibition of pseudolysin and thermolysin by hydroxamate-based MMP inhibitors.

I. Sylte, Stian Sjøli, O. A. Adekoya, 2015, European journal of medicinal chemistry.

Bifunctional Inhibitors as a New Tool To Reduce Cancer Cell Invasion by Impairing MMP-9 Homodimerization.

C. Martini, E. Stura, L. Vera, 2017, ACS medicinal chemistry letters.

Amino Acid Derivatives as New Zinc Binding Groups for the Design of Selective Matrix Metalloproteinase Inhibitors

E. Novellino, A. Di Pizio, A. Bertamino, 2013, Journal of amino acids.

Potent arylsulfonamide inhibitors of tumor necrosis factor-alpha converting enzyme able to reduce activated leukocyte cell adhesion molecule shedding in cancer cell models.

E. Novellino, S. Ferrini, V. Limongelli, 2010, Journal of medicinal chemistry.

F. Da Settimo, S. Taliani, C. La Motta, 2012, Journal of medicinal chemistry.